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PubMed code 21273063

Compile data set for download or QSAR
Found 100 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342692
PNG
(4-(1'-(5-chloropyrimidin-2-yl)-4,4'-bipiperidin-1-...)
Show SMILES Cc1cc(nc(n1)C#N)N1CCC(CC1)C1CCN(CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24ClN7/c1-14-10-19(26-18(11-22)25-14)27-6-2-15(3-7-27)16-4-8-28(9-5-16)20-23-12-17(21)13-24-20/h10,12-13,15-16H,2-9H2,1H3
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n/an/a 277n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342698
PNG
((rac)-cis-4-((2-((1-(5-chloropyrimidin-2-yl)piperi...)
Show SMILES Fc1cc(OCC2CC2CC2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-18-12-27-24(28-13-18)30-7-5-15(6-8-30)9-16-10-17(16)14-32-20-3-4-21(22(26)11-20)23(31)29-19-1-2-19/h3-4,11-13,15-17,19H,1-2,5-10,14H2,(H,29,31)
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PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342696
PNG
((rac)-cis-4-((2-(1-(5-chloropyrimidin-2-yl)piperid...)
Show SMILES Fc1cc(OCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C23H26ClFN4O2/c24-16-11-26-23(27-12-16)29-7-5-14(6-8-29)20-9-15(20)13-31-18-3-4-19(21(25)10-18)22(30)28-17-1-2-17/h3-4,10-12,14-15,17,20H,1-2,5-9,13H2,(H,28,30)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342693
PNG
(2-methyl-6-(1'-(5-methylpyrimidin-2-yl)-4,4'-bipip...)
Show SMILES Cc1cnc(nc1)N1CCC(CC1)C1CCN(CC1)c1cc(nc(C)n1)C#N
Show InChI InChI=1S/C21H27N7/c1-15-13-23-21(24-14-15)28-9-5-18(6-10-28)17-3-7-27(8-4-17)20-11-19(12-22)25-16(2)26-20/h11,13-14,17-18H,3-10H2,1-2H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342696
PNG
((rac)-cis-4-((2-(1-(5-chloropyrimidin-2-yl)piperid...)
Show SMILES Fc1cc(OCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C23H26ClFN4O2/c24-16-11-26-23(27-12-16)29-7-5-14(6-8-29)20-9-15(20)13-31-18-3-4-19(21(25)10-18)22(30)28-17-1-2-17/h3-4,10-12,14-15,17,20H,1-2,5-9,13H2,(H,28,30)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342697
PNG
((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Show SMILES Fc1cc(OCCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342702
PNG
(6-methyl-2-(2-((1S,2R)-2-(1-(5-methylpyrimidin-2-y...)
Show SMILES Cc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1CCOc1nc(C)cc(n1)C#N
Show InChI InChI=1S/C21H26N6O/c1-14-12-23-20(24-13-14)27-6-3-16(4-7-27)19-10-17(19)5-8-28-21-25-15(2)9-18(11-22)26-21/h9,12-13,16-17,19H,3-8,10H2,1-2H3/t17-,19-/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp technique


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342694
PNG
(2-methyl-6-(1'-(5-methylpyrazin-2-yl)-4,4'-bipiper...)
Show SMILES Cc1cnc(cn1)N1CCC(CC1)C1CCN(CC1)c1cc(nc(C)n1)C#N
Show InChI InChI=1S/C21H27N7/c1-15-13-24-21(14-23-15)28-9-5-18(6-10-28)17-3-7-27(8-4-17)20-11-19(12-22)25-16(2)26-20/h11,13-14,17-18H,3-10H2,1-2H3
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n/an/a 5.40E+3n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342695
PNG
(4-methyl-6-(1'-(5-methylpyrazin-2-yl)-4,4'-bipiper...)
Show SMILES Cc1cnc(cn1)N1CCC(CC1)C1CCN(CC1)c1cc(C)nc(n1)C#N
Show InChI InChI=1S/C21H27N7/c1-15-11-20(26-19(12-22)25-15)27-7-3-17(4-8-27)18-5-9-28(10-6-18)21-14-23-16(2)13-24-21/h11,13-14,17-18H,3-10H2,1-2H3
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n/an/a 1.06E+4n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342699
PNG
(5-chloro-2-(4-((1R,2S)-2-(2-(5-(methylsulfonyl)pyr...)
Show SMILES CS(=O)(=O)c1ccc(OCC[C@@H]2C[C@@H]2C2CCN(CC2)c2ncc(Cl)cn2)nc1
Show InChI InChI=1S/C20H25ClN4O3S/c1-29(26,27)17-2-3-19(22-13-17)28-9-6-15-10-18(15)14-4-7-25(8-5-14)20-23-11-16(21)12-24-20/h2-3,11-15,18H,4-10H2,1H3/t15-,18-/m1/s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp technique


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342700
PNG
(2-(4-((1R,2S)-2-(2-(4-(1H-1,2,3-triazol-1-yl)pheno...)
Show SMILES Clc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1CCOc1ccc(cc1)-n1ccnn1
Show InChI InChI=1S/C22H25ClN6O/c23-18-14-24-22(25-15-18)28-9-5-16(6-10-28)21-13-17(21)7-12-30-20-3-1-19(2-4-20)29-11-8-26-27-29/h1-4,8,11,14-17,21H,5-7,9-10,12-13H2/t17-,21-/m1/s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp technique


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342703
PNG
(CHEMBL1771104 | rac-4-(3-(2-(3-(1-(5-chloropyrimid...)
Show SMILES Fc1cc(OCCCC2CC2CCCC2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C28H36ClFN4O2/c29-22-17-31-28(32-18-22)34-12-10-19(11-13-34)3-1-4-20-15-21(20)5-2-14-36-24-8-9-25(26(30)16-24)27(35)33-23-6-7-23/h8-9,16-21,23H,1-7,10-15H2,(H,33,35)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342698
PNG
((rac)-cis-4-((2-((1-(5-chloropyrimidin-2-yl)piperi...)
Show SMILES Fc1cc(OCC2CC2CC2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-18-12-27-24(28-13-18)30-7-5-15(6-8-30)9-16-10-17(16)14-32-20-3-4-21(22(26)11-20)23(31)29-19-1-2-19/h3-4,11-13,15-17,19H,1-2,5-10,14H2,(H,29,31)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342697
PNG
((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Show SMILES Fc1cc(OCCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342697
PNG
((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Show SMILES Fc1cc(OCCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50342701
PNG
(2-(4-((1R,2S)-2-(2-(5-(1H-1,2,3-triazol-1-yl)pyrid...)
Show SMILES Clc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1CCOc1ccc(cn1)-n1ccnn1
Show InChI InChI=1S/C21H24ClN7O/c22-17-12-24-21(25-13-17)28-7-3-15(4-8-28)19-11-16(19)5-10-30-20-2-1-18(14-23-20)29-9-6-26-27-29/h1-2,6,9,12-16,19H,3-5,7-8,10-11H2/t16-,19-/m1/s1
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n/an/a 4.40E+4n/an/an/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp technique


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342672
PNG
(CHEMBL1771072 | tert-butyl 1'-(4-(methylthio)pheny...)
Show SMILES CSc1ccc(cc1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C22H34N2O2S/c1-22(2,3)26-21(25)24-15-11-18(12-16-24)17-9-13-23(14-10-17)19-5-7-20(27-4)8-6-19/h5-8,17-18H,9-16H2,1-4H3
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n/an/an/an/a 600n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342682
PNG
(1-(4-(methylsulfonyl)phenyl)-1'-(pyridin-2-yl)-4,4...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C22H29N3O2S/c1-28(26,27)21-7-5-20(6-8-21)24-14-9-18(10-15-24)19-11-16-25(17-12-19)22-4-2-3-13-23-22/h2-8,13,18-19H,9-12,14-17H2,1H3
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n/an/an/an/a 39n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342674
PNG
(CHEMBL1771075 | tert-butyl 1'-(pyridin-2-yl)-4,4'-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C20H31N3O2/c1-20(2,3)25-19(24)23-14-9-17(10-15-23)16-7-12-22(13-8-16)18-6-4-5-11-21-18/h4-6,11,16-17H,7-10,12-15H2,1-3H3
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n/an/an/an/a 2.50E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342683
PNG
(1-(4-(methylsulfonyl)phenyl)-1'-(pyrazin-2-yl)-4,4...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1cnccn1
Show InChI InChI=1S/C21H28N4O2S/c1-28(26,27)20-4-2-19(3-5-20)24-12-6-17(7-13-24)18-8-14-25(15-9-18)21-16-22-10-11-23-21/h2-5,10-11,16-18H,6-9,12-15H2,1H3
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n/an/an/an/a 239n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342684
PNG
(1-(4-(methylsulfonyl)phenyl)-1'-(pyrimidin-2-yl)-4...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H28N4O2S/c1-28(26,27)20-5-3-19(4-6-20)24-13-7-17(8-14-24)18-9-15-25(16-10-18)21-22-11-2-12-23-21/h2-6,11-12,17-18H,7-10,13-16H2,1H3
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n/an/an/an/a 887n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342685
PNG
(1-(5-methylpyrimidin-2-yl)-1'-(4-(methylsulfonyl)p...)
Show SMILES Cc1cnc(nc1)N1CCC(CC1)C1CCN(CC1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H30N4O2S/c1-17-15-23-22(24-16-17)26-13-9-19(10-14-26)18-7-11-25(12-8-18)20-3-5-21(6-4-20)29(2,27)28/h3-6,15-16,18-19H,7-14H2,1-2H3
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n/an/an/an/a 45n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342686
PNG
(1-(5-chloropyridin-2-yl)-1'-(4-(methylsulfonyl)phe...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccc(Cl)cn1
Show InChI InChI=1S/C22H28ClN3O2S/c1-29(27,28)21-5-3-20(4-6-21)25-12-8-17(9-13-25)18-10-14-26(15-11-18)22-7-2-19(23)16-24-22/h2-7,16-18H,8-15H2,1H3
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n/an/an/an/a 131n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342699
PNG
(5-chloro-2-(4-((1R,2S)-2-(2-(5-(methylsulfonyl)pyr...)
Show SMILES CS(=O)(=O)c1ccc(OCC[C@@H]2C[C@@H]2C2CCN(CC2)c2ncc(Cl)cn2)nc1
Show InChI InChI=1S/C20H25ClN4O3S/c1-29(26,27)17-2-3-19(22-13-17)28-9-6-15-10-18(15)14-4-7-25(8-5-14)20-23-11-16(21)12-24-20/h2-3,11-15,18H,4-10H2,1H3/t15-,18-/m1/s1
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n/an/an/an/a 4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342669
PNG
(CHEMBL1771069 | tert-butyl 1'-(3-(methylsulfonyl)p...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C22H34N2O4S/c1-22(2,3)28-21(25)24-14-10-18(11-15-24)17-8-12-23(13-9-17)19-6-5-7-20(16-19)29(4,26)27/h5-7,16-18H,8-15H2,1-4H3
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n/an/an/an/a 1.90E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342684
PNG
(1-(4-(methylsulfonyl)phenyl)-1'-(pyrimidin-2-yl)-4...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H28N4O2S/c1-28(26,27)20-5-3-19(4-6-20)24-13-7-17(8-14-24)18-9-15-25(16-10-18)21-22-11-2-12-23-21/h2-6,11-12,17-18H,7-10,13-16H2,1H3
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n/an/an/an/a 98n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342687
PNG
(1-(5-fluoropyridin-2-yl)-1'-(4-(methylsulfonyl)phe...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccc(F)cn1
Show InChI InChI=1S/C22H28FN3O2S/c1-29(27,28)21-5-3-20(4-6-21)25-12-8-17(9-13-25)18-10-14-26(15-11-18)22-7-2-19(23)16-24-22/h2-7,16-18H,8-15H2,1H3
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n/an/an/an/a 19n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342688
PNG
(1-(5-methylpyridin-2-yl)-1'-(4-(methylsulfonyl)phe...)
Show SMILES Cc1ccc(nc1)N1CCC(CC1)C1CCN(CC1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H31N3O2S/c1-18-3-8-23(24-17-18)26-15-11-20(12-16-26)19-9-13-25(14-10-19)21-4-6-22(7-5-21)29(2,27)28/h3-8,17,19-20H,9-16H2,1-2H3
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n/an/an/an/a 18n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342697
PNG
((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Show SMILES Fc1cc(OCCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
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n/an/an/an/a 3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342698
PNG
((rac)-cis-4-((2-((1-(5-chloropyrimidin-2-yl)piperi...)
Show SMILES Fc1cc(OCC2CC2CC2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-18-12-27-24(28-13-18)30-7-5-15(6-8-30)9-16-10-17(16)14-32-20-3-4-21(22(26)11-20)23(31)29-19-1-2-19/h3-4,11-13,15-17,19H,1-2,5-10,14H2,(H,29,31)
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n/an/an/an/a 18n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342702
PNG
(6-methyl-2-(2-((1S,2R)-2-(1-(5-methylpyrimidin-2-y...)
Show SMILES Cc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1CCOc1nc(C)cc(n1)C#N
Show InChI InChI=1S/C21H26N6O/c1-14-12-23-20(24-13-14)27-6-3-16(4-7-27)19-10-17(19)5-8-28-21-25-15(2)9-18(11-22)26-21/h9,12-13,16-17,19H,3-8,10H2,1-2H3/t17-,19-/m1/s1
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n/an/an/an/a 2n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342667
PNG
(CHEMBL1771067 | tert-butyl 1'-p-tolyl-4,4'-bipiper...)
Show SMILES Cc1ccc(cc1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C22H34N2O2/c1-17-5-7-20(8-6-17)23-13-9-18(10-14-23)19-11-15-24(16-12-19)21(25)26-22(2,3)4/h5-8,18-19H,9-16H2,1-4H3
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n/an/an/an/a 1.90E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342668
PNG
(CHEMBL1771068 | tert-butyl 1'-(4-(methylsulfonyl)p...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H34N2O4S/c1-22(2,3)28-21(25)24-15-11-18(12-16-24)17-9-13-23(14-10-17)19-5-7-20(8-6-19)29(4,26)27/h5-8,17-18H,9-16H2,1-4H3
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n/an/an/an/a 36n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342679
PNG
(CHEMBL1771080 | tert-butyl 1'-(6-cyanopyrimidin-4-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1cc(ncn1)C#N
Show InChI InChI=1S/C20H29N5O2/c1-20(2,3)27-19(26)25-10-6-16(7-11-25)15-4-8-24(9-5-15)18-12-17(13-21)22-14-23-18/h12,14-16H,4-11H2,1-3H3
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n/an/an/an/a 31n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342682
PNG
(1-(4-(methylsulfonyl)phenyl)-1'-(pyridin-2-yl)-4,4...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C22H29N3O2S/c1-28(26,27)21-7-5-20(6-8-21)24-14-9-18(10-15-24)19-11-16-25(17-12-19)22-4-2-3-13-23-22/h2-8,13,18-19H,9-12,14-17H2,1H3
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n/an/an/an/a 682n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342688
PNG
(1-(5-methylpyridin-2-yl)-1'-(4-(methylsulfonyl)phe...)
Show SMILES Cc1ccc(nc1)N1CCC(CC1)C1CCN(CC1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H31N3O2S/c1-18-3-8-23(24-17-18)26-15-11-20(12-16-26)19-9-13-25(14-10-19)21-4-6-22(7-5-21)29(2,27)28/h3-8,17,19-20H,9-16H2,1-2H3
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n/an/an/an/a 73n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342703
PNG
(CHEMBL1771104 | rac-4-(3-(2-(3-(1-(5-chloropyrimid...)
Show SMILES Fc1cc(OCCCC2CC2CCCC2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C28H36ClFN4O2/c29-22-17-31-28(32-18-22)34-12-10-19(11-13-34)3-1-4-20-15-21(20)5-2-14-36-24-8-9-25(26(30)16-24)27(35)33-23-6-7-23/h8-9,16-21,23H,1-7,10-15H2,(H,33,35)
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n/an/an/an/a 0.800n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342697
PNG
((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Show SMILES Fc1cc(OCCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
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n/an/an/an/a 5n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342697
PNG
((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Show SMILES Fc1cc(OCCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342668
PNG
(CHEMBL1771068 | tert-butyl 1'-(4-(methylsulfonyl)p...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H34N2O4S/c1-22(2,3)28-21(25)24-15-11-18(12-16-24)17-9-13-23(14-10-17)19-5-7-20(8-6-19)29(4,26)27/h5-8,17-18H,9-16H2,1-4H3
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n/an/an/an/a 22n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342685
PNG
(1-(5-methylpyrimidin-2-yl)-1'-(4-(methylsulfonyl)p...)
Show SMILES Cc1cnc(nc1)N1CCC(CC1)C1CCN(CC1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H30N4O2S/c1-17-15-23-22(24-16-17)26-13-9-19(10-14-26)18-7-11-25(12-8-18)20-3-5-21(6-4-20)29(2,27)28/h3-6,15-16,18-19H,7-14H2,1-2H3
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n/an/an/an/a 57n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342692
PNG
(4-(1'-(5-chloropyrimidin-2-yl)-4,4'-bipiperidin-1-...)
Show SMILES Cc1cc(nc(n1)C#N)N1CCC(CC1)C1CCN(CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24ClN7/c1-14-10-19(26-18(11-22)25-14)27-6-2-15(3-7-27)16-4-8-28(9-5-16)20-23-12-17(21)13-24-20/h10,12-13,15-16H,2-9H2,1H3
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n/an/an/an/a 2n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342696
PNG
((rac)-cis-4-((2-(1-(5-chloropyrimidin-2-yl)piperid...)
Show SMILES Fc1cc(OCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C23H26ClFN4O2/c24-16-11-26-23(27-12-16)29-7-5-14(6-8-29)20-9-15(20)13-31-18-3-4-19(21(25)10-18)22(30)28-17-1-2-17/h3-4,10-12,14-15,17,20H,1-2,5-9,13H2,(H,28,30)
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n/an/an/an/a 38n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342675
PNG
(CHEMBL1771076 | tert-butyl 1'-(pyrimidin-4-yl)-4,4...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccncn1
Show InChI InChI=1S/C19H30N4O2/c1-19(2,3)25-18(24)23-12-7-16(8-13-23)15-5-10-22(11-6-15)17-4-9-20-14-21-17/h4,9,14-16H,5-8,10-13H2,1-3H3
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n/an/an/an/a 379n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342677
PNG
(CHEMBL1771078 | tert-butyl 1'-(pyrazin-2-yl)-4,4'-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1cnccn1
Show InChI InChI=1S/C19H30N4O2/c1-19(2,3)25-18(24)23-12-6-16(7-13-23)15-4-10-22(11-5-15)17-14-20-8-9-21-17/h8-9,14-16H,4-7,10-13H2,1-3H3
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n/an/an/an/a 142n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342687
PNG
(1-(5-fluoropyridin-2-yl)-1'-(4-(methylsulfonyl)phe...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccc(F)cn1
Show InChI InChI=1S/C22H28FN3O2S/c1-29(27,28)21-5-3-20(4-6-21)25-12-8-17(9-13-25)18-10-14-26(15-11-18)22-7-2-19(23)16-24-22/h2-7,16-18H,8-15H2,1H3
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n/an/an/an/a 206n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342701
PNG
(2-(4-((1R,2S)-2-(2-(5-(1H-1,2,3-triazol-1-yl)pyrid...)
Show SMILES Clc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1CCOc1ccc(cn1)-n1ccnn1
Show InChI InChI=1S/C21H24ClN7O/c22-17-12-24-21(25-13-17)28-7-3-15(4-8-28)19-11-16(19)5-10-30-20-2-1-18(14-23-20)29-9-6-26-27-29/h1-2,6,9,12-16,19H,3-5,7-8,10-11H2/t16-,19-/m1/s1
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n/an/an/an/a 4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342671
PNG
(CHEMBL1771071 | tert-butyl 1'-(4-acetylphenyl)-4,4...)
Show SMILES CC(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C23H34N2O3/c1-17(26)18-5-7-21(8-6-18)24-13-9-19(10-14-24)20-11-15-25(16-12-20)22(27)28-23(2,3)4/h5-8,19-20H,9-16H2,1-4H3
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n/an/an/an/a 25n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342680
PNG
(CHEMBL1771081 | tert-butyl 1'-(2-cyano-6-methylpyr...)
Show SMILES Cc1cc(nc(n1)C#N)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C21H31N5O2/c1-15-13-19(24-18(14-22)23-15)25-9-5-16(6-10-25)17-7-11-26(12-8-17)20(27)28-21(2,3)4/h13,16-17H,5-12H2,1-4H3
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n/an/an/an/a 1n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342681
PNG
(CHEMBL1771082 | tert-butyl 1'-(6-cyano-2-methylpyr...)
Show SMILES Cc1nc(cc(n1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C)C#N
Show InChI InChI=1S/C21H31N5O2/c1-15-23-18(14-22)13-19(24-15)25-9-5-16(6-10-25)17-7-11-26(12-8-17)20(27)28-21(2,3)4/h13,16-17H,5-12H2,1-4H3
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n/an/an/an/a 2n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342694
PNG
(2-methyl-6-(1'-(5-methylpyrazin-2-yl)-4,4'-bipiper...)
Show SMILES Cc1cnc(cn1)N1CCC(CC1)C1CCN(CC1)c1cc(nc(C)n1)C#N
Show InChI InChI=1S/C21H27N7/c1-15-13-24-21(14-23-15)28-9-5-18(6-10-28)17-3-7-27(8-4-17)20-11-19(12-22)25-16(2)26-20/h11,13-14,17-18H,3-10H2,1-2H3
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n/an/an/an/a 30n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342680
PNG
(CHEMBL1771081 | tert-butyl 1'-(2-cyano-6-methylpyr...)
Show SMILES Cc1cc(nc(n1)C#N)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C21H31N5O2/c1-15-13-19(24-18(14-22)23-15)25-9-5-16(6-10-25)17-7-11-26(12-8-17)20(27)28-21(2,3)4/h13,16-17H,5-12H2,1-4H3
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342691
PNG
(1-(5-chloropyrimidin-2-yl)-1'-(4-(methylsulfonyl)p...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H27ClN4O2S/c1-29(27,28)20-4-2-19(3-5-20)25-10-6-16(7-11-25)17-8-12-26(13-9-17)21-23-14-18(22)15-24-21/h2-5,14-17H,6-13H2,1H3
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n/an/an/an/a 8n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342692
PNG
(4-(1'-(5-chloropyrimidin-2-yl)-4,4'-bipiperidin-1-...)
Show SMILES Cc1cc(nc(n1)C#N)N1CCC(CC1)C1CCN(CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24ClN7/c1-14-10-19(26-18(11-22)25-14)27-6-2-15(3-7-27)16-4-8-28(9-5-16)20-23-12-17(21)13-24-20/h10,12-13,15-16H,2-9H2,1H3
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n/an/an/an/a 11n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342674
PNG
(CHEMBL1771075 | tert-butyl 1'-(pyridin-2-yl)-4,4'-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C20H31N3O2/c1-20(2,3)25-19(24)23-14-9-17(10-15-23)16-7-12-22(13-8-16)18-6-4-5-11-21-18/h4-6,11,16-17H,7-10,12-15H2,1-3H3
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n/an/an/an/a 831n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342691
PNG
(1-(5-chloropyrimidin-2-yl)-1'-(4-(methylsulfonyl)p...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H27ClN4O2S/c1-29(27,28)20-4-2-19(3-5-20)25-10-6-16(7-11-25)17-8-12-26(13-9-17)21-23-14-18(22)15-24-21/h2-5,14-17H,6-13H2,1H3
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342697
PNG
((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Show SMILES Fc1cc(OCCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
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n/an/an/an/a 14n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342699
PNG
(5-chloro-2-(4-((1R,2S)-2-(2-(5-(methylsulfonyl)pyr...)
Show SMILES CS(=O)(=O)c1ccc(OCC[C@@H]2C[C@@H]2C2CCN(CC2)c2ncc(Cl)cn2)nc1
Show InChI InChI=1S/C20H25ClN4O3S/c1-29(26,27)17-2-3-19(22-13-17)28-9-6-15-10-18(15)14-4-7-25(8-5-14)20-23-11-16(21)12-24-20/h2-3,11-15,18H,4-10H2,1H3/t15-,18-/m1/s1
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n/an/an/an/a 4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342698
PNG
((rac)-cis-4-((2-((1-(5-chloropyrimidin-2-yl)piperi...)
Show SMILES Fc1cc(OCC2CC2CC2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-18-12-27-24(28-13-18)30-7-5-15(6-8-30)9-16-10-17(16)14-32-20-3-4-21(22(26)11-20)23(31)29-19-1-2-19/h3-4,11-13,15-17,19H,1-2,5-10,14H2,(H,29,31)
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n/an/an/an/a 18n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342700
PNG
(2-(4-((1R,2S)-2-(2-(4-(1H-1,2,3-triazol-1-yl)pheno...)
Show SMILES Clc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1CCOc1ccc(cc1)-n1ccnn1
Show InChI InChI=1S/C22H25ClN6O/c23-18-14-24-22(25-15-18)28-9-5-16(6-10-28)21-13-17(21)7-12-30-20-3-1-19(2-4-20)29-11-8-26-27-29/h1-4,8,11,14-17,21H,5-7,9-10,12-13H2/t17-,21-/m1/s1
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342665
PNG
(CHEMBL1771064 | tert-butyl 1'-phenyl-4,4'-bipiperi...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C21H32N2O2/c1-21(2,3)25-20(24)23-15-11-18(12-16-23)17-9-13-22(14-10-17)19-7-5-4-6-8-19/h4-8,17-18H,9-16H2,1-3H3
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n/an/an/an/a 1.40E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342666
PNG
(CHEMBL1771066 | tert-butyl 1'-m-tolyl-4,4'-bipiper...)
Show SMILES Cc1cccc(c1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C22H34N2O2/c1-17-6-5-7-20(16-17)23-12-8-18(9-13-23)19-10-14-24(15-11-19)21(25)26-22(2,3)4/h5-7,16,18-19H,8-15H2,1-4H3
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n/an/an/an/a 514n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342670
PNG
(CHEMBL1771070 | tert-butyl 1'-(4-(methylsulfinyl)p...)
Show SMILES CS(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C22H34N2O3S/c1-22(2,3)27-21(25)24-15-11-18(12-16-24)17-9-13-23(14-10-17)19-5-7-20(8-6-19)28(4)26/h5-8,17-18H,9-16H2,1-4H3
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n/an/an/an/a 11n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342673
PNG
(CHEMBL1771073 | tert-butyl 1'-(4-carbamoylphenyl)-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C22H33N3O3/c1-22(2,3)28-21(27)25-14-10-17(11-15-25)16-8-12-24(13-9-16)19-6-4-18(5-7-19)20(23)26/h4-7,16-17H,8-15H2,1-3H3,(H2,23,26)
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n/an/an/an/a 76n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342676
PNG
(CHEMBL1771077 | tert-butyl 1'-(pyrimidin-2-yl)-4,4...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C19H30N4O2/c1-19(2,3)25-18(24)23-13-7-16(8-14-23)15-5-11-22(12-6-15)17-20-9-4-10-21-17/h4,9-10,15-16H,5-8,11-14H2,1-3H3
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n/an/an/an/a 526n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342678
PNG
(CHEMBL1771079 | tert-butyl 1'-(2-cyanopyrimidin-4-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccnc(n1)C#N
Show InChI InChI=1S/C20H29N5O2/c1-20(2,3)27-19(26)25-12-7-16(8-13-25)15-5-10-24(11-6-15)18-4-9-22-17(14-21)23-18/h4,9,15-16H,5-8,10-13H2,1-3H3
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n/an/an/an/a 6n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342686
PNG
(1-(5-chloropyridin-2-yl)-1'-(4-(methylsulfonyl)phe...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccc(Cl)cn1
Show InChI InChI=1S/C22H28ClN3O2S/c1-29(27,28)21-5-3-20(4-6-21)25-12-8-17(9-13-25)18-10-14-26(15-11-18)22-7-2-19(23)16-24-22/h2-7,16-18H,8-15H2,1H3
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n/an/an/an/a 48n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342690
PNG
(1-(4-(methylsulfonyl)phenyl)-1'-(5-(trifluoromethy...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C23H28F3N3O2S/c1-32(30,31)21-5-3-20(4-6-21)28-12-8-17(9-13-28)18-10-14-29(15-11-18)22-7-2-19(16-27-22)23(24,25)26/h2-7,16-18H,8-15H2,1H3
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n/an/an/an/a 13n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342697
PNG
((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Show SMILES Fc1cc(OCCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
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n/an/an/an/a 0.300n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342698
PNG
((rac)-cis-4-((2-((1-(5-chloropyrimidin-2-yl)piperi...)
Show SMILES Fc1cc(OCC2CC2CC2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-18-12-27-24(28-13-18)30-7-5-15(6-8-30)9-16-10-17(16)14-32-20-3-4-21(22(26)11-20)23(31)29-19-1-2-19/h3-4,11-13,15-17,19H,1-2,5-10,14H2,(H,29,31)
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n/an/an/an/a 9n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342700
PNG
(2-(4-((1R,2S)-2-(2-(4-(1H-1,2,3-triazol-1-yl)pheno...)
Show SMILES Clc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1CCOc1ccc(cc1)-n1ccnn1
Show InChI InChI=1S/C22H25ClN6O/c23-18-14-24-22(25-15-18)28-9-5-16(6-10-28)21-13-17(21)7-12-30-20-3-1-19(2-4-20)29-11-8-26-27-29/h1-4,8,11,14-17,21H,5-7,9-10,12-13H2/t17-,21-/m1/s1
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n/an/an/an/a 4n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342689
PNG
(6-(1'-(4-(methylsulfonyl)phenyl)-4,4'-bipiperidin-...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C23H28N4O2S/c1-30(28,29)22-5-3-21(4-6-22)26-12-8-19(9-13-26)20-10-14-27(15-11-20)23-7-2-18(16-24)17-25-23/h2-7,17,19-20H,8-15H2,1H3
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n/an/an/an/a 41n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342703
PNG
(CHEMBL1771104 | rac-4-(3-(2-(3-(1-(5-chloropyrimid...)
Show SMILES Fc1cc(OCCCC2CC2CCCC2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C28H36ClFN4O2/c29-22-17-31-28(32-18-22)34-12-10-19(11-13-34)3-1-4-20-15-21(20)5-2-14-36-24-8-9-25(26(30)16-24)27(35)33-23-6-7-23/h8-9,16-21,23H,1-7,10-15H2,(H,33,35)
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n/an/an/an/a 0.200n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342702
PNG
(6-methyl-2-(2-((1S,2R)-2-(1-(5-methylpyrimidin-2-y...)
Show SMILES Cc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1CCOc1nc(C)cc(n1)C#N
Show InChI InChI=1S/C21H26N6O/c1-14-12-23-20(24-13-14)27-6-3-16(4-7-27)19-10-17(19)5-8-28-21-25-15(2)9-18(11-22)26-21/h9,12-13,16-17,19H,3-8,10H2,1-2H3/t17-,19-/m1/s1
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Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342675
PNG
(CHEMBL1771076 | tert-butyl 1'-(pyrimidin-4-yl)-4,4...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccncn1
Show InChI InChI=1S/C19H30N4O2/c1-19(2,3)25-18(24)23-12-7-16(8-13-23)15-5-10-22(11-6-15)17-4-9-20-14-21-17/h4,9,14-16H,5-8,10-13H2,1-3H3
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n/an/an/an/a 116n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342677
PNG
(CHEMBL1771078 | tert-butyl 1'-(pyrazin-2-yl)-4,4'-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1cnccn1
Show InChI InChI=1S/C19H30N4O2/c1-19(2,3)25-18(24)23-12-6-16(7-13-23)15-4-10-22(11-5-15)17-14-20-8-9-21-17/h8-9,14-16H,4-7,10-13H2,1-3H3
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n/an/an/an/a 103n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342679
PNG
(CHEMBL1771080 | tert-butyl 1'-(6-cyanopyrimidin-4-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1cc(ncn1)C#N
Show InChI InChI=1S/C20H29N5O2/c1-20(2,3)27-19(26)25-10-6-16(7-11-25)15-4-8-24(9-5-15)18-12-17(13-21)22-14-23-18/h12,14-16H,4-11H2,1-3H3
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n/an/an/an/a 6n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342683
PNG
(1-(4-(methylsulfonyl)phenyl)-1'-(pyrazin-2-yl)-4,4...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1cnccn1
Show InChI InChI=1S/C21H28N4O2S/c1-28(26,27)20-4-2-19(3-5-20)24-12-6-17(7-13-24)18-8-14-25(15-9-18)21-16-22-10-11-23-21/h2-5,10-11,16-18H,6-9,12-15H2,1H3
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n/an/an/an/a 201n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342695
PNG
(4-methyl-6-(1'-(5-methylpyrazin-2-yl)-4,4'-bipiper...)
Show SMILES Cc1cnc(cn1)N1CCC(CC1)C1CCN(CC1)c1cc(C)nc(n1)C#N
Show InChI InChI=1S/C21H27N7/c1-15-11-20(26-19(12-22)25-15)27-7-3-17(4-8-27)18-5-9-28(10-6-18)21-14-23-16(2)13-24-21/h11,13-14,17-18H,3-10H2,1-2H3
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n/an/an/an/a 19n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342696
PNG
((rac)-cis-4-((2-(1-(5-chloropyrimidin-2-yl)piperid...)
Show SMILES Fc1cc(OCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C23H26ClFN4O2/c24-16-11-26-23(27-12-16)29-7-5-14(6-8-29)20-9-15(20)13-31-18-3-4-19(21(25)10-18)22(30)28-17-1-2-17/h3-4,10-12,14-15,17,20H,1-2,5-9,13H2,(H,28,30)
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n/an/an/an/a 20n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342671
PNG
(CHEMBL1771071 | tert-butyl 1'-(4-acetylphenyl)-4,4...)
Show SMILES CC(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C23H34N2O3/c1-17(26)18-5-7-21(8-6-18)24-13-9-19(10-14-24)20-11-15-25(16-12-20)22(27)28-23(2,3)4/h5-8,19-20H,9-16H2,1-4H3
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n/an/an/an/a 341n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342672
PNG
(CHEMBL1771072 | tert-butyl 1'-(4-(methylthio)pheny...)
Show SMILES CSc1ccc(cc1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C22H34N2O2S/c1-22(2,3)26-21(25)24-15-11-18(12-16-24)17-9-13-23(14-10-17)19-5-7-20(27-4)8-6-19/h5-8,17-18H,9-16H2,1-4H3
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n/an/an/an/a 513n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342673
PNG
(CHEMBL1771073 | tert-butyl 1'-(4-carbamoylphenyl)-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C22H33N3O3/c1-22(2,3)28-21(27)25-14-10-17(11-15-25)16-8-12-24(13-9-16)19-6-4-18(5-7-19)20(23)26/h4-7,16-17H,8-15H2,1-3H3,(H2,23,26)
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n/an/an/an/a 165n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342676
PNG
(CHEMBL1771077 | tert-butyl 1'-(pyrimidin-2-yl)-4,4...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C19H30N4O2/c1-19(2,3)25-18(24)23-13-7-16(8-14-23)15-5-11-22(12-6-15)17-20-9-4-10-21-17/h4,9-10,15-16H,5-8,11-14H2,1-3H3
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n/an/an/an/a 523n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342678
PNG
(CHEMBL1771079 | tert-butyl 1'-(2-cyanopyrimidin-4-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1ccnc(n1)C#N
Show InChI InChI=1S/C20H29N5O2/c1-20(2,3)27-19(26)25-12-7-16(8-13-25)15-5-10-24(11-6-15)18-4-9-22-17(14-21)23-18/h4,9,15-16H,5-8,10-13H2,1-3H3
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n/an/an/an/a 11n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342681
PNG
(CHEMBL1771082 | tert-butyl 1'-(6-cyano-2-methylpyr...)
Show SMILES Cc1nc(cc(n1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C)C#N
Show InChI InChI=1S/C21H31N5O2/c1-15-23-18(14-22)13-19(24-15)25-9-5-16(6-10-25)17-7-11-26(12-8-17)20(27)28-21(2,3)4/h13,16-17H,5-12H2,1-4H3
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n/an/an/an/a 2n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342690
PNG
(1-(4-(methylsulfonyl)phenyl)-1'-(5-(trifluoromethy...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C23H28F3N3O2S/c1-32(30,31)21-5-3-20(4-6-21)28-12-8-17(9-13-28)18-10-14-29(15-11-18)22-7-2-19(16-27-22)23(24,25)26/h2-7,16-18H,8-15H2,1H3
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n/an/an/an/a 8n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342693
PNG
(2-methyl-6-(1'-(5-methylpyrimidin-2-yl)-4,4'-bipip...)
Show SMILES Cc1cnc(nc1)N1CCC(CC1)C1CCN(CC1)c1cc(nc(C)n1)C#N
Show InChI InChI=1S/C21H27N7/c1-15-13-23-21(24-14-15)28-9-5-18(6-10-28)17-3-7-27(8-4-17)20-11-19(12-22)25-16(2)26-20/h11,13-14,17-18H,3-10H2,1-2H3
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n/an/an/an/a 10n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342694
PNG
(2-methyl-6-(1'-(5-methylpyrazin-2-yl)-4,4'-bipiper...)
Show SMILES Cc1cnc(cn1)N1CCC(CC1)C1CCN(CC1)c1cc(nc(C)n1)C#N
Show InChI InChI=1S/C21H27N7/c1-15-13-24-21(14-23-15)28-9-5-18(6-10-28)17-3-7-27(8-4-17)20-11-19(12-22)25-16(2)26-20/h11,13-14,17-18H,3-10H2,1-2H3
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n/an/an/an/a 82n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342696
PNG
((rac)-cis-4-((2-(1-(5-chloropyrimidin-2-yl)piperid...)
Show SMILES Fc1cc(OCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C23H26ClFN4O2/c24-16-11-26-23(27-12-16)29-7-5-14(6-8-29)20-9-15(20)13-31-18-3-4-19(21(25)10-18)22(30)28-17-1-2-17/h3-4,10-12,14-15,17,20H,1-2,5-9,13H2,(H,28,30)
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n/an/an/an/a 23n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342698
PNG
((rac)-cis-4-((2-((1-(5-chloropyrimidin-2-yl)piperi...)
Show SMILES Fc1cc(OCC2CC2CC2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-18-12-27-24(28-13-18)30-7-5-15(6-8-30)9-16-10-17(16)14-32-20-3-4-21(22(26)11-20)23(31)29-19-1-2-19/h3-4,11-13,15-17,19H,1-2,5-10,14H2,(H,29,31)
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n/an/an/an/a 36n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342664
PNG
(CHEMBL1770918 | tert-butyl 1'-(pyridin-3-yl)-4,4'-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)C1CCN(CC1)c1cccnc1
Show InChI InChI=1S/C20H31N3O2/c1-20(2,3)25-19(24)23-13-8-17(9-14-23)16-6-11-22(12-7-16)18-5-4-10-21-15-18/h4-5,10,15-17H,6-9,11-14H2,1-3H3
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n/an/an/an/a 3.60E+3n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342667
PNG
(CHEMBL1771067 | tert-butyl 1'-p-tolyl-4,4'-bipiper...)
Show SMILES Cc1ccc(cc1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C22H34N2O2/c1-17-5-7-20(8-6-17)23-13-9-18(10-14-23)19-11-15-24(16-12-19)21(25)26-22(2,3)4/h5-8,18-19H,9-16H2,1-4H3
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n/an/an/an/a 338n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342689
PNG
(6-(1'-(4-(methylsulfonyl)phenyl)-4,4'-bipiperidin-...)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C23H28N4O2S/c1-30(28,29)22-5-3-21(4-6-22)26-12-8-19(9-13-26)20-10-14-27(15-11-20)23-7-2-18(16-24)17-25-23/h2-7,17,19-20H,8-15H2,1H3
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n/an/an/an/a 62n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342693
PNG
(2-methyl-6-(1'-(5-methylpyrimidin-2-yl)-4,4'-bipip...)
Show SMILES Cc1cnc(nc1)N1CCC(CC1)C1CCN(CC1)c1cc(nc(C)n1)C#N
Show InChI InChI=1S/C21H27N7/c1-15-13-23-21(24-14-15)28-9-5-18(6-10-28)17-3-7-27(8-4-17)20-11-19(12-22)25-16(2)26-20/h11,13-14,17-18H,3-10H2,1-2H3
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n/an/an/an/a 8n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50342701
PNG
(2-(4-((1R,2S)-2-(2-(5-(1H-1,2,3-triazol-1-yl)pyrid...)
Show SMILES Clc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1CCOc1ccc(cn1)-n1ccnn1
Show InChI InChI=1S/C21H24ClN7O/c22-17-12-24-21(25-13-17)28-7-3-15(4-8-28)19-11-16(19)5-10-30-20-2-1-18(14-23-20)29-9-6-26-27-29/h1-2,6,9,12-16,19H,3-5,7-8,10-11H2/t16-,19-/m1/s1
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n/an/an/an/a 2n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342670
PNG
(CHEMBL1771070 | tert-butyl 1'-(4-(methylsulfinyl)p...)
Show SMILES CS(=O)c1ccc(cc1)N1CCC(CC1)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C22H34N2O3S/c1-22(2,3)27-21(25)24-15-11-18(12-16-24)17-9-13-23(14-10-17)19-5-7-20(8-6-19)28(4)26/h5-8,17-18H,9-16H2,1-4H3
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PubMed
n/an/an/an/a 132n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342695
PNG
(4-methyl-6-(1'-(5-methylpyrazin-2-yl)-4,4'-bipiper...)
Show SMILES Cc1cnc(cn1)N1CCC(CC1)C1CCN(CC1)c1cc(C)nc(n1)C#N
Show InChI InChI=1S/C21H27N7/c1-15-11-20(26-19(12-22)25-15)27-7-3-17(4-8-27)18-5-9-28(10-6-18)21-14-23-16(2)13-24-21/h11,13-14,17-18H,3-10H2,1-2H3
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n/an/an/an/a 64n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342696
PNG
((rac)-cis-4-((2-(1-(5-chloropyrimidin-2-yl)piperid...)
Show SMILES Fc1cc(OCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C23H26ClFN4O2/c24-16-11-26-23(27-12-16)29-7-5-14(6-8-29)20-9-15(20)13-31-18-3-4-19(21(25)10-18)22(30)28-17-1-2-17/h3-4,10-12,14-15,17,20H,1-2,5-9,13H2,(H,28,30)
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n/an/an/an/a 9n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50342697
PNG
((+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piper...)
Show SMILES Fc1cc(OCCC2CC2C2CCN(CC2)c2ncc(Cl)cn2)ccc1C(=O)NC1CC1
Show InChI InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
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n/an/an/an/a 0.400n/an/an/an/a



Merck& Co.

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 expressed in CHO cells co-expressing Galpha15 assessed as increase of intracellular cAMP accumulation after 60 mins ...


Bioorg Med Chem Lett 21: 2665-9 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.086
BindingDB Entry DOI: 10.7270/Q2M61KJV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%