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PubMed code 22071299

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50359630
PNG
(CHEMBL1928639)
Show SMILES Cc1c(C)c2OC(C)(CCc2c(C)c1O)C(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C20H22O7/c1-10-11(2)18-14(12(3)17(10)23)5-6-20(4,27-18)19(24)26-8-13-7-15(21)16(22)9-25-13/h7,9,22-23H,5-6,8H2,1-4H3
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PubMed
n/an/a 5.36E+3n/an/an/an/an/an/a



Kyung Hee University Skin Biotechnology Center

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase activity using L-tyrosin as substrate after 20 mins


Bioorg Med Chem Lett 21: 7466-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.122
BindingDB Entry DOI: 10.7270/Q2DR2VZK
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50359632
PNG
(CHEMBL1928641)
Show SMILES Oc1ccc(cc1)C(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C13H10O6/c14-9-3-1-8(2-4-9)13(17)19-6-10-5-11(15)12(16)7-18-10/h1-5,7,14,16H,6H2
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n/an/a 5.51E+3n/an/an/an/an/an/a



Kyung Hee University Skin Biotechnology Center

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase activity using L-tyrosin as substrate after 20 mins


Bioorg Med Chem Lett 21: 7466-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.122
BindingDB Entry DOI: 10.7270/Q2DR2VZK
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50359631
PNG
(CHEMBL1928640)
Show SMILES Oc1ccc2cc(ccc2c1)C(=O)OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C17H12O6/c18-13-4-3-10-5-12(2-1-11(10)6-13)17(21)23-8-14-7-15(19)16(20)9-22-14/h1-7,9,18,20H,8H2
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n/an/a 9.65E+3n/an/an/an/an/an/a



Kyung Hee University Skin Biotechnology Center

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase activity using L-tyrosin as substrate after 20 mins


Bioorg Med Chem Lett 21: 7466-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.122
BindingDB Entry DOI: 10.7270/Q2DR2VZK
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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PubMed
n/an/a 6.94E+4n/an/an/an/an/an/a



Kyung Hee University Skin Biotechnology Center

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase activity using L-tyrosin as substrate after 20 mins


Bioorg Med Chem Lett 21: 7466-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.122
BindingDB Entry DOI: 10.7270/Q2DR2VZK
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50359629
PNG
(TROLOX)
Show SMILES Cc1c(C)c2OC(C)(CCc2c(C)c1O)C(O)=O
Show InChI InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Kyung Hee University Skin Biotechnology Center

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase activity using L-tyrosin as substrate after 20 mins


Bioorg Med Chem Lett 21: 7466-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.122
BindingDB Entry DOI: 10.7270/Q2DR2VZK
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (Common mushroom))
BDBM50359633
PNG
(CHEMBL1928642)
Show SMILES COc1coc(COC(=O)C2(C)CCc3c(C)c(O)c(C)c(C)c3O2)cc1=O
Show InChI InChI=1S/C21H24O7/c1-11-12(2)19-15(13(3)18(11)23)6-7-21(4,28-19)20(24)27-9-14-8-16(22)17(25-5)10-26-14/h8,10,23H,6-7,9H2,1-5H3
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Article
PubMed
n/an/a>2.00E+5n/an/an/an/an/an/a



Kyung Hee University Skin Biotechnology Center

Curated by ChEMBL


Assay Description
Inhibition of mushroom tyrosinase activity using L-tyrosin as substrate after 20 mins


Bioorg Med Chem Lett 21: 7466-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.122
BindingDB Entry DOI: 10.7270/Q2DR2VZK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%