BindingDB logo
myBDB logout

PubMed code 22104142

Compile data set for download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50360473
PNG
(CHEMBL1934749)
Show SMILES CCCCN(CC)c1nc(C)nc2n(c(CO)c(C)c12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H34N4O/c1-8-10-11-27(9-2)23-21-18(6)20(14-29)28(24(21)26-19(7)25-23)22-16(4)12-15(3)13-17(22)5/h12-13,29H,8-11,14H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells by cAMP assay


Bioorg Med Chem Lett 22: 723-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.066
BindingDB Entry DOI: 10.7270/Q2J67HCF
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50360475
PNG
(CHEMBL1934751)
Show SMILES CCCCN(CC)c1nc(C)nc2n(c(COC)c(C)c12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C25H36N4O/c1-9-11-12-28(10-2)24-22-19(6)21(15-30-8)29(25(22)27-20(7)26-24)23-17(4)13-16(3)14-18(23)5/h13-14H,9-12,15H2,1-8H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
11n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells by cAMP assay


Bioorg Med Chem Lett 22: 723-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.066
BindingDB Entry DOI: 10.7270/Q2J67HCF
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50074501
PNG
(Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-ph...)
Show SMILES CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
32n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells by cAMP assay


Bioorg Med Chem Lett 22: 723-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.066
BindingDB Entry DOI: 10.7270/Q2J67HCF
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50360474
PNG
(CHEMBL1934750)
Show SMILES CCCCN(CC)c1nc(C)nc2n(c(C=O)c(C)c12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H32N4O/c1-8-10-11-27(9-2)23-21-18(6)20(14-29)28(24(21)26-19(7)25-23)22-16(4)12-15(3)13-17(22)5/h12-14H,8-11H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
52n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells by cAMP assay


Bioorg Med Chem Lett 22: 723-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.066
BindingDB Entry DOI: 10.7270/Q2J67HCF
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50360470
PNG
(CHEMBL1934746)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C=O
Show InChI InChI=1S/C29H33NO3/c1-4-14-29(33)15-13-26-24-11-7-20-16-22(32)10-12-23(20)27(24)25(17-28(26,29)2)19-5-8-21(9-6-19)30(3)18-31/h5-6,8-9,16,18,24-26,33H,7,10-13,15,17H2,1-3H3/t24-,25+,26-,28-,29-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor


Bioorg Med Chem Lett 22: 723-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.066
BindingDB Entry DOI: 10.7270/Q2J67HCF
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor


Bioorg Med Chem Lett 22: 723-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.066
BindingDB Entry DOI: 10.7270/Q2J67HCF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50360471
PNG
(CHEMBL1934747)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C(=C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H33NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17-18,24,26,32H,8,11-14,16H2,1-4H3/t24-,26-,28-,29-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 307n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor


Bioorg Med Chem Lett 22: 723-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.066
BindingDB Entry DOI: 10.7270/Q2J67HCF
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50360469
PNG
(CHEMBL1934745)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC(=O)C(CCC(O)=O)=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C=O
Show InChI InChI=1S/C28H33NO5/c1-4-14-28(34)15-13-23-20-9-11-24(31)21(10-12-25(32)33)26(20)22(16-27(23,28)2)18-5-7-19(8-6-18)29(3)17-30/h5-8,17,20,22-23,34H,9-13,15-16H2,1-3H3,(H,32,33)/t20-,22+,23-,27-,28-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 430n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor


Bioorg Med Chem Lett 22: 723-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.066
BindingDB Entry DOI: 10.7270/Q2J67HCF
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50360472
PNG
(CHEMBL1934748)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@](Cl)(C[C@]12C)c1cc(Cl)c(N(C)C)c(Cl)c1
Show InChI InChI=1S/C29H32Cl3NO2/c1-5-11-28(35)12-10-22-21-8-6-17-13-19(34)7-9-20(17)25(21)29(32,16-27(22,28)2)18-14-23(30)26(33(3)4)24(31)15-18/h13-15,21-22,35H,6-10,12,16H2,1-4H3/t21-,22-,27-,28-,29-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 771n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor


Bioorg Med Chem Lett 22: 723-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.066
BindingDB Entry DOI: 10.7270/Q2J67HCF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%