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PubMed code 21353569

Compile data set for download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338853
PNG
(1-(3-(Furan-2-yl)-4,5-dihydro-5-(pyridin-4-yl)pyra...)
Show SMILES CC(=O)N1N=C(CC1c1ccncc1)c1ccco1
Show InChI InChI=1S/C14H13N3O2/c1-10(18)17-13(11-4-6-15-7-5-11)9-12(16-17)14-3-2-8-19-14/h2-8,13H,9H2,1H3
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n/an/a 5.30E+3n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM35440
PNG
(ALLOPURINOL | MLS000069453 | SMR000059083 | cid_20...)
Show SMILES O=c1[nH]cnc2n[nH]cc12
Show InChI InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)
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n/an/a 8.30E+3n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338839
PNG
(1-(3-(furan-2-yl)-4,5-dihydro-5-(4-nitrophenyl)pyr...)
Show SMILES CC(=O)N1N=C(CC1c1ccc(cc1)[N+]([O-])=O)c1ccco1
Show InChI InChI=1S/C15H13N3O4/c1-10(19)17-14(9-13(16-17)15-3-2-8-22-15)11-4-6-12(7-5-11)18(20)21/h2-8,14H,9H2,1H3
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n/an/a 1.24E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338837
PNG
(1-(3-(furan-2-yl)-4,5-dihydro-5-(3-nitrophenyl)pyr...)
Show SMILES CC(=O)N1N=C(CC1c1cccc(c1)[N+]([O-])=O)c1ccco1
Show InChI InChI=1S/C15H13N3O4/c1-10(19)17-14(9-13(16-17)15-6-3-7-22-15)11-4-2-5-12(8-11)18(20)21/h2-8,14H,9H2,1H3
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n/an/a 1.31E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338836
PNG
(1-(3-(Furan-2-yl)-4,5-dihydro-5-(2-nitrophenyl)pyr...)
Show SMILES CC(=O)N1N=C(CC1c1ccccc1[N+]([O-])=O)c1ccco1
Show InChI InChI=1S/C15H13N3O4/c1-10(19)17-14(9-12(16-17)15-7-4-8-22-15)11-5-2-3-6-13(11)18(20)21/h2-8,14H,9H2,1H3
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n/an/a 1.42E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338850
PNG
(1-(3-(Furan-2-yl)-4,5-dihydro-5-(2,3-dichloropheny...)
Show SMILES CC(=O)N1N=C(CC1c1cccc(Cl)c1Cl)c1ccco1
Show InChI InChI=1S/C15H12Cl2N2O2/c1-9(20)19-13(10-4-2-5-11(16)15(10)17)8-12(18-19)14-6-3-7-21-14/h2-7,13H,8H2,1H3
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n/an/a 1.48E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338841
PNG
(1-(3-(furan-2-yl)-4,5-dihydro-5-(4-chlorophenyl)py...)
Show SMILES CC(=O)N1N=C(CC1c1ccc(Cl)cc1)c1ccco1
Show InChI InChI=1S/C15H13ClN2O2/c1-10(19)18-14(11-4-6-12(16)7-5-11)9-13(17-18)15-3-2-8-20-15/h2-8,14H,9H2,1H3
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n/an/a 1.52E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338840
PNG
(1-(3-(furan-2-yl)-4,5-dihydro-5-(4-bromophenyl)-py...)
Show SMILES CC(=O)N1N=C(CC1c1ccc(Br)cc1)c1ccco1
Show InChI InChI=1S/C15H13BrN2O2/c1-10(19)18-14(11-4-6-12(16)7-5-11)9-13(17-18)15-3-2-8-20-15/h2-8,14H,9H2,1H3
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n/an/a 1.76E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338844
PNG
(1-(3-(furan-2-yl)-4,5-dihydro-5-(4-methylphenyl)py...)
Show SMILES CC(=O)N1N=C(CC1c1ccc(C)cc1)c1ccco1
Show InChI InChI=1S/C16H16N2O2/c1-11-5-7-13(8-6-11)15-10-14(16-4-3-9-20-16)17-18(15)12(2)19/h3-9,15H,10H2,1-2H3
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n/an/a 1.92E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338842
PNG
(1-(3-(furan-2-yl)-4,5-dihydro-5-(4-methoxyphenyl)p...)
Show SMILES COc1ccc(cc1)C1CC(=NN1C(C)=O)c1ccco1
Show InChI InChI=1S/C16H16N2O3/c1-11(19)18-15(12-5-7-13(20-2)8-6-12)10-14(17-18)16-4-3-9-21-16/h3-9,15H,10H2,1-2H3
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n/an/a 2.13E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338843
PNG
(1-(3-(furan-2-yl)-4,5-dihydro-5-(4-N,N-dimethylami...)
Show SMILES CN(C)c1ccc(cc1)C1CC(=NN1C(C)=O)c1ccco1
Show InChI InChI=1S/C17H19N3O2/c1-12(21)20-16(11-15(18-20)17-5-4-10-22-17)13-6-8-14(9-7-13)19(2)3/h4-10,16H,11H2,1-3H3
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n/an/a 2.30E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338835
PNG
(1-(3-(furan-2-yl)-4,5-dihydro-5-phenylpyrazol-1-yl...)
Show SMILES CC(=O)N1N=C(CC1c1ccccc1)c1ccco1
Show InChI InChI=1S/C15H14N2O2/c1-11(18)17-14(12-6-3-2-4-7-12)10-13(16-17)15-8-5-9-19-15/h2-9,14H,10H2,1H3
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n/an/a 2.64E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338849
PNG
(1-(3-(Furan-2-yl)-4,5-dihydro-5-(4-hydroxy-3-metho...)
Show SMILES COc1cc(ccc1O)C1CC(=NN1C(C)=O)c1ccco1
Show InChI InChI=1S/C16H16N2O4/c1-10(19)18-13(9-12(17-18)15-4-3-7-22-15)11-5-6-14(20)16(8-11)21-2/h3-8,13,20H,9H2,1-2H3
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n/an/a 2.68E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338838
PNG
(1-(3-(furan-2-yl)-4,5-dihydro-5-(3-hydroxyphenyl)p...)
Show SMILES CC(=O)N1N=C(CC1c1cccc(O)c1)c1ccco1
Show InChI InChI=1S/C15H14N2O3/c1-10(18)17-14(11-4-2-5-12(19)8-11)9-13(16-17)15-6-3-7-20-15/h2-8,14,19H,9H2,1H3
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n/an/a 2.72E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338845
PNG
(1-(3-(Furan-2-yl)-4,5-dihydro-5-(2,5-dimethoxyphen...)
Show SMILES COc1ccc(OC)c(c1)C1CC(=NN1C(C)=O)c1ccco1
Show InChI InChI=1S/C17H18N2O4/c1-11(20)19-15(10-14(18-19)17-5-4-8-23-17)13-9-12(21-2)6-7-16(13)22-3/h4-9,15H,10H2,1-3H3
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n/an/a 2.73E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338851
PNG
(1-(5-(Benzo[d][1,3]dioxol-5-yl)-3-(furan-2-yl)-4,5...)
Show SMILES CC(=O)N1N=C(CC1c1ccc2OCOc2c1)c1ccco1
Show InChI InChI=1S/C16H14N2O4/c1-10(19)18-13(8-12(17-18)14-3-2-6-20-14)11-4-5-15-16(7-11)22-9-21-15/h2-7,13H,8-9H2,1H3
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n/an/a 2.81E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338846
PNG
(1-(3-(Furan-2-yl)-4,5-dihydro-5-(3,4,5-trimethoxyp...)
Show SMILES COc1cc(cc(OC)c1OC)C1CC(=NN1C(C)=O)c1ccco1
Show InChI InChI=1S/C18H20N2O5/c1-11(21)20-14(10-13(19-20)15-6-5-7-25-15)12-8-16(22-2)18(24-4)17(9-12)23-3/h5-9,14H,10H2,1-4H3
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n/an/a 2.87E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338847
PNG
(1-(3-(Furan-2-yl)-4,5-dihydro-5-(3,4-dimethoxyphen...)
Show SMILES COc1ccc(cc1OC)C1CC(=NN1C(C)=O)c1ccco1
Show InChI InChI=1S/C17H18N2O4/c1-11(20)19-14(10-13(18-19)15-5-4-8-23-15)12-6-7-16(21-2)17(9-12)22-3/h4-9,14H,10H2,1-3H3
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n/an/a 2.94E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338848
PNG
(1-(3-(Furan-2-yl)-4,5-dihydro-5-(2,4,5-trimethoxyp...)
Show SMILES COc1cc(OC)c(cc1OC)C1CC(=NN1C(C)=O)c1ccco1
Show InChI InChI=1S/C18H20N2O5/c1-11(21)20-14(9-13(19-20)15-6-5-7-25-15)12-8-17(23-3)18(24-4)10-16(12)22-2/h5-8,10,14H,9H2,1-4H3
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n/an/a 3.02E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338822
PNG
(1-(4,5-dihydro-3-(naphth-1-yl)-5-(4-nitrophenyl)-1...)
Show SMILES CC(=O)N1N=C(CC1c1ccc(cc1)[N+]([O-])=O)c1cccc2ccccc12
Show InChI InChI=1S/C21H17N3O3/c1-14(25)23-21(16-9-11-17(12-10-16)24(26)27)13-20(22-23)19-8-4-6-15-5-2-3-7-18(15)19/h2-12,21H,13H2,1H3
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n/an/a 3.22E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338832
PNG
(1-(5-(2,3-Dichlorophenyl)-4,5-dihydro-3-(naphth-1-...)
Show SMILES CC(=O)N1N=C(CC1c1cccc(Cl)c1Cl)c1cccc2ccccc12
Show InChI InChI=1S/C21H16Cl2N2O/c1-13(26)25-20(17-10-5-11-18(22)21(17)23)12-19(24-25)16-9-4-7-14-6-2-3-8-15(14)16/h2-11,20H,12H2,1H3
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n/an/a 3.42E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338823
PNG
(1-(4,5-Dihydro-3-(naphth-1-yl)-5-(3-nitrophenyl)-1...)
Show SMILES CC(=O)N1N=C(CC1c1cccc(c1)[N+]([O-])=O)c1cccc2ccccc12
Show InChI InChI=1S/C21H17N3O3/c1-14(25)23-21(16-8-4-9-17(12-16)24(26)27)13-20(22-23)19-11-5-7-15-6-2-3-10-18(15)19/h2-12,21H,13H2,1H3
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n/an/a 3.64E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338826
PNG
(1-(4,5-Dihydro-3-(naphth-1-yl)-5-(2-nitrophenyl)-1...)
Show SMILES CC(=O)N1N=C(CC1c1ccccc1[N+]([O-])=O)c1cccc2ccccc12
Show InChI InChI=1S/C21H17N3O3/c1-14(25)23-21(18-10-4-5-12-20(18)24(26)27)13-19(22-23)17-11-6-8-15-7-2-3-9-16(15)17/h2-12,21H,13H2,1H3
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n/an/a 3.72E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338825
PNG
(1-(5-(3-Bromophenyl)-4,5-dihydro-3-(naphth-1-yl)-1...)
Show SMILES CC(=O)N1N=C(CC1c1cccc(Br)c1)c1cccc2ccccc12
Show InChI InChI=1S/C21H17BrN2O/c1-14(25)24-21(16-8-4-9-17(22)12-16)13-20(23-24)19-11-5-7-15-6-2-3-10-18(15)19/h2-12,21H,13H2,1H3
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n/an/a 3.87E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338872
PNG
(1-(4,5-dihydro-3-(naphth-1-yl)-5-phenyl)-1H-pyrazo...)
Show SMILES CC(=O)N1N=C(CC1c1ccccc1)c1cccc2ccccc12
Show InChI InChI=1S/C21H18N2O/c1-15(24)23-21(17-9-3-2-4-10-17)14-20(22-23)19-13-7-11-16-8-5-6-12-18(16)19/h2-13,21H,14H2,1H3
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n/an/a 4.13E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338824
PNG
(1-(4,5-Dihydro-5-(4-methoxyphenyl)-3-(naphth-1-yl)...)
Show SMILES COc1ccc(cc1)C1CC(=NN1C(C)=O)c1cccc2ccccc12
Show InChI InChI=1S/C22H20N2O2/c1-15(25)24-22(17-10-12-18(26-2)13-11-17)14-21(23-24)20-9-5-7-16-6-3-4-8-19(16)20/h3-13,22H,14H2,1-2H3
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n/an/a 4.35E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338827
PNG
(1-(4,5-Dihydro-5-(2,5-dimethoxyphenyl)-3-(naphth-1...)
Show SMILES COc1ccc(OC)c(c1)C1CC(=NN1C(C)=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H22N2O3/c1-15(26)25-22(20-13-17(27-2)11-12-23(20)28-3)14-21(24-25)19-10-6-8-16-7-4-5-9-18(16)19/h4-13,22H,14H2,1-3H3
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n/an/a 4.48E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338828
PNG
(1-(4,5-Dihydro-5-(3,4-dimethoxyphenyl)-3-(naphth-1...)
Show SMILES COc1ccc(cc1OC)C1CC(=NN1C(C)=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H22N2O3/c1-15(26)25-21(17-11-12-22(27-2)23(13-17)28-3)14-20(24-25)19-10-6-8-16-7-4-5-9-18(16)19/h4-13,21H,14H2,1-3H3
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n/an/a 4.56E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338831
PNG
(1-(4,5-Dihydro-5-(4-hydroxy-3-methoxyphenyl)-3-(na...)
Show SMILES COc1cc(ccc1O)C1CC(=NN1C(C)=O)c1cccc2ccccc12
Show InChI InChI=1S/C22H20N2O3/c1-14(25)24-20(16-10-11-21(26)22(12-16)27-2)13-19(23-24)18-9-5-7-15-6-3-4-8-17(15)18/h3-12,20,26H,13H2,1-2H3
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n/an/a 4.57E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338830
PNG
(1-(4,5-Dihydro-5-(2,3,4-trimethoxyphenyl)-3-(napht...)
Show SMILES COc1cc(OC)c(cc1OC)C1CC(=NN1C(C)=O)c1cccc2ccccc12
Show InChI InChI=1S/C24H24N2O4/c1-15(27)26-21(19-12-23(29-3)24(30-4)14-22(19)28-2)13-20(25-26)18-11-7-9-16-8-5-6-10-17(16)18/h5-12,14,21H,13H2,1-4H3
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n/an/a 4.62E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338833
PNG
(1-(5-(Benzo[d][1,3]dioxol-5-yl)-4,5-dihydro-3-(nap...)
Show SMILES CC(=O)N1N=C(CC1c1ccc2OCOc2c1)c1cccc2ccccc12
Show InChI InChI=1S/C22H18N2O3/c1-14(25)24-20(16-9-10-21-22(11-16)27-13-26-21)12-19(23-24)18-8-4-6-15-5-2-3-7-17(15)18/h2-11,20H,12-13H2,1H3
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n/an/a 4.70E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338829
PNG
(1-(4,5-Dihydro-5-(3,4,5-trimethoxyphenyl)-3-(napht...)
Show SMILES COc1cc(cc(OC)c1OC)C1CC(=NN1C(C)=O)c1cccc2ccccc12
Show InChI InChI=1S/C24H24N2O4/c1-15(27)26-21(17-12-22(28-2)24(30-4)23(13-17)29-3)14-20(25-26)19-11-7-9-16-8-5-6-10-18(16)19/h5-13,21H,14H2,1-4H3
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n/an/a 4.95E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338865
PNG
(1-Acetyl-3-(4-bromophenyl)-5-(2,3-dichlorophenyl)-...)
Show SMILES CC(=O)N1N=C(CC1c1cccc(Cl)c1Cl)c1ccc(Br)cc1
Show InChI InChI=1S/C17H13BrCl2N2O/c1-10(23)22-16(13-3-2-4-14(19)17(13)20)9-15(21-22)11-5-7-12(18)8-6-11/h2-8,16H,9H2,1H3
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n/an/a 5.17E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338857
PNG
(1-Acetyl-5-(2,3-dichlorophenyl)-3-phenyl-4,5-dihyd...)
Show SMILES CC(=O)N1N=C(CC1c1cccc(Cl)c1Cl)c1ccccc1
Show InChI InChI=1S/C17H14Cl2N2O/c1-11(22)21-16(13-8-5-9-14(18)17(13)19)10-15(20-21)12-6-3-2-4-7-12/h2-9,16H,10H2,1H3
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n/an/a 5.51E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338870
PNG
(1-Acetyl-5-(2,3-dichlorophenyl)-3-(3-nitrophenyl)-...)
Show SMILES CC(=O)N1N=C(CC1c1cccc(Cl)c1Cl)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C17H13Cl2N3O3/c1-10(23)21-16(13-6-3-7-14(18)17(13)19)9-15(20-21)11-4-2-5-12(8-11)22(24)25/h2-8,16H,9H2,1H3
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n/an/a 5.80E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50164871
PNG
(1-(3,5-Diphenyl-4,5-dihydro-pyrazol-1-yl)-ethanone...)
Show SMILES CC(=O)N1N=C(CC1c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H16N2O/c1-13(20)19-17(15-10-6-3-7-11-15)12-16(18-19)14-8-4-2-5-9-14/h2-11,17H,12H2,1H3
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n/an/a 6.14E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338863
PNG
(1-Acetyl-3-(4-bromophenyl)-5-(3,4-dimethoxyphenyl)...)
Show SMILES COc1ccc(cc1OC)C1CC(=NN1C(C)=O)c1ccc(Br)cc1
Show InChI InChI=1S/C19H19BrN2O3/c1-12(23)22-17(14-6-9-18(24-2)19(10-14)25-3)11-16(21-22)13-4-7-15(20)8-5-13/h4-10,17H,11H2,1-3H3
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n/an/a 6.41E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338866
PNG
(1-(5-(Benzo[d][1,3]dioxol-6-yl)-3-(4-bromophenyl)-...)
Show SMILES CC(=O)N1N=C(CC1c1ccc2OCOc2c1)c1ccc(Br)cc1
Show InChI InChI=1S/C18H15BrN2O3/c1-11(22)21-16(13-4-7-17-18(8-13)24-10-23-17)9-15(20-21)12-2-5-14(19)6-3-12/h2-8,16H,9-10H2,1H3
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n/an/a 6.63E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338862
PNG
(1-(3-(4-bromophenyl)-5-(4-methoxyphenyl)-4,5-dihyd...)
Show SMILES COc1ccc(cc1)C1CC(=NN1C(C)=O)c1ccc(Br)cc1
Show InChI InChI=1S/C18H17BrN2O2/c1-12(22)21-18(14-5-9-16(23-2)10-6-14)11-17(20-21)13-3-7-15(19)8-4-13/h3-10,18H,11H2,1-2H3
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n/an/a 6.65E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338860
PNG
(1-(5-(Benzo[d][1,3]dioxol-6-yl)-4,5-dihydro-3-phen...)
Show SMILES CC(=O)N1N=C(CC1c1ccc2OCOc2c1)c1ccccc1
Show InChI InChI=1S/C18H16N2O3/c1-12(21)20-16(10-15(19-20)13-5-3-2-4-6-13)14-7-8-17-18(9-14)23-11-22-17/h2-9,16H,10-11H2,1H3
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n/an/a 7.08E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338861
PNG
(1-(3-(4-bromophenyl)-5-phenyl-4,5-dihydro-1H-pyraz...)
Show SMILES CC(=O)N1N=C(CC1c1ccccc1)c1ccc(Br)cc1
Show InChI InChI=1S/C17H15BrN2O/c1-12(21)20-17(14-5-3-2-4-6-14)11-16(19-20)13-7-9-15(18)10-8-13/h2-10,17H,11H2,1H3
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n/an/a 7.13E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338868
PNG
(1-Acetyl-5-(4-methoxyphenyl)-3-(3-nitrophenyl)-4,5...)
Show SMILES COc1ccc(cc1)C1CC(=NN1C(C)=O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C18H17N3O4/c1-12(22)20-18(13-6-8-16(25-2)9-7-13)11-17(19-20)14-4-3-5-15(10-14)21(23)24/h3-10,18H,11H2,1-2H3
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n/an/a 7.33E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338856
PNG
(1-Acetyl-5-(4-dimethylaminophenyl)-3-phenyl-4,5-di...)
Show SMILES CN(C)c1ccc(cc1)C1CC(=NN1C(C)=O)c1ccccc1
Show InChI InChI=1S/C19H21N3O/c1-14(23)22-19(16-9-11-17(12-10-16)21(2)3)13-18(20-22)15-7-5-4-6-8-15/h4-12,19H,13H2,1-3H3
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n/an/a 7.36E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338864
PNG
(1-Acetyl-3-(4-bromophenyl)-5-(3,4,5-trimethoxyphen...)
Show SMILES COc1cc(cc(OC)c1OC)C1CC(=NN1C(C)=O)c1ccc(Br)cc1
Show InChI InChI=1S/C20H21BrN2O4/c1-12(24)23-17(11-16(22-23)13-5-7-15(21)8-6-13)14-9-18(25-2)20(27-4)19(10-14)26-3/h5-10,17H,11H2,1-4H3
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n/an/a 7.49E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338869
PNG
(1-Acetyl-5-(3,4-dimethoxyphenyl)-3-(3-nitrophenyl)...)
Show SMILES COc1ccc(cc1OC)C1CC(=NN1C(C)=O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C19H19N3O5/c1-12(23)21-17(14-7-8-18(26-2)19(10-14)27-3)11-16(20-21)13-5-4-6-15(9-13)22(24)25/h4-10,17H,11H2,1-3H3
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n/an/a 7.52E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338871
PNG
(1-(5-(Benzo[d][1,3]dioxol-6-yl)-4,5-dihydro-3-(3-n...)
Show SMILES CC(=O)N1N=C(CC1c1ccc2OCOc2c1)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C18H15N3O5/c1-11(22)20-16(13-5-6-17-18(8-13)26-10-25-17)9-15(19-20)12-3-2-4-14(7-12)21(23)24/h2-8,16H,9-10H2,1H3
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n/an/a 7.61E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338855
PNG
(1-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyr...)
Show SMILES COc1ccc(cc1)C1CC(=NN1C(C)=O)c1ccccc1
Show InChI InChI=1S/C18H18N2O2/c1-13(21)20-18(15-8-10-16(22-2)11-9-15)12-17(19-20)14-6-4-3-5-7-14/h3-11,18H,12H2,1-2H3
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n/an/a 7.62E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338867
PNG
(1-Acetyl-3-(3-nitrophenyl)-5-phenyl-4,5-dihydro(1H...)
Show SMILES CC(=O)N1N=C(CC1c1ccccc1)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C17H15N3O3/c1-12(21)19-17(13-6-3-2-4-7-13)11-16(18-19)14-8-5-9-15(10-14)20(22)23/h2-10,17H,11H2,1H3
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n/an/a 7.91E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338858
PNG
(1-Acetyl-5-(4-hydroxy-3-methoxy)-3-phenyl-4,5-dihy...)
Show SMILES COc1cc(ccc1O)C1CC(=NN1C(C)=O)c1ccccc1
Show InChI InChI=1S/C18H18N2O3/c1-12(21)20-16(14-8-9-17(22)18(10-14)23-2)11-15(19-20)13-6-4-3-5-7-13/h3-10,16,22H,11H2,1-2H3
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n/an/a 8.12E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50297427
PNG
(1-(5-(3,4-dimethoxyphenyl)-3-phenyl-4,5-dihydro-1H...)
Show SMILES COc1ccc(cc1OC)C1CC(=NN1C(C)=O)c1ccccc1
Show InChI InChI=1S/C19H20N2O3/c1-13(22)21-17(12-16(20-21)14-7-5-4-6-8-14)15-9-10-18(23-2)19(11-15)24-3/h4-11,17H,12H2,1-3H3
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n/an/a 8.37E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338859
PNG
(1-Acetyl-5-(3,4,5-trimethoxyphenyl)-3-phenyl-4,5-d...)
Show SMILES COc1cc(cc(OC)c1OC)C1CC(=NN1C(C)=O)c1ccccc1
Show InChI InChI=1S/C20H22N2O4/c1-13(23)22-17(12-16(21-22)14-8-6-5-7-9-14)15-10-18(24-2)20(26-4)19(11-15)25-3/h5-11,17H,12H2,1-4H3
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n/an/a 8.64E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338852
PNG
(1-(3-(Furan-2-yl)-4,5-dihydro-5-(naphthalen-2-yl)-...)
Show SMILES CC(=O)N1N=C(CC1c1ccc2ccccc2c1)c1ccco1
Show InChI InChI=1S/C19H16N2O2/c1-13(22)21-18(12-17(20-21)19-7-4-10-23-19)16-9-8-14-5-2-3-6-15(14)11-16/h2-11,18H,12H2,1H3
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n/an/a 9.14E+4n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338854
PNG
(3,5-diphenyl-4,5-dihydro-1H-pyrazole | CHEMBL16847...)
Show SMILES C1C(N=NC1c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H14N2/c1-3-7-12(8-4-1)14-11-15(17-16-14)13-9-5-2-6-10-13/h1-10,14-15H,11H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
Xanthine dehydrogenase


(Bos taurus (Bovine))
BDBM50338834
PNG
(1-(4,5-Dihydro-5-(naphth-2-yl)-3-(naphth-1-yl)-1Hp...)
Show SMILES CC(=O)N1N=C(CC1c1ccc2ccccc2c1)c1cccc2ccccc12
Show InChI InChI=1S/C25H20N2O/c1-17(28)27-25(21-14-13-18-7-2-3-9-20(18)15-21)16-24(26-27)23-12-6-10-19-8-4-5-11-22(19)23/h2-15,25H,16H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Indo-Soviet Friendship College of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of bovine Xanthine oxidase assessed as decrease in uric acid production preincubated at 293 nM of compound for 5 mins by spectrophotometry


Bioorg Med Chem 19: 1950-8 (2011)


Article DOI: 10.1016/j.bmc.2011.01.058
BindingDB Entry DOI: 10.7270/Q237791S
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%