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PubMed code 21193308

Compile data set for download or QSAR
Found 24 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/a 0.490n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333628
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-3-((5-(furan-2-yl)thi...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C20H20ClNO6S/c21-12-4-3-10(20-19(26)18(25)17(24)14(9-23)28-20)6-11(12)7-16-22-8-15(29-16)13-2-1-5-27-13/h1-6,8,14,17-20,23-26H,7,9H2/t14-,17-,18+,19-,20+/s2
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n/an/a 1.75n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333627
PNG
((2S,3R,4S,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES C[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C20H20ClNO5S/c1-10-17(23)18(24)19(25)20(27-10)11-4-5-13(21)12(7-11)8-16-22-9-15(28-16)14-3-2-6-26-14/h2-7,9-10,17-20,23-25H,8H2,1H3/t10-,17-,18+,19-,20+/s2
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n/an/a 7.01n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333635
PNG
((2S,3R,4R,5S,6S)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES O[C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1)C(F)F
Show InChI InChI=1/C20H18ClF2NO5S/c21-11-4-3-9(18-16(26)15(25)17(27)19(29-18)20(22)23)6-10(11)7-14-24-8-13(30-14)12-2-1-5-28-12/h1-6,8,15-20,25-27H,7H2/t15-,16-,17+,18+,19+/s2
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n/an/a 9.55n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333634
PNG
((2S,3R,4R,5S,6S)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES O[C@@H]1[C@@H](CF)O[C@H]([C@H](O)[C@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C20H19ClFNO5S/c21-12-4-3-10(20-19(26)18(25)17(24)14(8-22)28-20)6-11(12)7-16-23-9-15(29-16)13-2-1-5-27-13/h1-6,9,14,17-20,24-26H,7-8H2/t14-,17-,18+,19-,20+/s2
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n/an/a 10.6n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333629
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES C[C@H](O)[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C21H22ClNO6S/c1-10(24)20-18(26)17(25)19(27)21(29-20)11-4-5-13(22)12(7-11)8-16-23-9-15(30-16)14-3-2-6-28-14/h2-7,9-10,17-21,24-27H,8H2,1H3/t10-,17-,18-,19+,20+,21-/s2
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n/an/a 13.5n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333639
PNG
((2S,3R,4R,5S,6S)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES CSC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C21H22ClNO5S2/c1-29-10-15-18(24)19(25)20(26)21(28-15)11-4-5-13(22)12(7-11)8-17-23-9-16(30-17)14-3-2-6-27-14/h2-7,9,15,18-21,24-26H,8,10H2,1H3/t15-,18-,19+,20-,21+/s2
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Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333633
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES OC(CC=C)[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C23H24ClNO6S/c1-2-4-15(26)23-21(29)19(27)20(28)22(31-23)12-6-7-14(24)13(9-12)10-18-25-11-17(32-18)16-5-3-8-30-16/h2-3,5-9,11,15,19-23,26-29H,1,4,10H2/t15?,19-,20-,21+,22+,23-/s2
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Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333636
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES COC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C21H22ClNO6S/c1-27-10-15-18(24)19(25)20(26)21(29-15)11-4-5-13(22)12(7-11)8-17-23-9-16(30-17)14-3-2-6-28-14/h2-7,9,15,18-21,24-26H,8,10H2,1H3/t15-,18-,19+,20-,21+/s2
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n/an/a 23.5n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333630
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES C[C@@H](O)[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C21H22ClNO6S/c1-10(24)20-18(26)17(25)19(27)21(29-20)11-4-5-13(22)12(7-11)8-16-23-9-15(30-16)14-3-2-6-28-14/h2-7,9-10,17-21,24-27H,8H2,1H3/t10-,17+,18+,19-,20-,21+/s2
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n/an/a 23.8n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333638
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES OCCOC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C22H24ClNO7S/c23-14-4-3-12(22-21(28)20(27)19(26)16(31-22)11-29-7-5-25)8-13(14)9-18-24-10-17(32-18)15-2-1-6-30-15/h1-4,6,8,10,16,19-22,25-28H,5,7,9,11H2/t16-,19-,20+,21-,22+/s2
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n/an/a 30.9n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333640
PNG
((2S,3R,4R,5S,6S)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES CCSC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C22H24ClNO5S2/c1-2-30-11-16-19(25)20(26)21(27)22(29-16)12-5-6-14(23)13(8-12)9-18-24-10-17(31-18)15-4-3-7-28-15/h3-8,10,16,19-22,25-27H,2,9,11H2,1H3/t16-,19-,20+,21-,22+/s2
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Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333643
PNG
((2S,3R,4R,5S,6S)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES O[C@@H]1[C@@H](O)[C@@H](O[C@@H]([C@H]1O)C1(O)CC1)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C22H22ClNO6S/c23-13-4-3-11(20-18(26)17(25)19(27)21(30-20)22(28)5-6-22)8-12(13)9-16-24-10-15(31-16)14-2-1-7-29-14/h1-4,7-8,10,17-21,25-28H,5-6,9H2/t17-,18-,19+,20+,21+/s2
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Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333632
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES O[C@H](C=C)[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C22H22ClNO6S/c1-2-14(25)22-20(28)18(26)19(27)21(30-22)11-5-6-13(23)12(8-11)9-17-24-10-16(31-17)15-4-3-7-29-15/h2-8,10,14,18-22,25-28H,1,9H2/t14-,18-,19-,20+,21+,22-/s2
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Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333631
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES O[C@@H](C=C)[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C22H22ClNO6S/c1-2-14(25)22-20(28)18(26)19(27)21(30-22)11-5-6-13(23)12(8-11)9-17-24-10-16(31-17)15-4-3-7-29-15/h2-8,10,14,18-22,25-28H,1,9H2/t14-,18+,19+,20-,21-,22+/s2
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Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333644
PNG
((2S,3S,4R,5R,6S)-methyl 6-(4-chloro-3-((5-(furan-2...)
Show SMILES COC(=O)[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C21H20ClNO7S/c1-28-21(27)20-18(26)16(24)17(25)19(30-20)10-4-5-12(22)11(7-10)8-15-23-9-14(31-15)13-3-2-6-29-13/h2-7,9,16-20,24-26H,8H2,1H3/t16-,17-,18+,19+,20+/s2
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n/an/a 59.1n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333637
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES CCOC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C22H24ClNO6S/c1-2-28-11-16-19(25)20(26)21(27)22(30-16)12-5-6-14(23)13(8-12)9-18-24-10-17(31-18)15-4-3-7-29-15/h3-8,10,16,19-22,25-27H,2,9,11H2,1H3/t16-,19-,20+,21-,22+/s2
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Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333625
PNG
((2R,3S,4R,5R,6S)-2-((1H-tetrazol-1-yl)methyl)-6-(4...)
Show SMILES O[C@@H]1[C@@H](Cn2cnnn2)O[C@H]([C@H](O)[C@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C21H20ClN5O5S/c22-13-4-3-11(6-12(13)7-17-23-8-16(33-17)14-2-1-5-31-14)21-20(30)19(29)18(28)15(32-21)9-27-10-24-25-26-27/h1-6,8,10,15,18-21,28-30H,7,9H2/t15-,18-,19+,20-,21+/s2
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n/an/a 68.9n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333642
PNG
((2S,3R,4R,5S,6S)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES CC(C)(O)[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C22H24ClNO6S/c1-22(2,28)21-19(27)17(25)18(26)20(30-21)11-5-6-13(23)12(8-11)9-16-24-10-15(31-16)14-4-3-7-29-14/h3-8,10,17-21,25-28H,9H2,1-2H3/t17-,18-,19+,20+,21+/s2
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n/an/a 89.5n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333626
PNG
((2R,3S,4R,5R,6S)-2-((2H-tetrazol-2-yl)methyl)-6-(4...)
Show SMILES O[C@@H]1[C@@H](Cn2ncnn2)O[C@H]([C@H](O)[C@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C21H20ClN5O5S/c22-13-4-3-11(6-12(13)7-17-23-8-16(33-17)14-2-1-5-31-14)21-20(30)19(29)18(28)15(32-21)9-27-25-10-24-26-27/h1-6,8,10,15,18-21,28-30H,7,9H2/t15-,18-,19+,20-,21+/s2
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n/an/a 106n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333622
PNG
(1-((2S,3S,4R,5R,6S)-6-(4-chloro-3-((5-(furan-2-yl)...)
Show SMILES CCC(=O)[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C22H22ClNO6S/c1-2-14(25)22-20(28)18(26)19(27)21(30-22)11-5-6-13(23)12(8-11)9-17-24-10-16(31-17)15-4-3-7-29-15/h3-8,10,18-22,26-28H,2,9H2,1H3/t18-,19-,20+,21+,22-/s2
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n/an/a 110n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333623
PNG
((2S,3R,4R,5S,6S)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)C[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C27H26ClNO7S2/c1-15-4-7-18(8-5-15)38(33,34)14-21-24(30)25(31)26(32)27(36-21)16-6-9-19(28)17(11-16)12-23-29-13-22(37-23)20-3-2-10-35-20/h2-11,13,21,24-27,30-32H,12,14H2,1H3/t21-,24-,25+,26-,27+/s2
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n/an/a 156n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333624
PNG
((2R,3S,4R,5R,6S)-2-((1H-1,2,4-triazol-1-yl)methyl)...)
Show SMILES O[C@@H]1[C@@H](Cn2cncn2)O[C@H]([C@H](O)[C@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C22H21ClN4O5S/c23-14-4-3-12(6-13(14)7-18-25-8-17(33-18)15-2-1-5-31-15)22-21(30)20(29)19(28)16(32-22)9-27-11-24-10-26-27/h1-6,8,10-11,16,19-22,28-30H,7,9H2/t16-,19-,20+,21-,22+/s2
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n/an/a 471n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50333641
PNG
((2S,3R,4R,5S,6S)-2-(4-chloro-3-((5-(furan-2-yl)thi...)
Show SMILES CS(=O)(=O)C[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ncc(s2)-c2ccco2)c1
Show InChI InChI=1/C21H22ClNO7S2/c1-32(27,28)10-15-18(24)19(25)20(26)21(30-15)11-4-5-13(22)12(7-11)8-17-23-9-16(31-17)14-3-2-6-29-14/h2-7,9,15,18-21,24-26H,8,10H2,1H3/t15-,18-,19+,20-,21+/s2
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n/an/a 1.45E+3n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintilla...


Bioorg Med Chem Lett 21: 742-6 (2011)


Article DOI: 10.1016/j.bmcl.2010.11.115
BindingDB Entry DOI: 10.7270/Q2C24WPZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%