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PubMed code 21967808

Compile data set for download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361566
PNG
(CHEMBL1939493)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)OC)c2)ncc1Cl
Show InChI InChI=1S/C26H27ClFN7O4/c1-26(2)11-19(33-25(38)39-4)23(37)32-18-10-13(8-9-15(18)26)31-24-30-12-16(27)21(35-24)34-20-14(22(36)29-3)6-5-7-17(20)28/h5-10,12,19H,11H2,1-4H3,(H,29,36)(H,32,37)(H,33,38)(H2,30,31,34,35)/t19-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334084
PNG
(2-[5-Chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahyd...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)CCC3(C)C)c2)ncc1Cl
Show InChI InChI=1S/C24H24ClFN6O2/c1-24(2)10-9-19(33)30-18-11-13(7-8-15(18)24)29-23-28-12-16(25)21(32-23)31-20-14(22(34)27-3)5-4-6-17(20)26/h4-8,11-12H,9-10H2,1-3H3,(H,27,34)(H,30,33)(H2,28,29,31,32)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334085
PNG
(2-[5-Chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-...)
Show SMILES CCN1c2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc2C(C)(C)CCC1=O
Show InChI InChI=1S/C26H28ClFN6O2/c1-5-34-20-13-15(9-10-17(20)26(2,3)12-11-21(34)35)31-25-30-14-18(27)23(33-25)32-22-16(24(36)29-4)7-6-8-19(22)28/h6-10,13-14H,5,11-12H2,1-4H3,(H,29,36)(H2,30,31,32,33)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361570
PNG
(CHEMBL1939481)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)CN(C)C)c2)ncc1Cl
Show InChI InChI=1S/C28H32ClFN8O3/c1-28(2)12-21(34-22(39)14-38(4)5)26(41)35-20-11-15(9-10-17(20)28)33-27-32-13-18(29)24(37-27)36-23-16(25(40)31-3)7-6-8-19(23)30/h6-11,13,21H,12,14H2,1-5H3,(H,31,40)(H,34,39)(H,35,41)(H2,32,33,36,37)
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n/an/a 11n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361569
PNG
(CHEMBL1939321)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(N)CC3(C)C)c2)ncc1Cl
Show InChI InChI=1S/C24H25ClFN7O2/c1-24(2)10-17(27)22(35)31-18-9-12(7-8-14(18)24)30-23-29-11-15(25)20(33-23)32-19-13(21(34)28-3)5-4-6-16(19)26/h4-9,11,17H,10,27H2,1-3H3,(H,28,34)(H,31,35)(H2,29,30,32,33)
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n/an/a 12n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361560
PNG
(CHEMBL1939486)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)C(F)(F)F)c2)ncc1Cl
Show InChI InChI=1S/C26H24ClF4N7O3/c1-25(2)10-18(36-23(41)26(29,30)31)22(40)35-17-9-12(7-8-14(17)25)34-24-33-11-15(27)20(38-24)37-19-13(21(39)32-3)5-4-6-16(19)28/h4-9,11,18H,10H2,1-3H3,(H,32,39)(H,35,40)(H,36,41)(H2,33,34,37,38)/t18-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361567
PNG
(CHEMBL1939494)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@H](CC3(C)C)NC(=O)OC)c2)ncc1Cl
Show InChI InChI=1S/C26H27ClFN7O4/c1-26(2)11-19(33-25(38)39-4)23(37)32-18-10-13(8-9-15(18)26)31-24-30-12-16(27)21(35-24)34-20-14(22(36)29-3)6-5-7-17(20)28/h5-10,12,19H,11H2,1-4H3,(H,29,36)(H,32,37)(H,33,38)(H2,30,31,34,35)/t19-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361568
PNG
(CHEMBL1939320)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)C(F)(F)F)c2)ncc1Cl
Show InChI InChI=1S/C26H24ClF4N7O3/c1-25(2)10-18(36-23(41)26(29,30)31)22(40)35-17-9-12(7-8-14(17)25)34-24-33-11-15(27)20(38-24)37-19-13(21(39)32-3)5-4-6-16(19)28/h4-9,11,18H,10H2,1-3H3,(H,32,39)(H,35,40)(H,36,41)(H2,33,34,37,38)
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n/an/a 13n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361570
PNG
(CHEMBL1939481)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)CN(C)C)c2)ncc1Cl
Show InChI InChI=1S/C28H32ClFN8O3/c1-28(2)12-21(34-22(39)14-38(4)5)26(41)35-20-11-15(9-10-17(20)28)33-27-32-13-18(29)24(37-27)36-23-16(25(40)31-3)7-6-8-19(23)30/h6-11,13,21H,12,14H2,1-5H3,(H,31,40)(H,34,39)(H,35,41)(H2,32,33,36,37)
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n/an/a 14n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361558
PNG
(CHEMBL1939484)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)N3CCCC3)c2)ncc1Cl
Show InChI InChI=1S/C29H32ClFN8O3/c1-29(2)14-22(36-28(42)39-11-4-5-12-39)26(41)35-21-13-16(9-10-18(21)29)34-27-33-15-19(30)24(38-27)37-23-17(25(40)32-3)7-6-8-20(23)31/h6-10,13,15,22H,4-5,11-12,14H2,1-3H3,(H,32,40)(H,35,41)(H,36,42)(H2,33,34,37,38)
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n/an/a 16n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361568
PNG
(CHEMBL1939320)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)C(F)(F)F)c2)ncc1Cl
Show InChI InChI=1S/C26H24ClF4N7O3/c1-25(2)10-18(36-23(41)26(29,30)31)22(40)35-17-9-12(7-8-14(17)25)34-24-33-11-15(27)20(38-24)37-19-13(21(39)32-3)5-4-6-16(19)28/h4-9,11,18H,10H2,1-3H3,(H,32,39)(H,35,40)(H,36,41)(H2,33,34,37,38)
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n/an/a 16n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361569
PNG
(CHEMBL1939321)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(N)CC3(C)C)c2)ncc1Cl
Show InChI InChI=1S/C24H25ClFN7O2/c1-24(2)10-17(27)22(35)31-18-9-12(7-8-14(18)24)30-23-29-11-15(25)20(33-23)32-19-13(21(34)28-3)5-4-6-16(19)26/h4-9,11,17H,10,27H2,1-3H3,(H,28,34)(H,31,35)(H2,29,30,32,33)
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n/an/a 17n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361561
PNG
(CHEMBL1939487)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@H](CC3(C)C)NC(=O)C(F)(F)F)c2)ncc1Cl
Show InChI InChI=1S/C26H24ClF4N7O3/c1-25(2)10-18(36-23(41)26(29,30)31)22(40)35-17-9-12(7-8-14(17)25)34-24-33-11-15(27)20(38-24)37-19-13(21(39)32-3)5-4-6-16(19)28/h4-9,11,18H,10H2,1-3H3,(H,32,39)(H,35,40)(H,36,41)(H2,33,34,37,38)/t18-/m0/s1
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361558
PNG
(CHEMBL1939484)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)N3CCCC3)c2)ncc1Cl
Show InChI InChI=1S/C29H32ClFN8O3/c1-29(2)14-22(36-28(42)39-11-4-5-12-39)26(41)35-21-13-16(9-10-18(21)29)34-27-33-15-19(30)24(38-27)37-23-17(25(40)32-3)7-6-8-20(23)31/h6-10,13,15,22H,4-5,11-12,14H2,1-3H3,(H,32,40)(H,35,41)(H,36,42)(H2,33,34,37,38)
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n/an/a 18n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361571
PNG
(CHEMBL1939482)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(C)=O)c2)ncc1Cl
Show InChI InChI=1S/C26H27ClFN7O3/c1-13(36)31-20-11-26(2,3)16-9-8-14(10-19(16)33-24(20)38)32-25-30-12-17(27)22(35-25)34-21-15(23(37)29-4)6-5-7-18(21)28/h5-10,12,20H,11H2,1-4H3,(H,29,37)(H,31,36)(H,33,38)(H2,30,32,34,35)
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n/an/a 18n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361559
PNG
(CHEMBL1939485)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)OC)c2)ncc1Cl
Show InChI InChI=1S/C26H27ClFN7O4/c1-26(2)11-19(33-25(38)39-4)23(37)32-18-10-13(8-9-15(18)26)31-24-30-12-16(27)21(35-24)34-20-14(22(36)29-3)6-5-7-17(20)28/h5-10,12,19H,11H2,1-4H3,(H,29,36)(H,32,37)(H,33,38)(H2,30,31,34,35)
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n/an/a 20n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361571
PNG
(CHEMBL1939482)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(C)=O)c2)ncc1Cl
Show InChI InChI=1S/C26H27ClFN7O3/c1-13(36)31-20-11-26(2,3)16-9-8-14(10-19(16)33-24(20)38)32-25-30-12-17(27)22(35-25)34-21-15(23(37)29-4)6-5-7-18(21)28/h5-10,12,20H,11H2,1-4H3,(H,29,37)(H,31,36)(H,33,38)(H2,30,32,34,35)
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n/an/a 22n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361572
PNG
(CHEMBL1939483)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)COC)c2)ncc1Cl
Show InChI InChI=1S/C27H29ClFN7O4/c1-27(2)11-20(33-21(37)13-40-4)25(39)34-19-10-14(8-9-16(19)27)32-26-31-12-17(28)23(36-26)35-22-15(24(38)30-3)6-5-7-18(22)29/h5-10,12,20H,11,13H2,1-4H3,(H,30,38)(H,33,37)(H,34,39)(H2,31,32,35,36)
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n/an/a 22n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361564
PNG
(CHEMBL1939491)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)N3CCCC3)c2)ncc1Cl
Show InChI InChI=1S/C29H32ClFN8O3/c1-29(2)14-22(36-28(42)39-11-4-5-12-39)26(41)35-21-13-16(9-10-18(21)29)34-27-33-15-19(30)24(38-27)37-23-17(25(40)32-3)7-6-8-20(23)31/h6-10,13,15,22H,4-5,11-12,14H2,1-3H3,(H,32,40)(H,35,41)(H,36,42)(H2,33,34,37,38)/t22-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361567
PNG
(CHEMBL1939494)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@H](CC3(C)C)NC(=O)OC)c2)ncc1Cl
Show InChI InChI=1S/C26H27ClFN7O4/c1-26(2)11-19(33-25(38)39-4)23(37)32-18-10-13(8-9-15(18)26)31-24-30-12-16(27)21(35-24)34-20-14(22(36)29-3)6-5-7-17(20)28/h5-10,12,19H,11H2,1-4H3,(H,29,36)(H,32,37)(H,33,38)(H2,30,31,34,35)/t19-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361560
PNG
(CHEMBL1939486)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)C(F)(F)F)c2)ncc1Cl
Show InChI InChI=1S/C26H24ClF4N7O3/c1-25(2)10-18(36-23(41)26(29,30)31)22(40)35-17-9-12(7-8-14(17)25)34-24-33-11-15(27)20(38-24)37-19-13(21(39)32-3)5-4-6-16(19)28/h4-9,11,18H,10H2,1-3H3,(H,32,39)(H,35,40)(H,36,41)(H2,33,34,37,38)/t18-/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361563
PNG
(CHEMBL1939489)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@H](CC3(C)C)NC(=O)COC)c2)ncc1Cl
Show InChI InChI=1S/C27H29ClFN7O4/c1-27(2)11-20(33-21(37)13-40-4)25(39)34-19-10-14(8-9-16(19)27)32-26-31-12-17(28)23(36-26)35-22-15(24(38)30-3)6-5-7-18(22)29/h5-10,12,20H,11,13H2,1-4H3,(H,30,38)(H,33,37)(H,34,39)(H2,31,32,35,36)/t20-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361564
PNG
(CHEMBL1939491)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)N3CCCC3)c2)ncc1Cl
Show InChI InChI=1S/C29H32ClFN8O3/c1-29(2)14-22(36-28(42)39-11-4-5-12-39)26(41)35-21-13-16(9-10-18(21)29)34-27-33-15-19(30)24(38-27)37-23-17(25(40)32-3)7-6-8-20(23)31/h6-10,13,15,22H,4-5,11-12,14H2,1-3H3,(H,32,40)(H,35,41)(H,36,42)(H2,33,34,37,38)/t22-/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361572
PNG
(CHEMBL1939483)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)COC)c2)ncc1Cl
Show InChI InChI=1S/C27H29ClFN7O4/c1-27(2)11-20(33-21(37)13-40-4)25(39)34-19-10-14(8-9-16(19)27)32-26-31-12-17(28)23(36-26)35-22-15(24(38)30-3)6-5-7-18(22)29/h5-10,12,20H,11,13H2,1-4H3,(H,30,38)(H,33,37)(H,34,39)(H2,31,32,35,36)
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n/an/a 27n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361562
PNG
(CHEMBL1939488)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)COC)c2)ncc1Cl
Show InChI InChI=1S/C27H29ClFN7O4/c1-27(2)11-20(33-21(37)13-40-4)25(39)34-19-10-14(8-9-16(19)27)32-26-31-12-17(28)23(36-26)35-22-15(24(38)30-3)6-5-7-18(22)29/h5-10,12,20H,11,13H2,1-4H3,(H,30,38)(H,33,37)(H,34,39)(H2,31,32,35,36)/t20-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361559
PNG
(CHEMBL1939485)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)OC)c2)ncc1Cl
Show InChI InChI=1S/C26H27ClFN7O4/c1-26(2)11-19(33-25(38)39-4)23(37)32-18-10-13(8-9-15(18)26)31-24-30-12-16(27)21(35-24)34-20-14(22(36)29-3)6-5-7-17(20)28/h5-10,12,19H,11H2,1-4H3,(H,29,36)(H,32,37)(H,33,38)(H2,30,31,34,35)
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n/an/a 28n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334089
PNG
(2-[5-Chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3CCCC(=O)Nc3c2)ncc1Cl
Show InChI InChI=1S/C22H20ClFN6O2/c1-25-21(32)14-5-3-6-16(24)19(14)29-20-15(23)11-26-22(30-20)27-13-9-8-12-4-2-7-18(31)28-17(12)10-13/h3,5-6,8-11H,2,4,7H2,1H3,(H,25,32)(H,28,31)(H2,26,27,29,30)
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n/an/a 30n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361565
PNG
(CHEMBL1939492)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@H](CC3(C)C)NC(=O)N3CCCC3)c2)ncc1Cl
Show InChI InChI=1S/C29H32ClFN8O3/c1-29(2)14-22(36-28(42)39-11-4-5-12-39)26(41)35-21-13-16(9-10-18(21)29)34-27-33-15-19(30)24(38-27)37-23-17(25(40)32-3)7-6-8-20(23)31/h6-10,13,15,22H,4-5,11-12,14H2,1-3H3,(H,32,40)(H,35,41)(H,36,42)(H2,33,34,37,38)/t22-/m0/s1
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n/an/a 34n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361562
PNG
(CHEMBL1939488)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)COC)c2)ncc1Cl
Show InChI InChI=1S/C27H29ClFN7O4/c1-27(2)11-20(33-21(37)13-40-4)25(39)34-19-10-14(8-9-16(19)27)32-26-31-12-17(28)23(36-26)35-22-15(24(38)30-3)6-5-7-18(22)29/h5-10,12,20H,11,13H2,1-4H3,(H,30,38)(H,33,37)(H,34,39)(H2,31,32,35,36)/t20-/m1/s1
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n/an/a 34n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361563
PNG
(CHEMBL1939489)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@H](CC3(C)C)NC(=O)COC)c2)ncc1Cl
Show InChI InChI=1S/C27H29ClFN7O4/c1-27(2)11-20(33-21(37)13-40-4)25(39)34-19-10-14(8-9-16(19)27)32-26-31-12-17(28)23(36-26)35-22-15(24(38)30-3)6-5-7-18(22)29/h5-10,12,20H,11,13H2,1-4H3,(H,30,38)(H,33,37)(H,34,39)(H2,31,32,35,36)/t20-/m0/s1
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n/an/a 37n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361561
PNG
(CHEMBL1939487)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@H](CC3(C)C)NC(=O)C(F)(F)F)c2)ncc1Cl
Show InChI InChI=1S/C26H24ClF4N7O3/c1-25(2)10-18(36-23(41)26(29,30)31)22(40)35-17-9-12(7-8-14(17)25)34-24-33-11-15(27)20(38-24)37-19-13(21(39)32-3)5-4-6-16(19)28/h4-9,11,18H,10H2,1-3H3,(H,32,39)(H,35,40)(H,36,41)(H2,33,34,37,38)/t18-/m0/s1
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n/an/a 38n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334085
PNG
(2-[5-Chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-...)
Show SMILES CCN1c2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc2C(C)(C)CCC1=O
Show InChI InChI=1S/C26H28ClFN6O2/c1-5-34-20-13-15(9-10-17(20)26(2,3)12-11-21(34)35)31-25-30-14-18(27)23(33-25)32-22-16(24(36)29-4)7-6-8-19(22)28/h6-10,13-14H,5,11-12H2,1-4H3,(H,29,36)(H2,30,31,32,33)
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n/an/a 44n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334084
PNG
(2-[5-Chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahyd...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)CCC3(C)C)c2)ncc1Cl
Show InChI InChI=1S/C24H24ClFN6O2/c1-24(2)10-9-19(33)30-18-11-13(7-8-15(18)24)29-23-28-12-16(25)21(32-23)31-20-14(22(34)27-3)5-4-6-17(20)26/h4-8,11-12H,9-10H2,1-3H3,(H,27,34)(H,30,33)(H2,28,29,31,32)
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n/an/a 54n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361565
PNG
(CHEMBL1939492)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@H](CC3(C)C)NC(=O)N3CCCC3)c2)ncc1Cl
Show InChI InChI=1S/C29H32ClFN8O3/c1-29(2)14-22(36-28(42)39-11-4-5-12-39)26(41)35-21-13-16(9-10-18(21)29)34-27-33-15-19(30)24(38-27)37-23-17(25(40)32-3)7-6-8-20(23)31/h6-10,13,15,22H,4-5,11-12,14H2,1-3H3,(H,32,40)(H,35,41)(H,36,42)(H2,33,34,37,38)/t22-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361569
PNG
(CHEMBL1939321)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(N)CC3(C)C)c2)ncc1Cl
Show InChI InChI=1S/C24H25ClFN7O2/c1-24(2)10-17(27)22(35)31-18-9-12(7-8-14(18)24)30-23-29-11-15(25)20(33-23)32-19-13(21(34)28-3)5-4-6-16(19)26/h4-9,11,17H,10,27H2,1-3H3,(H,28,34)(H,31,35)(H2,29,30,32,33)
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n/an/a 71n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50361566
PNG
(CHEMBL1939493)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)OC)c2)ncc1Cl
Show InChI InChI=1S/C26H27ClFN7O4/c1-26(2)11-19(33-25(38)39-4)23(37)32-18-10-13(8-9-15(18)26)31-24-30-12-16(27)21(35-24)34-20-14(22(36)29-3)6-5-7-17(20)28/h5-10,12,19H,11H2,1-4H3,(H,29,36)(H,32,37)(H,33,38)(H2,30,31,34,35)/t19-/m1/s1
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n/an/a 78n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334089
PNG
(2-[5-Chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3CCCC(=O)Nc3c2)ncc1Cl
Show InChI InChI=1S/C22H20ClFN6O2/c1-25-21(32)14-5-3-6-16(24)19(14)29-20-15(23)11-26-22(30-20)27-13-9-8-12-4-2-7-18(31)28-17(12)10-13/h3,5-6,8-11H,2,4,7H2,1H3,(H,25,32)(H,28,31)(H2,26,27,29,30)
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n/an/a 99n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50334084
PNG
(2-[5-Chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahyd...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)CCC3(C)C)c2)ncc1Cl
Show InChI InChI=1S/C24H24ClFN6O2/c1-24(2)10-9-19(33)30-18-11-13(7-8-15(18)24)29-23-28-12-16(25)21(32-23)31-20-14(22(34)27-3)5-4-6-17(20)26/h4-8,11-12H,9-10H2,1-3H3,(H,27,34)(H,30,33)(H2,28,29,31,32)
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n/an/a 153n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361566
PNG
(CHEMBL1939493)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)OC)c2)ncc1Cl
Show InChI InChI=1S/C26H27ClFN7O4/c1-26(2)11-19(33-25(38)39-4)23(37)32-18-10-13(8-9-15(18)26)31-24-30-12-16(27)21(35-24)34-20-14(22(36)29-3)6-5-7-17(20)28/h5-10,12,19H,11H2,1-4H3,(H,29,36)(H,32,37)(H,33,38)(H2,30,31,34,35)/t19-/m1/s1
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n/an/a 273n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361570
PNG
(CHEMBL1939481)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)CN(C)C)c2)ncc1Cl
Show InChI InChI=1S/C28H32ClFN8O3/c1-28(2)12-21(34-22(39)14-38(4)5)26(41)35-20-11-15(9-10-17(20)28)33-27-32-13-18(29)24(37-27)36-23-16(25(40)31-3)7-6-8-19(23)30/h6-11,13,21H,12,14H2,1-5H3,(H,31,40)(H,34,39)(H,35,41)(H2,32,33,36,37)
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n/an/a 370n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361568
PNG
(CHEMBL1939320)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)C(F)(F)F)c2)ncc1Cl
Show InChI InChI=1S/C26H24ClF4N7O3/c1-25(2)10-18(36-23(41)26(29,30)31)22(40)35-17-9-12(7-8-14(17)25)34-24-33-11-15(27)20(38-24)37-19-13(21(39)32-3)5-4-6-16(19)28/h4-9,11,18H,10H2,1-3H3,(H,32,39)(H,35,40)(H,36,41)(H2,33,34,37,38)
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n/an/a 473n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361560
PNG
(CHEMBL1939486)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)C(F)(F)F)c2)ncc1Cl
Show InChI InChI=1S/C26H24ClF4N7O3/c1-25(2)10-18(36-23(41)26(29,30)31)22(40)35-17-9-12(7-8-14(17)25)34-24-33-11-15(27)20(38-24)37-19-13(21(39)32-3)5-4-6-16(19)28/h4-9,11,18H,10H2,1-3H3,(H,32,39)(H,35,40)(H,36,41)(H2,33,34,37,38)/t18-/m1/s1
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n/an/a 583n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361567
PNG
(CHEMBL1939494)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@H](CC3(C)C)NC(=O)OC)c2)ncc1Cl
Show InChI InChI=1S/C26H27ClFN7O4/c1-26(2)11-19(33-25(38)39-4)23(37)32-18-10-13(8-9-15(18)26)31-24-30-12-16(27)21(35-24)34-20-14(22(36)29-3)6-5-7-17(20)28/h5-10,12,19H,11H2,1-4H3,(H,29,36)(H,32,37)(H,33,38)(H2,30,31,34,35)/t19-/m0/s1
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n/an/a 598n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361559
PNG
(CHEMBL1939485)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)OC)c2)ncc1Cl
Show InChI InChI=1S/C26H27ClFN7O4/c1-26(2)11-19(33-25(38)39-4)23(37)32-18-10-13(8-9-15(18)26)31-24-30-12-16(27)21(35-24)34-20-14(22(36)29-3)6-5-7-17(20)28/h5-10,12,19H,11H2,1-4H3,(H,29,36)(H,32,37)(H,33,38)(H2,30,31,34,35)
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n/an/a 886n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361561
PNG
(CHEMBL1939487)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@H](CC3(C)C)NC(=O)C(F)(F)F)c2)ncc1Cl
Show InChI InChI=1S/C26H24ClF4N7O3/c1-25(2)10-18(36-23(41)26(29,30)31)22(40)35-17-9-12(7-8-14(17)25)34-24-33-11-15(27)20(38-24)37-19-13(21(39)32-3)5-4-6-16(19)28/h4-9,11,18H,10H2,1-3H3,(H,32,39)(H,35,40)(H,36,41)(H2,33,34,37,38)/t18-/m0/s1
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n/an/a 945n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361564
PNG
(CHEMBL1939491)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)N3CCCC3)c2)ncc1Cl
Show InChI InChI=1S/C29H32ClFN8O3/c1-29(2)14-22(36-28(42)39-11-4-5-12-39)26(41)35-21-13-16(9-10-18(21)29)34-27-33-15-19(30)24(38-27)37-23-17(25(40)32-3)7-6-8-20(23)31/h6-10,13,15,22H,4-5,11-12,14H2,1-3H3,(H,32,40)(H,35,41)(H,36,42)(H2,33,34,37,38)/t22-/m1/s1
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n/an/a 1.42E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361558
PNG
(CHEMBL1939484)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)N3CCCC3)c2)ncc1Cl
Show InChI InChI=1S/C29H32ClFN8O3/c1-29(2)14-22(36-28(42)39-11-4-5-12-39)26(41)35-21-13-16(9-10-18(21)29)34-27-33-15-19(30)24(38-27)37-23-17(25(40)32-3)7-6-8-20(23)31/h6-10,13,15,22H,4-5,11-12,14H2,1-3H3,(H,32,40)(H,35,41)(H,36,42)(H2,33,34,37,38)
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n/an/a 1.73E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361562
PNG
(CHEMBL1939488)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)COC)c2)ncc1Cl
Show InChI InChI=1S/C27H29ClFN7O4/c1-27(2)11-20(33-21(37)13-40-4)25(39)34-19-10-14(8-9-16(19)27)32-26-31-12-17(28)23(36-26)35-22-15(24(38)30-3)6-5-7-18(22)29/h5-10,12,20H,11,13H2,1-4H3,(H,30,38)(H,33,37)(H,34,39)(H2,31,32,35,36)/t20-/m1/s1
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n/an/a 1.81E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361565
PNG
(CHEMBL1939492)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@H](CC3(C)C)NC(=O)N3CCCC3)c2)ncc1Cl
Show InChI InChI=1S/C29H32ClFN8O3/c1-29(2)14-22(36-28(42)39-11-4-5-12-39)26(41)35-21-13-16(9-10-18(21)29)34-27-33-15-19(30)24(38-27)37-23-17(25(40)32-3)7-6-8-20(23)31/h6-10,13,15,22H,4-5,11-12,14H2,1-3H3,(H,32,40)(H,35,41)(H,36,42)(H2,33,34,37,38)/t22-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361563
PNG
(CHEMBL1939489)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@H](CC3(C)C)NC(=O)COC)c2)ncc1Cl
Show InChI InChI=1S/C27H29ClFN7O4/c1-27(2)11-20(33-21(37)13-40-4)25(39)34-19-10-14(8-9-16(19)27)32-26-31-12-17(28)23(36-26)35-22-15(24(38)30-3)6-5-7-18(22)29/h5-10,12,20H,11,13H2,1-4H3,(H,30,38)(H,33,37)(H,34,39)(H2,31,32,35,36)/t20-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361572
PNG
(CHEMBL1939483)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)COC)c2)ncc1Cl
Show InChI InChI=1S/C27H29ClFN7O4/c1-27(2)11-20(33-21(37)13-40-4)25(39)34-19-10-14(8-9-16(19)27)32-26-31-12-17(28)23(36-26)35-22-15(24(38)30-3)6-5-7-18(22)29/h5-10,12,20H,11,13H2,1-4H3,(H,30,38)(H,33,37)(H,34,39)(H2,31,32,35,36)
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n/an/a 3.11E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361571
PNG
(CHEMBL1939482)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(C)=O)c2)ncc1Cl
Show InChI InChI=1S/C26H27ClFN7O3/c1-13(36)31-20-11-26(2,3)16-9-8-14(10-19(16)33-24(20)38)32-25-30-12-17(27)22(35-25)34-21-15(23(37)29-4)6-5-7-18(21)28/h5-10,12,20H,11H2,1-4H3,(H,29,37)(H,31,36)(H,33,38)(H2,30,32,34,35)
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n/an/a 3.21E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay


Bioorg Med Chem 19: 6274-84 (2011)


Article DOI: 10.1016/j.bmc.2011.09.006
BindingDB Entry DOI: 10.7270/Q24M950J
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%