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PubMed code 21797275

Compile data set for download or QSAR
Found 139 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 3A


(Homo sapiens (human))
BDBM33971
PNG
(AEB071 | Sotrastaurin)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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Article
PubMed
2.90E+3n/an/an/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4-catalyzed midazolam 1'-hydroxylation in human liver microsomes


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393214
PNG
(CHEMBL2151411)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3c(C)cccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-8-16-18(14-27-22(15)16)20-21(25(34)30-24(20)33)23-17-7-3-4-9-19(17)28-26(29-23)32-12-10-31(2)11-13-32/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 0.100n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393214
PNG
(CHEMBL2151411)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3c(C)cccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-8-16-18(14-27-22(15)16)20-21(25(34)30-24(20)33)23-17-7-3-4-9-19(17)28-26(29-23)32-12-10-31(2)11-13-32/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 0.100n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393214
PNG
(CHEMBL2151411)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3c(C)cccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-8-16-18(14-27-22(15)16)20-21(25(34)30-24(20)33)23-17-7-3-4-9-19(17)28-26(29-23)32-12-10-31(2)11-13-32/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 0.200n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393214
PNG
(CHEMBL2151411)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3c(C)cccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-8-16-18(14-27-22(15)16)20-21(25(34)30-24(20)33)23-17-7-3-4-9-19(17)28-26(29-23)32-12-10-31(2)11-13-32/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 0.400n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393218
PNG
(CHEMBL1996510)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1nc(nc2ccccc12)N1CCNCC1
Show InChI InChI=1S/C24H20N6O2/c31-22-19(16-13-26-17-7-3-1-5-14(16)17)20(23(32)29-22)21-15-6-2-4-8-18(15)27-24(28-21)30-11-9-25-10-12-30/h1-8,13,25-26H,9-12H2,(H,29,31,32)
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n/an/a 0.400n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393218
PNG
(CHEMBL1996510)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1nc(nc2ccccc12)N1CCNCC1
Show InChI InChI=1S/C24H20N6O2/c31-22-19(16-13-26-17-7-3-1-5-14(16)17)20(23(32)29-22)21-15-6-2-4-8-18(15)27-24(28-21)30-11-9-25-10-12-30/h1-8,13,25-26H,9-12H2,(H,29,31,32)
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n/an/a 0.5n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393218
PNG
(CHEMBL1996510)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1nc(nc2ccccc12)N1CCNCC1
Show InChI InChI=1S/C24H20N6O2/c31-22-19(16-13-26-17-7-3-1-5-14(16)17)20(23(32)29-22)21-15-6-2-4-8-18(15)27-24(28-21)30-11-9-25-10-12-30/h1-8,13,25-26H,9-12H2,(H,29,31,32)
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n/an/a 0.5n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393228
PNG
(CHEMBL2153750)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(F)ccc2n1
Show InChI InChI=1S/C25H21FN6O2/c1-31-8-10-32(11-9-31)25-28-19-7-6-14(26)12-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 0.600n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393218
PNG
(CHEMBL1996510)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1nc(nc2ccccc12)N1CCNCC1
Show InChI InChI=1S/C24H20N6O2/c31-22-19(16-13-26-17-7-3-1-5-14(16)17)20(23(32)29-22)21-15-6-2-4-8-18(15)27-24(28-21)30-11-9-25-10-12-30/h1-8,13,25-26H,9-12H2,(H,29,31,32)
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n/an/a 0.600n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393228
PNG
(CHEMBL2153750)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(F)ccc2n1
Show InChI InChI=1S/C25H21FN6O2/c1-31-8-10-32(11-9-31)25-28-19-7-6-14(26)12-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 0.600n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393214
PNG
(CHEMBL2151411)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3c(C)cccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-8-16-18(14-27-22(15)16)20-21(25(34)30-24(20)33)23-17-7-3-4-9-19(17)28-26(29-23)32-12-10-31(2)11-13-32/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 0.700n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393218
PNG
(CHEMBL1996510)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1nc(nc2ccccc12)N1CCNCC1
Show InChI InChI=1S/C24H20N6O2/c31-22-19(16-13-26-17-7-3-1-5-14(16)17)20(23(32)29-22)21-15-6-2-4-8-18(15)27-24(28-21)30-11-9-25-10-12-30/h1-8,13,25-26H,9-12H2,(H,29,31,32)
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n/an/a 0.900n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM33970
PNG
(maleimide derivative, 12)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2c1
Show InChI InChI=1S/C27H24N4O2/c1-30-10-12-31(13-11-30)18-14-17-6-2-3-7-19(17)21(15-18)24-25(27(33)29-26(24)32)22-16-28-23-9-5-4-8-20(22)23/h2-9,14-16,28H,10-13H2,1H3,(H,29,32,33)
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n/an/a 0.900n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393228
PNG
(CHEMBL2153750)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(F)ccc2n1
Show InChI InChI=1S/C25H21FN6O2/c1-31-8-10-32(11-9-31)25-28-19-7-6-14(26)12-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 1n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393219
PNG
(CHEMBL2151415)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2nc(nc3ccccc23)N2CCNCC2)c2ccccc12
Show InChI InChI=1S/C25H22N6O2/c1-30-14-17(15-6-3-5-9-19(15)30)20-21(24(33)29-23(20)32)22-16-7-2-4-8-18(16)27-25(28-22)31-12-10-26-11-13-31/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM33971
PNG
(AEB071 | Sotrastaurin)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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n/an/a 1n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393218
PNG
(CHEMBL1996510)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1nc(nc2ccccc12)N1CCNCC1
Show InChI InChI=1S/C24H20N6O2/c31-22-19(16-13-26-17-7-3-1-5-14(16)17)20(23(32)29-22)21-15-6-2-4-8-18(15)27-24(28-21)30-11-9-25-10-12-30/h1-8,13,25-26H,9-12H2,(H,29,31,32)
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n/an/a 1n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393219
PNG
(CHEMBL2151415)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2nc(nc3ccccc23)N2CCNCC2)c2ccccc12
Show InChI InChI=1S/C25H22N6O2/c1-30-14-17(15-6-3-5-9-19(15)30)20-21(24(33)29-23(20)32)22-16-7-2-4-8-18(16)27-25(28-22)31-12-10-26-11-13-31/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393228
PNG
(CHEMBL2153750)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(F)ccc2n1
Show InChI InChI=1S/C25H21FN6O2/c1-31-8-10-32(11-9-31)25-28-19-7-6-14(26)12-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393229
PNG
(CHEMBL2153751)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-7-6-14(26)12-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393229
PNG
(CHEMBL2153751)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-7-6-14(26)12-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM33971
PNG
(AEB071 | Sotrastaurin)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393219
PNG
(CHEMBL2151415)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2nc(nc3ccccc23)N2CCNCC2)c2ccccc12
Show InChI InChI=1S/C25H22N6O2/c1-30-14-17(15-6-3-5-9-19(15)30)20-21(24(33)29-23(20)32)22-16-7-2-4-8-18(16)27-25(28-22)31-12-10-26-11-13-31/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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n/an/a 1.40n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393226
PNG
(CHEMBL2153748)
Show SMILES CN1CCN(CC1)c1cc2ccccc2c(n1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H23N5O2/c1-30-10-12-31(13-11-30)21-14-16-6-2-3-7-17(16)24(28-21)23-22(25(32)29-26(23)33)19-15-27-20-9-5-4-8-18(19)20/h2-9,14-15,27H,10-13H2,1H3,(H,29,32,33)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393219
PNG
(CHEMBL2151415)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2nc(nc3ccccc23)N2CCNCC2)c2ccccc12
Show InChI InChI=1S/C25H22N6O2/c1-30-14-17(15-6-3-5-9-19(15)30)20-21(24(33)29-23(20)32)22-16-7-2-4-8-18(16)27-25(28-22)31-12-10-26-11-13-31/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393214
PNG
(CHEMBL2151411)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3c(C)cccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-8-16-18(14-27-22(15)16)20-21(25(34)30-24(20)33)23-17-7-3-4-9-19(17)28-26(29-23)32-12-10-31(2)11-13-32/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 1.70n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393229
PNG
(CHEMBL2153751)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-7-6-14(26)12-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393226
PNG
(CHEMBL2153748)
Show SMILES CN1CCN(CC1)c1cc2ccccc2c(n1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H23N5O2/c1-30-10-12-31(13-11-30)21-14-16-6-2-3-7-17(16)24(28-21)23-22(25(32)29-26(23)33)19-15-27-20-9-5-4-8-18(19)20/h2-9,14-15,27H,10-13H2,1H3,(H,29,32,33)
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n/an/a 1.80n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33970
PNG
(maleimide derivative, 12)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2c1
Show InChI InChI=1S/C27H24N4O2/c1-30-10-12-31(13-11-30)18-14-17-6-2-3-7-19(17)21(15-18)24-25(27(33)29-26(24)32)22-16-28-23-9-5-4-8-20(22)23/h2-9,14-16,28H,10-13H2,1H3,(H,29,32,33)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393228
PNG
(CHEMBL2153750)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(F)ccc2n1
Show InChI InChI=1S/C25H21FN6O2/c1-31-8-10-32(11-9-31)25-28-19-7-6-14(26)12-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 1.90n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33971
PNG
(AEB071 | Sotrastaurin)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393226
PNG
(CHEMBL2153748)
Show SMILES CN1CCN(CC1)c1cc2ccccc2c(n1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H23N5O2/c1-30-10-12-31(13-11-30)21-14-16-6-2-3-7-17(16)24(28-21)23-22(25(32)29-26(23)33)19-15-27-20-9-5-4-8-18(19)20/h2-9,14-15,27H,10-13H2,1H3,(H,29,32,33)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393228
PNG
(CHEMBL2153750)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(F)ccc2n1
Show InChI InChI=1S/C25H21FN6O2/c1-31-8-10-32(11-9-31)25-28-19-7-6-14(26)12-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 2n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393226
PNG
(CHEMBL2153748)
Show SMILES CN1CCN(CC1)c1cc2ccccc2c(n1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H23N5O2/c1-30-10-12-31(13-11-30)21-14-16-6-2-3-7-17(16)24(28-21)23-22(25(32)29-26(23)33)19-15-27-20-9-5-4-8-18(19)20/h2-9,14-15,27H,10-13H2,1H3,(H,29,32,33)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM33971
PNG
(AEB071 | Sotrastaurin)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393222
PNG
(CHEMBL2151408)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(Cl)cc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-5-3-2-4-15(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-7-6-14(26)12-16(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393216
PNG
(CHEMBL2151413)
Show SMILES CC(C)n1cc(C2=C(C(=O)NC2=O)c2nc(nc3ccccc23)N2CCN(C)CC2)c2ccccc12
Show InChI InChI=1S/C28H28N6O2/c1-17(2)34-16-20(18-8-5-7-11-22(18)34)23-24(27(36)31-26(23)35)25-19-9-4-6-10-21(19)29-28(30-25)33-14-12-32(3)13-15-33/h4-11,16-17H,12-15H2,1-3H3,(H,31,35,36)
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n/an/a 2.70n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393227
PNG
(CHEMBL2153749)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2c(C)cccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-9-19-20(15)23(29-26(28-19)32-12-10-31(2)11-13-32)22-21(24(33)30-25(22)34)17-14-27-18-8-4-3-7-16(17)18/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 2.90n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393227
PNG
(CHEMBL2153749)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2c(C)cccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-9-19-20(15)23(29-26(28-19)32-12-10-31(2)11-13-32)22-21(24(33)30-25(22)34)17-14-27-18-8-4-3-7-16(17)18/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 3.20n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393219
PNG
(CHEMBL2151415)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2nc(nc3ccccc23)N2CCNCC2)c2ccccc12
Show InChI InChI=1S/C25H22N6O2/c1-30-14-17(15-6-3-5-9-19(15)30)20-21(24(33)29-23(20)32)22-16-7-2-4-8-18(16)27-25(28-22)31-12-10-26-11-13-31/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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n/an/a 3.30n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393227
PNG
(CHEMBL2153749)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2c(C)cccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-9-19-20(15)23(29-26(28-19)32-12-10-31(2)11-13-32)22-21(24(33)30-25(22)34)17-14-27-18-8-4-3-7-16(17)18/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 3.60n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393225
PNG
(CHEMBL2153747)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H23N5O2/c1-30-10-12-31(13-11-30)22-14-18(16-6-3-5-9-21(16)28-22)23-24(26(33)29-25(23)32)19-15-27-20-8-4-2-7-17(19)20/h2-9,14-15,27H,10-13H2,1H3,(H,29,32,33)
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n/an/a 3.60n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393219
PNG
(CHEMBL2151415)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2nc(nc3ccccc23)N2CCNCC2)c2ccccc12
Show InChI InChI=1S/C25H22N6O2/c1-30-14-17(15-6-3-5-9-19(15)30)20-21(24(33)29-23(20)32)22-16-7-2-4-8-18(16)27-25(28-22)31-12-10-26-11-13-31/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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n/an/a 3.80n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393227
PNG
(CHEMBL2153749)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2c(C)cccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-9-19-20(15)23(29-26(28-19)32-12-10-31(2)11-13-32)22-21(24(33)30-25(22)34)17-14-27-18-8-4-3-7-16(17)18/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 3.80n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393216
PNG
(CHEMBL2151413)
Show SMILES CC(C)n1cc(C2=C(C(=O)NC2=O)c2nc(nc3ccccc23)N2CCN(C)CC2)c2ccccc12
Show InChI InChI=1S/C28H28N6O2/c1-17(2)34-16-20(18-8-5-7-11-22(18)34)23-24(27(36)31-26(23)35)25-19-9-4-6-10-21(19)29-28(30-25)33-14-12-32(3)13-15-33/h4-11,16-17H,12-15H2,1-3H3,(H,31,35,36)
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n/an/a 3.80n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393229
PNG
(CHEMBL2153751)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-7-6-14(26)12-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 3.90n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393230
PNG
(CHEMBL2153752)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(C)ccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-7-8-20-17(13-15)23(29-26(28-20)32-11-9-31(2)10-12-32)22-21(24(33)30-25(22)34)18-14-27-19-6-4-3-5-16(18)19/h3-8,13-14,27H,9-12H2,1-2H3,(H,30,33,34)
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n/an/a 4.10n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393226
PNG
(CHEMBL2153748)
Show SMILES CN1CCN(CC1)c1cc2ccccc2c(n1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H23N5O2/c1-30-10-12-31(13-11-30)21-14-16-6-2-3-7-17(16)24(28-21)23-22(25(32)29-26(23)33)19-15-27-20-9-5-4-8-18(19)20/h2-9,14-15,27H,10-13H2,1H3,(H,29,32,33)
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n/an/a 4.30n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393233
PNG
(CHEMBL2153755)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccc(F)cc2n1
Show InChI InChI=1S/C25H21FN6O2/c1-31-8-10-32(11-9-31)25-28-19-12-14(26)6-7-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 4.5n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM33970
PNG
(maleimide derivative, 12)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2c1
Show InChI InChI=1S/C27H24N4O2/c1-30-10-12-31(13-11-30)18-14-17-6-2-3-7-19(17)21(15-18)24-25(27(33)29-26(24)32)22-16-28-23-9-5-4-8-20(22)23/h2-9,14-16,28H,10-13H2,1H3,(H,29,32,33)
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n/an/a 4.80n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393233
PNG
(CHEMBL2153755)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccc(F)cc2n1
Show InChI InChI=1S/C25H21FN6O2/c1-31-8-10-32(11-9-31)25-28-19-12-14(26)6-7-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 5n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393215
PNG
(CHEMBL2151412)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-30-11-13-32(14-12-30)26-27-19-9-5-3-8-17(19)23(28-26)22-21(24(33)29-25(22)34)18-15-31(2)20-10-6-4-7-16(18)20/h3-10,15H,11-14H2,1-2H3,(H,29,33,34)
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n/an/a 5.10n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393230
PNG
(CHEMBL2153752)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(C)ccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-7-8-20-17(13-15)23(29-26(28-20)32-11-9-31(2)10-12-32)22-21(24(33)30-25(22)34)18-14-27-19-6-4-3-5-16(18)19/h3-8,13-14,27H,9-12H2,1-2H3,(H,30,33,34)
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n/an/a 5.10n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393225
PNG
(CHEMBL2153747)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H23N5O2/c1-30-10-12-31(13-11-30)22-14-18(16-6-3-5-9-21(16)28-22)23-24(26(33)29-25(23)32)19-15-27-20-8-4-2-7-17(19)20/h2-9,14-15,27H,10-13H2,1H3,(H,29,32,33)
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n/an/a 5.20n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393229
PNG
(CHEMBL2153751)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-7-6-14(26)12-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 5.40n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393215
PNG
(CHEMBL2151412)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-30-11-13-32(14-12-30)26-27-19-9-5-3-8-17(19)23(28-26)22-21(24(33)29-25(22)34)18-15-31(2)20-10-6-4-7-16(18)20/h3-10,15H,11-14H2,1-2H3,(H,29,33,34)
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n/an/a 5.70n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393215
PNG
(CHEMBL2151412)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-30-11-13-32(14-12-30)26-27-19-9-5-3-8-17(19)23(28-26)22-21(24(33)29-25(22)34)18-15-31(2)20-10-6-4-7-16(18)20/h3-10,15H,11-14H2,1-2H3,(H,29,33,34)
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n/an/a 5.80n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393224
PNG
(CHEMBL2151410)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3c(Cl)cccc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-9-11-32(12-10-31)25-28-18-8-3-2-5-15(18)22(29-25)20-19(23(33)30-24(20)34)16-13-27-21-14(16)6-4-7-17(21)26/h2-8,13,27H,9-12H2,1H3,(H,30,33,34)
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n/an/a 6n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM33971
PNG
(AEB071 | Sotrastaurin)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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n/an/a 6.10n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM33971
PNG
(AEB071 | Sotrastaurin)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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n/an/a 6.20n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393224
PNG
(CHEMBL2151410)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3c(Cl)cccc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-9-11-32(12-10-31)25-28-18-8-3-2-5-15(18)22(29-25)20-19(23(33)30-24(20)34)16-13-27-21-14(16)6-4-7-17(21)26/h2-8,13,27H,9-12H2,1H3,(H,30,33,34)
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n/an/a 6.20n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393226
PNG
(CHEMBL2153748)
Show SMILES CN1CCN(CC1)c1cc2ccccc2c(n1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H23N5O2/c1-30-10-12-31(13-11-30)21-14-16-6-2-3-7-17(16)24(28-21)23-22(25(32)29-26(23)33)19-15-27-20-9-5-4-8-18(19)20/h2-9,14-15,27H,10-13H2,1H3,(H,29,32,33)
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n/an/a 6.20n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393227
PNG
(CHEMBL2153749)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2c(C)cccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-9-19-20(15)23(29-26(28-19)32-12-10-31(2)11-13-32)22-21(24(33)30-25(22)34)17-14-27-18-8-4-3-7-16(17)18/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 6.20n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393233
PNG
(CHEMBL2153755)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccc(F)cc2n1
Show InChI InChI=1S/C25H21FN6O2/c1-31-8-10-32(11-9-31)25-28-19-12-14(26)6-7-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 6.30n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393215
PNG
(CHEMBL2151412)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-30-11-13-32(14-12-30)26-27-19-9-5-3-8-17(19)23(28-26)22-21(24(33)29-25(22)34)18-15-31(2)20-10-6-4-7-16(18)20/h3-10,15H,11-14H2,1-2H3,(H,29,33,34)
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n/an/a 6.40n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393222
PNG
(CHEMBL2151408)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(Cl)cc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-5-3-2-4-15(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-7-6-14(26)12-16(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 6.5n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393224
PNG
(CHEMBL2151410)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3c(Cl)cccc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-9-11-32(12-10-31)25-28-18-8-3-2-5-15(18)22(29-25)20-19(23(33)30-24(20)34)16-13-27-21-14(16)6-4-7-17(21)26/h2-8,13,27H,9-12H2,1H3,(H,30,33,34)
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n/an/a 7n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM33970
PNG
(maleimide derivative, 12)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2c1
Show InChI InChI=1S/C27H24N4O2/c1-30-10-12-31(13-11-30)18-14-17-6-2-3-7-19(17)21(15-18)24-25(27(33)29-26(24)32)22-16-28-23-9-5-4-8-20(22)23/h2-9,14-16,28H,10-13H2,1H3,(H,29,32,33)
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n/an/a 7.30n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393230
PNG
(CHEMBL2153752)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(C)ccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-7-8-20-17(13-15)23(29-26(28-20)32-11-9-31(2)10-12-32)22-21(24(33)30-25(22)34)18-14-27-19-6-4-3-5-16(18)19/h3-8,13-14,27H,9-12H2,1-2H3,(H,30,33,34)
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n/an/a 7.5n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393223
PNG
(CHEMBL2151409)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3cc(Cl)ccc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-18-5-3-2-4-16(18)22(29-25)21-20(23(33)30-24(21)34)17-13-27-19-12-14(26)6-7-15(17)19/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 7.70n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393216
PNG
(CHEMBL2151413)
Show SMILES CC(C)n1cc(C2=C(C(=O)NC2=O)c2nc(nc3ccccc23)N2CCN(C)CC2)c2ccccc12
Show InChI InChI=1S/C28H28N6O2/c1-17(2)34-16-20(18-8-5-7-11-22(18)34)23-24(27(36)31-26(23)35)25-19-9-4-6-10-21(19)29-28(30-25)33-14-12-32(3)13-15-33/h4-11,16-17H,12-15H2,1-3H3,(H,31,35,36)
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n/an/a 7.80n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393233
PNG
(CHEMBL2153755)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccc(F)cc2n1
Show InChI InChI=1S/C25H21FN6O2/c1-31-8-10-32(11-9-31)25-28-19-12-14(26)6-7-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393223
PNG
(CHEMBL2151409)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3cc(Cl)ccc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-18-5-3-2-4-16(18)22(29-25)21-20(23(33)30-24(21)34)17-13-27-19-12-14(26)6-7-15(17)19/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 8.20n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393222
PNG
(CHEMBL2151408)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(Cl)cc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-5-3-2-4-15(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-7-6-14(26)12-16(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 8.30n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393222
PNG
(CHEMBL2151408)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(Cl)cc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-5-3-2-4-15(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-7-6-14(26)12-16(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 8.30n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393223
PNG
(CHEMBL2151409)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3cc(Cl)ccc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-18-5-3-2-4-16(18)22(29-25)21-20(23(33)30-24(21)34)17-13-27-19-12-14(26)6-7-15(17)19/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 8.5n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393233
PNG
(CHEMBL2153755)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccc(F)cc2n1
Show InChI InChI=1S/C25H21FN6O2/c1-31-8-10-32(11-9-31)25-28-19-12-14(26)6-7-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 9n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393222
PNG
(CHEMBL2151408)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(Cl)cc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-5-3-2-4-15(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-7-6-14(26)12-16(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 9.10n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393224
PNG
(CHEMBL2151410)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3c(Cl)cccc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-9-11-32(12-10-31)25-28-18-8-3-2-5-15(18)22(29-25)20-19(23(33)30-24(20)34)16-13-27-21-14(16)6-4-7-17(21)26/h2-8,13,27H,9-12H2,1H3,(H,30,33,34)
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n/an/a 9.10n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393227
PNG
(CHEMBL2153749)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2c(C)cccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-9-19-20(15)23(29-26(28-19)32-12-10-31(2)11-13-32)22-21(24(33)30-25(22)34)17-14-27-18-8-4-3-7-16(17)18/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 9.20n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393222
PNG
(CHEMBL2151408)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(Cl)cc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-5-3-2-4-15(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-7-6-14(26)12-16(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 9.80n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393223
PNG
(CHEMBL2151409)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3cc(Cl)ccc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-18-5-3-2-4-16(18)22(29-25)21-20(23(33)30-24(21)34)17-13-27-19-12-14(26)6-7-15(17)19/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 9.80n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393216
PNG
(CHEMBL2151413)
Show SMILES CC(C)n1cc(C2=C(C(=O)NC2=O)c2nc(nc3ccccc23)N2CCN(C)CC2)c2ccccc12
Show InChI InChI=1S/C28H28N6O2/c1-17(2)34-16-20(18-8-5-7-11-22(18)34)23-24(27(36)31-26(23)35)25-19-9-4-6-10-21(19)29-28(30-25)33-14-12-32(3)13-15-33/h4-11,16-17H,12-15H2,1-3H3,(H,31,35,36)
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n/an/a 11n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393216
PNG
(CHEMBL2151413)
Show SMILES CC(C)n1cc(C2=C(C(=O)NC2=O)c2nc(nc3ccccc23)N2CCN(C)CC2)c2ccccc12
Show InChI InChI=1S/C28H28N6O2/c1-17(2)34-16-20(18-8-5-7-11-22(18)34)23-24(27(36)31-26(23)35)25-19-9-4-6-10-21(19)29-28(30-25)33-14-12-32(3)13-15-33/h4-11,16-17H,12-15H2,1-3H3,(H,31,35,36)
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n/an/a 11n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393216
PNG
(CHEMBL2151413)
Show SMILES CC(C)n1cc(C2=C(C(=O)NC2=O)c2nc(nc3ccccc23)N2CCN(C)CC2)c2ccccc12
Show InChI InChI=1S/C28H28N6O2/c1-17(2)34-16-20(18-8-5-7-11-22(18)34)23-24(27(36)31-26(23)35)25-19-9-4-6-10-21(19)29-28(30-25)33-14-12-32(3)13-15-33/h4-11,16-17H,12-15H2,1-3H3,(H,31,35,36)
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n/an/a 11n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393231
PNG
(CHEMBL2153753)
Show SMILES CC(C)c1ccc2nc(nc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c2c1)N1CCN(C)CC1
Show InChI InChI=1S/C28H28N6O2/c1-16(2)17-8-9-22-19(14-17)25(31-28(30-22)34-12-10-33(3)11-13-34)24-23(26(35)32-27(24)36)20-15-29-21-7-5-4-6-18(20)21/h4-9,14-16,29H,10-13H2,1-3H3,(H,32,35,36)
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n/an/a 12n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393233
PNG
(CHEMBL2153755)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccc(F)cc2n1
Show InChI InChI=1S/C25H21FN6O2/c1-31-8-10-32(11-9-31)25-28-19-12-14(26)6-7-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 15n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393230
PNG
(CHEMBL2153752)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(C)ccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-7-8-20-17(13-15)23(29-26(28-20)32-11-9-31(2)10-12-32)22-21(24(33)30-25(22)34)18-14-27-19-6-4-3-5-16(18)19/h3-8,13-14,27H,9-12H2,1-2H3,(H,30,33,34)
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n/an/a 16n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393224
PNG
(CHEMBL2151410)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3c(Cl)cccc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-9-11-32(12-10-31)25-28-18-8-3-2-5-15(18)22(29-25)20-19(23(33)30-24(20)34)16-13-27-21-14(16)6-4-7-17(21)26/h2-8,13,27H,9-12H2,1H3,(H,30,33,34)
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n/an/a 17n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393224
PNG
(CHEMBL2151410)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3c(Cl)cccc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-9-11-32(12-10-31)25-28-18-8-3-2-5-15(18)22(29-25)20-19(23(33)30-24(20)34)16-13-27-21-14(16)6-4-7-17(21)26/h2-8,13,27H,9-12H2,1H3,(H,30,33,34)
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n/an/a 19n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393223
PNG
(CHEMBL2151409)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3cc(Cl)ccc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-18-5-3-2-4-16(18)22(29-25)21-20(23(33)30-24(21)34)17-13-27-19-12-14(26)6-7-15(17)19/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 19n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM33970
PNG
(maleimide derivative, 12)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2c1
Show InChI InChI=1S/C27H24N4O2/c1-30-10-12-31(13-11-30)18-14-17-6-2-3-7-19(17)21(15-18)24-25(27(33)29-26(24)32)22-16-28-23-9-5-4-8-20(22)23/h2-9,14-16,28H,10-13H2,1H3,(H,29,32,33)
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n/an/a 19n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393215
PNG
(CHEMBL2151412)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-30-11-13-32(14-12-30)26-27-19-9-5-3-8-17(19)23(28-26)22-21(24(33)29-25(22)34)18-15-31(2)20-10-6-4-7-16(18)20/h3-10,15H,11-14H2,1-2H3,(H,29,33,34)
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n/an/a 20n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393217
PNG
(CHEMBL2151414)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c(C)[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-20(16-7-3-5-9-18(16)27-15)21-22(25(34)30-24(21)33)23-17-8-4-6-10-19(17)28-26(29-23)32-13-11-31(2)12-14-32/h3-10,27H,11-14H2,1-2H3,(H,30,33,34)
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n/an/a 22n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393229
PNG
(CHEMBL2153751)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(Cl)ccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-7-6-14(26)12-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 23n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393217
PNG
(CHEMBL2151414)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c(C)[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-20(16-7-3-5-9-18(16)27-15)21-22(25(34)30-24(21)33)23-17-8-4-6-10-19(17)28-26(29-23)32-13-11-31(2)12-14-32/h3-10,27H,11-14H2,1-2H3,(H,30,33,34)
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n/an/a 25n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393230
PNG
(CHEMBL2153752)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(C)ccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-7-8-20-17(13-15)23(29-26(28-20)32-11-9-31(2)10-12-32)22-21(24(33)30-25(22)34)18-14-27-19-6-4-3-5-16(18)19/h3-8,13-14,27H,9-12H2,1-2H3,(H,30,33,34)
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n/an/a 25n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393215
PNG
(CHEMBL2151412)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-30-11-13-32(14-12-30)26-27-19-9-5-3-8-17(19)23(28-26)22-21(24(33)29-25(22)34)18-15-31(2)20-10-6-4-7-16(18)20/h3-10,15H,11-14H2,1-2H3,(H,29,33,34)
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n/an/a 25n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM33970
PNG
(maleimide derivative, 12)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2c1
Show InChI InChI=1S/C27H24N4O2/c1-30-10-12-31(13-11-30)18-14-17-6-2-3-7-19(17)21(15-18)24-25(27(33)29-26(24)32)22-16-28-23-9-5-4-8-20(22)23/h2-9,14-16,28H,10-13H2,1H3,(H,29,32,33)
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n/an/a 25n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393217
PNG
(CHEMBL2151414)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c(C)[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-20(16-7-3-5-9-18(16)27-15)21-22(25(34)30-24(21)33)23-17-8-4-6-10-19(17)28-26(29-23)32-13-11-31(2)12-14-32/h3-10,27H,11-14H2,1-2H3,(H,30,33,34)
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n/an/a 26n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393225
PNG
(CHEMBL2153747)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H23N5O2/c1-30-10-12-31(13-11-30)22-14-18(16-6-3-5-9-21(16)28-22)23-24(26(33)29-25(23)32)19-15-27-20-8-4-2-7-17(19)20/h2-9,14-15,27H,10-13H2,1H3,(H,29,32,33)
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n/an/a 27n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393225
PNG
(CHEMBL2153747)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H23N5O2/c1-30-10-12-31(13-11-30)22-14-18(16-6-3-5-9-21(16)28-22)23-24(26(33)29-25(23)32)19-15-27-20-8-4-2-7-17(19)20/h2-9,14-15,27H,10-13H2,1H3,(H,29,32,33)
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n/an/a 31n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393223
PNG
(CHEMBL2151409)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3cc(Cl)ccc23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-18-5-3-2-4-16(18)22(29-25)21-20(23(33)30-24(21)34)17-13-27-19-12-14(26)6-7-15(17)19/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 32n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393221
PNG
(CHEMBL2151407)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3cccc(Cl)c23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-9-11-32(12-10-31)25-28-17-7-3-2-5-14(17)22(29-25)21-20(23(33)30-24(21)34)15-13-27-18-8-4-6-16(26)19(15)18/h2-8,13,27H,9-12H2,1H3,(H,30,33,34)
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n/an/a 48n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393220
PNG
(CHEMBL2151406)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cccc(C)c2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-8-17-22(15)28-26(32-12-10-31(2)11-13-32)29-23(17)21-20(24(33)30-25(21)34)18-14-27-19-9-4-3-7-16(18)19/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 52n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393217
PNG
(CHEMBL2151414)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c(C)[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-20(16-7-3-5-9-18(16)27-15)21-22(25(34)30-24(21)33)23-17-8-4-6-10-19(17)28-26(29-23)32-13-11-31(2)12-14-32/h3-10,27H,11-14H2,1-2H3,(H,30,33,34)
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n/an/a 63n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393217
PNG
(CHEMBL2151414)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c(C)[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-20(16-7-3-5-9-18(16)27-15)21-22(25(34)30-24(21)33)23-17-8-4-6-10-19(17)28-26(29-23)32-13-11-31(2)12-14-32/h3-10,27H,11-14H2,1-2H3,(H,30,33,34)
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n/an/a 65n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393220
PNG
(CHEMBL2151406)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cccc(C)c2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-8-17-22(15)28-26(32-12-10-31(2)11-13-32)29-23(17)21-20(24(33)30-25(21)34)18-14-27-19-9-4-3-7-16(18)19/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 67n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393231
PNG
(CHEMBL2153753)
Show SMILES CC(C)c1ccc2nc(nc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c2c1)N1CCN(C)CC1
Show InChI InChI=1S/C28H28N6O2/c1-16(2)17-8-9-22-19(14-17)25(31-28(30-22)34-12-10-33(3)11-13-34)24-23(26(35)32-27(24)36)20-15-29-21-7-5-4-6-18(20)21/h4-9,14-16,29H,10-13H2,1-3H3,(H,32,35,36)
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n/an/a 71n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393225
PNG
(CHEMBL2153747)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H23N5O2/c1-30-10-12-31(13-11-30)22-14-18(16-6-3-5-9-21(16)28-22)23-24(26(33)29-25(23)32)19-15-27-20-8-4-2-7-17(19)20/h2-9,14-15,27H,10-13H2,1H3,(H,29,32,33)
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n/an/a 72n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393217
PNG
(CHEMBL2151414)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c(C)[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-20(16-7-3-5-9-18(16)27-15)21-22(25(34)30-24(21)33)23-17-8-4-6-10-19(17)28-26(29-23)32-13-11-31(2)12-14-32/h3-10,27H,11-14H2,1-2H3,(H,30,33,34)
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n/an/a 73n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393221
PNG
(CHEMBL2151407)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3cccc(Cl)c23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-9-11-32(12-10-31)25-28-17-7-3-2-5-14(17)22(29-25)21-20(23(33)30-24(21)34)15-13-27-18-8-4-6-16(26)19(15)18/h2-8,13,27H,9-12H2,1H3,(H,30,33,34)
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n/an/a 93n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393225
PNG
(CHEMBL2153747)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C26H23N5O2/c1-30-10-12-31(13-11-30)22-14-18(16-6-3-5-9-21(16)28-22)23-24(26(33)29-25(23)32)19-15-27-20-8-4-2-7-17(19)20/h2-9,14-15,27H,10-13H2,1H3,(H,29,32,33)
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n/an/a 118n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393230
PNG
(CHEMBL2153752)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(C)ccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-7-8-20-17(13-15)23(29-26(28-20)32-11-9-31(2)10-12-32)22-21(24(33)30-25(22)34)18-14-27-19-6-4-3-5-16(18)19/h3-8,13-14,27H,9-12H2,1-2H3,(H,30,33,34)
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n/an/a 140n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393234
PNG
(CHEMBL2153756)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccc(Cl)cc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-12-14(26)6-7-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 192n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393220
PNG
(CHEMBL2151406)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cccc(C)c2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-8-17-22(15)28-26(32-12-10-31(2)11-13-32)29-23(17)21-20(24(33)30-25(21)34)18-14-27-19-9-4-3-7-16(18)19/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 197n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393221
PNG
(CHEMBL2151407)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3cccc(Cl)c23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-9-11-32(12-10-31)25-28-17-7-3-2-5-14(17)22(29-25)21-20(23(33)30-24(21)34)15-13-27-18-8-4-6-16(26)19(15)18/h2-8,13,27H,9-12H2,1H3,(H,30,33,34)
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n/an/a 202n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393221
PNG
(CHEMBL2151407)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3cccc(Cl)c23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-9-11-32(12-10-31)25-28-17-7-3-2-5-14(17)22(29-25)21-20(23(33)30-24(21)34)15-13-27-18-8-4-6-16(26)19(15)18/h2-8,13,27H,9-12H2,1H3,(H,30,33,34)
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n/an/a 202n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393221
PNG
(CHEMBL2151407)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3cccc(Cl)c23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-9-11-32(12-10-31)25-28-17-7-3-2-5-14(17)22(29-25)21-20(23(33)30-24(21)34)15-13-27-18-8-4-6-16(26)19(15)18/h2-8,13,27H,9-12H2,1H3,(H,30,33,34)
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n/an/a 221n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393234
PNG
(CHEMBL2153756)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccc(Cl)cc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-12-14(26)6-7-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 224n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393220
PNG
(CHEMBL2151406)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cccc(C)c2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-8-17-22(15)28-26(32-12-10-31(2)11-13-32)29-23(17)21-20(24(33)30-25(21)34)18-14-27-19-9-4-3-7-16(18)19/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 235n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393234
PNG
(CHEMBL2153756)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccc(Cl)cc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-12-14(26)6-7-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 280n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393231
PNG
(CHEMBL2153753)
Show SMILES CC(C)c1ccc2nc(nc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c2c1)N1CCN(C)CC1
Show InChI InChI=1S/C28H28N6O2/c1-16(2)17-8-9-22-19(14-17)25(31-28(30-22)34-12-10-33(3)11-13-34)24-23(26(35)32-27(24)36)20-15-29-21-7-5-4-6-18(20)21/h4-9,14-16,29H,10-13H2,1-3H3,(H,32,35,36)
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n/an/a 283n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393234
PNG
(CHEMBL2153756)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccc(Cl)cc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-12-14(26)6-7-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 304n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393234
PNG
(CHEMBL2153756)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccc(Cl)cc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-12-14(26)6-7-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 316n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (human))
BDBM50393232
PNG
(CHEMBL2153754)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(ccc2n1)C(C)(C)C
Show InChI InChI=1S/C29H30N6O2/c1-29(2,3)17-9-10-22-19(15-17)25(32-28(31-22)35-13-11-34(4)12-14-35)24-23(26(36)33-27(24)37)20-16-30-21-8-6-5-7-18(20)21/h5-10,15-16,30H,11-14H2,1-4H3,(H,33,36,37)
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n/an/a>316n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393232
PNG
(CHEMBL2153754)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(ccc2n1)C(C)(C)C
Show InChI InChI=1S/C29H30N6O2/c1-29(2,3)17-9-10-22-19(15-17)25(32-28(31-22)35-13-11-34(4)12-14-35)24-23(26(36)33-27(24)37)20-16-30-21-8-6-5-7-18(20)21/h5-10,15-16,30H,11-14H2,1-4H3,(H,33,36,37)
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n/an/a>316n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393232
PNG
(CHEMBL2153754)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(ccc2n1)C(C)(C)C
Show InChI InChI=1S/C29H30N6O2/c1-29(2,3)17-9-10-22-19(15-17)25(32-28(31-22)35-13-11-34(4)12-14-35)24-23(26(36)33-27(24)37)20-16-30-21-8-6-5-7-18(20)21/h5-10,15-16,30H,11-14H2,1-4H3,(H,33,36,37)
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n/an/a>316n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393221
PNG
(CHEMBL2151407)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3cccc(Cl)c23)c2ccccc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-9-11-32(12-10-31)25-28-17-7-3-2-5-14(17)22(29-25)21-20(23(33)30-24(21)34)15-13-27-18-8-4-6-16(26)19(15)18/h2-8,13,27H,9-12H2,1H3,(H,30,33,34)
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n/an/a>316n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393232
PNG
(CHEMBL2153754)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(ccc2n1)C(C)(C)C
Show InChI InChI=1S/C29H30N6O2/c1-29(2,3)17-9-10-22-19(15-17)25(32-28(31-22)35-13-11-34(4)12-14-35)24-23(26(36)33-27(24)37)20-16-30-21-8-6-5-7-18(20)21/h5-10,15-16,30H,11-14H2,1-4H3,(H,33,36,37)
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n/an/a>316n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (human))
BDBM50393232
PNG
(CHEMBL2153754)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(ccc2n1)C(C)(C)C
Show InChI InChI=1S/C29H30N6O2/c1-29(2,3)17-9-10-22-19(15-17)25(32-28(31-22)35-13-11-34(4)12-14-35)24-23(26(36)33-27(24)37)20-16-30-21-8-6-5-7-18(20)21/h5-10,15-16,30H,11-14H2,1-4H3,(H,33,36,37)
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n/an/a>316n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (human))
BDBM50393232
PNG
(CHEMBL2153754)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(ccc2n1)C(C)(C)C
Show InChI InChI=1S/C29H30N6O2/c1-29(2,3)17-9-10-22-19(15-17)25(32-28(31-22)35-13-11-34(4)12-14-35)24-23(26(36)33-27(24)37)20-16-30-21-8-6-5-7-18(20)21/h5-10,15-16,30H,11-14H2,1-4H3,(H,33,36,37)
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n/an/a>316n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393231
PNG
(CHEMBL2153753)
Show SMILES CC(C)c1ccc2nc(nc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c2c1)N1CCN(C)CC1
Show InChI InChI=1S/C28H28N6O2/c1-16(2)17-8-9-22-19(14-17)25(31-28(30-22)34-12-10-33(3)11-13-34)24-23(26(35)32-27(24)36)20-15-29-21-7-5-4-6-18(20)21/h4-9,14-16,29H,10-13H2,1-3H3,(H,32,35,36)
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n/an/a>316n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393234
PNG
(CHEMBL2153756)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccc(Cl)cc2n1
Show InChI InChI=1S/C25H21ClN6O2/c1-31-8-10-32(11-9-31)25-28-19-12-14(26)6-7-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a>316n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393220
PNG
(CHEMBL2151406)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cccc(C)c2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-8-17-22(15)28-26(32-12-10-31(2)11-13-32)29-23(17)21-20(24(33)30-25(21)34)18-14-27-19-9-4-3-7-16(18)19/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a>316n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (human))
BDBM50393231
PNG
(CHEMBL2153753)
Show SMILES CC(C)c1ccc2nc(nc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c2c1)N1CCN(C)CC1
Show InChI InChI=1S/C28H28N6O2/c1-16(2)17-8-9-22-19(14-17)25(31-28(30-22)34-12-10-33(3)11-13-34)24-23(26(35)32-27(24)36)20-15-29-21-7-5-4-6-18(20)21/h4-9,14-16,29H,10-13H2,1-3H3,(H,32,35,36)
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n/an/a>316n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50393231
PNG
(CHEMBL2153753)
Show SMILES CC(C)c1ccc2nc(nc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c2c1)N1CCN(C)CC1
Show InChI InChI=1S/C28H28N6O2/c1-16(2)17-8-9-22-19(14-17)25(31-28(30-22)34-12-10-33(3)11-13-34)24-23(26(35)32-27(24)36)20-15-29-21-7-5-4-6-18(20)21/h4-9,14-16,29H,10-13H2,1-3H3,(H,32,35,36)
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PubMed
n/an/a>316n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta-1 by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (human))
BDBM50393220
PNG
(CHEMBL2151406)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cccc(C)c2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-8-17-22(15)28-26(32-12-10-31(2)11-13-32)29-23(17)21-20(24(33)30-25(21)34)18-14-27-19-9-4-3-7-16(18)19/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 334n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%