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Found 17 Enz. Inhib. hit(s) with all data for entry = 50033509
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50346543(CHEMBL1797750)
Affinity DataIC50:  98nMAssay Description:Inhibition of SIRT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM3175(3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methy...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human N-terminally His6-tagged Sirt2 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50346550(CHEMBL270110)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of SIRT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM3175(3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methy...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human recombinant N-terminally GST-tagged Sirt1 expressed in Escherichia coli using ZMAL as substrate after 4 hrs by homogeneous fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM3175(3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methy...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human C-terminally His6-tagged Sirt3 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50346546(CHEMBL1797926)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human N-terminally His6-tagged Sirt2 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50346546(CHEMBL1797926)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of human recombinant N-terminally GST-tagged Sirt1 expressed in Escherichia coli using ZMAL as substrate after 4 hrs by homogeneous fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM74978(1,3-dihydrobenzo[e]benzimidazole-2-thione | CHEMBL...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of human recombinant N-terminally GST-tagged Sirt1 expressed in Escherichia coli using ZMAL as substrate after 4 hrs by homogeneous fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM74978(1,3-dihydrobenzo[e]benzimidazole-2-thione | CHEMBL...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human N-terminally His6-tagged Sirt2 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50346547(CHEMBL1797919)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human N-terminally His6-tagged Sirt2 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50346545(CHEMBL1797923)
Affinity DataIC50:  1.63E+4nMAssay Description:Inhibition of human N-terminally His6-tagged Sirt2 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50346545(CHEMBL1797923)
Affinity DataIC50:  2.14E+4nMAssay Description:Inhibition of human recombinant N-terminally GST-tagged Sirt1 expressed in Escherichia coli using ZMAL as substrate after 4 hrs by homogeneous fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50346548(CHEMBL1797922)
Affinity DataIC50:  2.69E+4nMAssay Description:Inhibition of human N-terminally His6-tagged Sirt2 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50346544(CHEMBL1797920)
Affinity DataIC50:  2.93E+4nMAssay Description:Inhibition of human recombinant N-terminally GST-tagged Sirt1 expressed in Escherichia coli using ZMAL as substrate after 4 hrs by homogeneous fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50346549(CHEMBL1797925)
Affinity DataIC50:  3.44E+4nMAssay Description:Inhibition of human N-terminally His6-tagged Sirt2 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50346544(CHEMBL1797920)
Affinity DataIC50:  3.83E+4nMAssay Description:Inhibition of human N-terminally His6-tagged Sirt2 using ZMAL as substrate after 4 hrs by homogeneous fluorescent deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Ernst-Moritz-Arndt University Greifswald

Curated by ChEMBL
LigandPNGBDBM50346548(CHEMBL1797922)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant N-terminally GST-tagged Sirt1 expressed in Escherichia coli using ZMAL as substrate after 4 hrs by homogeneous fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed