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PubMed code 22141319

Compile data set for download or QSAR
Found 56 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393620
PNG
(CHEMBL2158531)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(C[C@H](O)CO)CC1
Show InChI InChI=1S/C28H33N5O4/c1-36-26-6-4-3-5-23(26)25-10-8-21-16-29-28(31-33(21)25)30-24-9-7-20(15-27(24)37-2)19-11-13-32(14-12-19)17-22(35)18-34/h3-10,15-16,19,22,34-35H,11-14,17-18H2,1-2H3,(H,30,31)/t22-/m0/s1
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n/an/a 2.90n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393619
PNG
(CHEMBL2158530)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(CC(O)CF)CC1
Show InChI InChI=1S/C28H32FN5O3/c1-36-26-6-4-3-5-23(26)25-10-8-21-17-30-28(32-34(21)25)31-24-9-7-20(15-27(24)37-2)19-11-13-33(14-12-19)18-22(35)16-29/h3-10,15,17,19,22,35H,11-14,16,18H2,1-2H3,(H,31,32)
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n/an/a 3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393618
PNG
(CHEMBL2158528)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(C[C@@H](C)O)CC1
Show InChI InChI=1S/C28H33N5O3/c1-19(34)18-32-14-12-20(13-15-32)21-8-10-24(27(16-21)36-3)30-28-29-17-22-9-11-25(33(22)31-28)23-6-4-5-7-26(23)35-2/h4-11,16-17,19-20,34H,12-15,18H2,1-3H3,(H,30,31)/t19-/m1/s1
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n/an/a 3.40n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393617
PNG
(CHEMBL2158519)
Show SMILES COc1cc(ccc1Nc1ncc2c(Cl)cc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C28H32ClN7O4S/c1-34(41(3,38)39)23-7-5-4-6-20(23)24-15-21(29)25-16-31-28(33-36(24)25)32-22-9-8-19(14-26(22)40-2)18-10-12-35(13-11-18)17-27(30)37/h4-9,14-16,18H,10-13,17H2,1-3H3,(H2,30,37)(H,32,33)
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n/an/a 4.70n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393613
PNG
(CHEMBL2158518)
Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C29H35N7O4S/c1-19-15-25(22-7-5-6-8-24(22)34(2)41(4,38)39)36-26(19)17-31-29(33-36)32-23-10-9-21(16-27(23)40-3)20-11-13-35(14-12-20)18-28(30)37/h5-10,15-17,20H,11-14,18H2,1-4H3,(H2,30,37)(H,32,33)
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n/an/a 6n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393615
PNG
(CHEMBL2158526)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)C1CCN(C[C@@H](C)O)CC1
Show InChI InChI=1S/C29H36N6O4S/c1-20(36)19-34-15-13-21(14-16-34)22-9-11-25(28(17-22)39-3)31-29-30-18-23-10-12-27(35(23)32-29)24-7-5-6-8-26(24)33(2)40(4,37)38/h5-12,17-18,20-21,36H,13-16,19H2,1-4H3,(H,31,32)/t20-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393616
PNG
(CHEMBL2158525)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)C1CCN(CCO)CC1
Show InChI InChI=1S/C28H34N6O4S/c1-32(39(3,36)37)25-7-5-4-6-23(25)26-11-9-22-19-29-28(31-34(22)26)30-24-10-8-21(18-27(24)38-2)20-12-14-33(15-13-20)16-17-35/h4-11,18-20,35H,12-17H2,1-3H3,(H,30,31)
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n/an/a 6n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50361205
PNG
(CHEMBL1934334)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C27H30N6O3/c1-35-24-6-4-3-5-21(24)23-10-8-20-16-29-27(31-33(20)23)30-22-9-7-19(15-25(22)36-2)18-11-13-32(14-12-18)17-26(28)34/h3-10,15-16,18H,11-14,17H2,1-2H3,(H2,28,34)(H,30,31)
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n/an/a 6n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393614
PNG
(CHEMBL2158529)
Show SMILES COc1ccccc1-c1ccc2cnc(Nc3ccc(cc3OC)C3CCN(C)CC3)nn12
Show InChI InChI=1S/C26H29N5O2/c1-30-14-12-18(13-15-30)19-8-10-22(25(16-19)33-3)28-26-27-17-20-9-11-23(31(20)29-26)21-6-4-5-7-24(21)32-2/h4-11,16-18H,12-15H2,1-3H3,(H,28,29)
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n/an/a 6n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393612
PNG
(CHEMBL2158586)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(CC1)C(=O)C(C)(C)N
Show InChI InChI=1S/C29H34N6O3/c1-29(2,30)27(36)34-15-13-19(14-16-34)20-9-11-23(26(17-20)38-4)32-28-31-18-21-10-12-24(35(21)33-28)22-7-5-6-8-25(22)37-3/h5-12,17-19H,13-16,30H2,1-4H3,(H,32,33)
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n/an/a 7n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393611
PNG
(CHEMBL2158515)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccncc3OC)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C26H29N7O3/c1-35-23-13-18(17-8-11-32(12-9-17)16-25(27)34)3-5-21(23)30-26-29-14-19-4-6-22(33(19)31-26)20-7-10-28-15-24(20)36-2/h3-7,10,13-15,17H,8-9,11-12,16H2,1-2H3,(H2,27,34)(H,30,31)
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n/an/a 9n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393610
PNG
(CHEMBL2158527)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)C1CCNCC1
Show InChI InChI=1S/C26H30N6O3S/c1-31(36(3,33)34)23-7-5-4-6-21(23)24-11-9-20-17-28-26(30-32(20)24)29-22-10-8-19(16-25(22)35-2)18-12-14-27-15-13-18/h4-11,16-18,27H,12-15H2,1-3H3,(H,29,30)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393609
PNG
(CHEMBL2158511)
Show SMILES CNC(=O)CN1CCC(CC1)c1ccc(Nc2ncc3ccc(-c4ccccc4OC)n3n2)c(OC)c1
Show InChI InChI=1S/C28H32N6O3/c1-29-27(35)18-33-14-12-19(13-15-33)20-8-10-23(26(16-20)37-3)31-28-30-17-21-9-11-24(34(21)32-28)22-6-4-5-7-25(22)36-2/h4-11,16-17,19H,12-15,18H2,1-3H3,(H,29,35)(H,31,32)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50353046
PNG
(CHEMBL1822525)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)N1CCN(C[C@H](C)O)CC1
Show InChI InChI=1S/C28H35N7O4S/c1-20(36)19-33-13-15-34(16-14-33)21-9-11-24(27(17-21)39-3)30-28-29-18-22-10-12-26(35(22)31-28)23-7-5-6-8-25(23)32(2)40(4,37)38/h5-12,17-18,20,36H,13-16,19H2,1-4H3,(H,30,31)/t20-/m0/s1
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393607
PNG
(CHEMBL2158517)
Show SMILES COc1cc(ccc1Nc1ncc2c(O)cc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C28H33N7O5S/c1-33(41(3,38)39)22-7-5-4-6-20(22)23-15-25(36)24-16-30-28(32-35(23)24)31-21-9-8-19(14-26(21)40-2)18-10-12-34(13-11-18)17-27(29)37/h4-9,14-16,18,36H,10-13,17H2,1-3H3,(H2,29,37)(H,31,32)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393608
PNG
(CHEMBL2158587)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(CC1)C(=O)C1CCN1
Show InChI InChI=1S/C29H32N6O3/c1-37-26-6-4-3-5-22(26)25-10-8-21-18-31-29(33-35(21)25)32-23-9-7-20(17-27(23)38-2)19-12-15-34(16-13-19)28(36)24-11-14-30-24/h3-10,17-19,24,30H,11-16H2,1-2H3,(H,32,33)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393622
PNG
(CHEMBL2158512)
Show SMILES COc1ccc(-c2ccc3cnc(Nc4ccc(cc4OC)C4CCN(CC(N)=O)CC4)nn23)c(OC)c1
Show InChI InChI=1S/C28H32N6O4/c1-36-21-6-7-22(25(15-21)37-2)24-9-5-20-16-30-28(32-34(20)24)31-23-8-4-19(14-26(23)38-3)18-10-12-33(13-11-18)17-27(29)35/h4-9,14-16,18H,10-13,17H2,1-3H3,(H2,29,35)(H,31,32)
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n/an/a 12n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393625
PNG
(CHEMBL2158521)
Show SMILES COc1cc(N2CCN(C[C@H](C)O)CC2)c(F)cc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1
Show InChI InChI=1S/C28H34FN7O4S/c1-19(37)18-34-11-13-35(14-12-34)26-16-27(40-3)23(15-22(26)29)31-28-30-17-20-9-10-25(36(20)32-28)21-7-5-6-8-24(21)33(2)41(4,38)39/h5-10,15-17,19,37H,11-14,18H2,1-4H3,(H,31,32)/t19-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393624
PNG
(CHEMBL2158516)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C28H33N7O4S/c1-33(40(3,37)38)24-7-5-4-6-22(24)25-11-9-21-17-30-28(32-35(21)25)31-23-10-8-20(16-26(23)39-2)19-12-14-34(15-13-19)18-27(29)36/h4-11,16-17,19H,12-15,18H2,1-3H3,(H2,29,36)(H,31,32)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393623
PNG
(CHEMBL2158513)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3C#N)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C27H27N7O2/c1-36-25-14-19(18-10-12-33(13-11-18)17-26(29)35)6-8-23(25)31-27-30-16-21-7-9-24(34(21)32-27)22-5-3-2-4-20(22)15-28/h2-9,14,16,18H,10-13,17H2,1H3,(H2,29,35)(H,31,32)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393629
PNG
(CHEMBL2158523)
Show SMILES COc1ccc(cc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)N1CCN(C)CC1
Show InChI InChI=1S/C26H31N7O3S/c1-30-13-15-32(16-14-30)19-10-12-25(36-3)22(17-19)28-26-27-18-20-9-11-24(33(20)29-26)21-7-5-6-8-23(21)31(2)37(4,34)35/h5-12,17-18H,13-16H2,1-4H3,(H,28,29)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393620
PNG
(CHEMBL2158531)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(C[C@H](O)CO)CC1
Show InChI InChI=1S/C28H33N5O4/c1-36-26-6-4-3-5-23(26)25-10-8-21-16-29-28(31-33(21)25)30-24-9-7-20(15-27(24)37-2)19-11-13-32(14-12-19)17-22(35)18-34/h3-10,15-16,19,22,34-35H,11-14,17-18H2,1-2H3,(H,30,31)/t22-/m0/s1
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393610
PNG
(CHEMBL2158527)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)C1CCNCC1
Show InChI InChI=1S/C26H30N6O3S/c1-31(36(3,33)34)23-7-5-4-6-21(23)24-11-9-20-17-28-26(30-32(20)24)29-22-10-8-19(16-25(22)35-2)18-12-14-27-15-13-18/h4-11,16-18,27H,12-15H2,1-3H3,(H,29,30)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393628
PNG
(CHEMBL2158520)
Show SMILES COc1c(Nc2ncc3ccc(-c4ccccc4N(C)S(C)(=O)=O)n3n2)ccc(N2CCN(C[C@H](C)O)CC2)c1F
Show InChI InChI=1S/C28H34FN7O4S/c1-19(37)18-34-13-15-35(16-14-34)25-12-10-22(27(40-3)26(25)29)31-28-30-17-20-9-11-24(36(20)32-28)21-7-5-6-8-23(21)33(2)41(4,38)39/h5-12,17,19,37H,13-16,18H2,1-4H3,(H,31,32)/t19-/m0/s1
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50353046
PNG
(CHEMBL1822525)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)N1CCN(C[C@H](C)O)CC1
Show InChI InChI=1S/C28H35N7O4S/c1-20(36)19-33-13-15-34(16-14-33)21-9-11-24(27(17-21)39-3)30-28-29-18-22-10-12-26(35(22)31-28)23-7-5-6-8-25(23)32(2)40(4,37)38/h5-12,17-18,20,36H,13-16,19H2,1-4H3,(H,30,31)/t20-/m0/s1
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393616
PNG
(CHEMBL2158525)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)C1CCN(CCO)CC1
Show InChI InChI=1S/C28H34N6O4S/c1-32(39(3,36)37)25-7-5-4-6-23(25)26-11-9-22-19-29-28(31-34(22)26)30-24-10-8-21(18-27(24)38-2)20-12-14-33(15-13-20)16-17-35/h4-11,18-20,35H,12-17H2,1-3H3,(H,30,31)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393615
PNG
(CHEMBL2158526)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)C1CCN(C[C@@H](C)O)CC1
Show InChI InChI=1S/C29H36N6O4S/c1-20(36)19-34-15-13-21(14-16-34)22-9-11-25(28(17-22)39-3)31-29-30-18-23-10-12-27(35(23)32-29)24-7-5-6-8-26(24)33(2)40(4,37)38/h5-12,17-18,20-21,36H,13-16,19H2,1-4H3,(H,31,32)/t20-/m1/s1
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393614
PNG
(CHEMBL2158529)
Show SMILES COc1ccccc1-c1ccc2cnc(Nc3ccc(cc3OC)C3CCN(C)CC3)nn12
Show InChI InChI=1S/C26H29N5O2/c1-30-14-12-18(13-15-30)19-8-10-22(25(16-19)33-3)28-26-27-17-20-9-11-23(31(20)29-26)21-6-4-5-7-24(21)32-2/h4-11,16-18H,12-15H2,1-3H3,(H,28,29)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393613
PNG
(CHEMBL2158518)
Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C29H35N7O4S/c1-19-15-25(22-7-5-6-8-24(22)34(2)41(4,38)39)36-26(19)17-31-29(33-36)32-23-10-9-21(16-27(23)40-3)20-11-13-35(14-12-20)18-28(30)37/h5-10,15-17,20H,11-14,18H2,1-4H3,(H2,30,37)(H,32,33)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393617
PNG
(CHEMBL2158519)
Show SMILES COc1cc(ccc1Nc1ncc2c(Cl)cc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C28H32ClN7O4S/c1-34(41(3,38)39)23-7-5-4-6-20(23)24-15-21(29)25-16-31-28(33-36(24)25)32-22-9-8-19(14-26(22)40-2)18-10-12-35(13-11-18)17-27(30)37/h4-9,14-16,18H,10-13,17H2,1-3H3,(H2,30,37)(H,32,33)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393619
PNG
(CHEMBL2158530)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(CC(O)CF)CC1
Show InChI InChI=1S/C28H32FN5O3/c1-36-26-6-4-3-5-23(26)25-10-8-21-17-30-28(32-34(21)25)31-24-9-7-20(15-27(24)37-2)19-11-13-33(14-12-19)18-22(35)16-29/h3-10,15,17,19,22,35H,11-14,16,18H2,1-2H3,(H,31,32)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393624
PNG
(CHEMBL2158516)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C28H33N7O4S/c1-33(40(3,37)38)24-7-5-4-6-22(24)25-11-9-21-17-30-28(32-35(21)25)31-23-10-8-20(16-26(23)39-2)19-12-14-34(15-13-19)18-27(29)36/h4-11,16-17,19H,12-15,18H2,1-3H3,(H2,29,36)(H,31,32)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393627
PNG
(CHEMBL2158522)
Show SMILES C[C@H](O)CN1CCN(CC1)c1cc(F)c(Nc2ncc3ccc(-c4ccccc4N(C)S(C)(=O)=O)n3n2)cc1F
Show InChI InChI=1S/C27H31F2N7O3S/c1-18(37)17-34-10-12-35(13-11-34)26-15-21(28)23(14-22(26)29)31-27-30-16-19-8-9-25(36(19)32-27)20-6-4-5-7-24(20)33(2)40(3,38)39/h4-9,14-16,18,37H,10-13,17H2,1-3H3,(H,31,32)/t18-/m0/s1
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393609
PNG
(CHEMBL2158511)
Show SMILES CNC(=O)CN1CCC(CC1)c1ccc(Nc2ncc3ccc(-c4ccccc4OC)n3n2)c(OC)c1
Show InChI InChI=1S/C28H32N6O3/c1-29-27(35)18-33-14-12-19(13-15-33)20-8-10-23(26(16-20)37-3)31-28-30-17-21-9-11-24(34(21)32-28)22-6-4-5-7-25(22)36-2/h4-11,16-17,19H,12-15,18H2,1-3H3,(H,29,35)(H,31,32)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393618
PNG
(CHEMBL2158528)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(C[C@@H](C)O)CC1
Show InChI InChI=1S/C28H33N5O3/c1-19(34)18-32-14-12-20(13-15-32)21-8-10-24(27(16-21)36-3)30-28-29-17-22-9-11-25(33(22)31-28)23-6-4-5-7-26(23)35-2/h4-11,16-17,19-20,34H,12-15,18H2,1-3H3,(H,30,31)/t19-/m1/s1
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50361205
PNG
(CHEMBL1934334)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C27H30N6O3/c1-35-24-6-4-3-5-21(24)23-10-8-20-16-29-27(31-33(20)23)30-22-9-7-19(15-25(22)36-2)18-11-13-32(14-12-18)17-26(28)34/h3-10,15-16,18H,11-14,17H2,1-2H3,(H2,28,34)(H,30,31)
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Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50393619
PNG
(CHEMBL2158530)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(CC(O)CF)CC1
Show InChI InChI=1S/C28H32FN5O3/c1-36-26-6-4-3-5-23(26)25-10-8-21-17-30-28(32-34(21)25)31-24-9-7-20(15-27(24)37-2)19-11-13-33(14-12-19)18-22(35)16-29/h3-10,15,17,19,22,35H,11-14,16,18H2,1-2H3,(H,31,32)
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n/an/a 149n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393611
PNG
(CHEMBL2158515)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccncc3OC)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C26H29N7O3/c1-35-23-13-18(17-8-11-32(12-9-17)16-25(27)34)3-5-21(23)30-26-29-14-19-4-6-22(33(19)31-26)20-7-10-28-15-24(20)36-2/h3-7,10,13-15,17H,8-9,11-12,16H2,1-2H3,(H2,27,34)(H,30,31)
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n/an/a 150n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393612
PNG
(CHEMBL2158586)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(CC1)C(=O)C(C)(C)N
Show InChI InChI=1S/C29H34N6O3/c1-29(2,30)27(36)34-15-13-19(14-16-34)20-9-11-23(26(17-20)38-4)32-28-31-18-21-10-12-24(35(21)33-28)22-7-5-6-8-25(22)37-3/h5-12,17-19H,13-16,30H2,1-4H3,(H,32,33)
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n/an/a 150n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50393609
PNG
(CHEMBL2158511)
Show SMILES CNC(=O)CN1CCC(CC1)c1ccc(Nc2ncc3ccc(-c4ccccc4OC)n3n2)c(OC)c1
Show InChI InChI=1S/C28H32N6O3/c1-29-27(35)18-33-14-12-19(13-15-33)20-8-10-23(26(16-20)37-3)31-28-30-17-21-9-11-24(34(21)32-28)22-6-4-5-7-25(22)36-2/h4-11,16-17,19H,12-15,18H2,1-3H3,(H,29,35)(H,31,32)
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n/an/a 161n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50393620
PNG
(CHEMBL2158531)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(C[C@H](O)CO)CC1
Show InChI InChI=1S/C28H33N5O4/c1-36-26-6-4-3-5-23(26)25-10-8-21-16-29-28(31-33(21)25)30-24-9-7-20(15-27(24)37-2)19-11-13-32(14-12-19)17-22(35)18-34/h3-10,15-16,19,22,34-35H,11-14,17-18H2,1-2H3,(H,30,31)/t22-/m0/s1
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n/an/a 164n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393626
PNG
(CHEMBL2158524)
Show SMILES COc1ccc(cc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)N1CCN(C)CC1
Show InChI InChI=1S/C25H28N6O2/c1-29-12-14-30(15-13-29)18-9-11-24(33-3)21(16-18)27-25-26-17-19-8-10-22(31(19)28-25)20-6-4-5-7-23(20)32-2/h4-11,16-17H,12-15H2,1-3H3,(H,27,28)
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n/an/a 187n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393608
PNG
(CHEMBL2158587)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(CC1)C(=O)C1CCN1
Show InChI InChI=1S/C29H32N6O3/c1-37-26-6-4-3-5-22(26)25-10-8-21-18-31-29(33-35(21)25)32-23-9-7-20(17-27(23)38-2)19-12-15-34(16-13-19)28(36)24-11-14-30-24/h3-10,17-19,24,30H,11-16H2,1-2H3,(H,32,33)
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n/an/a 200n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393625
PNG
(CHEMBL2158521)
Show SMILES COc1cc(N2CCN(C[C@H](C)O)CC2)c(F)cc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1
Show InChI InChI=1S/C28H34FN7O4S/c1-19(37)18-34-11-13-35(14-12-34)26-16-27(40-3)23(15-22(26)29)31-28-30-17-20-9-10-25(36(20)32-28)21-7-5-6-8-24(21)33(2)41(4,38)39/h5-10,15-17,19,37H,11-14,18H2,1-4H3,(H,31,32)/t19-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50361205
PNG
(CHEMBL1934334)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C27H30N6O3/c1-35-24-6-4-3-5-21(24)23-10-8-20-16-29-27(31-33(20)23)30-22-9-7-19(15-25(22)36-2)18-11-13-32(14-12-18)17-26(28)34/h3-10,15-16,18H,11-14,17H2,1-2H3,(H2,28,34)(H,30,31)
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n/an/a 222n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50393614
PNG
(CHEMBL2158529)
Show SMILES COc1ccccc1-c1ccc2cnc(Nc3ccc(cc3OC)C3CCN(C)CC3)nn12
Show InChI InChI=1S/C26H29N5O2/c1-30-14-12-18(13-15-30)19-8-10-22(25(16-19)33-3)28-26-27-17-20-9-11-23(31(20)29-26)21-6-4-5-7-24(21)32-2/h4-11,16-18H,12-15H2,1-3H3,(H,28,29)
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n/an/a 222n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393623
PNG
(CHEMBL2158513)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3C#N)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C27H27N7O2/c1-36-25-14-19(18-10-12-33(13-11-18)17-26(29)35)6-8-23(25)31-27-30-16-21-7-9-24(34(21)32-27)22-5-3-2-4-20(22)15-28/h2-9,14,16,18H,10-13,17H2,1H3,(H2,29,35)(H,31,32)
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n/an/a 250n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50393608
PNG
(CHEMBL2158587)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(CC1)C(=O)C1CCN1
Show InChI InChI=1S/C29H32N6O3/c1-37-26-6-4-3-5-22(26)25-10-8-21-18-31-29(33-35(21)25)32-23-9-7-20(17-27(23)38-2)19-12-15-34(16-13-19)28(36)24-11-14-30-24/h3-10,17-19,24,30H,11-16H2,1-2H3,(H,32,33)
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n/an/a 335n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50393611
PNG
(CHEMBL2158515)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccncc3OC)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C26H29N7O3/c1-35-23-13-18(17-8-11-32(12-9-17)16-25(27)34)3-5-21(23)30-26-29-14-19-4-6-22(33(19)31-26)20-7-10-28-15-24(20)36-2/h3-7,10,13-15,17H,8-9,11-12,16H2,1-2H3,(H2,27,34)(H,30,31)
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n/an/a 410n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin


(Homo sapiens (Human))
BDBM50393622
PNG
(CHEMBL2158512)
Show SMILES COc1ccc(-c2ccc3cnc(Nc4ccc(cc4OC)C4CCN(CC(N)=O)CC4)nn23)c(OC)c1
Show InChI InChI=1S/C28H32N6O4/c1-36-21-6-7-22(25(15-21)37-2)24-9-5-20-16-30-28(32-34(20)24)31-23-8-4-19(14-26(23)38-3)18-10-12-33(13-11-18)17-27(29)35/h4-9,14-16,18H,10-13,17H2,1-3H3,(H2,29,35)(H,31,32)
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n/an/a 500n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assay


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50393624
PNG
(CHEMBL2158516)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C28H33N7O4S/c1-33(40(3,37)38)24-7-5-4-6-22(24)25-11-9-21-17-30-28(32-35(21)25)31-23-10-8-20(16-26(23)39-2)19-12-14-34(15-13-19)18-27(29)36/h4-11,16-17,19H,12-15,18H2,1-3H3,(H2,29,36)(H,31,32)
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n/an/a 552n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50393612
PNG
(CHEMBL2158586)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1)C1CCN(CC1)C(=O)C(C)(C)N
Show InChI InChI=1S/C29H34N6O3/c1-29(2,30)27(36)34-15-13-19(14-16-34)20-9-11-23(26(17-20)38-4)32-28-31-18-21-10-12-24(35(21)33-28)22-7-5-6-8-25(22)37-3/h5-12,17-19H,13-16,30H2,1-4H3,(H,32,33)
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n/an/a 579n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50393623
PNG
(CHEMBL2158513)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ccccc3C#N)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C27H27N7O2/c1-36-25-14-19(18-10-12-33(13-11-18)17-26(29)35)6-8-23(25)31-27-30-16-21-7-9-24(34(21)32-27)22-5-3-2-4-20(22)15-28/h2-9,14,16,18H,10-13,17H2,1H3,(H2,29,35)(H,31,32)
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n/an/a 747n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50393621
PNG
(CHEMBL2158514)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ncccc3OC)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C26H29N7O3/c1-35-22-4-3-11-28-25(22)21-8-6-19-15-29-26(31-33(19)21)30-20-7-5-18(14-23(20)36-2)17-9-12-32(13-10-17)16-24(27)34/h3-8,11,14-15,17H,9-10,12-13,16H2,1-2H3,(H2,27,34)(H,30,31)
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n/an/a 1.06E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human ALK cytoplasmic domain (1058-1620) expressed in Sf21 insect cells using GST-tagged human recombinant PLC-gamma/substra...


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50393622
PNG
(CHEMBL2158512)
Show SMILES COc1ccc(-c2ccc3cnc(Nc4ccc(cc4OC)C4CCN(CC(N)=O)CC4)nn23)c(OC)c1
Show InChI InChI=1S/C28H32N6O4/c1-36-21-6-7-22(25(15-21)37-2)24-9-5-20-16-30-28(32-34(20)24)31-23-8-4-19(14-26(23)38-3)18-10-12-33(13-11-18)17-27(29)35/h4-9,14-16,18H,10-13,17H2,1-3H3,(H2,29,35)(H,31,32)
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n/an/a 2.97E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50393621
PNG
(CHEMBL2158514)
Show SMILES COc1cc(ccc1Nc1ncc2ccc(-c3ncccc3OC)n2n1)C1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C26H29N7O3/c1-35-22-4-3-11-28-25(22)21-8-6-19-15-29-26(31-33(19)21)30-20-7-5-18(14-23(20)36-2)17-9-12-32(13-10-17)16-24(27)34/h3-8,11,14-15,17H,9-10,12-13,16H2,1-2H3,(H2,27,34)(H,30,31)
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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IR


J Med Chem 55: 115-25 (2012)


Article DOI: 10.1021/jm2010767
BindingDB Entry DOI: 10.7270/Q2G73FV3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%