Compile Data Set for Download or QSAR
maximum 50k data
Found 44 Enz. Inhib. hit(s) with all data for entry = 50033417
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344933((R)-5-ethyl-2-(4-fluorophenyl)-7-isopropyl-1-(3,4,...)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344920((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344903((R)-1-(3,4-difluorobenzyl)-2-(6-(3,3-difluoropiper...)
Affinity DataIC50:  28nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344937((R)-1-(3,4-difluorobenzyl)-5-ethyl-2-(4-fluorophen...)
Affinity DataIC50:  29nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344936((R)-1-(2,4-difluorobenzyl)-5-ethyl-2-(4-fluorophen...)
Affinity DataIC50:  35nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344914((R)-1-(3,4-difluorobenzyl)-5-ethyl-2-(6-fluoropyri...)
Affinity DataIC50:  35nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344934((R)-1-(3,5-difluorobenzyl)-5-ethyl-2-(4-fluorophen...)
Affinity DataIC50:  36nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344918((R)-4-(1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344929((R)-7-tert-butyl-1-(3,4-difluorobenzyl)-5-ethyl-2-...)
Affinity DataIC50:  41nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344913((R)-5-(1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-...)
Affinity DataIC50:  41nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344907((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  42nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344926((R)-7-sec-butyl-1-(3,4-difluorobenzyl)-5-ethyl-2-(...)
Affinity DataIC50:  43nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344906((R)-1-(3,4-difluorobenzyl)-2-(6-((2R,6S)-2,6-dimet...)
Affinity DataIC50:  43nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344912((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344904((R)-1-(3,4-difluorobenzyl)-2-(6-(4,4-difluoropiper...)
Affinity DataIC50:  51nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344928((R)-7-cyclopropyl-1-(3,4-difluorobenzyl)-5-ethyl-2...)
Affinity DataIC50:  52nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344935((R)-5-ethyl-1-(4-fluorobenzyl)-2-(4-fluorophenyl)-...)
Affinity DataIC50:  52nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344910((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  64nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344919((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  64nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344916((R)-5-(1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-...)
Affinity DataIC50:  73nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344905((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  82nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344927((R)-7-cyclopentyl-1-(3,4-difluorobenzyl)-5-ethyl-2...)
Affinity DataIC50:  111nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344917((R)-4-(1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-...)
Affinity DataIC50:  114nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344932((R)-1-(cyclopentylmethyl)-5-ethyl-2-(4-fluoropheny...)
Affinity DataIC50:  114nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344923(1-(3,4-difluorobenzyl)-5-ethyl-2-(4-fluorophenyl)-...)
Affinity DataIC50:  117nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344925(1-(3,4-difluorobenzyl)-5-ethyl-2-(4-fluorophenyl)-...)
Affinity DataIC50:  121nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344911((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  132nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344902(1,2-dibenzyl-5-ethyl-2',3',5,8-tetrahydrospiro[imi...)
Affinity DataIC50:  140nMAssay Description:Inhibition of PDE11More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344940((R)-1-benzyl-5-ethyl-2-(4-fluorophenyl)-7-isopropy...)
Affinity DataIC50:  141nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344924(1'-(3,4-difluorobenzyl)-5'-ethyl-2'-(4-fluoropheny...)
Affinity DataIC50:  143nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344939((R)-1-benzyl-2-(4-fluorophenyl)-7-isopropyl-5-prop...)
Affinity DataIC50:  158nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344909((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  207nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344902(1,2-dibenzyl-5-ethyl-2',3',5,8-tetrahydrospiro[imi...)
Affinity DataIC50:  233nMAssay Description:Antagonist activity at rat P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344902(1,2-dibenzyl-5-ethyl-2',3',5,8-tetrahydrospiro[imi...)
Affinity DataIC50:  248nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344915((R)-1-(3,4-difluorobenzyl)-5-ethyl-7-isopropyl-2-(...)
Affinity DataIC50:  252nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344921((7R)-1-(3,4-difluorobenzyl)-5-ethyl-2-(2-fluorophe...)
Affinity DataIC50:  439nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344938((R)-1-benzyl-2-(4-fluorophenyl)-5,7-diisopropyl-7,...)
Affinity DataIC50:  470nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344908((R)-2-(6-aminopyridin-3-yl)-1-(3,4-difluorobenzyl)...)
Affinity DataIC50:  1.24E+3nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344941((R)-1-benzyl-2-(4-fluorophenyl)-7-isopropyl-7,8-di...)
Affinity DataIC50:  1.25E+3nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344922((RS)-1-(3,4-difluorobenzyl)-5-ethyl-2,7-bis(4-fluo...)
Affinity DataIC50:  1.47E+3nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344902(1,2-dibenzyl-5-ethyl-2',3',5,8-tetrahydrospiro[imi...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human ERG by voltage-clamp electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344931((R)-5-ethyl-2-(4-fluorophenyl)-7-isopropyl-1-(pyri...)
Affinity DataIC50:  3.21E+3nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344930((R)-5-ethyl-2-(4-fluorophenyl)-7-isopropyl-1-(pyri...)
Affinity DataIC50:  4.07E+3nMAssay Description:Antagonist activity at human P2X7 receptor by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344902(1,2-dibenzyl-5-ethyl-2',3',5,8-tetrahydrospiro[imi...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed