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PubMed code 21128592

Compile data set for download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335112
PNG
(3-Benzyl-4-methyl-1-(beta-D-xylopyranosyl)-1H-indo...)
Show SMILES Cc1cccc2n(cc(Cc3ccccc3)c12)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C21H23NO4/c1-13-6-5-9-16-18(13)15(10-14-7-3-2-4-8-14)11-22(16)21-20(25)19(24)17(23)12-26-21/h2-9,11,17,19-21,23-25H,10,12H2,1H3/t17-,19+,20-,21-/s2
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n/an/an/an/a 1.09E+3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50335145
PNG
(4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyr...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1/C23H24ClNO4/c24-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-25(18)23-22(28)21(27)19(26)12-29-23/h1-7,11,15,19,21-23,26-28H,8-10,12H2/t19-,21+,22-,23-/s2
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n/an/an/an/a 209n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335118
PNG
(3-Benzyl-6-fluoro-1-(beta-D-xylopyranosyl)-1H-indo...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccccc2)c2ccc(F)cc12
Show InChI InChI=1/C20H20FNO4/c21-14-6-7-15-13(8-12-4-2-1-3-5-12)10-22(16(15)9-14)20-19(25)18(24)17(23)11-26-20/h1-7,9-10,17-20,23-25H,8,11H2/t17-,18+,19-,20-/s2
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n/an/an/an/a 2.36E+4n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335128
PNG
(3-Benzyl-6-chloro-5-fluoro-1-(beta-D-xylopyranosyl...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccccc2)c2cc(F)c(Cl)cc12
Show InChI InChI=1/C20H19ClFNO4/c21-14-8-16-13(7-15(14)22)12(6-11-4-2-1-3-5-11)9-23(16)20-19(26)18(25)17(24)10-27-20/h1-5,7-9,17-20,24-26H,6,10H2/t17-,18+,19-,20-/s2
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n/an/an/an/a 8.60E+3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335131
PNG
(4-Chloro-3-(4-methoxybenzyl)-1-(beta-D-xylopyranos...)
Show SMILES COc1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)cc1
Show InChI InChI=1/C21H22ClNO5/c1-27-14-7-5-12(6-8-14)9-13-10-23(16-4-2-3-15(22)18(13)16)21-20(26)19(25)17(24)11-28-21/h2-8,10,17,19-21,24-26H,9,11H2,1H3/t17-,19+,20-,21-/s2
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n/an/an/an/a 275n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335133
PNG
(4-Chloro-3-(4-fluorobenzyl)-1-(beta-D-xylopyranosy...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(F)cc2)c2c(Cl)cccc12
Show InChI InChI=1/C20H19ClFNO4/c21-14-2-1-3-15-17(14)12(8-11-4-6-13(22)7-5-11)9-23(15)20-19(26)18(25)16(24)10-27-20/h1-7,9,16,18-20,24-26H,8,10H2/t16-,18+,19-,20-/s2
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n/an/an/an/a 1.38E+3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335144
PNG
(4-Chloro-3-[4-(N,N-dimethylamino)benzyl]-1-(beta-D...)
Show SMILES CN(C)c1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)cc1
Show InChI InChI=1/C22H25ClN2O4/c1-24(2)15-8-6-13(7-9-15)10-14-11-25(17-5-3-4-16(23)19(14)17)22-21(28)20(27)18(26)12-29-22/h3-9,11,18,20-22,26-28H,10,12H2,1-2H3/t18-,20+,21-,22-/s2
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n/an/an/an/a 297n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50335139
PNG
(4-Chloro-3-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc3OCCOc3c2)c2c(Cl)cccc12
Show InChI InChI=1/C22H22ClNO6/c23-14-2-1-3-15-19(14)13(8-12-4-5-17-18(9-12)29-7-6-28-17)10-24(15)22-21(27)20(26)16(25)11-30-22/h1-5,9-10,16,20-22,25-27H,6-8,11H2/t16-,20+,21-,22-/s2
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n/an/an/an/a 306n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335111
PNG
(3-Benzyl-1-(beta-D-xylopyranosyl)-1H-indole | CHEM...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccccc2)c2ccccc12
Show InChI InChI=1/C20H21NO4/c22-17-12-25-20(19(24)18(17)23)21-11-14(10-13-6-2-1-3-7-13)15-8-4-5-9-16(15)21/h1-9,11,17-20,22-24H,10,12H2/t17-,18+,19-,20-/s2
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n/an/an/an/a 7.13E+3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335116
PNG
(3-Benzyl-4-fluoro-1-(beta-D-xylopyranosyl)-1H-indo...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccccc2)c2c(F)cccc12
Show InChI InChI=1/C20H20FNO4/c21-14-7-4-8-15-17(14)13(9-12-5-2-1-3-6-12)10-22(15)20-19(25)18(24)16(23)11-26-20/h1-8,10,16,18-20,23-25H,9,11H2/t16-,18+,19-,20-/s2
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n/an/an/an/a 2.24E+3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335119
PNG
(3-Benzyl-7-fluoro-1-(beta-D-xylopyranosyl)-1H-indo...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccccc2)c2cccc(F)c12
Show InChI InChI=1/C20H20FNO4/c21-15-8-4-7-14-13(9-12-5-2-1-3-6-12)10-22(17(14)15)20-19(25)18(24)16(23)11-26-20/h1-8,10,16,18-20,23-25H,9,11H2/t16-,18+,19-,20-/s2
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n/an/an/an/a 9.82E+3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335122
PNG
(3-Benzyl-6-chloro-1-(beta-D-xylopyranosyl)-1H-indo...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccccc2)c2ccc(Cl)cc12
Show InChI InChI=1/C20H20ClNO4/c21-14-6-7-15-13(8-12-4-2-1-3-5-12)10-22(16(15)9-14)20-19(25)18(24)17(23)11-26-20/h1-7,9-10,17-20,23-25H,8,11H2/t17-,18+,19-,20-/s2
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n/an/an/an/a 1.03E+4n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335124
PNG
(3-Benzyl-4-bromo-1-(beta-D-xylopyranosyl)-1H-indol...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccccc2)c2c(Br)cccc12
Show InChI InChI=1/C20H20BrNO4/c21-14-7-4-8-15-17(14)13(9-12-5-2-1-3-6-12)10-22(15)20-19(25)18(24)16(23)11-26-20/h1-8,10,16,18-20,23-25H,9,11H2/t16-,18+,19-,20-/s2
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n/an/an/an/a 923n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335147
PNG
(4-Chloro-3-[4-(2-phenoxyethoxy)benzyl]-1-(beta-D-x...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(OCCOc3ccccc3)cc2)c2c(Cl)cccc12
Show InChI InChI=1/C28H28ClNO6/c29-22-7-4-8-23-25(22)19(16-30(23)28-27(33)26(32)24(31)17-36-28)15-18-9-11-21(12-10-18)35-14-13-34-20-5-2-1-3-6-20/h1-12,16,24,26-28,31-33H,13-15,17H2/t24-,26+,27-,28-/s2
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n/an/an/an/a 1.33E+3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50335146
PNG
(4-Chloro-3-(4-hydroxybenzyl)-1-(beta-D-xylopyranos...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(O)cc2)c2c(Cl)cccc12
Show InChI InChI=1/C20H20ClNO5/c21-14-2-1-3-15-17(14)12(8-11-4-6-13(23)7-5-11)9-22(15)20-19(26)18(25)16(24)10-27-20/h1-7,9,16,18-20,23-26H,8,10H2/t16-,18+,19-,20-/s2
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n/an/an/an/a 234n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 429n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335138
PNG
(3-(1,3-Benzodioxol-5-ylmethyl)-4-chloro-1-(beta-D-...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc3OCOc3c2)c2c(Cl)cccc12
Show InChI InChI=1/C21H20ClNO6/c22-13-2-1-3-14-18(13)12(6-11-4-5-16-17(7-11)29-10-28-16)8-23(14)21-20(26)19(25)15(24)9-27-21/h1-5,7-8,15,19-21,24-26H,6,9-10H2/t15-,19+,20-,21-/s2
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n/an/an/an/a 863n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335141
PNG
(4-Chloro-3-(4-n-propylbenzyl)-1-(beta-D-xylopyrano...)
Show SMILES CCCc1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)cc1
Show InChI InChI=1/C23H26ClNO4/c1-2-4-14-7-9-15(10-8-14)11-16-12-25(18-6-3-5-17(24)20(16)18)23-22(28)21(27)19(26)13-29-23/h3,5-10,12,19,21-23,26-28H,2,4,11,13H2,1H3/t19-,21+,22-,23-/s2
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n/an/an/an/a 1.41E+3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335117
PNG
(3-Benzyl-5-fluoro-1-(beta-D-xylopyranosyl)-1H-indo...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccccc2)c2cc(F)ccc12
Show InChI InChI=1/C20H20FNO4/c21-14-6-7-16-15(9-14)13(8-12-4-2-1-3-5-12)10-22(16)20-19(25)18(24)17(23)11-26-20/h1-7,9-10,17-20,23-25H,8,11H2/t17-,18+,19-,20-/s2
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n/an/an/an/a 1.24E+4n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335123
PNG
(3-Benzyl-7-chloro-1-(beta-D-xylopyranosyl)-1H-indo...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccccc2)c2cccc(Cl)c12
Show InChI InChI=1/C20H20ClNO4/c21-15-8-4-7-14-13(9-12-5-2-1-3-6-12)10-22(17(14)15)20-19(25)18(24)16(23)11-26-20/h1-8,10,16,18-20,23-25H,9,11H2/t16-,18+,19-,20-/s2
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n/an/an/an/a 1.07E+4n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335134
PNG
(4-Chloro-3-(2,4-dimethoxybenzyl)-1-(beta-D-xylopyr...)
Show SMILES COc1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)c(OC)c1
Show InChI InChI=1/C22H24ClNO6/c1-28-14-7-6-12(18(9-14)29-2)8-13-10-24(16-5-3-4-15(23)19(13)16)22-21(27)20(26)17(25)11-30-22/h3-7,9-10,17,20-22,25-27H,8,11H2,1-2H3/t17-,20+,21-,22-/s2
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n/an/an/an/a 3.09E+4n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335135
PNG
(4-Chloro-3-(3-fluoro-4-methoxybenzyl)-1-(beta-D-xy...)
Show SMILES COc1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)cc1F
Show InChI InChI=1/C21H21ClFNO5/c1-28-17-6-5-11(8-14(17)23)7-12-9-24(15-4-2-3-13(22)18(12)15)21-20(27)19(26)16(25)10-29-21/h2-6,8-9,16,19-21,25-27H,7,10H2,1H3/t16-,19+,20-,21-/s2
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n/an/an/an/a 473n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335136
PNG
(4-Chloro-3-(2-thienylmethyl)-1-(beta-D-xylopyranos...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2cccs2)c2c(Cl)cccc12
Show InChI InChI=1/C18H18ClNO4S/c19-12-4-1-5-13-15(12)10(7-11-3-2-6-25-11)8-20(13)18-17(23)16(22)14(21)9-24-18/h1-6,8,14,16-18,21-23H,7,9H2/t14-,16+,17-,18-/s2
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n/an/an/an/a 1.68E+3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335137
PNG
(4-Chloro-3-(6-methoxy-2-naphthylmethyl)-1-(beta-D-...)
Show SMILES COc1ccc2cc(Cc3cn([C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)c4cccc(Cl)c34)ccc2c1
Show InChI InChI=1/C25H24ClNO5/c1-31-18-8-7-15-9-14(5-6-16(15)11-18)10-17-12-27(20-4-2-3-19(26)22(17)20)25-24(30)23(29)21(28)13-32-25/h2-9,11-12,21,23-25,28-30H,10,13H2,1H3/t21-,23+,24-,25-/s2
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n/an/an/an/a 633n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335143
PNG
(4-Chloro-3-[4-(methylsulfanyl)benzyl]-1-(beta-D-xy...)
Show SMILES CSc1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)cc1
Show InChI InChI=1/C21H22ClNO4S/c1-28-14-7-5-12(6-8-14)9-13-10-23(16-4-2-3-15(22)18(13)16)21-20(26)19(25)17(24)11-27-21/h2-8,10,17,19-21,24-26H,9,11H2,1H3/t17-,19+,20-,21-/s2
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n/an/an/an/a 426n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335146
PNG
(4-Chloro-3-(4-hydroxybenzyl)-1-(beta-D-xylopyranos...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(O)cc2)c2c(Cl)cccc12
Show InChI InChI=1/C20H20ClNO5/c21-14-2-1-3-15-17(14)12(8-11-4-6-13(23)7-5-11)9-22(15)20-19(26)18(25)16(24)10-27-20/h1-7,9,16,18-20,23-26H,8,10H2/t16-,18+,19-,20-/s2
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n/an/an/an/a 255n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335115
PNG
(3-Benzyl-7-methyl-1-(beta-D-xylopyranosyl)-1H-indo...)
Show SMILES Cc1cccc2c(Cc3ccccc3)cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c12
Show InChI InChI=1/C21H23NO4/c1-13-6-5-9-16-15(10-14-7-3-2-4-8-14)11-22(18(13)16)21-20(25)19(24)17(23)12-26-21/h2-9,11,17,19-21,23-25H,10,12H2,1H3/t17-,19+,20-,21-/s2
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n/an/an/an/a 1.30E+4n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335121
PNG
(3-Benzyl-5-chloro-1-(beta-D-xylopyranosyl)-1H-indo...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1/C20H20ClNO4/c21-14-6-7-16-15(9-14)13(8-12-4-2-1-3-5-12)10-22(16)20-19(25)18(24)17(23)11-26-20/h1-7,9-10,17-20,23-25H,8,11H2/t17-,18+,19-,20-/s2
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n/an/an/an/a 2.82E+4n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335129
PNG
(4-Chloro-3-(2-methoxybenzyl)-1-(beta-D-xylopyranos...)
Show SMILES COc1ccccc1Cc1cn([C@@H]2OC[C@@H](O)[C@H](O)[C@H]2O)c2cccc(Cl)c12
Show InChI InChI=1/C21H22ClNO5/c1-27-17-8-3-2-5-12(17)9-13-10-23(15-7-4-6-14(22)18(13)15)21-20(26)19(25)16(24)11-28-21/h2-8,10,16,19-21,24-26H,9,11H2,1H3/t16-,19+,20-,21-/s2
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n/an/an/an/a 1.29E+4n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335132
PNG
(4-Chloro-3-(3-fluorobenzyl)-1-(beta-D-xylopyranosy...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2cccc(F)c2)c2c(Cl)cccc12
Show InChI InChI=1/C20H19ClFNO4/c21-14-5-2-6-15-17(14)12(7-11-3-1-4-13(22)8-11)9-23(15)20-19(26)18(25)16(24)10-27-20/h1-6,8-9,16,18-20,24-26H,7,10H2/t16-,18+,19-,20-/s2
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n/an/an/an/a 1.16E+3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335140
PNG
(4-Chloro-3-(4-isopropylbenzyl)-1-(beta-D-xylopyran...)
Show SMILES CC(C)c1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)cc1
Show InChI InChI=1/C23H26ClNO4/c1-13(2)15-8-6-14(7-9-15)10-16-11-25(18-5-3-4-17(24)20(16)18)23-22(28)21(27)19(26)12-29-23/h3-9,11,13,19,21-23,26-28H,10,12H2,1-2H3/t19-,21+,22-,23-/s2
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n/an/an/an/a 1.29E+3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335145
PNG
(4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyr...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1/C23H24ClNO4/c24-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-25(18)23-22(28)21(27)19(26)12-29-23/h1-7,11,15,19,21-23,26-28H,8-10,12H2/t19-,21+,22-,23-/s2
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n/an/an/an/a 161n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335148
PNG
(4-Chloro-3-[4-(prop-2-yn-1-yloxy)benzyl]-1-(beta-D...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(OCC#C)cc2)c2c(Cl)cccc12
Show InChI InChI=1/C23H22ClNO5/c1-2-10-29-16-8-6-14(7-9-16)11-15-12-25(18-5-3-4-17(24)20(15)18)23-22(28)21(27)19(26)13-30-23/h1,3-9,12,19,21-23,26-28H,10-11,13H2/t19-,21+,22-,23-/s2
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n/an/an/an/a 530n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50335144
PNG
(4-Chloro-3-[4-(N,N-dimethylamino)benzyl]-1-(beta-D...)
Show SMILES CN(C)c1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)cc1
Show InChI InChI=1/C22H25ClN2O4/c1-24(2)15-8-6-13(7-9-15)10-14-11-25(17-5-3-4-16(23)19(14)17)22-21(28)20(27)18(26)12-29-22/h3-9,11,18,20-22,26-28H,10,12H2,1-2H3/t18-,20+,21-,22-/s2
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n/an/an/an/a 629n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335113
PNG
(3-Benzyl-5-methyl-1-(beta-D-xylopyranosyl)-1H-indo...)
Show SMILES Cc1ccc2n(cc(Cc3ccccc3)c2c1)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C21H23NO4/c1-13-7-8-17-16(9-13)15(10-14-5-3-2-4-6-14)11-22(17)21-20(25)19(24)18(23)12-26-21/h2-9,11,18-21,23-25H,10,12H2,1H3/t18-,19+,20-,21-/s2
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n/an/an/an/a 4.06E+4n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335149
PNG
(4-Chloro-3-{4-[2-(2-ethoxyethoxy)ethoxy]benzyl}-1-...)
Show SMILES CCOCCOCCOc1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)cc1
Show InChI InChI=1/C26H32ClNO7/c1-2-32-10-11-33-12-13-34-19-8-6-17(7-9-19)14-18-15-28(21-5-3-4-20(27)23(18)21)26-25(31)24(30)22(29)16-35-26/h3-9,15,22,24-26,29-31H,2,10-14,16H2,1H3/t22-,24+,25-,26-/s2
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n/an/an/an/a 577n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335120
PNG
(3-Benzyl-4-chloro-1-(beta-D-xylopyranosyl)-1H-indo...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccccc2)c2c(Cl)cccc12
Show InChI InChI=1/C20H20ClNO4/c21-14-7-4-8-15-17(14)13(9-12-5-2-1-3-6-12)10-22(15)20-19(25)18(24)16(23)11-26-20/h1-8,10,16,18-20,23-25H,9,11H2/t16-,18+,19-,20-/s2
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n/an/an/an/a 865n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335130
PNG
(4-Chloro-3-(3-methoxybenzyl)-1-(beta-D-xylopyranos...)
Show SMILES COc1cccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)c1
Show InChI InChI=1/C21H22ClNO5/c1-27-14-5-2-4-12(9-14)8-13-10-23(16-7-3-6-15(22)18(13)16)21-20(26)19(25)17(24)11-28-21/h2-7,9-10,17,19-21,24-26H,8,11H2,1H3/t17-,19+,20-,21-/s2
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n/an/an/an/a 893n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335139
PNG
(4-Chloro-3-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc3OCCOc3c2)c2c(Cl)cccc12
Show InChI InChI=1/C22H22ClNO6/c23-14-2-1-3-15-19(14)13(8-12-4-5-17-18(9-12)29-7-6-28-17)10-24(15)22-21(27)20(26)16(25)11-30-22/h1-5,9-10,16,20-22,25-27H,6-8,11H2/t16-,20+,21-,22-/s2
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n/an/an/an/a 233n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335142
PNG
(4-Chloro-3-(4-phenylbenzyl)-1-(beta-D-xylopyranosy...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)-c2ccccc2)c2c(Cl)cccc12
Show InChI InChI=1/C26H24ClNO4/c27-20-7-4-8-21-23(20)19(14-28(21)26-25(31)24(30)22(29)15-32-26)13-16-9-11-18(12-10-16)17-5-2-1-3-6-17/h1-12,14,22,24-26,29-31H,13,15H2/t22-,24+,25-,26-/s2
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n/an/an/an/a 1.11E+4n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 108n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50335150
PNG
(4-Bromo-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyra...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Br)cccc12
Show InChI InChI=1/C23H24BrNO4/c24-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-25(18)23-22(28)21(27)19(26)12-29-23/h1-7,11,15,19,21-23,26-28H,8-10,12H2/t19-,21+,22-,23-/s2
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n/an/an/an/a 327n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 197n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335125
PNG
(3-Benzyl-4-nitro-1-(beta-D-xylopyranosyl)-1H-indol...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccccc2)c2c(cccc12)[N+]([O-])=O
Show InChI InChI=1/C20H20N2O6/c23-16-11-28-20(19(25)18(16)24)21-10-13(9-12-5-2-1-3-6-12)17-14(21)7-4-8-15(17)22(26)27/h1-8,10,16,18-20,23-25H,9,11H2/t16-,18+,19-,20-/s2
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n/an/an/an/a 1.82E+3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335126
PNG
(3-Benzyl-4-methoxy-1-(beta-D-xylopyranosyl)-1H-ind...)
Show SMILES COc1cccc2n(cc(Cc3ccccc3)c12)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C21H23NO5/c1-26-17-9-5-8-15-18(17)14(10-13-6-3-2-4-7-13)11-22(15)21-20(25)19(24)16(23)12-27-21/h2-9,11,16,19-21,23-25H,10,12H2,1H3/t16-,19+,20-,21-/s2
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n/an/an/an/a 5.49E+3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335127
PNG
(3-Benzyl-4-hydroxy-1-(beta-D-xylopyranosyl)-1H-ind...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccccc2)c2c(O)cccc12
Show InChI InChI=1/C20H21NO5/c22-15-8-4-7-14-17(15)13(9-12-5-2-1-3-6-12)10-21(14)20-19(25)18(24)16(23)11-26-20/h1-8,10,16,18-20,22-25H,9,11H2/t16-,18+,19-,20-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335150
PNG
(4-Bromo-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyra...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Br)cccc12
Show InChI InChI=1/C23H24BrNO4/c24-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-25(18)23-22(28)21(27)19(26)12-29-23/h1-7,11,15,19,21-23,26-28H,8-10,12H2/t19-,21+,22-,23-/s2
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n/an/an/an/a 241n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50335131
PNG
(4-Chloro-3-(4-methoxybenzyl)-1-(beta-D-xylopyranos...)
Show SMILES COc1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)cc1
Show InChI InChI=1/C21H22ClNO5/c1-27-14-7-5-12(6-8-14)9-13-10-23(16-4-2-3-15(22)18(13)16)21-20(26)19(25)17(24)11-28-21/h2-8,10,17,19-21,24-26H,9,11H2,1H3/t17-,19+,20-,21-/s2
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n/an/an/an/a 230n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50335143
PNG
(4-Chloro-3-[4-(methylsulfanyl)benzyl]-1-(beta-D-xy...)
Show SMILES CSc1ccc(Cc2cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(Cl)c23)cc1
Show InChI InChI=1/C21H22ClNO4S/c1-28-14-7-5-12(6-8-14)9-13-10-23(16-4-2-3-15(22)18(13)16)21-20(26)19(25)17(24)11-27-21/h2-8,10,17,19-21,24-26H,9,11H2,1H3/t17-,19+,20-,21-/s2
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n/an/an/an/a 462n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50335114
PNG
(3-Benzyl-6-methyl-1-(beta-D-xylopyranosyl)-1H-indo...)
Show SMILES Cc1ccc2c(Cc3ccccc3)cn([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c2c1
Show InChI InChI=1/C21H23NO4/c1-13-7-8-16-15(10-14-5-3-2-4-6-14)11-22(17(16)9-13)21-20(25)19(24)18(23)12-26-21/h2-9,11,18-21,23-25H,10,12H2,1H3/t18-,19+,20-,21-/s2
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n/an/an/an/a 3.03E+3n/an/an/an/a



Taiwan National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


J Med Chem 54: 166-78 (2011)


Article DOI: 10.1021/jm101072y
BindingDB Entry DOI: 10.7270/Q2445NG8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%