Compile Data Set for Download or QSAR
maximum 50k data
Found 44 Enz. Inhib. hit(s) with all data for entry = 50039344
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335165(3-[2-(1-Oxa-2-aza-spiro[4.5]dec-2-en-3-yl)-6-(2-tr...)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50:  0.413nMAssay Description:Inhibition of human TRPM8 expressed in HEK293 cells assessed as inhibition of cold-induced channel current by whole cell electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335170(3-[5-(2-Fluoro-6-trifluoromethylphenyl)-1H-benzimi...)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335160(2-(1-Oxa-2-aza-spiro[4.5]dec-2-en-3-yl)-6-(2-trifl...)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335171(3-[5-(2-Fluoro-6-trifluoromethoxyphenyl)-1H-benzim...)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335173(8,8-Difluoro-3-[5-(2-trifluoromethylphenyl)-1H-ben...)
Affinity DataIC50:  0.900nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335164(3-[5-(2-Chlorophenyl)-7-trifluoromethyl-1H-benzimi...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335154(3-[5-(2-Trifluoromethoxyphenyl)-1H-benzimidazol-2-...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335163(3-[5-(2-Trifluoromethoxyphenyl)-7-trifluoromethyl-...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335174(3-[7-Trifluoromethyl-5-(2-trifluoromethylphenyl)-1...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335162(3-[5-(2-Fluorophenyl)-7-trifluoromethyl-1H-benzimi...)
Affinity DataIC50:  1.70nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335158(3-[7-Fluoro-5-(2-trifluoromethylphenyl)-1H-benzimi...)
Affinity DataIC50:  2.20nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335169(3-[5-(2,6-Difluorophenyl)-1H-benzimidazol-2-yl]-1-...)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335151(3-[5-(2-Chlorophenyl)-1H-benzimidazol-2-yl]-1-oxa-...)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335153(3-[5-(2-Difluoromethoxyphenyl)-1H-benzimidazol-2-y...)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335161(3-[7-Bromo-5-(2-trifluoromethylphenyl)-1H-benzimid...)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335155(3-[5-(2-Fluorophenyl)-1H-benzimidazol-2-yl]-1-oxa-...)
Affinity DataIC50:  2.90nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation at 0.2 uM by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335156(3-[5-(2-Trifluoromethyl-phenyl)-1H-benzimidazol-2-...)
Affinity DataIC50:  3.10nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335159(3-[7-Chloro-5-(2-trifluoromethylphenyl)-1H-benzimi...)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation at 0.2 uM by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335175(3-[7-Chloro-5-(2-trifluoromethyl-phenyl)-1H-benzim...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335166(2-(5-(2-(Trifluoromethyl)phenyl)-1H-benzo[d]imidaz...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335172(3-[5-(2-Trifluoromethylphenyl)-1H-benzimidazol-2-y...)
Affinity DataIC50:  6.70nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335168(2-{2-[2-(1-Oxa-2-aza-spiro[4.5]dec-2-en-3-yl)-1H-b...)
Affinity DataIC50:  7.90nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335167(2-(5-(2-(Trifluoromethyl)phenyl)-1H-benzimidazol-2...)
Affinity DataIC50:  61nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential M8 protein(Canis lupus familiaris (Dog))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335152(3-[5-(2,2-Difluorobenzo[1,3]dioxol-4-yl)-1H-benzim...)
Affinity DataIC50:  91nMAssay Description:Antagonist activity at canine TRPM8 expressed in HEK293 cells assessed as inhibition of intracellular calcium accumulation by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335156(3-[5-(2-Trifluoromethyl-phenyl)-1H-benzimidazol-2-...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 15 misMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335160(2-(1-Oxa-2-aza-spiro[4.5]dec-2-en-3-yl)-6-(2-trifl...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 15 misMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335161(3-[7-Bromo-5-(2-trifluoromethylphenyl)-1H-benzimid...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 15 misMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335159(3-[7-Chloro-5-(2-trifluoromethylphenyl)-1H-benzimi...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 15 misMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335158(3-[7-Fluoro-5-(2-trifluoromethylphenyl)-1H-benzimi...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 15 misMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335165(3-[2-(1-Oxa-2-aza-spiro[4.5]dec-2-en-3-yl)-6-(2-tr...)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 15 misMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335164(3-[5-(2-Chlorophenyl)-7-trifluoromethyl-1H-benzimi...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 15 misMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335163(3-[5-(2-Trifluoromethoxyphenyl)-7-trifluoromethyl-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 15 misMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 15 misMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335162(3-[5-(2-Fluorophenyl)-7-trifluoromethyl-1H-benzimi...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 15 misMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50:  1.60E+4nMAssay Description:Displacement of [3H]astemizole from human ERG by whole cell patch-clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed