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PubMed code 21543226

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-RAF


(Homo sapiens (human))
BDBM50344532
PNG
(4-(2-(3-tert-butylphenylamino)benzo[d]thiazol-5-yl...)
Show SMILES CNC(=O)c1cc(Oc2ccc3sc(Nc4cccc(c4)C(C)(C)C)nc3c2)ccn1
Show InChI InChI=1S/C24H24N4O2S/c1-24(2,3)15-6-5-7-16(12-15)27-23-28-19-13-17(8-9-21(19)31-23)30-18-10-11-26-20(14-18)22(29)25-4/h5-14H,1-4H3,(H,25,29)(H,27,28)
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n/an/a 1n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344540
PNG
(4-(2-(4-isopropylphenylamino)benzo[d]oxazol-5-ylox...)
Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(cc4)C(C)C)nc3c2)ccn1
Show InChI InChI=1S/C23H22N4O3/c1-14(2)15-4-6-16(7-5-15)26-23-27-19-12-17(8-9-21(19)30-23)29-18-10-11-25-20(13-18)22(28)24-3/h4-14H,1-3H3,(H,24,28)(H,26,27)
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n/an/a 1n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344541
PNG
(4-(2-(4-ethylphenylamino)benzo[d]oxazol-5-yloxy)-N...)
Show SMILES CCc1ccc(Nc2nc3cc(Oc4ccnc(c4)C(=O)NC)ccc3o2)cc1
Show InChI InChI=1S/C22H20N4O3/c1-3-14-4-6-15(7-5-14)25-22-26-18-12-16(8-9-20(18)29-22)28-17-10-11-24-19(13-17)21(27)23-2/h4-13H,3H2,1-2H3,(H,23,27)(H,25,26)
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n/an/a 1n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344548
PNG
(4-(2-(3-tert-butyl phenylamino)benzo[d]oxazol-5-yl...)
Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4cccc(c4)C(C)(C)C)nc3c2)ccn1
Show InChI InChI=1S/C24H24N4O3/c1-24(2,3)15-6-5-7-16(12-15)27-23-28-19-13-17(8-9-21(19)31-23)30-18-10-11-26-20(14-18)22(29)25-4/h5-14H,1-4H3,(H,25,29)(H,27,28)
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n/an/a 1n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344525
PNG
(4-(2-(3-tert-butylphenylamino)benzo[d]thiazol-5-yl...)
Show SMILES CC(C)(C)c1cccc(Nc2nc3cc(Oc4ccnc(c4)C(N)=O)ccc3s2)c1
Show InChI InChI=1S/C23H22N4O2S/c1-23(2,3)14-5-4-6-15(11-14)26-22-27-18-12-16(7-8-20(18)30-22)29-17-9-10-25-19(13-17)21(24)28/h4-13H,1-3H3,(H2,24,28)(H,26,27)
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n/an/a 1n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344539
PNG
(4-(2-(4-butylphenylamino)benzo[d]oxazol-5-yloxy)-N...)
Show SMILES CCCCc1ccc(Nc2nc3cc(Oc4ccnc(c4)C(=O)NC)ccc3o2)cc1
Show InChI InChI=1S/C24H24N4O3/c1-3-4-5-16-6-8-17(9-7-16)27-24-28-20-14-18(10-11-22(20)31-24)30-19-12-13-26-21(15-19)23(29)25-2/h6-15H,3-5H2,1-2H3,(H,25,29)(H,27,28)
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n/an/a 2n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344538
PNG
(CHEMBL1778397 | N-methyl-4-(2-(4-(trifluoromethoxy...)
Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(OC(F)(F)F)cc4)nc3c2)ccn1
Show InChI InChI=1S/C21H15F3N4O4/c1-25-19(29)17-11-15(8-9-26-17)30-14-6-7-18-16(10-14)28-20(31-18)27-12-2-4-13(5-3-12)32-21(22,23)24/h2-11H,1H3,(H,25,29)(H,27,28)
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n/an/a 2n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344530
PNG
(4-(2-(4-bromophenylamino)benzo[d]thiazol-5-yloxy)-...)
Show SMILES CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(Br)cc4)nc3c2)ccn1
Show InChI InChI=1S/C20H15BrN4O2S/c1-22-19(26)17-11-15(8-9-23-17)27-14-6-7-18-16(10-14)25-20(28-18)24-13-4-2-12(21)3-5-13/h2-11H,1H3,(H,22,26)(H,24,25)
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n/an/a 2n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344527
PNG
(4-(2-(4-isopropylphenylamino)benzo[d]thiazol-5-ylo...)
Show SMILES CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(cc4)C(C)C)nc3c2)ccn1
Show InChI InChI=1S/C23H22N4O2S/c1-14(2)15-4-6-16(7-5-15)26-23-27-19-12-17(8-9-21(19)30-23)29-18-10-11-25-20(13-18)22(28)24-3/h4-14H,1-3H3,(H,24,28)(H,26,27)
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n/an/a 3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344542
PNG
(4-(2-(4-bromophenylamino)benzo[d]oxazol-5-yloxy)-N...)
Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Br)cc4)nc3c2)ccn1
Show InChI InChI=1S/C20H15BrN4O3/c1-22-19(26)17-11-15(8-9-23-17)27-14-6-7-18-16(10-14)25-20(28-18)24-13-4-2-12(21)3-5-13/h2-11H,1H3,(H,22,26)(H,24,25)
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n/an/a 3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344543
PNG
(4-(2-(3-isopropylphenylamino)benzo[d]oxazol-5-ylox...)
Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4cccc(c4)C(C)C)nc3c2)ccn1
Show InChI InChI=1S/C23H22N4O3/c1-14(2)15-5-4-6-16(11-15)26-23-27-19-12-17(7-8-21(19)30-23)29-18-9-10-25-20(13-18)22(28)24-3/h4-14H,1-3H3,(H,24,28)(H,26,27)
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n/an/a 3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344534
PNG
(4-(2-(3-isopropylphenylamino)benzo[d]oxazol-5-ylox...)
Show SMILES CC(C)c1cccc(Nc2nc3cc(Oc4ccnc(c4)C(N)=O)ccc3o2)c1
Show InChI InChI=1S/C22H20N4O3/c1-13(2)14-4-3-5-15(10-14)25-22-26-18-11-16(6-7-20(18)29-22)28-17-8-9-24-19(12-17)21(23)27/h3-13H,1-2H3,(H2,23,27)(H,25,26)
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n/an/a 4n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344526
PNG
(CHEMBL1778409 | N-methyl-4-(2-(4-(trifluoromethoxy...)
Show SMILES CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(OC(F)(F)F)cc4)nc3c2)ccn1
Show InChI InChI=1S/C21H15F3N4O3S/c1-25-19(29)17-11-15(8-9-26-17)30-14-6-7-18-16(10-14)28-20(32-18)27-12-2-4-13(5-3-12)31-21(22,23)24/h2-11H,1H3,(H,25,29)(H,27,28)
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n/an/a 4n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344531
PNG
(4-(2-(4-chlorophenylamino)benzo[d]thiazol-5-yloxy)...)
Show SMILES CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(Cl)cc4)nc3c2)ccn1
Show InChI InChI=1S/C20H15ClN4O2S/c1-22-19(26)17-11-15(8-9-23-17)27-14-6-7-18-16(10-14)25-20(28-18)24-13-4-2-12(21)3-5-13/h2-11H,1H3,(H,22,26)(H,24,25)
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n/an/a 4n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344529
PNG
(CHEMBL1778406 | N-methyl-4-(2-(p-tolylamino)benzo[...)
Show SMILES CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(C)cc4)nc3c2)ccn1
Show InChI InChI=1S/C21H18N4O2S/c1-13-3-5-14(6-4-13)24-21-25-17-11-15(7-8-19(17)28-21)27-16-9-10-23-18(12-16)20(26)22-2/h3-12H,1-2H3,(H,22,26)(H,24,25)
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n/an/a 7n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344528
PNG
(4-(2-(4-butylphenylamino)benzo[d]thiazol-5-yloxy)-...)
Show SMILES CCCCc1ccc(Nc2nc3cc(Oc4ccnc(c4)C(=O)NC)ccc3s2)cc1
Show InChI InChI=1S/C24H24N4O2S/c1-3-4-5-16-6-8-17(9-7-16)27-24-28-20-14-18(10-11-22(20)31-24)30-19-12-13-26-21(15-19)23(29)25-2/h6-15H,3-5H2,1-2H3,(H,25,29)(H,27,28)
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n/an/a 9n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344536
PNG
(4-(2-(4-(dimethylamino)phenylamino)benzo[d]oxazol-...)
Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(cc4)N(C)C)nc3c2)ccn1
Show InChI InChI=1S/C22H21N5O3/c1-23-21(28)19-13-17(10-11-24-19)29-16-8-9-20-18(12-16)26-22(30-20)25-14-4-6-15(7-5-14)27(2)3/h4-13H,1-3H3,(H,23,28)(H,25,26)
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n/an/a 12n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM17696
PNG
(2-aminobenzoxazole, 21 | 4-({2-[(4-chlorophenyl)am...)
Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)cc4)nc3c2)ccn1
Show InChI InChI=1S/C20H15ClN4O3/c1-22-19(26)17-11-15(8-9-23-17)27-14-6-7-18-16(10-14)25-20(28-18)24-13-4-2-12(21)3-5-13/h2-11H,1H3,(H,22,26)(H,24,25)
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n/an/a 19n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344544
PNG
(CHEMBL1778391 | N-methyl-4-(2-(3-(trifluoromethyl)...)
Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4cccc(c4)C(F)(F)F)nc3c2)ccn1
Show InChI InChI=1S/C21H15F3N4O3/c1-25-19(29)17-11-15(7-8-26-17)30-14-5-6-18-16(10-14)28-20(31-18)27-13-4-2-3-12(9-13)21(22,23)24/h2-11H,1H3,(H,25,29)(H,27,28)
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n/an/a 27n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344524
PNG
(4-(2-(4-bromophenylamino)benzo[d]thiazol-5-yloxy)-...)
Show SMILES Brc1ccc(Nc2nc3cc(Oc4ccnc(c4)C(=O)NCCN4CCOCC4)ccc3s2)cc1
Show InChI InChI=1S/C25H24BrN5O3S/c26-17-1-3-18(4-2-17)29-25-30-21-15-19(5-6-23(21)35-25)34-20-7-8-27-22(16-20)24(32)28-9-10-31-11-13-33-14-12-31/h1-8,15-16H,9-14H2,(H,28,32)(H,29,30)
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n/an/a 41n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344537
PNG
(CHEMBL1778398 | N-methyl-4-(2-(4-phenoxyphenylamin...)
Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Oc5ccccc5)cc4)nc3c2)ccn1
Show InChI InChI=1S/C26H20N4O4/c1-27-25(31)23-16-21(13-14-28-23)33-20-11-12-24-22(15-20)30-26(34-24)29-17-7-9-19(10-8-17)32-18-5-3-2-4-6-18/h2-16H,1H3,(H,27,31)(H,29,30)
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n/an/a 53n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344545
PNG
(4-(2-(2-ethylphenylamino)benzo[d]oxazol-5-yloxy)-N...)
Show SMILES CCc1ccccc1Nc1nc2cc(Oc3ccnc(c3)C(=O)NC)ccc2o1
Show InChI InChI=1S/C22H20N4O3/c1-3-14-6-4-5-7-17(14)25-22-26-18-12-15(8-9-20(18)29-22)28-16-10-11-24-19(13-16)21(27)23-2/h4-13H,3H2,1-2H3,(H,23,27)(H,25,26)
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n/an/a 110n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344546
PNG
(4-(2-(2-chlorophenylamino)benzo[d]oxazol-5-yloxy)-...)
Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccccc4Cl)nc3c2)ccn1
Show InChI InChI=1S/C20H15ClN4O3/c1-22-19(26)17-11-13(8-9-23-17)27-12-6-7-18-16(10-12)25-20(28-18)24-15-5-3-2-4-14(15)21/h2-11H,1H3,(H,22,26)(H,24,25)
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n/an/a 120n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344533
PNG
(4-(2-(3-isopropylphenylamino)benzo[d]oxazol-5-ylox...)
Show SMILES CC(C)c1cccc(Nc2nc3cc(Oc4ccnc(c4)C(=O)NCCN4CCOCC4)ccc3o2)c1
Show InChI InChI=1S/C28H31N5O4/c1-19(2)20-4-3-5-21(16-20)31-28-32-24-17-22(6-7-26(24)37-28)36-23-8-9-29-25(18-23)27(34)30-10-11-33-12-14-35-15-13-33/h3-9,16-19H,10-15H2,1-2H3,(H,30,34)(H,31,32)
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n/an/a 140n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344547
PNG
(4-(2-(2-fluorophenylamino)benzo[d]oxazol-5-yloxy)-...)
Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccccc4F)nc3c2)ccn1
Show InChI InChI=1S/C20H15FN4O3/c1-22-19(26)17-11-13(8-9-23-17)27-12-6-7-18-16(10-12)25-20(28-18)24-15-5-3-2-4-14(15)21/h2-11H,1H3,(H,22,26)(H,24,25)
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n/an/a 200n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
C-RAF


(Homo sapiens (human))
BDBM50344535
PNG
(4-(2-(4-(4-ethylpiperazin-1-yl)phenylamino)benzo[d...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2nc3cc(Oc4ccnc(c4)C(=O)NC)ccc3o2)cc1
Show InChI InChI=1S/C26H28N6O3/c1-3-31-12-14-32(15-13-31)19-6-4-18(5-7-19)29-26-30-22-16-20(8-9-24(22)35-26)34-21-10-11-28-23(17-21)25(33)27-2/h4-11,16-17H,3,12-15H2,1-2H3,(H,27,33)(H,29,30)
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n/an/a 7.30E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of c-Raf assessed as phosphorylation of MEK1/2 by ELISA


Bioorg Med Chem Lett 21: 3286-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.023
BindingDB Entry DOI: 10.7270/Q2R78FH0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%