BindingDB logo
myBDB logout

PubMed code 22266037

Compile data set for download or QSAR
Found 2 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM50364742
PNG
(CHEMBL1951891)
Show SMILES CCOC(=O)c1ccc(Nc2cc(C)nc(Nc3ccc(cc3)C(=O)OCC)n2)cc1
Show InChI InChI=1S/C23H24N4O4/c1-4-30-21(28)16-6-10-18(11-7-16)25-20-14-15(3)24-23(27-20)26-19-12-8-17(9-13-19)22(29)31-5-2/h6-14H,4-5H2,1-3H3,(H2,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDK1 using P2925 peptide as substrate by fluorescence polarization assay


Bioorg Med Chem Lett 22: 1629-32 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.121
BindingDB Entry DOI: 10.7270/Q29887GC
More data for this
Ligand-Target Pair
3-phosphoinositide dependent protein kinase-1


(Homo sapiens (human))
BDBM11639
PNG
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

DrugBank
Article
PubMed
n/an/a 4.80E+4n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of recombinant PDK1 using RPRAATF as substrate by scintillation counting


Bioorg Med Chem Lett 22: 1629-32 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.121
BindingDB Entry DOI: 10.7270/Q29887GC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%