BindingDB logo
myBDB logout

PubMed code 21843941

Compile data set for download or QSAR
Found 40 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354216
PNG
(CHEMBL1836004)
Show SMILES Cc1nc2ccccc2n1-c1ccc(cc1)C(=O)N1CC[C@@H](C1)N1CCCC1
Show InChI InChI=1S/C23H26N4O/c1-17-24-21-6-2-3-7-22(21)27(17)19-10-8-18(9-11-19)23(28)26-15-12-20(16-26)25-13-4-5-14-25/h2-3,6-11,20H,4-5,12-16H2,1H3/t20-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.400n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354214
PNG
(CHEMBL1835992)
Show SMILES CC(C)N1CC[C@H](C1)N(C)C(=O)c1ccc(Cn2c(C)nc3ccccc23)cc1
Show InChI InChI=1S/C24H30N4O/c1-17(2)27-14-13-21(16-27)26(4)24(29)20-11-9-19(10-12-20)15-28-18(3)25-22-7-5-6-8-23(22)28/h5-12,17,21H,13-16H2,1-4H3/t21-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.60n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354205
PNG
(CHEMBL1835999)
Show SMILES CN([C@@H]1CCN(C1)C1CCC1)C(=O)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C19H24N4O/c1-21(18-10-13-22(14-18)16-4-2-5-16)19(24)15-6-8-17(9-7-15)23-12-3-11-20-23/h3,6-9,11-12,16,18H,2,4-5,10,13-14H2,1H3/t18-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.80n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354215
PNG
(CHEMBL1835993)
Show SMILES CN([C@@H]1CCN(C1)C1CCC1)C(=O)c1ccc(Cn2c(C)nc3ccccc23)cc1
Show InChI InChI=1S/C25H30N4O/c1-18-26-23-8-3-4-9-24(23)29(18)16-19-10-12-20(13-11-19)25(30)27(2)22-14-15-28(17-22)21-6-5-7-21/h3-4,8-13,21-22H,5-7,14-17H2,1-2H3/t22-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.70n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354212
PNG
(CHEMBL1836039)
Show SMILES CN([C@@H]1CCN(C1)C1CCCC1)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C25H30N4O/c1-18-26-23-9-5-6-10-24(23)29(18)21-13-11-19(12-14-21)25(30)27(2)22-15-16-28(17-22)20-7-3-4-8-20/h5-6,9-14,20,22H,3-4,7-8,15-17H2,1-2H3/t22-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.5n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354206
PNG
(CHEMBL1836000)
Show SMILES CN([C@@H]1CCN(C1)C1CCCC1)C(=O)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C20H26N4O/c1-22(19-11-14-23(15-19)17-5-2-3-6-17)20(25)16-7-9-18(10-8-16)24-13-4-12-21-24/h4,7-10,12-13,17,19H,2-3,5-6,11,14-15H2,1H3/t19-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.60n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354201
PNG
(CHEMBL1835995)
Show SMILES CC(C)N1CC[C@H](C1)N(C)C(=O)c1ccc(Cn2cnc3ccccc23)cc1
Show InChI InChI=1S/C23H28N4O/c1-17(2)26-13-12-20(15-26)25(3)23(28)19-10-8-18(9-11-19)14-27-16-24-21-6-4-5-7-22(21)27/h4-11,16-17,20H,12-15H2,1-3H3/t20-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354210
PNG
(CHEMBL1836035)
Show SMILES CC(C)N1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C23H28N4O/c1-16(2)26-14-13-20(15-26)25(4)23(28)18-9-11-19(12-10-18)27-17(3)24-21-7-5-6-8-22(21)27/h5-12,16,20H,13-15H2,1-4H3/t20-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.20n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354213
PNG
(CHEMBL1836040)
Show SMILES CN([C@@H]1CCN(C1)C1CCCCC1)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C26H32N4O/c1-19-27-24-10-6-7-11-25(24)30(19)22-14-12-20(13-15-22)26(31)28(2)23-16-17-29(18-23)21-8-4-3-5-9-21/h6-7,10-15,21,23H,3-5,8-9,16-18H2,1-2H3/t23-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.70n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50309847
PNG
((S)-1,3'-bipyrrolidin-1'-yl(4-((2-methyl-1H-benzo[...)
Show SMILES Cc1nc2ccccc2n1Cc1ccc(cc1)C(=O)N1CC[C@@H](C1)N1CCCC1
Show InChI InChI=1S/C24H28N4O/c1-18-25-22-6-2-3-7-23(22)28(18)16-19-8-10-20(11-9-19)24(29)27-15-12-21(17-27)26-13-4-5-14-26/h2-3,6-11,21H,4-5,12-17H2,1H3/t21-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354222
PNG
(CHEMBL1833994)
Show SMILES CN([C@H]1CCN(C1)C1CCCC1)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C25H30N4O/c1-18-26-23-9-5-6-10-24(23)29(18)21-13-11-19(12-14-21)25(30)27(2)22-15-16-28(17-22)20-7-3-4-8-20/h5-6,9-14,20,22H,3-4,7-8,15-17H2,1-2H3/t22-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.20n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354211
PNG
(CHEMBL1836037)
Show SMILES CN([C@@H]1CCN(C1)C1CCC1)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C24H28N4O/c1-17-25-22-8-3-4-9-23(22)28(17)20-12-10-18(11-13-20)24(29)26(2)21-14-15-27(16-21)19-6-5-7-19/h3-4,8-13,19,21H,5-7,14-16H2,1-2H3/t21-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.70n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354204
PNG
(CHEMBL1835998)
Show SMILES CC(C)N1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C18H24N4O/c1-14(2)21-12-9-17(13-21)20(3)18(23)15-5-7-16(8-6-15)22-11-4-10-19-22/h4-8,10-11,14,17H,9,12-13H2,1-3H3/t17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
7n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354202
PNG
(CHEMBL1835996)
Show SMILES CN([C@@H]1CCN(C1)C1CCC1)C(=O)c1ccc(Cn2cnc3ccccc23)cc1
Show InChI InChI=1S/C24H28N4O/c1-26(21-13-14-27(16-21)20-5-4-6-20)24(29)19-11-9-18(10-12-19)15-28-17-25-22-7-2-3-8-23(22)28/h2-3,7-12,17,20-21H,4-6,13-16H2,1H3/t21-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
7.30n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354230
PNG
(CHEMBL1835994)
Show SMILES CN([C@@H]1CCN(C1)C1CCCC1)C(=O)c1ccc(Cn2c(C)nc3ccccc23)cc1
Show InChI InChI=1S/C26H32N4O/c1-19-27-24-9-5-6-10-25(24)30(19)17-20-11-13-21(14-12-20)26(31)28(2)23-15-16-29(18-23)22-7-3-4-8-22/h5-6,9-14,22-23H,3-4,7-8,15-18H2,1-2H3/t23-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
9n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50309845
PNG
((S)-1,3'-bipyrrolidin-1'-yl(4-((1H-benzo[d]imidazo...)
Show SMILES O=C(N1CC[C@@H](C1)N1CCCC1)c1ccc(Cn2cnc3ccccc23)cc1
Show InChI InChI=1S/C23H26N4O/c28-23(26-14-11-20(16-26)25-12-3-4-13-25)19-9-7-18(8-10-19)15-27-17-24-21-5-1-2-6-22(21)27/h1-2,5-10,17,20H,3-4,11-16H2/t20-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
10n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354227
PNG
(CHEMBL1835989)
Show SMILES CCN([C@@H]1CCN(C1)C1CCC1)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C25H30N4O/c1-3-28(22-15-16-27(17-22)20-7-6-8-20)25(30)19-11-13-21(14-12-19)29-18(2)26-23-9-4-5-10-24(23)29/h4-5,9-14,20,22H,3,6-8,15-17H2,1-2H3/t22-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
15n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354231
PNG
(CHEMBL1836034)
Show SMILES CCN1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C22H26N4O/c1-4-25-14-13-19(15-25)24(3)22(27)17-9-11-18(12-10-17)26-16(2)23-20-7-5-6-8-21(20)26/h5-12,19H,4,13-15H2,1-3H3/t19-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
15n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354203
PNG
(CHEMBL1835997)
Show SMILES CN([C@@H]1CCN(C1)C1CCCC1)C(=O)c1ccc(Cn2cnc3ccccc23)cc1
Show InChI InChI=1S/C25H30N4O/c1-27(22-14-15-28(17-22)21-6-2-3-7-21)25(30)20-12-10-19(11-13-20)16-29-18-26-23-8-4-5-9-24(23)29/h4-5,8-13,18,21-22H,2-3,6-7,14-17H2,1H3/t22-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
15n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354219
PNG
(CHEMBL1836031)
Show SMILES CCCN1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C23H28N4O/c1-4-14-26-15-13-20(16-26)25(3)23(28)18-9-11-19(12-10-18)27-17(2)24-21-7-5-6-8-22(21)27/h5-12,20H,4,13-16H2,1-3H3/t20-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
17n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354226
PNG
(CHEMBL1835988)
Show SMILES CCN([C@@H]1CCN(C1)C(C)C)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C24H30N4O/c1-5-27(21-14-15-26(16-21)17(2)3)24(29)19-10-12-20(13-11-19)28-18(4)25-22-8-6-7-9-23(22)28/h6-13,17,21H,5,14-16H2,1-4H3/t21-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
19n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354221
PNG
(CHEMBL1836038)
Show SMILES CN([C@H]1CCN(C1)C1CCC1)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C24H28N4O/c1-17-25-22-8-3-4-9-23(22)28(17)20-12-10-18(11-13-20)24(29)26(2)21-14-15-27(16-21)19-6-5-7-19/h3-4,8-13,19,21H,5-7,14-16H2,1-2H3/t21-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
21n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354220
PNG
(CHEMBL1836036)
Show SMILES CC(C)N1CC[C@@H](C1)N(C)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C23H28N4O/c1-16(2)26-14-13-20(15-26)25(4)23(28)18-9-11-19(12-10-18)27-17(3)24-21-7-5-6-8-22(21)27/h5-12,16,20H,13-15H2,1-4H3/t20-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
26n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354229
PNG
(CHEMBL1835991)
Show SMILES CCN([C@@H]1CCN(C1)C1CCCC1)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C26H32N4O/c1-3-29(23-16-17-28(18-23)21-8-4-5-9-21)26(31)20-12-14-22(15-13-20)30-19(2)27-24-10-6-7-11-25(24)30/h6-7,10-15,21,23H,3-5,8-9,16-18H2,1-2H3/t23-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
26n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354224
PNG
(CHEMBL1835986)
Show SMILES CN([C@@H]1CCN(C1)C1CCCCCC1)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C27H34N4O/c1-20-28-25-11-7-8-12-26(25)31(20)23-15-13-21(14-16-23)27(32)29(2)24-17-18-30(19-24)22-9-5-3-4-6-10-22/h7-8,11-16,22,24H,3-6,9-10,17-19H2,1-2H3/t24-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
32n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354223
PNG
(CHEMBL1836041)
Show SMILES CN([C@H]1CCN(C1)C1CCCCC1)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C26H32N4O/c1-19-27-24-10-6-7-11-25(24)30(19)22-14-12-20(13-15-22)26(31)28(2)23-16-17-29(18-23)21-8-4-3-5-9-21/h6-7,10-15,21,23H,3-5,8-9,16-18H2,1-2H3/t23-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
49n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354208
PNG
(CHEMBL1836002)
Show SMILES CN([C@@H]1CCN(C1)C1CCC1)C(=O)c1ccc(Cn2cccn2)cc1
Show InChI InChI=1S/C20H26N4O/c1-22(19-10-13-23(15-19)18-4-2-5-18)20(25)17-8-6-16(7-9-17)14-24-12-3-11-21-24/h3,6-9,11-12,18-19H,2,4-5,10,13-15H2,1H3/t19-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
144n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354225
PNG
(CHEMBL1835987)
Show SMILES CC(C)N1CC[C@H](C1)NC(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C22H26N4O/c1-15(2)25-13-12-18(14-25)24-22(27)17-8-10-19(11-9-17)26-16(3)23-20-6-4-5-7-21(20)26/h4-11,15,18H,12-14H2,1-3H3,(H,24,27)/t18-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
173n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354207
PNG
(CHEMBL1836001)
Show SMILES CC(C)N1CC[C@H](C1)N(C)C(=O)c1ccc(Cn2cccn2)cc1
Show InChI InChI=1S/C19H26N4O/c1-15(2)22-12-9-18(14-22)21(3)19(24)17-7-5-16(6-8-17)13-23-11-4-10-20-23/h4-8,10-11,15,18H,9,12-14H2,1-3H3/t18-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
184n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354228
PNG
(CHEMBL1835990)
Show SMILES Cc1nc2ccccc2n1-c1ccc(cc1)C(=O)N[C@@H]1CCN(C1)C1CCCC1
Show InChI InChI=1S/C24H28N4O/c1-17-25-22-8-4-5-9-23(22)28(17)21-12-10-18(11-13-21)24(29)26-19-14-15-27(16-19)20-6-2-3-7-20/h4-5,8-13,19-20H,2-3,6-7,14-16H2,1H3,(H,26,29)/t19-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
197n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354209
PNG
(CHEMBL1836003)
Show SMILES CN([C@@H]1CCN(C1)C1CCCC1)C(=O)c1ccc(Cn2cccn2)cc1
Show InChI InChI=1S/C21H28N4O/c1-23(20-11-14-24(16-20)19-5-2-3-6-19)21(26)18-9-7-17(8-10-18)15-25-13-4-12-22-25/h4,7-10,12-13,19-20H,2-3,5-6,11,14-16H2,1H3/t20-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
210n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354218
PNG
(CHEMBL1836033)
Show SMILES CN([C@@H]1CCN(C)C1)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C21H24N4O/c1-15-22-19-6-4-5-7-20(19)25(15)17-10-8-16(9-11-17)21(26)24(3)18-12-13-23(2)14-18/h4-11,18H,12-14H2,1-3H3/t18-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
252n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354217
PNG
(CHEMBL1836032)
Show SMILES CN([C@@H]1CCNC1)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C20H22N4O/c1-14-22-18-5-3-4-6-19(18)24(14)16-9-7-15(8-10-16)20(25)23(2)17-11-12-21-13-17/h3-10,17,21H,11-13H2,1-2H3/t17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)alpha-methylhistamine from human histamine H3 receptor expressed in human HEK293T cells


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50354212
PNG
(CHEMBL1836039)
Show SMILES CN([C@@H]1CCN(C1)C1CCCC1)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C25H30N4O/c1-18-26-23-9-5-6-10-24(23)29(18)21-13-11-19(12-14-21)25(30)27(2)22-15-16-28(17-22)20-7-3-4-8-20/h5-6,9-14,20,22H,3-4,7-8,15-17H2,1-2H3/t22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.30E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50354213
PNG
(CHEMBL1836040)
Show SMILES CN([C@@H]1CCN(C1)C1CCCCC1)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C26H32N4O/c1-19-27-24-10-6-7-11-25(24)30(19)22-14-12-20(13-15-22)26(31)28(2)23-16-17-29(18-23)21-8-4-3-5-9-21/h6-7,10-15,21,23H,3-5,8-9,16-18H2,1-2H3/t23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.80E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50354205
PNG
(CHEMBL1835999)
Show SMILES CN([C@@H]1CCN(C1)C1CCC1)C(=O)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C19H24N4O/c1-21(18-10-13-22(14-18)16-4-2-5-16)19(24)15-6-8-17(9-7-15)23-12-3-11-20-23/h3,6-9,11-12,16,18H,2,4-5,10,13-14H2,1H3/t18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50354211
PNG
(CHEMBL1836037)
Show SMILES CN([C@@H]1CCN(C1)C1CCC1)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C24H28N4O/c1-17-25-22-8-3-4-9-23(22)28(17)20-12-10-18(11-13-20)24(29)26(2)21-14-15-27(16-21)19-6-5-7-19/h3-4,8-13,19,21H,5-7,14-16H2,1-2H3/t21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50354215
PNG
(CHEMBL1835993)
Show SMILES CN([C@@H]1CCN(C1)C1CCC1)C(=O)c1ccc(Cn2c(C)nc3ccccc23)cc1
Show InChI InChI=1S/C25H30N4O/c1-18-26-23-8-3-4-9-24(23)29(18)16-19-10-12-20(13-11-19)25(30)27(2)22-14-15-28(17-22)21-6-5-7-21/h3-4,8-13,21-22H,5-7,14-17H2,1-2H3/t22-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50354214
PNG
(CHEMBL1835992)
Show SMILES CC(C)N1CC[C@H](C1)N(C)C(=O)c1ccc(Cn2c(C)nc3ccccc23)cc1
Show InChI InChI=1S/C24H30N4O/c1-17(2)27-14-13-21(16-27)26(4)24(29)20-11-9-19(10-12-20)15-28-18(3)25-22-7-5-6-8-23(22)28/h5-12,17,21H,13-16H2,1-4H3/t21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50354210
PNG
(CHEMBL1836035)
Show SMILES CC(C)N1CC[C@H](C1)N(C)C(=O)c1ccc(cc1)-n1c(C)nc2ccccc12
Show InChI InChI=1S/C23H28N4O/c1-16(2)26-14-13-20(15-26)25(4)23(28)18-9-11-19(12-10-18)27-17(3)24-21-7-5-6-8-22(21)27/h5-12,16,20H,13-15H2,1-4H3/t20-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.50E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 21: 5957-60 (2011)


Article DOI: 10.1016/j.bmcl.2011.07.061
BindingDB Entry DOI: 10.7270/Q2QN6753
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%