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PubMed code 22264481

Compile data set for download or QSAR
Found 58 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50364553
PNG
(CHEMBL1951022)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H29N5O5S/c1-13(2)30-21(27)26-10-8-16(9-11-26)31-20-14(3)19(22-12-23-20)25-17-6-7-18(24-15(17)4)32(5,28)29/h6-7,12-13,16H,8-11H2,1-5H3,(H,22,23,25)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50364541
PNG
(CHEMBL1951011)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(cc2F)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H26FN3O6S/c1-13(2)29-21(26)25-9-7-15(8-10-25)30-19-14(3)20(24-12-23-19)31-18-6-5-16(11-17(18)22)32(4,27)28/h5-6,11-13,15H,7-10H2,1-4H3
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n/an/a 5.30E+3n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50364559
PNG
(CHEMBL1951032)
Show SMILES COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50364559
PNG
(CHEMBL1951032)
Show SMILES COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human ERG


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50364559
PNG
(CHEMBL1951032)
Show SMILES COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364540
PNG
(CHEMBL1951026)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccncc2C)c1C
Show InChI InChI=1S/C20H26N4O4/c1-13(2)26-20(25)24-9-6-16(7-10-24)27-18-15(4)19(23-12-22-18)28-17-5-8-21-11-14(17)3/h5,8,11-13,16H,6-7,9-10H2,1-4H3
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n/an/an/an/a>5.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50341309
PNG
(CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cccnc2C)c1C
Show InChI InChI=1S/C20H26N4O4/c1-13(2)26-20(25)24-10-7-16(8-11-24)27-18-14(3)19(23-12-22-18)28-17-6-5-9-21-15(17)4/h5-6,9,12-13,16H,7-8,10-11H2,1-4H3
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n/an/an/an/a 83n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364547
PNG
(CHEMBL1951017)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cnccc2C)c1C
Show InChI InChI=1S/C20H26N4O4/c1-13(2)26-20(25)24-9-6-16(7-10-24)27-18-15(4)19(23-12-22-18)28-17-11-21-8-5-14(17)3/h5,8,11-13,16H,6-7,9-10H2,1-4H3
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n/an/an/an/a>4.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364549
PNG
(CHEMBL1951018)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cncc(F)c2)c1C
Show InChI InChI=1S/C19H23FN4O4/c1-12(2)26-19(25)24-6-4-15(5-7-24)27-17-13(3)18(23-11-22-17)28-16-8-14(20)9-21-10-16/h8-12,15H,4-7H2,1-3H3
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n/an/an/an/a 530n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364553
PNG
(CHEMBL1951022)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H29N5O5S/c1-13(2)30-21(27)26-10-8-16(9-11-26)31-20-14(3)19(22-12-23-20)25-17-6-7-18(24-15(17)4)32(5,28)29/h6-7,12-13,16H,8-11H2,1-5H3,(H,22,23,25)
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n/an/an/an/a 920n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364560
PNG
(CHEMBL1951033)
Show SMILES CCOc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C22H31N5O6S/c1-6-31-19-20(26-17-7-8-18(25-15(17)4)34(5,29)30)23-13-24-21(19)33-16-9-11-27(12-10-16)22(28)32-14(2)3/h7-8,13-14,16H,6,9-12H2,1-5H3,(H,23,24,26)
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n/an/an/an/a 486n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364565
PNG
(CHEMBL1949688)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1cc(Nc2ccc(nc2[N+]([O-])=O)S(C)(=O)=O)ncn1
Show InChI InChI=1S/C19H24N6O7S/c1-12(2)31-19(26)24-8-6-13(7-9-24)32-16-10-15(20-11-21-16)22-14-4-5-17(33(3,29)30)23-18(14)25(27)28/h4-5,10-13H,6-9H2,1-3H3,(H,20,21,22)
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n/an/an/an/a>5.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364545
PNG
(CHEMBL1951015)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2cccnc2C)c1C
Show InChI InChI=1S/C20H27N5O3/c1-13(2)27-20(26)25-10-7-16(8-11-25)28-19-14(3)18(22-12-23-19)24-17-6-5-9-21-15(17)4/h5-6,9,12-13,16H,7-8,10-11H2,1-4H3,(H,22,23,24)
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n/an/an/an/a 92n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364547
PNG
(CHEMBL1951017)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cnccc2C)c1C
Show InChI InChI=1S/C20H26N4O4/c1-13(2)26-20(25)24-9-6-16(7-10-24)27-18-15(4)19(23-12-22-18)28-17-11-21-8-5-14(17)3/h5,8,11-13,16H,6-7,9-10H2,1-4H3
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n/an/an/an/a 490n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364551
PNG
(CHEMBL1951020)
Show SMILES COc1ccc(Oc2ncnc(OC3CCN(CC3)C(=O)OC(C)C)c2C)c(C)n1
Show InChI InChI=1S/C21H28N4O5/c1-13(2)28-21(26)25-10-8-16(9-11-25)29-19-14(3)20(23-12-22-19)30-17-6-7-18(27-5)24-15(17)4/h6-7,12-13,16H,8-11H2,1-5H3
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n/an/an/an/a 132n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364539
PNG
(CHEMBL1951025)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2cnc(cc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H29N5O5S/c1-13(2)30-21(27)26-8-6-16(7-9-26)31-20-15(4)19(23-12-24-20)25-17-11-22-18(10-14(17)3)32(5,28)29/h10-13,16H,6-9H2,1-5H3,(H,23,24,25)
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n/an/an/an/a 250n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364545
PNG
(CHEMBL1951015)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2cccnc2C)c1C
Show InChI InChI=1S/C20H27N5O3/c1-13(2)27-20(26)25-10-7-16(8-11-25)28-19-14(3)18(22-12-23-19)24-17-6-5-9-21-15(17)4/h5-6,9,12-13,16H,7-8,10-11H2,1-4H3,(H,22,23,24)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364548
PNG
(CHEMBL1949674)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(C)nc2C)c1C
Show InChI InChI=1S/C21H28N4O4/c1-13(2)27-21(26)25-10-8-17(9-11-25)28-19-15(4)20(23-12-22-19)29-18-7-6-14(3)24-16(18)5/h6-7,12-13,17H,8-11H2,1-5H3
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n/an/an/an/a 5.40n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364566
PNG
(CHEMBL1951118)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1cc(Nc2ccc(cc2F)S(C)(=O)=O)ncn1
Show InChI InChI=1S/C20H25FN4O5S/c1-13(2)29-20(26)25-8-6-14(7-9-25)30-19-11-18(22-12-23-19)24-17-5-4-15(10-16(17)21)31(3,27)28/h4-5,10-14H,6-9H2,1-3H3,(H,22,23,24)
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n/an/an/an/a 31n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364538
PNG
(CHEMBL1951024)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cnc(cc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H28N4O6S/c1-13(2)29-21(26)25-8-6-16(7-9-25)30-19-15(4)20(24-12-23-19)31-17-11-22-18(10-14(17)3)32(5,27)28/h10-13,16H,6-9H2,1-5H3
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364542
PNG
(CHEMBL1951012)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H27FN4O5S/c1-13(2)30-21(27)26-9-7-15(8-10-26)31-20-14(3)19(23-12-24-20)25-18-6-5-16(11-17(18)22)32(4,28)29/h5-6,11-13,15H,7-10H2,1-4H3,(H,23,24,25)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364544
PNG
(CHEMBL1951014)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(c(C)n2)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H29N5O5S/c1-13(2)30-21(27)26-10-8-16(9-11-26)31-20-14(3)19(22-12-23-20)25-18-7-6-17(15(4)24-18)32(5,28)29/h6-7,12-13,16H,8-11H2,1-5H3,(H,22,23,24,25)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364554
PNG
(CHEMBL1951027)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1cc(Nc2ccc(nc2C)S(C)(=O)=O)ncn1
Show InChI InChI=1S/C20H27N5O5S/c1-13(2)29-20(26)25-9-7-15(8-10-25)30-18-11-17(21-12-22-18)24-16-5-6-19(23-14(16)3)31(4,27)28/h5-6,11-13,15H,7-10H2,1-4H3,(H,21,22,24)
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n/an/an/an/a 2.33E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364559
PNG
(CHEMBL1951032)
Show SMILES COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
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n/an/an/an/a 46n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364560
PNG
(CHEMBL1951033)
Show SMILES CCOc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C22H31N5O6S/c1-6-31-19-20(26-17-7-8-18(25-15(17)4)34(5,29)30)23-13-24-21(19)33-16-9-11-27(12-10-16)22(28)32-14(2)3/h7-8,13-14,16H,6,9-12H2,1-5H3,(H,23,24,26)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364563
PNG
(CHEMBL1951115)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1OC(F)F
Show InChI InChI=1S/C21H27F2N5O6S/c1-12(2)32-21(29)28-9-7-14(8-10-28)33-19-17(34-20(22)23)18(24-11-25-19)27-15-5-6-16(26-13(15)3)35(4,30)31/h5-6,11-12,14,20H,7-10H2,1-4H3,(H,24,25,27)
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n/an/an/an/a 115n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364555
PNG
(CHEMBL1951028)
Show SMILES CCc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C22H31N5O5S/c1-6-17-20(26-18-7-8-19(25-15(18)4)33(5,29)30)23-13-24-21(17)32-16-9-11-27(12-10-16)22(28)31-14(2)3/h7-8,13-14,16H,6,9-12H2,1-5H3,(H,23,24,26)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364552
PNG
(CHEMBL1951021)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H28N4O6S/c1-13(2)29-21(26)25-10-8-16(9-11-25)30-19-14(3)20(23-12-22-19)31-17-6-7-18(24-15(17)4)32(5,27)28/h6-7,12-13,16H,8-11H2,1-5H3
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n/an/an/an/a 25n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364543
PNG
(CHEMBL1951013)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ncc(cc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H29N5O5S/c1-13(2)30-21(27)26-8-6-16(7-9-26)31-20-15(4)19(23-12-24-20)25-18-14(3)10-17(11-22-18)32(5,28)29/h10-13,16H,6-9H2,1-5H3,(H,22,23,24,25)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364540
PNG
(CHEMBL1951026)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccncc2C)c1C
Show InChI InChI=1S/C20H26N4O4/c1-13(2)26-20(25)24-9-6-16(7-10-24)27-18-15(4)19(23-12-22-18)28-17-5-8-21-11-14(17)3/h5,8,11-13,16H,6-7,9-10H2,1-4H3
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364559
PNG
(CHEMBL1951032)
Show SMILES COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364553
PNG
(CHEMBL1951022)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H29N5O5S/c1-13(2)30-21(27)26-10-8-16(9-11-26)31-20-14(3)19(22-12-23-20)25-17-6-7-18(24-15(17)4)32(5,28)29/h6-7,12-13,16H,8-11H2,1-5H3,(H,22,23,25)
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n/an/an/an/a 131n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364550
PNG
(CHEMBL1951019)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cncc(c2)C#N)c1C
Show InChI InChI=1S/C20H23N5O4/c1-13(2)27-20(26)25-6-4-16(5-7-25)28-18-14(3)19(24-12-23-18)29-17-8-15(9-21)10-22-11-17/h8,10-13,16H,4-7H2,1-3H3
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n/an/an/an/a 1.75E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364537
PNG
(CHEMBL1951023)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2)S(C)(=O)=O)c1C
Show InChI InChI=1S/C20H27N5O5S/c1-13(2)29-20(26)25-9-7-16(8-10-25)30-19-14(3)18(22-12-23-19)24-15-5-6-17(21-11-15)31(4,27)28/h5-6,11-13,16H,7-10H2,1-4H3,(H,22,23,24)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364538
PNG
(CHEMBL1951024)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cnc(cc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H28N4O6S/c1-13(2)29-21(26)25-8-6-16(7-9-25)30-19-15(4)20(24-12-23-19)31-17-11-22-18(10-14(17)3)32(5,27)28/h10-13,16H,6-9H2,1-5H3
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364539
PNG
(CHEMBL1951025)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2cnc(cc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H29N5O5S/c1-13(2)30-21(27)26-8-6-16(7-9-26)31-20-15(4)19(23-12-24-20)25-17-11-22-18(10-14(17)3)32(5,28)29/h10-13,16H,6-9H2,1-5H3,(H,23,24,25)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364556
PNG
(CHEMBL1951029)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1C1CC1
Show InChI InChI=1S/C23H31N5O5S/c1-14(2)32-23(29)28-11-9-17(10-12-28)33-22-20(16-5-6-16)21(24-13-25-22)27-18-7-8-19(26-15(18)3)34(4,30)31/h7-8,13-14,16-17H,5-6,9-12H2,1-4H3,(H,24,25,27)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364558
PNG
(CHEMBL1951031)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1CO
Show InChI InChI=1S/C21H29N5O6S/c1-13(2)31-21(28)26-9-7-15(8-10-26)32-20-16(11-27)19(22-12-23-20)25-17-5-6-18(24-14(17)3)33(4,29)30/h5-6,12-13,15,27H,7-11H2,1-4H3,(H,22,23,25)
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n/an/an/an/a 1.10E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364544
PNG
(CHEMBL1951014)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(c(C)n2)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H29N5O5S/c1-13(2)30-21(27)26-10-8-16(9-11-26)31-20-14(3)19(22-12-23-20)25-18-7-6-17(15(4)24-18)32(5,28)29/h6-7,12-13,16H,8-11H2,1-5H3,(H,22,23,24,25)
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364548
PNG
(CHEMBL1949674)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(C)nc2C)c1C
Show InChI InChI=1S/C21H28N4O4/c1-13(2)27-21(26)25-10-8-17(9-11-25)28-19-15(4)20(23-12-22-19)29-18-7-6-14(3)24-16(18)5/h6-7,12-13,17H,8-11H2,1-5H3
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n/an/an/an/a 270n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364552
PNG
(CHEMBL1951021)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(nc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H28N4O6S/c1-13(2)29-21(26)25-10-8-16(9-11-25)30-19-14(3)20(23-12-22-19)31-17-6-7-18(24-15(17)4)32(5,27)28/h6-7,12-13,16H,8-11H2,1-5H3
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n/an/an/an/a 190n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364561
PNG
(CHEMBL1951034)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1OC(C)C
Show InChI InChI=1S/C23H33N5O6S/c1-14(2)32-20-21(27-18-7-8-19(26-16(18)5)35(6,30)31)24-13-25-22(20)34-17-9-11-28(12-10-17)23(29)33-15(3)4/h7-8,13-15,17H,9-12H2,1-6H3,(H,24,25,27)
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n/an/an/an/a 71n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364543
PNG
(CHEMBL1951013)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ncc(cc2C)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H29N5O5S/c1-13(2)30-21(27)26-8-6-16(7-9-26)31-20-15(4)19(23-12-24-20)25-18-14(3)10-17(11-22-18)32(5,28)29/h10-13,16H,6-9H2,1-5H3,(H,22,23,24,25)
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n/an/an/an/a 235n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364546
PNG
(CHEMBL1951016)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2cccnc2)c1C
Show InChI InChI=1S/C19H25N5O3/c1-13(2)26-19(25)24-9-6-16(7-10-24)27-18-14(3)17(21-12-22-18)23-15-5-4-8-20-11-15/h4-5,8,11-13,16H,6-7,9-10H2,1-3H3,(H,21,22,23)
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n/an/an/an/a>5.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364551
PNG
(CHEMBL1951020)
Show SMILES COc1ccc(Oc2ncnc(OC3CCN(CC3)C(=O)OC(C)C)c2C)c(C)n1
Show InChI InChI=1S/C21H28N4O5/c1-13(2)28-21(26)25-10-8-16(9-11-25)29-19-14(3)20(23-12-22-19)30-17-6-7-18(27-5)24-15(17)4/h6-7,12-13,16H,8-11H2,1-5H3
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Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364555
PNG
(CHEMBL1951028)
Show SMILES CCc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C
Show InChI InChI=1S/C22H31N5O5S/c1-6-17-20(26-18-7-8-19(25-15(18)4)33(5,29)30)23-13-24-21(17)32-16-9-11-27(12-10-16)22(28)31-14(2)3/h7-8,13-14,16H,6,9-12H2,1-5H3,(H,23,24,26)
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n/an/an/an/a 50n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364557
PNG
(CHEMBL1951030)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1C(F)F
Show InChI InChI=1S/C21H27F2N5O5S/c1-12(2)32-21(29)28-9-7-14(8-10-28)33-20-17(18(22)23)19(24-11-25-20)27-15-5-6-16(26-13(15)3)34(4,30)31/h5-6,11-12,14,18H,7-10H2,1-4H3,(H,24,25,27)
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n/an/an/an/a 47n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364562
PNG
(CHEMBL1951114)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1O
Show InChI InChI=1S/C20H27N5O6S/c1-12(2)30-20(27)25-9-7-14(8-10-25)31-19-17(26)18(21-11-22-19)24-15-5-6-16(23-13(15)3)32(4,28)29/h5-6,11-12,14,26H,7-10H2,1-4H3,(H,21,22,24)
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n/an/an/an/a 1.32E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364564
PNG
(CHEMBL1951116)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2C)S(C)(=O)=O)c1C#N
Show InChI InChI=1S/C21H26N6O5S/c1-13(2)31-21(28)27-9-7-15(8-10-27)32-20-16(11-22)19(23-12-24-20)26-17-5-6-18(25-14(17)3)33(4,29)30/h5-6,12-13,15H,7-10H2,1-4H3,(H,23,24,26)
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n/an/an/an/a 120n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364565
PNG
(CHEMBL1949688)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1cc(Nc2ccc(nc2[N+]([O-])=O)S(C)(=O)=O)ncn1
Show InChI InChI=1S/C19H24N6O7S/c1-12(2)31-19(26)24-8-6-13(7-9-24)32-16-10-15(20-11-21-16)22-14-4-5-17(33(3,29)30)23-18(14)25(27)28/h4-5,10-13H,6-9H2,1-3H3,(H,20,21,22)
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n/an/an/an/a 1.41E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364542
PNG
(CHEMBL1951012)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H27FN4O5S/c1-13(2)30-21(27)26-9-7-15(8-10-26)31-20-14(3)19(23-12-24-20)25-18-6-5-16(11-17(18)22)32(4,28)29/h5-6,11-13,15H,7-10H2,1-4H3,(H,23,24,25)
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n/an/an/an/a 34n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364541
PNG
(CHEMBL1951011)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(cc2F)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H26FN3O6S/c1-13(2)29-21(26)25-9-7-15(8-10-25)30-19-14(3)20(24-12-23-19)31-18-6-5-16(11-17(18)22)32(4,27)28/h5-6,11-13,15H,7-10H2,1-4H3
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n/an/an/an/a 9.70n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364537
PNG
(CHEMBL1951023)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2ccc(nc2)S(C)(=O)=O)c1C
Show InChI InChI=1S/C20H27N5O5S/c1-13(2)29-20(26)25-9-7-16(8-10-25)30-19-14(3)18(22-12-23-19)24-15-5-6-17(21-11-15)31(4,27)28/h5-6,11-13,16H,7-10H2,1-4H3,(H,22,23,24)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364549
PNG
(CHEMBL1951018)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cncc(F)c2)c1C
Show InChI InChI=1S/C19H23FN4O4/c1-12(2)26-19(25)24-6-4-15(5-7-24)27-17-13(3)18(23-11-22-17)28-16-8-14(20)9-21-10-16/h8-12,15H,4-7H2,1-3H3
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n/an/an/an/a 210n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50341309
PNG
(CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cccnc2C)c1C
Show InChI InChI=1S/C20H26N4O4/c1-13(2)26-20(25)24-10-7-16(8-11-24)27-18-14(3)19(23-12-22-18)28-17-6-5-9-21-15(17)4/h5-6,9,12-13,16H,7-8,10-11H2,1-4H3
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n/an/an/an/a 7.30n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364550
PNG
(CHEMBL1951019)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2cncc(c2)C#N)c1C
Show InChI InChI=1S/C20H23N5O4/c1-13(2)27-20(26)25-6-4-16(5-7-25)28-18-14(3)19(24-12-23-18)29-17-8-15(9-21)10-22-11-17/h8,10-13,16H,4-7H2,1-3H3
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n/an/an/an/a 260n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364541
PNG
(CHEMBL1951011)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(cc2F)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H26FN3O6S/c1-13(2)29-21(26)25-9-7-15(8-10-25)30-19-14(3)20(24-12-23-19)31-18-6-5-16(11-17(18)22)32(4,27)28/h5-6,11-13,15H,7-10H2,1-4H3
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n/an/an/an/a 55n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Rattus norvegicus)
BDBM50364546
PNG
(CHEMBL1951016)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Nc2cccnc2)c1C
Show InChI InChI=1S/C19H25N5O3/c1-13(2)26-19(25)24-9-6-16(7-10-24)27-18-14(3)17(21-12-22-18)23-15-5-4-8-20-11-15/h4-5,8,11-13,16H,6-7,9-10H2,1-3H3,(H,21,22,23)
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n/an/an/an/a>5.00E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at rat GPR119 receptor assessed as cAMP production by HTRF assay


Bioorg Med Chem Lett 22: 1750-5 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.092
BindingDB Entry DOI: 10.7270/Q26H4HW1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%