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PubMed code 2157007

Compile data set for download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50022536
PNG
(CHEMBL15228)
Show SMILES Cl.Oc1ccc(Cc2ncc[nH]2)cc1O
Show InChI InChI=1S/C10H10N2O2.ClH/c13-8-2-1-7(5-9(8)14)6-10-11-3-4-12-10;/h1-5,13-14H,6H2,(H,11,12);1H
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PC sid
UniChem
Article
PubMed
n/an/a 1.62E+5n/an/an/an/an/an/a



Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of AA+phentolamine by the compound in response of SEC


J Med Chem 33: 1138-44 (1990)


Article DOI: 10.1021/jm00166a009
BindingDB Entry DOI: 10.7270/Q2ZC853J
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50022536
PNG
(CHEMBL15228)
Show SMILES Cl.Oc1ccc(Cc2ncc[nH]2)cc1O
Show InChI InChI=1S/C10H10N2O2.ClH/c13-8-2-1-7(5-9(8)14)6-10-11-3-4-12-10;/h1-5,13-14H,6H2,(H,11,12);1H
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PC sid
UniChem
Article
PubMed
n/an/a 3.47E+5n/an/an/an/an/an/a



Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of ADP by the compound in response of SEC


J Med Chem 33: 1138-44 (1990)


Article DOI: 10.1021/jm00166a009
BindingDB Entry DOI: 10.7270/Q2ZC853J
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50022536
PNG
(CHEMBL15228)
Show SMILES Cl.Oc1ccc(Cc2ncc[nH]2)cc1O
Show InChI InChI=1S/C10H10N2O2.ClH/c13-8-2-1-7(5-9(8)14)6-10-11-3-4-12-10;/h1-5,13-14H,6H2,(H,11,12);1H
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.61E+5n/an/an/an/an/an/a



Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of Arachidonic acid by the compound in response of SEC


J Med Chem 33: 1138-44 (1990)


Article DOI: 10.1021/jm00166a009
BindingDB Entry DOI: 10.7270/Q2ZC853J
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50022536
PNG
(CHEMBL15228)
Show SMILES Cl.Oc1ccc(Cc2ncc[nH]2)cc1O
Show InChI InChI=1S/C10H10N2O2.ClH/c13-8-2-1-7(5-9(8)14)6-10-11-3-4-12-10;/h1-5,13-14H,6H2,(H,11,12);1H
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.13E+5n/an/an/an/an/an/a



Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of U-46,619 + phentolamine by the compound in response of SEC


J Med Chem 33: 1138-44 (1990)


Article DOI: 10.1021/jm00166a009
BindingDB Entry DOI: 10.7270/Q2ZC853J
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50022536
PNG
(CHEMBL15228)
Show SMILES Cl.Oc1ccc(Cc2ncc[nH]2)cc1O
Show InChI InChI=1S/C10H10N2O2.ClH/c13-8-2-1-7(5-9(8)14)6-10-11-3-4-12-10;/h1-5,13-14H,6H2,(H,11,12);1H
PDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.55E+6n/an/an/an/an/an/a



Ohio State University

Curated by ChEMBL


Assay Description
Inhibition of U-46,619 by the compound in response of SEC


J Med Chem 33: 1138-44 (1990)


Article DOI: 10.1021/jm00166a009
BindingDB Entry DOI: 10.7270/Q2ZC853J
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50022596
PNG
(CHEMBL14837)
Show SMILES Cl.OC(c1ncc[nH]1)c1ccc(O)c(O)c1
Show InChI InChI=1/C10H10N2O3.ClH/c13-7-2-1-6(5-8(7)14)9(15)10-11-3-4-12-10;/h1-5,9,13-15H,(H,11,12);1H
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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 2.29E+12n/an/an/an/an/an/a



Ohio State University

Curated by ChEMBL


Assay Description
Stimulatory activity against serotonin secretion (SEC).


J Med Chem 33: 1138-44 (1990)


Article DOI: 10.1021/jm00166a009
BindingDB Entry DOI: 10.7270/Q2ZC853J
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50022537
PNG
(CHEMBL14508)
Show SMILES Cl.Oc1cc(F)c(CC2=NCCN2)cc1O
Show InChI InChI=1S/C10H11FN2O2.ClH/c11-7-5-9(15)8(14)3-6(7)4-10-12-1-2-13-10;/h3,5,14-15H,1-2,4H2,(H,12,13);1H
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PC sid
UniChem
Article
PubMed
n/an/a 3.63E+13n/an/an/an/an/an/a



Ohio State University

Curated by ChEMBL


Assay Description
Stimulatory activity against serotonin secretion (SEC).


J Med Chem 33: 1138-44 (1990)


Article DOI: 10.1021/jm00166a009
BindingDB Entry DOI: 10.7270/Q2ZC853J
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50022538
PNG
(CHEMBL14651)
Show SMILES Cl.Oc1cc(CC2=NCCN2)cc(F)c1O
Show InChI InChI=1S/C10H11FN2O2.ClH/c11-7-3-6(4-8(14)10(7)15)5-9-12-1-2-13-9;/h3-4,14-15H,1-2,5H2,(H,12,13);1H
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Article
PubMed
n/an/a 5.50E+13n/an/an/an/an/an/a



Ohio State University

Curated by ChEMBL


Assay Description
Stimulatory activity against serotonin secretion (SEC).


J Med Chem 33: 1138-44 (1990)


Article DOI: 10.1021/jm00166a009
BindingDB Entry DOI: 10.7270/Q2ZC853J
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50022539
PNG
(CHEMBL14982)
Show SMILES Cl.Oc1ccc(CC2=NCCN2)c(F)c1O
Show InChI InChI=1S/C10H11FN2O2.ClH/c11-9-6(1-2-7(14)10(9)15)5-8-12-3-4-13-8;/h1-2,14-15H,3-5H2,(H,12,13);1H
PDB

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.46E+13n/an/an/an/an/an/a



Ohio State University

Curated by ChEMBL


Assay Description
Stimulatory activity against serotonin secretion (SEC).


J Med Chem 33: 1138-44 (1990)


Article DOI: 10.1021/jm00166a009
BindingDB Entry DOI: 10.7270/Q2ZC853J
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%