BindingDB logo
myBDB logout

PubMed code 21316964

Compile data set for download or QSAR
Found 108 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338310
PNG
((+/-)-(3R,4S)-7-fluoro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(F)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23FN2O/c1-11-15-10-16(14-7-5-6-13-8-9-23-19(13)14)17(22)12(2)18(15)24-21(3,4)20(11)25/h5-11,20,23-25H,1-4H3/t11-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.900n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338303
PNG
((+/-)-(3R,4S)-8-chloro-5,7-difluoro-6-(1H-indol-7-...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(Cl)c(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H19ClF2N2O/c1-9-12-15(22)13(11-6-4-5-10-7-8-24-17(10)11)16(23)14(21)18(12)25-20(2,3)19(9)26/h4-9,19,24-26H,1-3H3/t9-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338321
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,5,8-pentamet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C22H26N2O/c1-12-11-17(16-8-6-7-15-9-10-23-20(15)16)13(2)18-14(3)21(25)22(4,5)24-19(12)18/h6-11,14,21,23-25H,1-5H3/t14-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.20n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338312
PNG
((+/-)-(3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(-c3cccc4cc[nH]c34)c(C#N)c12
Show InChI InChI=1S/C22H23N3O/c1-12-10-16(15-7-5-6-14-8-9-24-20(14)15)17(11-23)18-13(2)21(26)22(3,4)25-19(12)18/h5-10,13,21,24-26H,1-4H3/t13-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.30n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338317
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES CCO\N=C\c1c(cc(C)c2NC(C)(C)[C@H](O)[C@@H](C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C24H29N3O2/c1-6-29-26-13-19-18(17-9-7-8-16-10-11-25-22(16)17)12-14(2)21-20(19)15(3)23(28)24(4,5)27-21/h7-13,15,23,25,27-28H,6H2,1-5H3/b26-13+/t15-,23+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.5n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50334054
PNG
((+/-)-(3R,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2O/c1-11-10-15(14-7-5-6-13-8-9-23-19(13)14)17(22)16-12(2)20(25)21(3,4)24-18(11)16/h5-10,12,20,23-25H,1-4H3/t12-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.70n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338325
PNG
((+/-)-(3R,4S)-7-chloro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(Cl)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2O/c1-11-15-10-16(14-7-5-6-13-8-9-23-19(13)14)17(22)12(2)18(15)24-21(3,4)20(11)25/h5-11,20,23-25H,1-4H3/t11-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.80n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338322
PNG
((+/-)-(3R,4S)-5-fluoro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23FN2O/c1-11-10-15(14-7-5-6-13-8-9-23-19(13)14)17(22)16-12(2)20(25)21(3,4)24-18(11)16/h5-10,12,20,23-25H,1-4H3/t12-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.30n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338305
PNG
((+/-)-(3R,4S)-7,8-difluoro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(F)c(F)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20F2N2O/c1-10-13-9-14(12-6-4-5-11-7-8-23-17(11)12)15(21)16(22)18(13)24-20(2,3)19(10)25/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.40n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338324
PNG
((+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20F2N2O/c1-10-15-14(24-20(2,3)19(10)25)9-13(21)16(17(15)22)12-6-4-5-11-7-8-23-18(11)12/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.5n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338307
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(C=C)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H26N2O/c1-6-16-13(2)20-18(14(3)22(26)23(4,5)25-20)12-19(16)17-9-7-8-15-10-11-24-21(15)17/h6-12,14,22,24-26H,1H2,2-5H3/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.10n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338315
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(\C=N\OCc3ccccc3)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C29H31N3O2/c1-18-15-23(22-12-8-11-21-13-14-30-27(21)22)24(16-31-34-17-20-9-6-5-7-10-20)25-19(2)28(33)29(3,4)32-26(18)25/h5-16,19,28,30,32-33H,17H2,1-4H3/b31-16+/t19-,28+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.5n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338304
PNG
((+/-)-(3R,4S)-5,7,8-trifluoro-6-(1H-indol-7-yl)-2,...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(F)c(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H19F3N2O/c1-9-12-14(21)13(11-6-4-5-10-7-8-24-17(10)11)15(22)16(23)18(12)25-20(2,3)19(9)26/h4-9,19,24-26H,1-3H3/t9-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM19190
PNG
((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
5.30n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338316
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(\C=N\OC(C)(C)C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C26H33N3O2/c1-15-13-19(18-10-8-9-17-11-12-27-23(17)18)20(14-28-31-25(3,4)5)21-16(2)24(30)26(6,7)29-22(15)21/h8-14,16,24,27,29-30H,1-7H3/b28-14+/t16-,24+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338318
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES CO\N=C\c1c(cc(C)c2NC(C)(C)[C@H](O)[C@@H](C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H27N3O2/c1-13-11-17(16-8-6-7-15-9-10-24-21(15)16)18(12-25-28-5)19-14(2)22(27)23(3,4)26-20(13)19/h6-12,14,22,24,26-27H,1-5H3/b25-12+/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.90n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338306
PNG
((+/-)-(3R,4S)-5-chloro-8-fluoro-6-(1H-indol-7-yl)-...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(F)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20ClFN2O/c1-10-15-16(21)13(12-6-4-5-11-7-8-23-17(11)12)9-14(22)18(15)24-20(2,3)19(10)25/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
8n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338323
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H24N2O/c1-12-10-15(16-7-5-6-14-8-9-22-19(14)16)11-17-13(2)20(24)21(3,4)23-18(12)17/h5-11,13,20,22-24H,1-4H3/t13-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
9n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338311
PNG
((+/-)-4-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(C=CC(C)=O)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C25H28N2O2/c1-14-13-20(19-8-6-7-17-11-12-26-23(17)19)18(10-9-15(2)28)21-16(3)24(29)25(4,5)27-22(14)21/h6-13,16,24,26-27,29H,1-5H3/t16-,24+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
10.4n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338320
PNG
((+/-)-(3R,4S)-5-ethyl-6-(1H-indol-7-yl)-2,2,4,8-te...)
Show SMILES CCc1c(cc(C)c2NC(C)(C)[C@H](O)[C@@H](C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H28N2O/c1-6-16-18(17-9-7-8-15-10-11-24-21(15)17)12-13(2)20-19(16)14(3)22(26)23(4,5)25-20/h7-12,14,22,24-26H,6H2,1-5H3/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
11.7n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338313
PNG
((+/-)-3-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(\C=C\C#N)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C24H25N3O/c1-14-13-19(18-8-5-7-16-10-12-26-22(16)18)17(9-6-11-25)20-15(2)23(28)24(3,4)27-21(14)20/h5-10,12-13,15,23,26-28H,1-4H3/b9-6+/t15-,23+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
16.6n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338314
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(C=C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H26N2O/c1-6-16-18(17-9-7-8-15-10-11-24-21(15)17)12-13(2)20-19(16)14(3)22(26)23(4,5)25-20/h6-12,14,22,24-26H,1H2,2-5H3/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
19.6n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338309
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,7,8-pentamet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(C)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C22H26N2O/c1-12-13(2)19-18(14(3)21(25)22(4,5)24-19)11-17(12)16-8-6-7-15-9-10-23-20(15)16/h6-11,14,21,23-25H,1-5H3/t14-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
38.3n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338308
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(c(cc12)-c1cccc2cc[nH]c12)C(F)(F)F
Show InChI InChI=1S/C22H23F3N2O/c1-11-15-10-16(14-7-5-6-13-8-9-26-19(13)14)17(22(23,24)25)12(2)18(15)27-21(3,4)20(11)28/h5-11,20,26-28H,1-4H3/t11-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
106n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338302
PNG
((+/-)-(3R,4S)-5,7-dichloro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2cc(Cl)c(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20Cl2N2O/c1-10-15-14(24-20(2,3)19(10)25)9-13(21)16(17(15)22)12-6-4-5-11-7-8-23-18(11)12/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
157n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50338325
PNG
((+/-)-(3R,4S)-7-chloro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(Cl)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2O/c1-11-15-10-16(14-7-5-6-13-8-9-23-19(13)14)17(22)12(2)18(15)24-21(3,4)20(11)25/h5-11,20,23-25H,1-4H3/t11-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
190n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to PR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338319
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(CN=O)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C22H25N3O2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)17(11-24-27)18-13(2)21(26)22(3,4)25-19(12)18/h5-10,13,21,23,25-26H,11H2,1-4H3/t13-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
319n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of radiolabeled dexamethasone from GR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50338324
PNG
((+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20F2N2O/c1-10-15-14(24-20(2,3)19(10)25)9-13(21)16(17(15)22)12-6-4-5-11-7-8-23-18(11)12/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.43E+3n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to AR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50338324
PNG
((+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20F2N2O/c1-10-15-14(24-20(2,3)19(10)25)9-13(21)16(17(15)22)12-6-4-5-11-7-8-23-18(11)12/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.52E+3n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to MR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50338324
PNG
((+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20F2N2O/c1-10-15-14(24-20(2,3)19(10)25)9-13(21)16(17(15)22)12-6-4-5-11-7-8-23-18(11)12/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.10E+3n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to PR


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338317
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES CCO\N=C\c1c(cc(C)c2NC(C)(C)[C@H](O)[C@@H](C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C24H29N3O2/c1-6-29-26-13-19-18(17-9-7-8-16-10-11-25-22(16)17)12-14(2)21-20(19)15(3)23(28)24(4,5)27-21/h7-13,15,23,25,27-28H,6H2,1-5H3/b26-13+/t15-,23+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.900n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50334054
PNG
((+/-)-(3R,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2O/c1-11-10-15(14-7-5-6-13-8-9-23-19(13)14)17(22)16-12(2)20(25)21(3,4)24-18(11)16/h5-10,12,20,23-25H,1-4H3/t12-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338324
PNG
((+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20F2N2O/c1-10-15-14(24-20(2,3)19(10)25)9-13(21)16(17(15)22)12-6-4-5-11-7-8-23-18(11)12/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338310
PNG
((+/-)-(3R,4S)-7-fluoro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(F)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23FN2O/c1-11-15-10-16(14-7-5-6-13-8-9-23-19(13)14)17(22)12(2)18(15)24-21(3,4)20(11)25/h5-11,20,23-25H,1-4H3/t11-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338318
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES CO\N=C\c1c(cc(C)c2NC(C)(C)[C@H](O)[C@@H](C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H27N3O2/c1-13-11-17(16-8-6-7-15-9-10-24-21(15)16)18(12-25-28-5)19-14(2)22(27)23(3,4)26-20(13)19/h6-12,14,22,24,26-27H,1-5H3/b25-12+/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338315
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(\C=N\OCc3ccccc3)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C29H31N3O2/c1-18-15-23(22-12-8-11-21-13-14-30-27(21)22)24(16-31-34-17-20-9-6-5-7-10-20)25-19(2)28(33)29(3,4)32-26(18)25/h5-16,19,28,30,32-33H,17H2,1-4H3/b31-16+/t19-,28+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.10n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338317
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES CCO\N=C\c1c(cc(C)c2NC(C)(C)[C@H](O)[C@@H](C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C24H29N3O2/c1-6-29-26-13-19-18(17-9-7-8-16-10-11-25-22(16)17)12-14(2)21-20(19)15(3)23(28)24(4,5)27-21/h7-13,15,23,25,27-28H,6H2,1-5H3/b26-13+/t15-,23+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.40n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338304
PNG
((+/-)-(3R,4S)-5,7,8-trifluoro-6-(1H-indol-7-yl)-2,...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(F)c(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H19F3N2O/c1-9-12-14(21)13(11-6-4-5-10-7-8-24-17(10)11)15(22)16(23)18(12)25-20(2,3)19(9)26/h4-9,19,24-26H,1-3H3/t9-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.80n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338316
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(\C=N\OC(C)(C)C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C26H33N3O2/c1-15-13-19(18-10-8-9-17-11-12-27-23(17)18)20(14-28-31-25(3,4)5)21-16(2)24(30)26(6,7)29-22(15)21/h8-14,16,24,27,29-30H,1-7H3/b28-14+/t16-,24+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.80n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338303
PNG
((+/-)-(3R,4S)-8-chloro-5,7-difluoro-6-(1H-indol-7-...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(Cl)c(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H19ClF2N2O/c1-9-12-15(22)13(11-6-4-5-10-7-8-24-17(10)11)16(23)14(21)18(12)25-20(2,3)19(9)26/h4-9,19,24-26H,1-3H3/t9-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.90n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338310
PNG
((+/-)-(3R,4S)-7-fluoro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(F)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23FN2O/c1-11-15-10-16(14-7-5-6-13-8-9-23-19(13)14)17(22)12(2)18(15)24-21(3,4)20(11)25/h5-11,20,23-25H,1-4H3/t11-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.10n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM19190
PNG
((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.10n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338318
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES CO\N=C\c1c(cc(C)c2NC(C)(C)[C@H](O)[C@@H](C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H27N3O2/c1-13-11-17(16-8-6-7-15-9-10-24-21(15)16)18(12-25-28-5)19-14(2)22(27)23(3,4)26-20(13)19/h6-12,14,22,24,26-27H,1-5H3/b25-12+/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.20n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338321
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,5,8-pentamet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C22H26N2O/c1-12-11-17(16-8-6-7-15-9-10-23-20(15)16)13(2)18-14(3)21(25)22(4,5)24-19(12)18/h6-11,14,21,23-25H,1-5H3/t14-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.70n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338312
PNG
((+/-)-(3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(-c3cccc4cc[nH]c34)c(C#N)c12
Show InChI InChI=1S/C22H23N3O/c1-12-10-16(15-7-5-6-14-8-9-24-20(14)15)17(11-23)18-13(2)21(26)22(3,4)25-19(12)18/h5-10,13,21,24-26H,1-4H3/t13-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.30n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338316
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(\C=N\OC(C)(C)C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C26H33N3O2/c1-15-13-19(18-10-8-9-17-11-12-27-23(17)18)20(14-28-31-25(3,4)5)21-16(2)24(30)26(6,7)29-22(15)21/h8-14,16,24,27,29-30H,1-7H3/b28-14+/t16-,24+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.5n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338322
PNG
((+/-)-(3R,4S)-5-fluoro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23FN2O/c1-11-10-15(14-7-5-6-13-8-9-23-19(13)14)17(22)16-12(2)20(25)21(3,4)24-18(11)16/h5-10,12,20,23-25H,1-4H3/t12-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.90n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338313
PNG
((+/-)-3-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(\C=C\C#N)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C24H25N3O/c1-14-13-19(18-8-5-7-16-10-12-26-22(16)18)17(9-6-11-25)20-15(2)23(28)24(3,4)27-21(14)20/h5-10,12-13,15,23,26-28H,1-4H3/b9-6+/t15-,23+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.5n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338322
PNG
((+/-)-(3R,4S)-5-fluoro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23FN2O/c1-11-10-15(14-7-5-6-13-8-9-23-19(13)14)17(22)16-12(2)20(25)21(3,4)24-18(11)16/h5-10,12,20,23-25H,1-4H3/t12-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.10n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338305
PNG
((+/-)-(3R,4S)-7,8-difluoro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(F)c(F)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20F2N2O/c1-10-13-9-14(12-6-4-5-11-7-8-23-17(11)12)15(21)16(22)18(13)24-20(2,3)19(10)25/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.70n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50334054
PNG
((+/-)-(3R,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2O/c1-11-10-15(14-7-5-6-13-8-9-23-19(13)14)17(22)16-12(2)20(25)21(3,4)24-18(11)16/h5-10,12,20,23-25H,1-4H3/t12-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.80n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338311
PNG
((+/-)-4-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(C=CC(C)=O)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C25H28N2O2/c1-14-13-20(19-8-6-7-17-11-12-26-23(17)19)18(10-9-15(2)28)21-16(3)24(29)25(4,5)27-22(14)21/h6-13,16,24,26-27,29H,1-5H3/t16-,24+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.80n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338321
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,5,8-pentamet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C22H26N2O/c1-12-11-17(16-8-6-7-15-9-10-23-20(15)16)13(2)18-14(3)21(25)22(4,5)24-19(12)18/h6-11,14,21,23-25H,1-5H3/t14-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.30n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338324
PNG
((+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20F2N2O/c1-10-15-14(24-20(2,3)19(10)25)9-13(21)16(17(15)22)12-6-4-5-11-7-8-23-18(11)12/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338319
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(CN=O)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C22H25N3O2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)17(11-24-27)18-13(2)21(26)22(3,4)25-19(12)18/h5-10,13,21,23,25-26H,11H2,1-4H3/t13-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338307
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(C=C)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H26N2O/c1-6-16-13(2)20-18(14(3)22(26)23(4,5)25-20)12-19(16)17-9-7-8-15-10-11-24-21(15)17/h6-12,14,22,24-26H,1H2,2-5H3/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338306
PNG
((+/-)-(3R,4S)-5-chloro-8-fluoro-6-(1H-indol-7-yl)-...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(F)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20ClFN2O/c1-10-15-16(21)13(12-6-4-5-11-7-8-23-17(11)12)9-14(22)18(15)24-20(2,3)19(10)25/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338315
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(\C=N\OCc3ccccc3)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C29H31N3O2/c1-18-15-23(22-12-8-11-21-13-14-30-27(21)22)24(16-31-34-17-20-9-6-5-7-10-20)25-19(2)28(33)29(3,4)32-26(18)25/h5-16,19,28,30,32-33H,17H2,1-4H3/b31-16+/t19-,28+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 14.4n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338320
PNG
((+/-)-(3R,4S)-5-ethyl-6-(1H-indol-7-yl)-2,2,4,8-te...)
Show SMILES CCc1c(cc(C)c2NC(C)(C)[C@H](O)[C@@H](C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H28N2O/c1-6-16-18(17-9-7-8-15-10-11-24-21(15)17)12-13(2)20-19(16)14(3)22(26)23(4,5)25-20/h7-12,14,22,24-26H,6H2,1-5H3/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338312
PNG
((+/-)-(3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(-c3cccc4cc[nH]c34)c(C#N)c12
Show InChI InChI=1S/C22H23N3O/c1-12-10-16(15-7-5-6-14-8-9-24-20(14)15)17(11-23)18-13(2)21(26)22(3,4)25-19(12)18/h5-10,13,21,24-26H,1-4H3/t13-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338313
PNG
((+/-)-3-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(\C=C\C#N)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C24H25N3O/c1-14-13-19(18-8-5-7-16-10-12-26-22(16)18)17(9-6-11-25)20-15(2)23(28)24(3,4)27-21(14)20/h5-10,12-13,15,23,26-28H,1-4H3/b9-6+/t15-,23+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338303
PNG
((+/-)-(3R,4S)-8-chloro-5,7-difluoro-6-(1H-indol-7-...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(Cl)c(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H19ClF2N2O/c1-9-12-15(22)13(11-6-4-5-10-7-8-24-17(10)11)16(23)14(21)18(12)25-20(2,3)19(9)26/h4-9,19,24-26H,1-3H3/t9-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338306
PNG
((+/-)-(3R,4S)-5-chloro-8-fluoro-6-(1H-indol-7-yl)-...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(F)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20ClFN2O/c1-10-15-16(21)13(12-6-4-5-11-7-8-23-17(11)12)9-14(22)18(15)24-20(2,3)19(10)25/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338304
PNG
((+/-)-(3R,4S)-5,7,8-trifluoro-6-(1H-indol-7-yl)-2,...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(F)c(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H19F3N2O/c1-9-12-14(21)13(11-6-4-5-10-7-8-24-17(10)11)15(22)16(23)18(12)25-20(2,3)19(9)26/h4-9,19,24-26H,1-3H3/t9-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338305
PNG
((+/-)-(3R,4S)-7,8-difluoro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(F)c(F)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20F2N2O/c1-10-13-9-14(12-6-4-5-11-7-8-23-17(11)12)15(21)16(22)18(13)24-20(2,3)19(10)25/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338323
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H24N2O/c1-12-10-15(16-7-5-6-14-8-9-22-19(14)16)11-17-13(2)20(24)21(3,4)23-18(12)17/h5-11,13,20,22-24H,1-4H3/t13-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338325
PNG
((+/-)-(3R,4S)-7-chloro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(Cl)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2O/c1-11-15-10-16(14-7-5-6-13-8-9-23-19(13)14)17(22)12(2)18(15)24-21(3,4)20(11)25/h5-11,20,23-25H,1-4H3/t11-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 21n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM19190
PNG
((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338325
PNG
((+/-)-(3R,4S)-7-chloro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(Cl)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2O/c1-11-15-10-16(14-7-5-6-13-8-9-23-19(13)14)17(22)12(2)18(15)24-21(3,4)20(11)25/h5-11,20,23-25H,1-4H3/t11-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 26n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338309
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,7,8-pentamet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(C)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C22H26N2O/c1-12-13(2)19-18(14(3)21(25)22(4,5)24-19)11-17(12)16-8-6-7-15-9-10-23-20(15)16/h6-11,14,21,23-25H,1-5H3/t14-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338302
PNG
((+/-)-(3R,4S)-5,7-dichloro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2cc(Cl)c(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20Cl2N2O/c1-10-15-14(24-20(2,3)19(10)25)9-13(21)16(17(15)22)12-6-4-5-11-7-8-23-18(11)12/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 301n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338319
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(CN=O)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C22H25N3O2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)17(11-24-27)18-13(2)21(26)22(3,4)25-19(12)18/h5-10,13,21,23,25-26H,11H2,1-4H3/t13-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338314
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(C=C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H26N2O/c1-6-16-18(17-9-7-8-15-10-11-24-21(15)17)12-13(2)20-19(16)14(3)22(26)23(4,5)25-20/h6-12,14,22,24-26H,1H2,2-5H3/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338323
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H24N2O/c1-12-10-15(16-7-5-6-14-8-9-22-19(14)16)11-17-13(2)20(24)21(3,4)23-18(12)17/h5-11,13,20,22-24H,1-4H3/t13-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338308
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(c(cc12)-c1cccc2cc[nH]c12)C(F)(F)F
Show InChI InChI=1S/C22H23F3N2O/c1-11-15-10-16(14-7-5-6-13-8-9-26-19(13)14)17(22(23,24)25)12(2)18(15)27-21(3,4)20(11)28/h5-11,20,26-28H,1-4H3/t11-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338320
PNG
((+/-)-(3R,4S)-5-ethyl-6-(1H-indol-7-yl)-2,2,4,8-te...)
Show SMILES CCc1c(cc(C)c2NC(C)(C)[C@H](O)[C@@H](C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H28N2O/c1-6-16-18(17-9-7-8-15-10-11-24-21(15)17)12-13(2)20-19(16)14(3)22(26)23(4,5)25-20/h7-12,14,22,24-26H,6H2,1-5H3/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338302
PNG
((+/-)-(3R,4S)-5,7-dichloro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2cc(Cl)c(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20Cl2N2O/c1-10-15-14(24-20(2,3)19(10)25)9-13(21)16(17(15)22)12-6-4-5-11-7-8-23-18(11)12/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338309
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,7,8-pentamet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(C)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C22H26N2O/c1-12-13(2)19-18(14(3)21(25)22(4,5)24-19)11-17(12)16-8-6-7-15-9-10-23-20(15)16/h6-11,14,21,23-25H,1-5H3/t14-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338314
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(C=C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H26N2O/c1-6-16-18(17-9-7-8-15-10-11-24-21(15)17)12-13(2)20-19(16)14(3)22(26)23(4,5)25-20/h6-12,14,22,24-26H,1H2,2-5H3/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338308
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(c(cc12)-c1cccc2cc[nH]c12)C(F)(F)F
Show InChI InChI=1S/C22H23F3N2O/c1-11-15-10-16(14-7-5-6-13-8-9-26-19(13)14)17(22(23,24)25)12(2)18(15)27-21(3,4)20(11)28/h5-11,20,26-28H,1-4H3/t11-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338307
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(C=C)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H26N2O/c1-6-16-13(2)20-18(14(3)22(26)23(4,5)25-20)12-19(16)17-9-7-8-15-10-11-24-21(15)17/h6-12,14,22,24-26H,1H2,2-5H3/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338311
PNG
((+/-)-4-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(C=CC(C)=O)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C25H28N2O2/c1-14-13-20(19-8-6-7-17-11-12-26-23(17)19)18(10-9-15(2)28)21-16(3)24(29)25(4,5)27-22(14)21/h6-13,16,24,26-27,29H,1-5H3/t16-,24+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasone


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338306
PNG
((+/-)-(3R,4S)-5-chloro-8-fluoro-6-(1H-indol-7-yl)-...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(F)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20ClFN2O/c1-10-15-16(21)13(12-6-4-5-11-7-8-23-17(11)12)9-14(22)18(15)24-20(2,3)19(10)25/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 89n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338304
PNG
((+/-)-(3R,4S)-5,7,8-trifluoro-6-(1H-indol-7-yl)-2,...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(F)c(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H19F3N2O/c1-9-12-14(21)13(11-6-4-5-10-7-8-24-17(10)11)15(22)16(23)18(12)25-20(2,3)19(9)26/h4-9,19,24-26H,1-3H3/t9-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 16n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338302
PNG
((+/-)-(3R,4S)-5,7-dichloro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2cc(Cl)c(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20Cl2N2O/c1-10-15-14(24-20(2,3)19(10)25)9-13(21)16(17(15)22)12-6-4-5-11-7-8-23-18(11)12/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 480n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338317
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES CCO\N=C\c1c(cc(C)c2NC(C)(C)[C@H](O)[C@@H](C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C24H29N3O2/c1-6-29-26-13-19-18(17-9-7-8-16-10-11-25-22(16)17)12-14(2)21-20(19)15(3)23(28)24(4,5)27-21/h7-13,15,23,25,27-28H,6H2,1-5H3/b26-13+/t15-,23+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.200n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338320
PNG
((+/-)-(3R,4S)-5-ethyl-6-(1H-indol-7-yl)-2,2,4,8-te...)
Show SMILES CCc1c(cc(C)c2NC(C)(C)[C@H](O)[C@@H](C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H28N2O/c1-6-16-18(17-9-7-8-15-10-11-24-21(15)17)12-13(2)20-19(16)14(3)22(26)23(4,5)25-20/h7-12,14,22,24-26H,6H2,1-5H3/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 16n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338319
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(CN=O)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C22H25N3O2/c1-12-10-16(15-7-5-6-14-8-9-23-20(14)15)17(11-24-27)18-13(2)21(26)22(3,4)25-19(12)18/h5-10,13,21,23,25-26H,11H2,1-4H3/t13-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 105n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338316
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(\C=N\OC(C)(C)C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C26H33N3O2/c1-15-13-19(18-10-8-9-17-11-12-27-23(17)18)20(14-28-31-25(3,4)5)21-16(2)24(30)26(6,7)29-22(15)21/h8-14,16,24,27,29-30H,1-7H3/b28-14+/t16-,24+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 34n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338325
PNG
((+/-)-(3R,4S)-7-chloro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(Cl)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2O/c1-11-15-10-16(14-7-5-6-13-8-9-23-19(13)14)17(22)12(2)18(15)24-21(3,4)20(11)25/h5-11,20,23-25H,1-4H3/t11-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 36n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338310
PNG
((+/-)-(3R,4S)-7-fluoro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(F)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23FN2O/c1-11-15-10-16(14-7-5-6-13-8-9-23-19(13)14)17(22)12(2)18(15)24-21(3,4)20(11)25/h5-11,20,23-25H,1-4H3/t11-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 40n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338309
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,7,8-pentamet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(C)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C22H26N2O/c1-12-13(2)19-18(14(3)21(25)22(4,5)24-19)11-17(12)16-8-6-7-15-9-10-23-20(15)16/h6-11,14,21,23-25H,1-5H3/t14-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 205n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338305
PNG
((+/-)-(3R,4S)-7,8-difluoro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(F)c(F)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20F2N2O/c1-10-13-9-14(12-6-4-5-11-7-8-23-17(11)12)15(21)16(22)18(13)24-20(2,3)19(10)25/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338321
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,5,8-pentamet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C22H26N2O/c1-12-11-17(16-8-6-7-15-9-10-23-20(15)16)13(2)18-14(3)21(25)22(4,5)24-19(12)18/h6-11,14,21,23-25H,1-5H3/t14-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.900n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338322
PNG
((+/-)-(3R,4S)-5-fluoro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23FN2O/c1-11-10-15(14-7-5-6-13-8-9-23-19(13)14)17(22)16-12(2)20(25)21(3,4)24-18(11)16/h5-10,12,20,23-25H,1-4H3/t12-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 56n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338303
PNG
((+/-)-(3R,4S)-8-chloro-5,7-difluoro-6-(1H-indol-7-...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(Cl)c(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H19ClF2N2O/c1-9-12-15(22)13(11-6-4-5-10-7-8-24-17(10)11)16(23)14(21)18(12)25-20(2,3)19(9)26/h4-9,19,24-26H,1-3H3/t9-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.30n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338323
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H24N2O/c1-12-10-15(16-7-5-6-14-8-9-22-19(14)16)11-17-13(2)20(24)21(3,4)23-18(12)17/h5-11,13,20,22-24H,1-4H3/t13-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 108n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338318
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES CO\N=C\c1c(cc(C)c2NC(C)(C)[C@H](O)[C@@H](C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H27N3O2/c1-13-11-17(16-8-6-7-15-9-10-24-21(15)16)18(12-25-28-5)19-14(2)22(27)23(3,4)26-20(13)19/h6-12,14,22,24,26-27H,1-5H3/b25-12+/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.400n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338307
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(C=C)c(cc12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H26N2O/c1-6-16-13(2)20-18(14(3)22(26)23(4,5)25-20)12-19(16)17-9-7-8-15-10-11-24-21(15)17/h6-12,14,22,24-26H,1H2,2-5H3/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 18n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM19190
PNG
((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO
Show InChI InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 5.30n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338313
PNG
((+/-)-3-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(\C=C\C#N)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C24H25N3O/c1-14-13-19(18-8-5-7-16-10-12-26-22(16)18)17(9-6-11-25)20-15(2)23(28)24(3,4)27-21(14)20/h5-10,12-13,15,23,26-28H,1-4H3/b9-6+/t15-,23+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 5.70n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338312
PNG
((+/-)-(3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(-c3cccc4cc[nH]c34)c(C#N)c12
Show InChI InChI=1S/C22H23N3O/c1-12-10-16(15-7-5-6-14-8-9-24-20(14)15)17(11-23)18-13(2)21(26)22(3,4)25-19(12)18/h5-10,13,21,24-26H,1-4H3/t13-,21+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 9.60n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338311
PNG
((+/-)-4-((3R,4S)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(C=CC(C)=O)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C25H28N2O2/c1-14-13-20(19-8-6-7-17-11-12-26-23(17)19)18(10-9-15(2)28)21-16(3)24(29)25(4,5)27-22(14)21/h6-13,16,24,26-27,29H,1-5H3/t16-,24+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 112n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338308
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)c(c(cc12)-c1cccc2cc[nH]c12)C(F)(F)F
Show InChI InChI=1S/C22H23F3N2O/c1-11-15-10-16(14-7-5-6-13-8-9-26-19(13)14)17(22(23,24)25)12(2)18(15)27-21(3,4)20(11)28/h5-11,20,26-28H,1-4H3/t11-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+3n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338324
PNG
((+/-)-(3R,4S)-5,7-difluoro-6-(1H-indol-7-yl)-2,2,4...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2cc(F)c(c(F)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C20H20F2N2O/c1-10-15-14(24-20(2,3)19(10)25)9-13(21)16(17(15)22)12-6-4-5-11-7-8-23-18(11)12/h4-10,19,23-25H,1-3H3/t10-,19+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.600n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50334054
PNG
((+/-)-(3R,4S)-5-chloro-6-(1H-indol-7-yl)-2,2,4,8-t...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(Cl)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C21H23ClN2O/c1-11-10-15(14-7-5-6-13-8-9-23-19(13)14)17(22)16-12(2)20(25)21(3,4)24-18(11)16/h5-10,12,20,23-25H,1-4H3/t12-,20+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 7.10n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338314
PNG
((+/-)-(3R,4S)-6-(1H-indol-7-yl)-2,2,4,8-tetramethy...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(C=C)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C23H26N2O/c1-6-16-18(17-9-7-8-15-10-11-24-21(15)17)12-13(2)20-19(16)14(3)22(26)23(4,5)25-20/h6-12,14,22,24-26H,1H2,2-5H3/t14-,22+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 40n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50338315
PNG
((+/-)-3-hydroxy-6-(1H-indol-7-yl)-2,2,4,8-tetramet...)
Show SMILES C[C@@H]1[C@@H](O)C(C)(C)Nc2c(C)cc(c(\C=N\OCc3ccccc3)c12)-c1cccc2cc[nH]c12
Show InChI InChI=1S/C29H31N3O2/c1-18-15-23(22-12-8-11-21-13-14-30-27(21)22)24(16-31-34-17-20-9-6-5-7-10-20)25-19(2)28(33)29(3,4)32-26(18)25/h5-16,19,28,30,32-33H,17H2,1-4H3/b31-16+/t19-,28+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.70n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...


Bioorg Med Chem Lett 21: 1697-700 (2011)


Article DOI: 10.1016/j.bmcl.2011.01.093
BindingDB Entry DOI: 10.7270/Q2639Q12
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%