BindingDB logo
myBDB logout

PubMed code 21840217

Compile data set for download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352936
PNG
(CHEMBL1824915)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C25H18ClNO/c26-24-12-5-4-11-23(24)25(28)27-22-15-13-19(14-16-22)21-10-6-9-20(17-21)18-7-2-1-3-8-18/h1-17H,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352935
PNG
(CHEMBL1824916)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1cc(ccn1)-c1ccccc1
Show InChI InChI=1S/C24H17ClN2O/c25-22-9-5-4-8-21(22)24(28)27-20-12-10-18(11-13-20)23-16-19(14-15-26-23)17-6-2-1-3-7-17/h1-16H,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.20n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352948
PNG
(CHEMBL1824904)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C20H15ClN2O2/c21-18-9-5-4-8-17(18)20(25)23-16-12-10-15(11-13-16)22-19(24)14-6-2-1-3-7-14/h1-13H,(H,22,24)(H,23,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352947
PNG
(CHEMBL1824905)
Show SMILES OC(Cc1ccc(NC(=O)c2ccccc2Cl)cc1)c1ccccc1
Show InChI InChI=1S/C21H18ClNO2/c22-19-9-5-4-8-18(19)21(25)23-17-12-10-15(11-13-17)14-20(24)16-6-2-1-3-7-16/h1-13,20,24H,14H2,(H,23,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
Smoothened homolog


(Mus musculus)
BDBM50352943
PNG
(CHEMBL1824909)
Show SMILES FC(F)(F)c1oc(nc1-c1ccccc1)-c1ccc(NC(=O)c2ccccc2Cl)cc1
Show InChI InChI=1S/C23H14ClF3N2O2/c24-18-9-5-4-8-17(18)21(30)28-16-12-10-15(11-13-16)22-29-19(14-6-2-1-3-7-14)20(31-22)23(25,26)27/h1-13H,(H,28,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at mouse SMO expressed in NIH/3T3 cells transfected with Gli-dependent luciferase-reporter after 15 hrs by luciferase reporter ge...


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
Smoothened homolog


(Mus musculus)
BDBM50352935
PNG
(CHEMBL1824916)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1cc(ccn1)-c1ccccc1
Show InChI InChI=1S/C24H17ClN2O/c25-22-9-5-4-8-21(22)24(28)27-20-12-10-18(11-13-20)23-16-19(14-15-26-23)17-6-2-1-3-7-17/h1-16H,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 26n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at mouse SMO expressed in NIH/3T3 cells transfected with Gli-dependent luciferase-reporter after 15 hrs by luciferase reporter ge...


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352949
PNG
(CHEMBL1824917)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1ccnc(n1)-c1ccccc1
Show InChI InChI=1S/C23H16ClN3O/c24-20-9-5-4-8-19(20)23(28)26-18-12-10-16(11-13-18)21-14-15-25-22(27-21)17-6-2-1-3-7-17/h1-15H,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352944
PNG
(CHEMBL1824908)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C22H15ClN2OS/c23-19-9-5-4-8-18(19)21(26)24-17-12-10-16(11-13-17)22-25-20(14-27-22)15-6-2-1-3-7-15/h1-14H,(H,24,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352934
PNG
(CHEMBL1824918)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1cncc(c1)-c1ccccc1
Show InChI InChI=1S/C24H17ClN2O/c25-23-9-5-4-8-22(23)24(28)27-21-12-10-18(11-13-21)20-14-19(15-26-16-20)17-6-2-1-3-7-17/h1-16H,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 28n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352943
PNG
(CHEMBL1824909)
Show SMILES FC(F)(F)c1oc(nc1-c1ccccc1)-c1ccc(NC(=O)c2ccccc2Cl)cc1
Show InChI InChI=1S/C23H14ClF3N2O2/c24-18-9-5-4-8-17(18)21(30)28-16-12-10-15(11-13-16)22-29-19(14-6-2-1-3-7-14)20(31-22)23(25,26)27/h1-13H,(H,28,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 31n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352933
PNG
(CHEMBL1824919)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1cccc(n1)-c1ccccc1
Show InChI InChI=1S/C24H17ClN2O/c25-21-10-5-4-9-20(21)24(28)26-19-15-13-18(14-16-19)23-12-6-11-22(27-23)17-7-2-1-3-8-17/h1-16H,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352932
PNG
(CHEMBL1824920)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1nccc(n1)-c1ccccc1
Show InChI InChI=1S/C23H16ClN3O/c24-20-9-5-4-8-19(20)23(28)26-18-12-10-17(11-13-18)22-25-15-14-21(27-22)16-6-2-1-3-7-16/h1-15H,(H,26,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 37n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352942
PNG
(CHEMBL1824910)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1ncc(o1)-c1ccccc1
Show InChI InChI=1S/C22H15ClN2O2/c23-19-9-5-4-8-18(19)21(26)25-17-12-10-16(11-13-17)22-24-14-20(27-22)15-6-2-1-3-7-15/h1-14H,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352941
PNG
(CHEMBL1824911)
Show SMILES Cc1oc(nc1-c1ccccc1)-c1ccc(NC(=O)c2ccccc2Cl)cc1
Show InChI InChI=1S/C23H17ClN2O2/c1-15-21(16-7-3-2-4-8-16)26-23(28-15)17-11-13-18(14-12-17)25-22(27)19-9-5-6-10-20(19)24/h2-14H,1H3,(H,25,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 44n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352931
PNG
(CHEMBL1824921)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1cc(ncn1)-c1ccccc1
Show InChI InChI=1S/C23H16ClN3O/c24-20-9-5-4-8-19(20)23(28)27-18-12-10-17(11-13-18)22-14-21(25-15-26-22)16-6-2-1-3-7-16/h1-15H,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 48n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352946
PNG
(CHEMBL1824906)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C21H16ClNO/c22-20-9-5-4-8-19(20)21(24)23-18-14-12-17(13-15-18)11-10-16-6-2-1-3-7-16/h1-15H,(H,23,24)/b11-10+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 49n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352940
PNG
(CHEMBL1824912)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1nc(co1)-c1ccccc1
Show InChI InChI=1S/C22H15ClN2O2/c23-19-9-5-4-8-18(19)21(26)24-17-12-10-16(11-13-17)22-25-20(14-27-22)15-6-2-1-3-7-15/h1-14H,(H,24,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 63n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352945
PNG
(CHEMBL1824907)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(CC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C21H16ClNO2/c22-19-9-5-4-8-18(19)21(25)23-17-12-10-15(11-13-17)14-20(24)16-6-2-1-3-7-16/h1-13H,14H2,(H,23,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 79n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352939
PNG
(CHEMBL1824913)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C21H14ClN3O2/c22-18-9-5-4-8-17(18)19(26)23-16-12-10-15(11-13-16)21-25-24-20(27-21)14-6-2-1-3-7-14/h1-13H,(H,23,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 89n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352937
PNG
(CHEMBL1824914)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1coc(n1)-c1ccccc1
Show InChI InChI=1S/C22H15ClN2O2/c23-19-9-5-4-8-18(19)21(26)24-17-12-10-15(11-13-17)20-14-27-22(25-20)16-6-2-1-3-7-16/h1-14H,(H,24,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 93n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352930
PNG
(CHEMBL1824922)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1ccnc(c1)-c1ccccc1
Show InChI InChI=1S/C24H17ClN2O/c25-22-9-5-4-8-21(22)24(28)27-20-12-10-17(11-13-20)19-14-15-26-23(16-19)18-6-2-1-3-7-18/h1-16H,(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 93n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo)


(Homo sapiens (Human))
BDBM50352938
PNG
(CHEMBL1580265)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cc1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C22H15ClN2OS/c23-19-9-5-4-8-18(19)21(26)24-17-12-10-15(11-13-17)20-14-27-22(25-20)16-6-2-1-3-7-16/h1-14H,(H,24,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 109n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay


Bioorg Med Chem Lett 21: 5206-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.052
BindingDB Entry DOI: 10.7270/Q2N58MRK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%