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PubMed code 21444206

Compile data set for download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50343442
PNG
(CHEMBL1775179 | isopropyl 4-(1-(2-fluoro-4-(methyl...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C21H24FN5O5S/c1-13(2)31-21(28)26-8-6-14(7-9-26)32-20-16-11-25-27(19(16)23-12-24-20)18-5-4-15(10-17(18)22)33(3,29)30/h4-5,10-14H,6-9H2,1-3H3
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100n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50343442
PNG
(CHEMBL1775179 | isopropyl 4-(1-(2-fluoro-4-(methyl...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C21H24FN5O5S/c1-13(2)31-21(28)26-8-6-14(7-9-26)32-20-16-11-25-27(19(16)23-12-24-20)18-5-4-15(10-17(18)22)33(3,29)30/h4-5,10-14H,6-9H2,1-3H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343444
PNG
(CHEMBL1773292 | tert-butyl 4-(9-(2-fluoro-4-(methy...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(-c3ccc(cc3F)S(C)(=O)=O)c(=O)[nH]c12
Show InChI InChI=1S/C22H26FN5O6S/c1-22(2,3)34-21(30)27-9-7-13(8-10-27)33-19-17-18(24-12-25-19)28(20(29)26-17)16-6-5-14(11-15(16)23)35(4,31)32/h5-6,11-13H,7-10H2,1-4H3,(H,26,29)
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n/an/an/an/a 0.600n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343443
PNG
(CHEMBL1773283 | tert-butyl 4-(1-(2-fluoro-4-(methy...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Sc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H26FN5O4S2/c1-22(2,3)32-21(29)27-9-7-14(8-10-27)33-20-16-12-26-28(19(16)24-13-25-20)18-6-5-15(11-17(18)23)34(4,30)31/h5-6,11-14H,7-10H2,1-4H3
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n/an/an/an/a 7.30n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343456
PNG
(CHEMBL1775176 | neopentyl 4-(1-(4-(methylsulfonyl)...)
Show SMILES CC(C)(C)COC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H29N5O5S/c1-23(2,3)14-32-22(29)27-11-9-17(10-12-27)33-21-19-13-26-28(20(19)24-15-25-21)16-5-7-18(8-6-16)34(4,30)31/h5-8,13,15,17H,9-12,14H2,1-4H3
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n/an/an/an/a 8.10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343447
PNG
(CHEMBL1775169 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O5S/c1-22(2,3)32-21(28)26-11-9-16(10-12-26)31-20-18-13-25-27(19(18)23-14-24-20)15-5-7-17(8-6-15)33(4,29)30/h5-8,13-14,16H,9-12H2,1-4H3
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n/an/an/an/a 9.80n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343442
PNG
(CHEMBL1775179 | isopropyl 4-(1-(2-fluoro-4-(methyl...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C21H24FN5O5S/c1-13(2)31-21(28)26-8-6-14(7-9-26)32-20-16-11-25-27(19(16)23-12-24-20)18-5-4-15(10-17(18)22)33(3,29)30/h4-5,10-14H,6-9H2,1-3H3
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n/an/an/an/a 33n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343439
PNG
(CHEMBL1773284 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)S(=O)c1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O5S2/c1-22(2,3)32-21(28)26-11-9-16(10-12-26)33(29)20-18-13-25-27(19(18)23-14-24-20)15-5-7-17(8-6-15)34(4,30)31/h5-8,13-14,16H,9-12H2,1-4H3
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n/an/an/an/a 2.40E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343445
PNG
(CHEMBL1773293 | tert-butyl 4-(3-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2c(noc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H26N4O6S/c1-22(2,3)31-21(27)26-11-9-15(10-12-26)30-20-19-18(23-13-24-20)17(25-32-19)14-5-7-16(8-6-14)33(4,28)29/h5-8,13,15H,9-12H2,1-4H3
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n/an/an/an/a 0.700n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343442
PNG
(CHEMBL1775179 | isopropyl 4-(1-(2-fluoro-4-(methyl...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C21H24FN5O5S/c1-13(2)31-21(28)26-8-6-14(7-9-26)32-20-16-11-25-27(19(16)23-12-24-20)18-5-4-15(10-17(18)22)33(3,29)30/h4-5,10-14H,6-9H2,1-3H3
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n/an/an/an/a 2.70n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343436
PNG
(CHEMBL1773281 | isopropyl 4-((ethyl(1-(2-fluoro-4-...)
Show SMILES CCN(CC1CCN(CC1)C(=O)OC(C)C)c1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C24H31FN6O4S/c1-5-29(14-17-8-10-30(11-9-17)24(32)35-16(2)3)22-19-13-28-31(23(19)27-15-26-22)21-7-6-18(12-20(21)25)36(4,33)34/h6-7,12-13,15-17H,5,8-11,14H2,1-4H3
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n/an/an/an/a 3.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343434
PNG
(CHEMBL1773286 | tert-butyl 4-((1-(4-(methylsulfony...)
Show SMILES CC(C)(C)OC(=O)N1CCC(Cc2ncnc3n(ncc23)-c2ccc(cc2)S(C)(=O)=O)CC1
Show InChI InChI=1S/C23H29N5O4S/c1-23(2,3)32-22(29)27-11-9-16(10-12-27)13-20-19-14-26-28(21(19)25-15-24-20)17-5-7-18(8-6-17)33(4,30)31/h5-8,14-16H,9-13H2,1-4H3
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n/an/an/an/a 7.30n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343454
PNG
(CHEMBL1773291 | tert-butyl 4-(3-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(nnc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H26N6O5S/c1-21(2,3)32-20(28)26-11-9-15(10-12-26)31-19-17-18(22-13-23-19)27(25-24-17)14-5-7-16(8-6-14)33(4,29)30/h5-8,13,15H,9-12H2,1-4H3
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n/an/an/an/a 7.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343456
PNG
(CHEMBL1775176 | neopentyl 4-(1-(4-(methylsulfonyl)...)
Show SMILES CC(C)(C)COC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H29N5O5S/c1-23(2,3)14-32-22(29)27-11-9-17(10-12-27)33-21-19-13-26-28(20(19)24-15-25-21)16-5-7-18(8-6-16)34(4,30)31/h5-8,13,15,17H,9-12,14H2,1-4H3
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n/an/an/an/a 65n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50244791
PNG
((2-Fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopr...)
Show SMILES CC(C)c1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25)
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n/an/an/an/a 0.650n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343438
PNG
(CHEMBL1775175 | tetrahydrofuran-3-yl 4-(1-(4-(meth...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1ncc2c(OC3CCN(CC3)C(=O)OC3CCOC3)ncnc12
Show InChI InChI=1S/C22H25N5O6S/c1-34(29,30)18-4-2-15(3-5-18)27-20-19(12-25-27)21(24-14-23-20)32-16-6-9-26(10-7-16)22(28)33-17-8-11-31-13-17/h2-5,12,14,16-17H,6-11,13H2,1H3
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n/an/an/an/a 435n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343440
PNG
(2-(dimethylamino)ethyl 4-(1-(4-(methylsulfonyl)phe...)
Show SMILES CN(C)CCOC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H28N6O5S/c1-26(2)12-13-32-22(29)27-10-8-17(9-11-27)33-21-19-14-25-28(20(19)23-15-24-21)16-4-6-18(7-5-16)34(3,30)31/h4-7,14-15,17H,8-13H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343441
PNG
(CHEMBL1773285 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)S(=O)(=O)c1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O6S2/c1-22(2,3)33-21(28)26-11-9-17(10-12-26)35(31,32)20-18-13-25-27(19(18)23-14-24-20)15-5-7-16(8-6-15)34(4,29)30/h5-8,13-14,17H,9-12H2,1-4H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343439
PNG
(CHEMBL1773284 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)S(=O)c1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O5S2/c1-22(2,3)32-21(28)26-11-9-16(10-12-26)33(29)20-18-13-25-27(19(18)23-14-24-20)15-5-7-17(8-6-15)34(4,30)31/h5-8,13-14,16H,9-12H2,1-4H3
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343450
PNG
(CHEMBL1775170 | ethyl 4-(1-(4-(methylsulfonyl)phen...)
Show SMILES CCOC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C20H23N5O5S/c1-3-29-20(26)24-10-8-15(9-11-24)30-19-17-12-23-25(18(17)21-13-22-19)14-4-6-16(7-5-14)31(2,27)28/h4-7,12-13,15H,3,8-11H2,1-2H3
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n/an/an/an/a 3.80n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343448
PNG
(CHEMBL1773287 | tert-butyl 4-((1-(2-fluoro-4-(meth...)
Show SMILES CC(C)(C)OC(=O)N1CCC(Cc2ncnc3n(ncc23)-c2ccc(cc2F)S(C)(=O)=O)CC1
Show InChI InChI=1S/C23H28FN5O4S/c1-23(2,3)33-22(30)28-9-7-15(8-10-28)11-19-17-13-27-29(21(17)26-14-25-19)20-6-5-16(12-18(20)24)34(4,31)32/h5-6,12-15H,7-11H2,1-4H3
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n/an/an/an/a 88n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343442
PNG
(CHEMBL1775179 | isopropyl 4-(1-(2-fluoro-4-(methyl...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C21H24FN5O5S/c1-13(2)31-21(28)26-8-6-14(7-9-26)32-20-16-11-25-27(19(16)23-12-24-20)18-5-4-15(10-17(18)22)33(3,29)30/h4-5,10-14H,6-9H2,1-3H3
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n/an/an/an/a 23n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in human HEK293 cells assessed as increase in adenylate cyclase activation


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343461
PNG
(CHEMBL1773290 | tert-butyl 4-(9-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(cnc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O5S/c1-22(2,3)32-21(28)26-11-9-16(10-12-26)31-20-18-19(23-13-24-20)27(14-25-18)15-5-7-17(8-6-15)33(4,29)30/h5-8,13-14,16H,9-12H2,1-4H3
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n/an/an/an/a 33.4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343433
PNG
(CHEMBL1773289 | tert-butyl 4-(3,6-dimethyl-1-(4-(m...)
Show SMILES Cc1nn(-c2ccc(cc2)S(C)(=O)=O)c2nc(C)nc(OC3CCN(CC3)C(=O)OC(C)(C)C)c12
Show InChI InChI=1S/C24H31N5O5S/c1-15-20-21(29(27-15)17-7-9-19(10-8-17)35(6,31)32)25-16(2)26-22(20)33-18-11-13-28(14-12-18)23(30)34-24(3,4)5/h7-10,18H,11-14H2,1-6H3
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n/an/an/an/a 116n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343435
PNG
(CHEMBL1773277 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Nc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H28N6O4S/c1-22(2,3)32-21(29)27-11-9-15(10-12-27)26-19-18-13-25-28(20(18)24-14-23-19)16-5-7-17(8-6-16)33(4,30)31/h5-8,13-15H,9-12H2,1-4H3,(H,23,24,26)
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n/an/an/an/a 250n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343441
PNG
(CHEMBL1773285 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)S(=O)(=O)c1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O6S2/c1-22(2,3)33-21(28)26-11-9-17(10-12-26)35(31,32)20-18-13-25-27(19(18)23-14-24-20)15-5-7-16(8-6-15)34(4,29)30/h5-8,13-14,17H,9-12H2,1-4H3
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343446
PNG
(CHEMBL1775178 | tert-butyl 4-(1-(2-fluoro-4-(methy...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H26FN5O5S/c1-22(2,3)33-21(29)27-9-7-14(8-10-27)32-20-16-12-26-28(19(16)24-13-25-20)18-6-5-15(11-17(18)23)34(4,30)31/h5-6,11-14H,7-10H2,1-4H3
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n/an/an/an/a 0.900n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343460
PNG
(CHEMBL1773288 | tert-butyl 4-(3-methyl-1-(4-(methy...)
Show SMILES Cc1nn(-c2ccc(cc2)S(C)(=O)=O)c2ncnc(OC3CCN(CC3)C(=O)OC(C)(C)C)c12
Show InChI InChI=1S/C23H29N5O5S/c1-15-19-20(28(26-15)16-6-8-18(9-7-16)34(5,30)31)24-14-25-21(19)32-17-10-12-27(13-11-17)22(29)33-23(2,3)4/h6-9,14,17H,10-13H2,1-5H3
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n/an/an/an/a 15n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343458
PNG
(CHEMBL1773294 | isopropyl 4-(3-(4-(methylsulfonyl)...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2c(noc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H24N4O6S/c1-13(2)29-21(26)25-10-8-15(9-11-25)30-20-19-18(22-12-23-20)17(24-31-19)14-4-6-16(7-5-14)32(3,27)28/h4-7,12-13,15H,8-11H2,1-3H3
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n/an/an/an/a 40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343432
PNG
(3-isopropyl-5-(1-(1-(4-(methylsulfonyl)phenyl)-1H-...)
Show SMILES CC(C)c1noc(n1)C1CCN(CC1)c1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H25N7O3S/c1-14(2)19-26-22(32-27-19)15-8-10-28(11-9-15)20-18-12-25-29(21(18)24-13-23-20)16-4-6-17(7-5-16)33(3,30)31/h4-7,12-15H,8-11H2,1-3H3
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n/an/an/an/a 42n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343434
PNG
(CHEMBL1773286 | tert-butyl 4-((1-(4-(methylsulfony...)
Show SMILES CC(C)(C)OC(=O)N1CCC(Cc2ncnc3n(ncc23)-c2ccc(cc2)S(C)(=O)=O)CC1
Show InChI InChI=1S/C23H29N5O4S/c1-23(2,3)32-22(29)27-11-9-16(10-12-27)13-20-19-14-26-28(21(19)25-15-24-20)17-5-7-18(8-6-17)33(4,30)31/h5-8,14-16H,9-13H2,1-4H3
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n/an/an/an/a 120n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343435
PNG
(CHEMBL1773277 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Nc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H28N6O4S/c1-22(2,3)32-21(29)27-11-9-15(10-12-27)26-19-18-13-25-28(20(18)24-14-23-19)16-5-7-17(8-6-16)33(4,30)31/h5-8,13-15H,9-12H2,1-4H3,(H,23,24,26)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343458
PNG
(CHEMBL1773294 | isopropyl 4-(3-(4-(methylsulfonyl)...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2c(noc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H24N4O6S/c1-13(2)29-21(26)25-10-8-15(9-11-25)30-20-19-18(22-12-23-20)17(24-31-19)14-4-6-16(7-5-14)32(3,27)28/h4-7,12-13,15H,8-11H2,1-3H3
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n/an/an/an/a 14n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343459
PNG
(CHEMBL1775174 | cyclopentyl 4-(1-(4-(methylsulfony...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1ncc2c(OC3CCN(CC3)C(=O)OC3CCCC3)ncnc12
Show InChI InChI=1S/C23H27N5O5S/c1-34(30,31)19-8-6-16(7-9-19)28-21-20(14-26-28)22(25-15-24-21)32-18-10-12-27(13-11-18)23(29)33-17-4-2-3-5-17/h6-9,14-15,17-18H,2-5,10-13H2,1H3
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n/an/an/an/a 14.6n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343459
PNG
(CHEMBL1775174 | cyclopentyl 4-(1-(4-(methylsulfony...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-n1ncc2c(OC3CCN(CC3)C(=O)OC3CCCC3)ncnc12
Show InChI InChI=1S/C23H27N5O5S/c1-34(30,31)19-8-6-16(7-9-19)28-21-20(14-26-28)22(25-15-24-21)32-18-10-12-27(13-11-18)23(29)33-17-4-2-3-5-17/h6-9,14-15,17-18H,2-5,10-13H2,1H3
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n/an/an/an/a 21n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343436
PNG
(CHEMBL1773281 | isopropyl 4-((ethyl(1-(2-fluoro-4-...)
Show SMILES CCN(CC1CCN(CC1)C(=O)OC(C)C)c1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C24H31FN6O4S/c1-5-29(14-17-8-10-30(11-9-17)24(32)35-16(2)3)22-19-13-28-31(23(19)27-15-26-22)21-7-6-18(12-20(21)25)36(4,33)34/h6-7,12-13,15-17H,5,8-11,14H2,1-4H3
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n/an/an/an/a 264n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343443
PNG
(CHEMBL1773283 | tert-butyl 4-(1-(2-fluoro-4-(methy...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Sc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H26FN5O4S2/c1-22(2,3)32-21(29)27-9-7-14(8-10-27)33-20-16-12-26-28(19(16)24-13-25-20)18-6-5-15(11-17(18)23)34(4,30)31/h5-6,11-14H,7-10H2,1-4H3
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n/an/an/an/a 0.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343448
PNG
(CHEMBL1773287 | tert-butyl 4-((1-(2-fluoro-4-(meth...)
Show SMILES CC(C)(C)OC(=O)N1CCC(Cc2ncnc3n(ncc23)-c2ccc(cc2F)S(C)(=O)=O)CC1
Show InChI InChI=1S/C23H28FN5O4S/c1-23(2,3)33-22(30)28-9-7-15(8-10-28)11-19-17-13-27-29(21(17)26-14-25-19)20-6-5-16(12-18(20)24)34(4,31)32/h5-6,12-15H,7-11H2,1-4H3
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n/an/an/an/a 3.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343449
PNG
(CHEMBL1775171 | isopropyl 4-(1-(4-(methylsulfonyl)...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H25N5O5S/c1-14(2)30-21(27)25-10-8-16(9-11-25)31-20-18-12-24-26(19(18)22-13-23-20)15-4-6-17(7-5-15)32(3,28)29/h4-7,12-14,16H,8-11H2,1-3H3
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n/an/an/an/a 3.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343453
PNG
(CHEMBL1773280 | tert-butyl 4-((ethyl(1-(4-(methyls...)
Show SMILES CCN(CC1CCN(CC1)C(=O)OC(C)(C)C)c1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C25H34N6O4S/c1-6-29(16-18-11-13-30(14-12-18)24(32)35-25(2,3)4)22-21-15-28-31(23(21)27-17-26-22)19-7-9-20(10-8-19)36(5,33)34/h7-10,15,17-18H,6,11-14,16H2,1-5H3
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n/an/an/an/a 6.30n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343455
PNG
(CHEMBL1775172 | butyl 4-(1-(4-(methylsulfonyl)phen...)
Show SMILES CCCCOC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O5S/c1-3-4-13-31-22(28)26-11-9-17(10-12-26)32-21-19-14-25-27(20(19)23-15-24-21)16-5-7-18(8-6-16)33(2,29)30/h5-8,14-15,17H,3-4,9-13H2,1-2H3
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n/an/an/an/a 7.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343457
PNG
(CHEMBL1773279 | tert-butyl 4-((methyl(1-(4-(methyl...)
Show SMILES CN(CC1CCN(CC1)C(=O)OC(C)(C)C)c1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H32N6O4S/c1-24(2,3)34-23(31)29-12-10-17(11-13-29)15-28(4)21-20-14-27-30(22(20)26-16-25-21)18-6-8-19(9-7-18)35(5,32)33/h6-9,14,16-17H,10-13,15H2,1-5H3
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n/an/an/an/a 11.6n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343445
PNG
(CHEMBL1773293 | tert-butyl 4-(3-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2c(noc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H26N4O6S/c1-22(2,3)31-21(27)26-11-9-15(10-12-26)30-20-19-18(23-13-24-20)17(25-32-19)14-5-7-16(8-6-14)33(4,28)29/h5-8,13,15H,9-12H2,1-4H3
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n/an/an/an/a 17n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343447
PNG
(CHEMBL1775169 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O5S/c1-22(2,3)32-21(28)26-11-9-16(10-12-26)31-20-18-13-25-27(19(18)23-14-24-20)15-5-7-17(8-6-15)33(4,29)30/h5-8,13-14,16H,9-12H2,1-4H3
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n/an/an/an/a 1.10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343451
PNG
(CHEMBL1775173 | isobutyl 4-(1-(4-(methylsulfonyl)p...)
Show SMILES CC(C)COC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O5S/c1-15(2)13-31-22(28)26-10-8-17(9-11-26)32-21-19-12-25-27(20(19)23-14-24-21)16-4-6-18(7-5-16)33(3,29)30/h4-7,12,14-15,17H,8-11,13H2,1-3H3
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n/an/an/an/a 4.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343452
PNG
(CHEMBL1773282 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Sc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O4S2/c1-22(2,3)31-21(28)26-11-9-16(10-12-26)32-20-18-13-25-27(19(18)23-14-24-20)15-5-7-17(8-6-15)33(4,29)30/h5-8,13-14,16H,9-12H2,1-4H3
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n/an/an/an/a 5.60n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343452
PNG
(CHEMBL1773282 | tert-butyl 4-(1-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Sc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H27N5O4S2/c1-22(2,3)31-21(28)26-11-9-16(10-12-26)32-20-18-13-25-27(19(18)23-14-24-20)15-5-7-17(8-6-15)33(4,29)30/h5-8,13-14,16H,9-12H2,1-4H3
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n/an/an/an/a 15.5n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343446
PNG
(CHEMBL1775178 | tert-butyl 4-(1-(2-fluoro-4-(methy...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H26FN5O5S/c1-22(2,3)33-21(29)27-9-7-14(8-10-27)32-20-16-12-26-28(19(16)24-13-25-20)18-6-5-15(11-17(18)23)34(4,30)31/h5-6,11-14H,7-10H2,1-4H3
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n/an/an/an/a 19.6n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343460
PNG
(CHEMBL1773288 | tert-butyl 4-(3-methyl-1-(4-(methy...)
Show SMILES Cc1nn(-c2ccc(cc2)S(C)(=O)=O)c2ncnc(OC3CCN(CC3)C(=O)OC(C)(C)C)c12
Show InChI InChI=1S/C23H29N5O5S/c1-15-19-20(28(26-15)16-6-8-18(9-7-16)34(5,30)31)24-14-25-21(19)32-17-10-12-27(13-11-17)22(29)33-23(2,3)4/h6-9,14,17H,10-13H2,1-5H3
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n/an/an/an/a 42n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343454
PNG
(CHEMBL1773291 | tert-butyl 4-(3-(4-(methylsulfonyl...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(nnc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H26N6O5S/c1-21(2,3)32-20(28)26-11-9-15(10-12-26)31-19-17-18(22-13-23-19)27(25-24-17)14-5-7-16(8-6-14)33(4,29)30/h5-8,13,15H,9-12H2,1-4H3
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n/an/an/an/a 42n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50343450
PNG
(CHEMBL1775170 | ethyl 4-(1-(4-(methylsulfonyl)phen...)
Show SMILES CCOC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C20H23N5O5S/c1-3-29-20(26)24-10-8-15(9-11-24)30-19-17-12-23-25(18(17)21-13-22-19)14-4-6-16(7-5-14)31(2,27)28/h4-7,12-13,15H,3,8-11H2,1-2H3
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n/an/an/an/a 53n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50244680
PNG
(CHEMBL462196 | {6-[4-(3-Isopropyl-[1,2,4]oxadiazol...)
Show SMILES CC(C)c1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C21H25N7O5S/c1-13(2)18-25-21(33-26-18)14-8-10-27(11-9-14)20-17(28(29)30)19(22-12-23-20)24-15-4-6-16(7-5-15)34(3,31)32/h4-7,12-14H,8-11H2,1-3H3,(H,22,23,24)
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n/an/an/an/a 5.10n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50343437
PNG
(CHEMBL1773278 | tert-butyl 4-((1-(4-(methylsulfony...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CNc2ncnc3n(ncc23)-c2ccc(cc2)S(C)(=O)=O)CC1
Show InChI InChI=1S/C23H30N6O4S/c1-23(2,3)33-22(30)28-11-9-16(10-12-28)13-24-20-19-14-27-29(21(19)26-15-25-20)17-5-7-18(8-6-17)34(4,31)32/h5-8,14-16H,9-13H2,1-4H3,(H,24,25,26)
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n/an/an/an/a 265n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 by melanophore assay


Bioorg Med Chem Lett 21: 3134-41 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.007
BindingDB Entry DOI: 10.7270/Q24T6JQF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%