BindingDB logo
myBDB logout

PubMed code 21514014

Compile data set for download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.490n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345359
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-5-((5-(furan-2-yl)thi...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccco2)c(Cl)cc1O
Show InChI InChI=1/C20H20ClNO7S/c21-11-6-12(24)10(20-19(27)18(26)17(25)14(8-23)29-20)4-9(11)5-16-22-7-15(30-16)13-2-1-3-28-13/h1-4,6-7,14,17-20,23-27H,5,8H2/t14-,17-,18+,19-,20+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.797n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345356
PNG
((2S,3R,4R,5S,6R)-2-(2-(Allyloxy)-4-chloro-5-((5-(t...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccsc2)c(Cl)cc1OCC=C
Show InChI InChI=1/C23H24ClNO6S2/c1-2-4-30-16-8-15(24)13(7-19-25-9-18(33-19)12-3-5-32-11-12)6-14(16)23-22(29)21(28)20(27)17(10-26)31-23/h2-3,5-6,8-9,11,17,20-23,26-29H,1,4,7,10H2/t17-,20-,21+,22-,23+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.934n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345350
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-2-ethoxy-5-((5-(thiop...)
Show SMILES CCOc1cc(Cl)c(Cc2ncc(s2)-c2ccsc2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C22H24ClNO6S2/c1-2-29-15-7-14(23)12(6-18-24-8-17(32-18)11-3-4-31-10-11)5-13(15)22-21(28)20(27)19(26)16(9-25)30-22/h3-5,7-8,10,16,19-22,25-28H,2,6,9H2,1H3/t16-,19-,20+,21-,22+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.18n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345353
PNG
((2S,3R,4R,5S,6R)-2-(2-(Allyloxy)-4-chloro-5-((5-(f...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccco2)c(Cl)cc1OCC=C
Show InChI InChI=1/C23H24ClNO7S/c1-2-5-30-16-9-14(24)12(8-19-25-10-18(33-19)15-4-3-6-31-15)7-13(16)23-22(29)21(28)20(27)17(11-26)32-23/h2-4,6-7,9-10,17,20-23,26-29H,1,5,8,11H2/t17-,20-,21+,22-,23+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.24n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345344
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-2-methoxy-5-((5-(thio...)
Show SMILES COc1cc(Cl)c(Cc2ncc(s2)-c2ccsc2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C21H22ClNO6S2/c1-28-14-6-13(22)11(5-17-23-7-16(31-17)10-2-3-30-9-10)4-12(14)21-20(27)19(26)18(25)15(8-24)29-21/h2-4,6-7,9,15,18-21,24-27H,5,8H2,1H3/t15-,18-,19+,20-,21+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.29n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345363
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-5-((5-(furan-2-yl)thi...)
Show SMILES OCCOc1cc(Cl)c(Cc2ncc(s2)-c2ccco2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C22H24ClNO8S/c23-13-8-15(31-5-3-25)12(22-21(29)20(28)19(27)16(10-26)32-22)6-11(13)7-18-24-9-17(33-18)14-2-1-4-30-14/h1-2,4,6,8-9,16,19-22,25-29H,3,5,7,10H2/t16-,19-,20+,21-,22+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.51n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345354
PNG
((2S,3R,4R,5S,6R)-2-(2-(Allyloxy)-4-chloro-5-((5-(f...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccoc2)c(Cl)cc1OCC=C
Show InChI InChI=1/C23H24ClNO7S/c1-2-4-31-16-8-15(24)13(7-19-25-9-18(33-19)12-3-5-30-11-12)6-14(16)23-22(29)21(28)20(27)17(10-26)32-23/h2-3,5-6,8-9,11,17,20-23,26-29H,1,4,7,10H2/t17-,20-,21+,22-,23+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.54n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345343
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-2-methoxy-5-((5-(thio...)
Show SMILES COc1cc(Cl)c(Cc2ncc(s2)-c2cccs2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C21H22ClNO6S2/c1-28-13-7-12(22)10(6-17-23-8-16(31-17)15-3-2-4-30-15)5-11(13)21-20(27)19(26)18(25)14(9-24)29-21/h2-5,7-8,14,18-21,24-27H,6,9H2,1H3/t14-,18-,19+,20-,21+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.59n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345355
PNG
((2S,3R,4R,5S,6R)-2-(2-(Allyloxy)-4-chloro-5-((5-(t...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2cccs2)c(Cl)cc1OCC=C
Show InChI InChI=1/C23H24ClNO6S2/c1-2-5-30-15-9-14(24)12(8-19-25-10-18(33-19)17-4-3-6-32-17)7-13(15)23-22(29)21(28)20(27)16(11-26)31-23/h2-4,6-7,9-10,16,20-23,26-29H,1,5,8,11H2/t16-,20-,21+,22-,23+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.69n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345345
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-2-methoxy-5-((5-pheny...)
Show SMILES COc1cc(Cl)c(Cc2ncc(s2)-c2ccccc2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C23H24ClNO6S/c1-30-16-9-15(24)13(8-19-25-10-18(32-19)12-5-3-2-4-6-12)7-14(16)23-22(29)21(28)20(27)17(11-26)31-23/h2-7,9-10,17,20-23,26-29H,8,11H2,1H3/t17-,20-,21+,22-,23+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.01n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345378
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-2-fluoro-5e((5-(thiop...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccsc2)c(Cl)cc1F
Show InChI InChI=1/C20H19ClFNO5S2/c21-12-5-13(22)11(20-19(27)18(26)17(25)14(7-24)28-20)3-10(12)4-16-23-6-15(30-16)9-1-2-29-8-9/h1-3,5-6,8,14,17-20,24-27H,4,7H2/t14-,17-,18+,19-,20+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.12n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345341
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-5-((5-(furan-2-yl)thi...)
Show SMILES COc1cc(Cl)c(Cc2ncc(s2)-c2ccco2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C21H22ClNO7S/c1-28-14-7-12(22)10(6-17-23-8-16(31-17)13-3-2-4-29-13)5-11(14)21-20(27)19(26)18(25)15(9-24)30-21/h2-5,7-8,15,18-21,24-27H,6,9H2,1H3/t15-,18-,19+,20-,21+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.15n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345361
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-5-((5-(furan-2-yl)thi...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccco2)c(Cl)cc1OCC#C
Show InChI InChI=1/C23H22ClNO7S/c1-2-5-30-16-9-14(24)12(8-19-25-10-18(33-19)15-4-3-6-31-15)7-13(16)23-22(29)21(28)20(27)17(11-26)32-23/h1,3-4,6-7,9-10,17,20-23,26-29H,5,8,11H2/t17-,20-,21+,22-,23+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.23n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345370
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-2-(hydroxymethyl)-5-(...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccsc2)c(Cl)cc1CO
Show InChI InChI=1/C21H22ClNO6S2/c22-14-4-12(7-24)13(21-20(28)19(27)18(26)15(8-25)29-21)3-11(14)5-17-23-6-16(31-17)10-1-2-30-9-10/h1-4,6,9,15,18-21,24-28H,5,7-8H2/t15-,18-,19+,20-,21+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.23n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345381
PNG
((2S,3R,4R,5S,6R)-2-(2,4-Dichloro-5-((5-(furan-2-yl...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccco2)c(Cl)cc1Cl
Show InChI InChI=1/C20H19Cl2NO6S/c21-11-6-12(22)10(20-19(27)18(26)17(25)14(8-24)29-20)4-9(11)5-16-23-7-15(30-16)13-2-1-3-28-13/h1-4,6-7,14,17-20,24-27H,5,8H2/t14-,17-,18+,19-,20+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.24n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345384
PNG
((2S,3R,4R,5S,6R)-2-(2,4-Dichloro-5-((5-(thiophen-3...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccsc2)c(Cl)cc1Cl
Show InChI InChI=1/C20H19Cl2NO5S2/c21-12-5-13(22)11(20-19(27)18(26)17(25)14(7-24)28-20)3-10(12)4-16-23-6-15(30-16)9-1-2-29-8-9/h1-3,5-6,8,14,17-20,24-27H,4,7H2/t14-,17-,18+,19-,20+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.31n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345351
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-2-ethoxy-5-((5-phenyl...)
Show SMILES CCOc1cc(Cl)c(Cc2ncc(s2)-c2ccccc2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C24H26ClNO6S/c1-2-31-17-10-16(25)14(9-20-26-11-19(33-20)13-6-4-3-5-7-13)8-15(17)24-23(30)22(29)21(28)18(12-27)32-24/h3-8,10-11,18,21-24,27-30H,2,9,12H2,1H3/t18-,21-,22+,23-,24+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.87n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345357
PNG
((2S,3R,4R,5S,6R)-2-(2-(Allyloxy)-4-chloro-5-((5-ph...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccccc2)c(Cl)cc1OCC=C
Show InChI InChI=1/C25H26ClNO6S/c1-2-8-32-18-11-17(26)15(10-21-27-12-20(34-21)14-6-4-3-5-7-14)9-16(18)25-24(31)23(30)22(29)19(13-28)33-25/h2-7,9,11-12,19,22-25,28-31H,1,8,10,13H2/t19-,22-,23+,24-,25+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.38n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345375
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-2-fluoro-5-((5-(furan...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccco2)c(Cl)cc1F
Show InChI InChI=1/C20H19ClFNO6S/c21-11-6-12(22)10(20-19(27)18(26)17(25)14(8-24)29-20)4-9(11)5-16-23-7-15(30-16)13-2-1-3-28-13/h1-4,6-7,14,17-20,24-27H,5,8H2/t14-,17-,18+,19-,20+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.49n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345377
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-2-fluoro-5-((5-(thiop...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2cccs2)c(Cl)cc1F
Show InChI InChI=1/C20H19ClFNO5S2/c21-11-6-12(22)10(20-19(27)18(26)17(25)13(8-24)28-20)4-9(11)5-16-23-7-15(30-16)14-2-1-3-29-14/h1-4,6-7,13,17-20,24-27H,5,8H2/t13-,17-,18+,19-,20+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.88n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345347
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-2-ethoxy-5-((5-(furan...)
Show SMILES CCOc1cc(Cl)c(Cc2ncc(s2)-c2ccco2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C22H24ClNO7S/c1-2-29-15-8-13(23)11(7-18-24-9-17(32-18)14-4-3-5-30-14)6-12(15)22-21(28)20(27)19(26)16(10-25)31-22/h3-6,8-9,16,19-22,25-28H,2,7,10H2,1H3/t16-,19-,20+,21-,22+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.98n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345358
PNG
((2S,3R,4R,5S,6R)-2-(2-(Allyloxy)-4-chloro-5-((5-(4...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccc(F)cc2)c(Cl)cc1OCC=C
Show InChI InChI=1/C25H25ClFNO6S/c1-2-7-33-18-10-17(26)14(8-16(18)25-24(32)23(31)22(30)19(12-29)34-25)9-21-28-11-20(35-21)13-3-5-15(27)6-4-13/h2-6,8,10-11,19,22-25,29-32H,1,7,9,12H2/t19-,22-,23+,24-,25+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.22n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345349
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-2-ethoxy-5-((5-(thiop...)
Show SMILES CCOc1cc(Cl)c(Cc2ncc(s2)-c2cccs2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C22H24ClNO6S2/c1-2-29-14-8-13(23)11(7-18-24-9-17(32-18)16-4-3-5-31-16)6-12(14)22-21(28)20(27)19(26)15(10-25)30-22/h3-6,8-9,15,19-22,25-28H,2,7,10H2,1H3/t15-,19-,20+,21-,22+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.29n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345348
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-2-ethoxy-5-((5-(furan...)
Show SMILES CCOc1cc(Cl)c(Cc2ncc(s2)-c2ccoc2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C22H24ClNO7S/c1-2-30-15-7-14(23)12(6-18-24-8-17(32-18)11-3-4-29-10-11)5-13(15)22-21(28)20(27)19(26)16(9-25)31-22/h3-5,7-8,10,16,19-22,25-28H,2,6,9H2,1H3/t16-,19-,20+,21-,22+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.35n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345379
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-2-fluoro-5-((5-phenyl...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccccc2)c(Cl)cc1F
Show InChI InChI=1/C22H21ClFNO5S/c23-14-8-15(24)13(22-21(29)20(28)19(27)16(10-26)30-22)6-12(14)7-18-25-9-17(31-18)11-4-2-1-3-5-11/h1-6,8-9,16,19-22,26-29H,7,10H2/t16-,19-,20+,21-,22+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.57n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345383
PNG
((2S,3R,4R,5S,6R)-2-(2,4-Dichloro-5-((5-(thiophen-2...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2cccs2)c(Cl)cc1Cl
Show InChI InChI=1/C20H19Cl2NO5S2/c21-11-6-12(22)10(20-19(27)18(26)17(25)13(8-24)28-20)4-9(11)5-16-23-7-15(30-16)14-2-1-3-29-14/h1-4,6-7,13,17-20,24-27H,5,8H2/t13-,17-,18+,19-,20+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.77n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345376
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-2-fluoro-5-((5-(furan...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccoc2)c(Cl)cc1F
Show InChI InChI=1/C20H19ClFNO6S/c21-12-5-13(22)11(20-19(27)18(26)17(25)14(7-24)29-20)3-10(12)4-16-23-6-15(30-16)9-1-2-28-8-9/h1-3,5-6,8,14,17-20,24-27H,4,7H2/t14-,17-,18+,19-,20+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.35n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345364
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-5-((5-(furan-2-yl)thi...)
Show SMILES COCCOc1cc(Cl)c(Cc2ncc(s2)-c2ccco2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C23H26ClNO8S/c1-30-5-6-32-16-9-14(24)12(8-19-25-10-18(34-19)15-3-2-4-31-15)7-13(16)23-22(29)21(28)20(27)17(11-26)33-23/h2-4,7,9-10,17,20-23,26-29H,5-6,8,11H2,1H3/t17-,20-,21+,22-,23+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.55n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345367
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-5-((5-(furan-2-yl)thi...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccco2)c(Cl)cc1CO
Show InChI InChI=1/C21H22ClNO7S/c22-13-5-11(8-24)12(21-20(28)19(27)18(26)15(9-25)30-21)4-10(13)6-17-23-7-16(31-17)14-2-1-3-29-14/h1-5,7,15,18-21,24-28H,6,8-9H2/t15-,18-,19+,20-,21+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.81n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345369
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-2-(hydroxymethyl)-5-(...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2cccs2)c(Cl)cc1CO
Show InChI InChI=1/C21H22ClNO6S2/c22-13-5-11(8-24)12(21-20(28)19(27)18(26)14(9-25)29-21)4-10(13)6-17-23-7-16(31-17)15-2-1-3-30-15/h1-5,7,14,18-21,24-28H,6,8-9H2/t14-,18-,19+,20-,21+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.88n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345346
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-5-((5-(4-fluorophenyl...)
Show SMILES COc1cc(Cl)c(Cc2ncc(s2)-c2ccc(F)cc2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C23H23ClFNO6S/c1-31-16-8-15(24)12(6-14(16)23-22(30)21(29)20(28)17(10-27)32-23)7-19-26-9-18(33-19)11-2-4-13(25)5-3-11/h2-6,8-9,17,20-23,27-30H,7,10H2,1H3/t17-,20-,21+,22-,23+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.08n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345342
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-5-((5-(furan-3-yl)thi...)
Show SMILES COc1cc(Cl)c(Cc2ncc(s2)-c2ccoc2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C21H22ClNO7S/c1-28-14-6-13(22)11(5-17-23-7-16(31-17)10-2-3-29-9-10)4-12(14)21-20(27)19(26)18(25)15(8-24)30-21/h2-4,6-7,9,15,18-21,24-27H,5,8H2,1H3/t15-,18-,19+,20-,21+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.37n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345352
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-2-ethoxy-5e((5-(4-flu...)
Show SMILES CCOc1cc(Cl)c(Cc2ncc(s2)-c2ccc(F)cc2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C24H25ClFNO6S/c1-2-32-17-9-16(25)13(7-15(17)24-23(31)22(30)21(29)18(11-28)33-24)8-20-27-10-19(34-20)12-3-5-14(26)6-4-12/h3-7,9-10,18,21-24,28-31H,2,8,11H2,1H3/t18-,21-,22+,23-,24+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.55n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345374
PNG
((2S,3R,4R,5S,6R)-2-(2-(Allyloxymethyl)-4-chloro-5-...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccsc2)c(Cl)cc1COCC=C
Show InChI InChI=1/C24H26ClNO6S2/c1-2-4-31-11-15-7-17(25)14(8-20-26-9-19(34-20)13-3-5-33-12-13)6-16(15)24-23(30)22(29)21(28)18(10-27)32-24/h2-3,5-7,9,12,18,21-24,27-30H,1,4,8,10-11H2/t18-,21-,22+,23-,24+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345382
PNG
((2S,3R,4R,5S,6R)-2-(2,4-Dichloro-5-((5-(furan-3-yl...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccoc2)c(Cl)cc1Cl
Show InChI InChI=1/C20H19Cl2NO6S/c21-12-5-13(22)11(20-19(27)18(26)17(25)14(7-24)29-20)3-10(12)4-16-23-6-15(30-16)9-1-2-28-8-9/h1-3,5-6,8,14,17-20,24-27H,4,7H2/t14-,17-,18+,19-,20+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13.3n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345373
PNG
((2S,3R,4R,5S,6R)-2-(2-(Allyloxymethyl)-4-chloro-5-...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2cccs2)c(Cl)cc1COCC=C
Show InChI InChI=1/C24H26ClNO6S2/c1-2-5-31-12-14-8-16(25)13(9-20-26-10-19(34-20)18-4-3-6-33-18)7-15(14)24-23(30)22(29)21(28)17(11-27)32-24/h2-4,6-8,10,17,21-24,27-30H,1,5,9,11-12H2/t17-,21-,22+,23-,24+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 16.2n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345371
PNG
((2S,3R,4R,5S,6R)-2-(2-(allyloxymethyl)-4-chloro-5-...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccco2)c(Cl)cc1COCC=C
Show InChI InChI=1/C24H26ClNO7S/c1-2-5-31-12-14-8-16(25)13(9-20-26-10-19(34-20)17-4-3-6-32-17)7-15(14)24-23(30)22(29)21(28)18(11-27)33-24/h2-4,6-8,10,18,21-24,27-30H,1,5,9,11-12H2/t18-,21-,22+,23-,24+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17.5n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345368
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-5-((5-(furan-3-yl)thi...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccoc2)c(Cl)cc1CO
Show InChI InChI=1/C21H22ClNO7S/c22-14-4-12(7-24)13(21-20(28)19(27)18(26)15(8-25)30-21)3-11(14)5-17-23-6-16(31-17)10-1-2-29-9-10/h1-4,6,9,15,18-21,24-28H,5,7-8H2/t15-,18-,19+,20-,21+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 20.5n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345360
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-5-((5-(furan-2-yl)thi...)
Show SMILES CCCOc1cc(Cl)c(Cc2ncc(s2)-c2ccco2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C23H26ClNO7S/c1-2-5-30-16-9-14(24)12(8-19-25-10-18(33-19)15-4-3-6-31-15)7-13(16)23-22(29)21(28)20(27)17(11-26)32-23/h3-4,6-7,9-10,17,20-23,26-29H,2,5,8,11H2,1H3/t17-,20-,21+,22-,23+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 21.6n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345380
PNG
((2S,3R,4R,5S,6R)-2-(4-Chloro-2-fluoro-5-((5-(4-flu...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccc(F)cc2)c(Cl)cc1F
Show InChI InChI=1/C22H20ClF2NO5S/c23-14-7-15(25)13(22-21(30)20(29)19(28)16(9-27)31-22)5-11(14)6-18-26-8-17(32-18)10-1-3-12(24)4-2-10/h1-5,7-8,16,19-22,27-30H,6,9H2/t16-,19-,20+,21-,22+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 27.4n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345362
PNG
((2S,3R,4R,5S,6R)-2-(2-(But-3-enyloxy)-4-chloro-5-(...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccco2)c(Cl)cc1OCCC=C
Show InChI InChI=1/C24H26ClNO7S/c1-2-3-6-32-17-10-15(25)13(9-20-26-11-19(34-20)16-5-4-7-31-16)8-14(17)24-23(30)22(29)21(28)18(12-27)33-24/h2,4-5,7-8,10-11,18,21-24,27-30H,1,3,6,9,12H2/t18-,21-,22+,23-,24+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 32.8n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345372
PNG
((2S,3R,4R,5S,6R)-2-(2-(Allyloxymethyl)-4-chloro-5-...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccoc2)c(Cl)cc1COCC=C
Show InChI InChI=1/C24H26ClNO7S/c1-2-4-31-12-15-7-17(25)14(8-20-26-9-19(34-20)13-3-5-32-11-13)6-16(15)24-23(30)22(29)21(28)18(10-27)33-24/h2-3,5-7,9,11,18,21-24,27-30H,1,4,8,10,12H2/t18-,21-,22+,23-,24+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 38.7n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345365
PNG
((2S,3R,4R,5S,6R)-2-(2-(2-(1H-1,2,4-triazol-1-yl)et...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cc(Cc2ncc(s2)-c2ccco2)c(Cl)cc1OCCn1cncn1
Show InChI InChI=1/C24H25ClN4O7S/c25-15-8-17(35-5-3-29-12-26-11-28-29)14(24-23(33)22(32)21(31)18(10-30)36-24)6-13(15)7-20-27-9-19(37-20)16-2-1-4-34-16/h1-2,4,6,8-9,11-12,18,21-24,30-33H,3,5,7,10H2/t18-,21-,22+,23-,24+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 131n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50345366
PNG
((2S,3R,4R,5S,6R)-2-(4-chloro-2-(2-(dimethylamino)e...)
Show SMILES CN(C)CCOc1cc(Cl)c(Cc2ncc(s2)-c2ccco2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1/C24H29ClN2O7S/c1-27(2)5-7-33-17-10-15(25)13(9-20-26-11-19(35-20)16-4-3-6-32-16)8-14(17)24-23(31)22(30)21(29)18(12-28)34-24/h3-4,6,8,10-11,18,21-24,28-31H,5,7,9,12H2,1-2H3/t18-,21-,22+,23-,24+/s2
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 713n/an/an/an/an/an/a



Green Cross Corporation Research Center

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scintillation counter


Eur J Med Chem 46: 2662-75 (2011)


Article DOI: 10.1016/j.ejmech.2011.03.052
BindingDB Entry DOI: 10.7270/Q2KD1Z74
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%