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PubMed code 21190849

Compile data set for download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333561
PNG
(2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl
Show InChI InChI=1S/C25H28ClFN6O2/c1-28-24(34)19-4-3-5-21(27)22(19)31-23-20(26)15-29-25(32-23)30-18-7-6-16-8-10-33(12-13-35-2)11-9-17(16)14-18/h3-7,14-15H,8-13H2,1-2H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 8n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333572
PNG
(2-{5-Chloro-2-[9-(2-methoxy-acetyl)-6,7,8,9-tetrah...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)COC)ncc1Cl
Show InChI InChI=1S/C24H24ClFN6O4/c1-27-23(34)15-5-3-6-17(26)21(15)30-22-16(25)12-28-24(31-22)29-14-7-8-18-19(11-14)36-10-4-9-32(18)20(33)13-35-2/h3,5-8,11-12H,4,9-10,13H2,1-2H3,(H,27,34)(H2,28,29,30,31)
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n/an/a 13n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333567
PNG
(2-[5-Chloro-2-(9-ethyl-6,7,8,9-tetrahydro-5-oxa-9-...)
Show SMILES CCN1CCCOc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc12
Show InChI InChI=1S/C23H24ClFN6O2/c1-3-31-10-5-11-33-19-12-14(8-9-18(19)31)28-23-27-13-16(24)21(30-23)29-20-15(22(32)26-2)6-4-7-17(20)25/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 14n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333575
PNG
(2-[2-(9-Acetyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benz...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3OCCCN(C(C)=O)c3c2)ncc1Cl
Show InChI InChI=1S/C23H22ClFN6O3/c1-13(32)31-9-4-10-34-19-8-7-14(11-18(19)31)28-23-27-12-16(24)21(30-23)29-20-15(22(33)26-2)5-3-6-17(20)25/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,33)(H2,27,28,29,30)
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n/an/a 17n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333567
PNG
(2-[5-Chloro-2-(9-ethyl-6,7,8,9-tetrahydro-5-oxa-9-...)
Show SMILES CCN1CCCOc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc12
Show InChI InChI=1S/C23H24ClFN6O2/c1-3-31-10-5-11-33-19-12-14(8-9-18(19)31)28-23-27-13-16(24)21(30-23)29-20-15(22(32)26-2)6-4-7-17(20)25/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 18n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333561
PNG
(2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl
Show InChI InChI=1S/C25H28ClFN6O2/c1-28-24(34)19-4-3-5-21(27)22(19)31-23-20(26)15-29-25(32-23)30-18-7-6-16-8-10-33(12-13-35-2)11-9-17(16)14-18/h3-7,14-15H,8-13H2,1-2H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 19n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333571
PNG
(2-{5-Chloro-2-[9-(2-pyrrolidin-1-yl-acetyl)-6,7,8,...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)CN2CCCC2)ncc1Cl
Show InChI InChI=1S/C27H29ClFN7O3/c1-30-26(38)18-6-4-7-20(29)24(18)33-25-19(28)15-31-27(34-25)32-17-8-9-21-22(14-17)39-13-5-12-36(21)23(37)16-35-10-2-3-11-35/h4,6-9,14-15H,2-3,5,10-13,16H2,1H3,(H,30,38)(H2,31,32,33,34)
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n/an/a 19n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333558
PNG
(2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl
Show InChI InChI=1S/C25H29ClN6O2/c1-27-24(33)20-5-3-4-6-22(20)30-23-21(26)16-28-25(31-23)29-19-8-7-17-9-11-32(13-14-34-2)12-10-18(17)15-19/h3-8,15-16H,9-14H2,1-2H3,(H,27,33)(H2,28,29,30,31)
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n/an/a 20n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333568
PNG
(2-{5-Chloro-2-[9-(2-pyrrolidin-1-yl-ethyl)-6,7,8,9...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCN4CCCC4)CCCOc3c2)ncc1Cl
Show InChI InChI=1S/C27H31ClFN7O2/c1-30-26(37)19-6-4-7-21(29)24(19)33-25-20(28)17-31-27(34-25)32-18-8-9-22-23(16-18)38-15-5-12-36(22)14-13-35-10-2-3-11-35/h4,6-9,16-17H,2-3,5,10-15H2,1H3,(H,30,37)(H2,31,32,33,34)
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n/an/a 21n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333568
PNG
(2-{5-Chloro-2-[9-(2-pyrrolidin-1-yl-ethyl)-6,7,8,9...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCN4CCCC4)CCCOc3c2)ncc1Cl
Show InChI InChI=1S/C27H31ClFN7O2/c1-30-26(37)19-6-4-7-21(29)24(19)33-25-20(28)17-31-27(34-25)32-18-8-9-22-23(16-18)38-15-5-12-36(22)14-13-35-10-2-3-11-35/h4,6-9,16-17H,2-3,5,10-15H2,1H3,(H,30,37)(H2,31,32,33,34)
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n/an/a 22n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333559
PNG
(3-Chloro-2-{5-chloro-2-[3-(2-methoxy-ethyl)-2,3,4,...)
Show SMILES CNC(=O)c1cccc(Cl)c1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl
Show InChI InChI=1S/C25H28Cl2N6O2/c1-28-24(34)19-4-3-5-20(26)22(19)31-23-21(27)15-29-25(32-23)30-18-7-6-16-8-10-33(12-13-35-2)11-9-17(16)14-18/h3-7,14-15H,8-13H2,1-2H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 24n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333563
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CCOC(=O)N1CCCOc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc12
Show InChI InChI=1S/C24H24ClFN6O4/c1-3-35-24(34)32-10-5-11-36-19-12-14(8-9-18(19)32)29-23-28-13-16(25)21(31-23)30-20-15(22(33)27-2)6-4-7-17(20)26/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,27,33)(H2,28,29,30,31)
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n/an/a 25n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333560
PNG
(2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...)
Show SMILES CNC(=O)c1cccc(C)c1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl
Show InChI InChI=1S/C26H31ClN6O2/c1-17-5-4-6-21(25(34)28-2)23(17)31-24-22(27)16-29-26(32-24)30-20-8-7-18-9-11-33(13-14-35-3)12-10-19(18)15-20/h4-8,15-16H,9-14H2,1-3H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 26n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333566
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OCCCN(C)C)ncc1Cl
Show InChI InChI=1S/C27H31ClFN7O4/c1-30-25(37)18-7-4-8-20(29)23(18)33-24-19(28)16-31-26(34-24)32-17-9-10-21-22(15-17)39-13-6-12-36(21)27(38)40-14-5-11-35(2)3/h4,7-10,15-16H,5-6,11-14H2,1-3H3,(H,30,37)(H2,31,32,33,34)
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n/an/a 28n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333570
PNG
(2-[2-(9-Acetyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benz...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(C)=O)ncc1Cl
Show InChI InChI=1S/C23H22ClFN6O3/c1-13(32)31-9-4-10-34-19-11-14(7-8-18(19)31)28-23-27-12-16(24)21(30-23)29-20-15(22(33)26-2)5-3-6-17(20)25/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,33)(H2,27,28,29,30)
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n/an/a 28n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333570
PNG
(2-[2-(9-Acetyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benz...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(C)=O)ncc1Cl
Show InChI InChI=1S/C23H22ClFN6O3/c1-13(32)31-9-4-10-34-19-11-14(7-8-18(19)31)28-23-27-12-16(24)21(30-23)29-20-15(22(33)26-2)5-3-6-17(20)25/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,33)(H2,27,28,29,30)
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n/an/a 30n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333562
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OC)ncc1Cl
Show InChI InChI=1S/C23H22ClFN6O4/c1-26-21(32)14-5-3-6-16(25)19(14)29-20-15(24)12-27-22(30-20)28-13-7-8-17-18(11-13)35-10-4-9-31(17)23(33)34-2/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 32n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333563
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CCOC(=O)N1CCCOc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc12
Show InChI InChI=1S/C24H24ClFN6O4/c1-3-35-24(34)32-10-5-11-36-19-12-14(8-9-18(19)32)29-23-28-13-16(25)21(31-23)30-20-15(22(33)27-2)6-4-7-17(20)26/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,27,33)(H2,28,29,30,31)
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n/an/a 36n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333574
PNG
(2-[5-Chloro-2-(9-ethyl-6,7,8,9-tetrahydro-5-oxa-9-...)
Show SMILES CCN1CCCOc2ccc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)cc12
Show InChI InChI=1S/C23H24ClFN6O2/c1-3-31-10-5-11-33-19-9-8-14(12-18(19)31)28-23-27-13-16(24)21(30-23)29-20-15(22(32)26-2)6-4-7-17(20)25/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 41n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333558
PNG
(2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl
Show InChI InChI=1S/C25H29ClN6O2/c1-27-24(33)20-5-3-4-6-22(20)30-23-21(26)16-28-25(31-23)29-19-8-7-17-9-11-32(13-14-34-2)12-10-18(17)15-19/h3-8,15-16H,9-14H2,1-2H3,(H,27,33)(H2,28,29,30,31)
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n/an/a 41n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333569
PNG
(2-[5-Chloro-2-(6,7,8,9-tetrahydro-5-oxa-9-aza-benz...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3NCCCOc3c2)ncc1Cl
Show InChI InChI=1S/C21H20ClFN6O2/c1-24-20(30)13-4-2-5-15(23)18(13)28-19-14(22)11-26-21(29-19)27-12-6-7-16-17(10-12)31-9-3-8-25-16/h2,4-7,10-11,25H,3,8-9H2,1H3,(H,24,30)(H2,26,27,28,29)
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n/an/a 42n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333571
PNG
(2-{5-Chloro-2-[9-(2-pyrrolidin-1-yl-acetyl)-6,7,8,...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)CN2CCCC2)ncc1Cl
Show InChI InChI=1S/C27H29ClFN7O3/c1-30-26(38)18-6-4-7-20(29)24(18)33-25-19(28)15-31-27(34-25)32-17-8-9-21-22(14-17)39-13-5-12-36(21)23(37)16-35-10-2-3-11-35/h4,6-9,14-15H,2-3,5,10-13,16H2,1H3,(H,30,38)(H2,31,32,33,34)
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n/an/a 44n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333566
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OCCCN(C)C)ncc1Cl
Show InChI InChI=1S/C27H31ClFN7O4/c1-30-25(37)18-7-4-8-20(29)23(18)33-24-19(28)16-31-26(34-24)32-17-9-10-21-22(15-17)39-13-6-12-36(21)27(38)40-14-5-11-35(2)3/h4,7-10,15-16H,5-6,11-14H2,1-3H3,(H,30,37)(H2,31,32,33,34)
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n/an/a 45n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333562
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OC)ncc1Cl
Show InChI InChI=1S/C23H22ClFN6O4/c1-26-21(32)14-5-3-6-16(25)19(14)29-20-15(24)12-27-22(30-20)28-13-7-8-17-18(11-13)35-10-4-9-31(17)23(33)34-2/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 46n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333564
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OC(C)C)ncc1Cl
Show InChI InChI=1S/C25H26ClFN6O4/c1-14(2)37-25(35)33-10-5-11-36-20-12-15(8-9-19(20)33)30-24-29-13-17(26)22(32-24)31-21-16(23(34)28-3)6-4-7-18(21)27/h4,6-9,12-14H,5,10-11H2,1-3H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 47n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333575
PNG
(2-[2-(9-Acetyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benz...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3OCCCN(C(C)=O)c3c2)ncc1Cl
Show InChI InChI=1S/C23H22ClFN6O3/c1-13(32)31-9-4-10-34-19-8-7-14(11-18(19)31)28-23-27-12-16(24)21(30-23)29-20-15(22(33)26-2)5-3-6-17(20)25/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,33)(H2,27,28,29,30)
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n/an/a 49n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333565
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OCCOC)ncc1Cl
Show InChI InChI=1S/C25H26ClFN6O5/c1-28-23(34)16-5-3-6-18(27)21(16)31-22-17(26)14-29-24(32-22)30-15-7-8-19-20(13-15)37-10-4-9-33(19)25(35)38-12-11-36-2/h3,5-8,13-14H,4,9-12H2,1-2H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 50n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333572
PNG
(2-{5-Chloro-2-[9-(2-methoxy-acetyl)-6,7,8,9-tetrah...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)COC)ncc1Cl
Show InChI InChI=1S/C24H24ClFN6O4/c1-27-23(34)15-5-3-6-17(26)21(15)30-22-16(25)12-28-24(31-22)29-14-7-8-18-19(11-14)36-10-4-9-32(18)20(33)13-35-2/h3,5-8,11-12H,4,9-10,13H2,1-2H3,(H,27,34)(H2,28,29,30,31)
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n/an/a 51n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333564
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OC(C)C)ncc1Cl
Show InChI InChI=1S/C25H26ClFN6O4/c1-14(2)37-25(35)33-10-5-11-36-20-12-15(8-9-19(20)33)30-24-29-13-17(26)22(32-24)31-21-16(23(34)28-3)6-4-7-18(21)27/h4,6-9,12-14H,5,10-11H2,1-3H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 53n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333569
PNG
(2-[5-Chloro-2-(6,7,8,9-tetrahydro-5-oxa-9-aza-benz...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3NCCCOc3c2)ncc1Cl
Show InChI InChI=1S/C21H20ClFN6O2/c1-24-20(30)13-4-2-5-15(23)18(13)28-19-14(22)11-26-21(29-19)27-12-6-7-16-17(10-12)31-9-3-8-25-16/h2,4-7,10-11,25H,3,8-9H2,1H3,(H,24,30)(H2,26,27,28,29)
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n/an/a 57n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333565
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OCCOC)ncc1Cl
Show InChI InChI=1S/C25H26ClFN6O5/c1-28-23(34)16-5-3-6-18(27)21(16)31-22-17(26)14-29-24(32-22)30-15-7-8-19-20(13-15)37-10-4-9-33(19)25(35)38-12-11-36-2/h3,5-8,13-14H,4,9-12H2,1-2H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 81n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333574
PNG
(2-[5-Chloro-2-(9-ethyl-6,7,8,9-tetrahydro-5-oxa-9-...)
Show SMILES CCN1CCCOc2ccc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)cc12
Show InChI InChI=1S/C23H24ClFN6O2/c1-3-31-10-5-11-33-19-9-8-14(12-18(19)31)28-23-27-13-16(24)21(30-23)29-20-15(22(32)26-2)6-4-7-17(20)25/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 120n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333573
PNG
(2-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CCOC(=O)N1CCCOc2ccc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)cc12
Show InChI InChI=1S/C24H24ClFN6O4/c1-3-35-24(34)32-10-5-11-36-19-9-8-14(12-18(19)32)29-23-28-13-16(25)21(31-23)30-20-15(22(33)27-2)6-4-7-17(20)26/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,27,33)(H2,28,29,30,31)
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n/an/a 140n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333558
PNG
(2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl
Show InChI InChI=1S/C25H29ClN6O2/c1-27-24(33)20-5-3-4-6-22(20)30-23-21(26)16-28-25(31-23)29-19-8-7-17-9-11-32(13-14-34-2)12-10-18(17)15-19/h3-8,15-16H,9-14H2,1-2H3,(H,27,33)(H2,28,29,30,31)
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n/an/a 220n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333561
PNG
(2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl
Show InChI InChI=1S/C25H28ClFN6O2/c1-28-24(34)19-4-3-5-21(27)22(19)31-23-20(26)15-29-25(32-23)30-18-7-6-16-8-10-33(12-13-35-2)11-9-17(16)14-18/h3-7,14-15H,8-13H2,1-2H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 230n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333568
PNG
(2-{5-Chloro-2-[9-(2-pyrrolidin-1-yl-ethyl)-6,7,8,9...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCN4CCCC4)CCCOc3c2)ncc1Cl
Show InChI InChI=1S/C27H31ClFN7O2/c1-30-26(37)19-6-4-7-21(29)24(19)33-25-20(28)17-31-27(34-25)32-18-8-9-22-23(16-18)38-15-5-12-36(22)14-13-35-10-2-3-11-35/h4,6-9,16-17H,2-3,5,10-15H2,1H3,(H,30,37)(H2,31,32,33,34)
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n/an/a 300n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333567
PNG
(2-[5-Chloro-2-(9-ethyl-6,7,8,9-tetrahydro-5-oxa-9-...)
Show SMILES CCN1CCCOc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc12
Show InChI InChI=1S/C23H24ClFN6O2/c1-3-31-10-5-11-33-19-12-14(8-9-18(19)31)28-23-27-13-16(24)21(30-23)29-20-15(22(32)26-2)6-4-7-17(20)25/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 370n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333573
PNG
(2-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CCOC(=O)N1CCCOc2ccc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)cc12
Show InChI InChI=1S/C24H24ClFN6O4/c1-3-35-24(34)32-10-5-11-36-19-9-8-14(12-18(19)32)29-23-28-13-16(25)21(31-23)30-20-15(22(33)27-2)6-4-7-17(20)26/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,27,33)(H2,28,29,30,31)
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n/an/a 440n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333574
PNG
(2-[5-Chloro-2-(9-ethyl-6,7,8,9-tetrahydro-5-oxa-9-...)
Show SMILES CCN1CCCOc2ccc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)cc12
Show InChI InChI=1S/C23H24ClFN6O2/c1-3-31-10-5-11-33-19-9-8-14(12-18(19)31)28-23-27-13-16(24)21(30-23)29-20-15(22(32)26-2)6-4-7-17(20)25/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 490n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333570
PNG
(2-[2-(9-Acetyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benz...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(C)=O)ncc1Cl
Show InChI InChI=1S/C23H22ClFN6O3/c1-13(32)31-9-4-10-34-19-11-14(7-8-18(19)31)28-23-27-12-16(24)21(30-23)29-20-15(22(33)26-2)5-3-6-17(20)25/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,33)(H2,27,28,29,30)
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n/an/a 500n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333562
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OC)ncc1Cl
Show InChI InChI=1S/C23H22ClFN6O4/c1-26-21(32)14-5-3-6-16(25)19(14)29-20-15(24)12-27-22(30-20)28-13-7-8-17-18(11-13)35-10-4-9-31(17)23(33)34-2/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,32)(H2,27,28,29,30)
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n/an/a 550n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333559
PNG
(3-Chloro-2-{5-chloro-2-[3-(2-methoxy-ethyl)-2,3,4,...)
Show SMILES CNC(=O)c1cccc(Cl)c1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl
Show InChI InChI=1S/C25H28Cl2N6O2/c1-28-24(34)19-4-3-5-20(26)22(19)31-23-21(27)15-29-25(32-23)30-18-7-6-16-8-10-33(12-13-35-2)11-9-17(16)14-18/h3-7,14-15H,8-13H2,1-2H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 550n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333569
PNG
(2-[5-Chloro-2-(6,7,8,9-tetrahydro-5-oxa-9-aza-benz...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3NCCCOc3c2)ncc1Cl
Show InChI InChI=1S/C21H20ClFN6O2/c1-24-20(30)13-4-2-5-15(23)18(13)28-19-14(22)11-26-21(29-19)27-12-6-7-16-17(10-12)31-9-3-8-25-16/h2,4-7,10-11,25H,3,8-9H2,1H3,(H,24,30)(H2,26,27,28,29)
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n/an/a 560n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333565
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OCCOC)ncc1Cl
Show InChI InChI=1S/C25H26ClFN6O5/c1-28-23(34)16-5-3-6-18(27)21(16)31-22-17(26)14-29-24(32-22)30-15-7-8-19-20(13-15)37-10-4-9-33(19)25(35)38-12-11-36-2/h3,5-8,13-14H,4,9-12H2,1-2H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 800n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333564
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OC(C)C)ncc1Cl
Show InChI InChI=1S/C25H26ClFN6O4/c1-14(2)37-25(35)33-10-5-11-36-20-12-15(8-9-19(20)33)30-24-29-13-17(26)22(32-24)31-21-16(23(34)28-3)6-4-7-18(21)27/h4,6-9,12-14H,5,10-11H2,1-3H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 820n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333572
PNG
(2-{5-Chloro-2-[9-(2-methoxy-acetyl)-6,7,8,9-tetrah...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)COC)ncc1Cl
Show InChI InChI=1S/C24H24ClFN6O4/c1-27-23(34)15-5-3-6-17(26)21(15)30-22-16(25)12-28-24(31-22)29-14-7-8-18-19(11-14)36-10-4-9-32(18)20(33)13-35-2/h3,5-8,11-12H,4,9-10,13H2,1-2H3,(H,27,34)(H2,28,29,30,31)
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n/an/a 930n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333563
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CCOC(=O)N1CCCOc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc12
Show InChI InChI=1S/C24H24ClFN6O4/c1-3-35-24(34)32-10-5-11-36-19-12-14(8-9-18(19)32)29-23-28-13-16(25)21(31-23)30-20-15(22(33)27-2)6-4-7-17(20)26/h4,6-9,12-13H,3,5,10-11H2,1-2H3,(H,27,33)(H2,28,29,30,31)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333575
PNG
(2-[2-(9-Acetyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benz...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3OCCCN(C(C)=O)c3c2)ncc1Cl
Show InChI InChI=1S/C23H22ClFN6O3/c1-13(32)31-9-4-10-34-19-8-7-14(11-18(19)31)28-23-27-12-16(24)21(30-23)29-20-15(22(33)26-2)5-3-6-17(20)25/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,26,33)(H2,27,28,29,30)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50333560
PNG
(2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...)
Show SMILES CNC(=O)c1cccc(C)c1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl
Show InChI InChI=1S/C26H31ClN6O2/c1-17-5-4-6-21(25(34)28-2)23(17)31-24-22(27)16-29-26(32-24)30-20-8-7-18-9-11-33(13-14-35-3)12-10-19(18)15-20/h4-8,15-16H,9-14H2,1-3H3,(H,28,34)(H2,29,30,31,32)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met expressed in human GTL-16 cells after 2 hrs


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333566
PNG
(3-[5-Chloro-4-(2-fluoro-6-methylcarbamoyl-phenylam...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)OCCCN(C)C)ncc1Cl
Show InChI InChI=1S/C27H31ClFN7O4/c1-30-25(37)18-7-4-8-20(29)23(18)33-24-19(28)16-31-26(34-24)32-17-9-10-21-22(15-17)39-13-6-12-36(21)27(38)40-14-5-11-35(2)3/h4,7-10,15-16H,5-6,11-14H2,1-3H3,(H,30,37)(H2,31,32,33,34)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333571
PNG
(2-{5-Chloro-2-[9-(2-pyrrolidin-1-yl-acetyl)-6,7,8,...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3N(CCCOc3c2)C(=O)CN2CCCC2)ncc1Cl
Show InChI InChI=1S/C27H29ClFN7O3/c1-30-26(38)18-6-4-7-20(29)24(18)33-25-19(28)15-31-27(34-25)32-17-8-9-21-22(14-17)39-13-5-12-36(21)23(37)16-35-10-2-3-11-35/h4,6-9,14-15H,2-3,5,10-13,16H2,1H3,(H,30,38)(H2,31,32,33,34)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333560
PNG
(2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...)
Show SMILES CNC(=O)c1cccc(C)c1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl
Show InChI InChI=1S/C26H31ClN6O2/c1-17-5-4-6-21(25(34)28-2)23(17)31-24-22(27)16-29-26(32-24)30-20-8-7-18-9-11-33(13-14-35-3)12-10-19(18)15-20/h4-8,15-16H,9-14H2,1-3H3,(H,28,34)(H2,29,30,31,32)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50333559
PNG
(3-Chloro-2-{5-chloro-2-[3-(2-methoxy-ethyl)-2,3,4,...)
Show SMILES CNC(=O)c1cccc(Cl)c1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl
Show InChI InChI=1S/C25H28Cl2N6O2/c1-28-24(34)19-4-3-5-20(26)22(19)31-23-21(27)15-29-25(32-23)30-18-7-6-16-8-10-33(12-13-35-2)11-9-17(16)14-18/h3-7,14-15H,8-13H2,1-2H3,(H,28,34)(H2,29,30,31,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 1 hr


Bioorg Med Chem Lett 21: 660-3 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.013
BindingDB Entry DOI: 10.7270/Q2RB74WV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%