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PubMed code 22313242

Compile data set for download or QSAR
Found 146 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383163
PNG
(CHEMBL2031885)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-28(20)17-18-30-16-12-24-19-23(10-11-25(24)27(30)32)21-6-8-22(9-7-21)26(31)29-13-2-3-14-29/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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0.200n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383144
PNG
(CHEMBL2031864)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(Oc3ccc(nc3)C#N)ccc2C1=O
Show InChI InChI=1S/C22H24N4O2/c1-16-3-2-9-25(16)11-12-26-10-8-17-13-19(6-7-21(17)22(26)27)28-20-5-4-18(14-23)24-15-20/h4-7,13,15-16H,2-3,8-12H2,1H3/t16-/m1/s1
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0.300n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50354216
PNG
(CHEMBL1836004)
Show SMILES Cc1nc2ccccc2n1-c1ccc(cc1)C(=O)N1CC[C@@H](C1)N1CCCC1
Show InChI InChI=1S/C23H26N4O/c1-17-24-21-6-2-3-7-22(21)27(17)19-10-8-18(9-11-19)23(28)26-15-12-20(16-26)25-13-4-5-14-25/h2-3,6-11,20H,4-5,12-16H2,1H3/t20-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383142
PNG
(CHEMBL2031862)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(Oc3ccc(cc3)C#N)ccc2C1=O
Show InChI InChI=1S/C23H25N3O2/c1-17-3-2-11-25(17)13-14-26-12-10-19-15-21(8-9-22(19)23(26)27)28-20-6-4-18(16-24)5-7-20/h4-9,15,17H,2-3,10-14H2,1H3/t17-/m1/s1
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0.600n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383138
PNG
(CHEMBL2031762)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H25N3O/c1-17-3-2-11-25(17)13-14-26-12-10-21-15-20(8-9-22(21)23(26)27)19-6-4-18(16-24)5-7-19/h4-9,15,17H,2-3,10-14H2,1H3/t17-/m1/s1
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0.800n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383167
PNG
(CHEMBL2031741)
Show SMILES O=C1N(CCN2CCCC2)CCc2cc(ccc12)-n1cnc2ccccc12
Show InChI InChI=1S/C22H24N4O/c27-22-19-8-7-18(26-16-23-20-5-1-2-6-21(20)26)15-17(19)9-12-25(22)14-13-24-10-3-4-11-24/h1-2,5-8,15-16H,3-4,9-14H2
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0.800n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383153
PNG
(CHEMBL2031874)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-25(2)23(28)19-7-5-18(6-8-19)20-9-10-22-21(17-20)11-14-27(24(22)29)16-15-26-12-3-4-13-26/h5-10,17H,3-4,11-16H2,1-2H3
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0.900n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383161
PNG
(CHEMBL2031883)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCC[C@H]3C)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-17-4-3-12-26(17)14-15-27-13-11-21-16-20(9-10-22(21)24(27)29)18-5-7-19(8-6-18)23(28)25-2/h5-10,16-17H,3-4,11-15H2,1-2H3,(H,25,28)/t17-/m1/s1
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1n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383162
PNG
(CHEMBL2031884)
Show SMILES CCNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCC[C@H]3C)CCc2c1
Show InChI InChI=1S/C25H31N3O2/c1-3-26-24(29)20-8-6-19(7-9-20)21-10-11-23-22(17-21)12-14-28(25(23)30)16-15-27-13-4-5-18(27)2/h6-11,17-18H,3-5,12-16H2,1-2H3,(H,26,29)/t18-/m1/s1
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1n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383149
PNG
(CHEMBL2031869)
Show SMILES CCNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-2-25-23(28)19-7-5-18(6-8-19)20-9-10-22-21(17-20)11-14-27(24(22)29)16-15-26-12-3-4-13-26/h5-10,17H,2-4,11-16H2,1H3,(H,25,28)
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1.20n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383136
PNG
(CHEMBL2031760)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C22H25FN2O/c1-16-3-2-11-24(16)13-14-25-12-10-19-15-18(6-9-21(19)22(25)26)17-4-7-20(23)8-5-17/h4-9,15-16H,2-3,10-14H2,1H3/t16-/m1/s1
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1.20n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383143
PNG
(CHEMBL2031863)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(Oc3ccc(cn3)C#N)ccc2C1=O
Show InChI InChI=1S/C22H24N4O2/c1-16-3-2-9-25(16)11-12-26-10-8-18-13-19(5-6-20(18)22(26)27)28-21-7-4-17(14-23)15-24-21/h4-7,13,15-16H,2-3,8-12H2,1H3/t16-/m1/s1
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1.20n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383148
PNG
(CHEMBL2031868)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C23H27N3O2/c1-24-22(27)18-6-4-17(5-7-18)19-8-9-21-20(16-19)10-13-26(23(21)28)15-14-25-11-2-3-12-25/h4-9,16H,2-3,10-15H2,1H3,(H,24,27)
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1.30n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383158
PNG
(CHEMBL2031879)
Show SMILES Fc1cc(ccc1C(=O)N1CCCC1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C26H30FN3O2/c27-24-18-20(6-8-23(24)26(32)29-12-3-4-13-29)19-5-7-22-21(17-19)9-14-30(25(22)31)16-15-28-10-1-2-11-28/h5-8,17-18H,1-4,9-16H2
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1.30n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383159
PNG
(CHEMBL2031880)
Show SMILES Clc1cc(ccc1C(=O)N1CCCC1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C26H30ClN3O2/c27-24-18-20(6-8-23(24)26(32)29-12-3-4-13-29)19-5-7-22-21(17-19)9-14-30(25(22)31)16-15-28-10-1-2-11-28/h5-8,17-18H,1-4,9-16H2
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1.60n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383156
PNG
(CHEMBL2031877)
Show SMILES C[C@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m0/s1
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1.70n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383160
PNG
(CHEMBL2031881)
Show SMILES CNC(=O)c1ccc(c(F)c1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C23H26FN3O2/c1-25-22(28)18-5-6-19(21(24)15-18)16-4-7-20-17(14-16)8-11-27(23(20)29)13-12-26-9-2-3-10-26/h4-7,14-15H,2-3,8-13H2,1H3,(H,25,28)
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1.70n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383155
PNG
(CHEMBL2031876)
Show SMILES C[C@@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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1.70n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383165
PNG
(CHEMBL2031870)
Show SMILES CC(C)NC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C25H31N3O2/c1-18(2)26-24(29)20-7-5-19(6-8-20)21-9-10-23-22(17-21)11-14-28(25(23)30)16-15-27-12-3-4-13-27/h5-10,17-18H,3-4,11-16H2,1-2H3,(H,26,29)
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1.90n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383152
PNG
(CHEMBL2031873)
Show SMILES O=C(NC1CCCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c31-26(28-24-5-1-2-6-24)21-9-7-20(8-10-21)22-11-12-25-23(19-22)13-16-30(27(25)32)18-17-29-14-3-4-15-29/h7-12,19,24H,1-6,13-18H2,(H,28,31)
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PubMed
1.90n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383137
PNG
(CHEMBL2031761)
Show SMILES C[C@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H25N3O/c1-17-3-2-11-25(17)13-14-26-12-10-21-15-20(8-9-22(21)23(26)27)19-6-4-18(16-24)5-7-19/h4-9,15,17H,2-3,10-14H2,1H3/t17-/m0/s1
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2.10n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383151
PNG
(CHEMBL2031872)
Show SMILES O=C(NC1CCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C26H31N3O2/c30-25(27-23-4-3-5-23)20-8-6-19(7-9-20)21-10-11-24-22(18-21)12-15-29(26(24)31)17-16-28-13-1-2-14-28/h6-11,18,23H,1-5,12-17H2,(H,27,30)
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2.10n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383140
PNG
(CHEMBL2031764)
Show SMILES C[C@@H]1CCCN1CCN1CCc2ccc(cc2C1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H25N3O/c1-17-3-2-11-25(17)13-14-26-12-10-20-8-9-21(15-22(20)23(26)27)19-6-4-18(16-24)5-7-19/h4-9,15,17H,2-3,10-14H2,1H3/t17-/m1/s1
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2.40n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383154
PNG
(CHEMBL2031875)
Show SMILES O=C(N1CCCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C26H31N3O2/c30-25(28-14-3-4-15-28)21-7-5-20(6-8-21)22-9-10-24-23(19-22)11-16-29(26(24)31)18-17-27-12-1-2-13-27/h5-10,19H,1-4,11-18H2
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2.40n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383150
PNG
(CHEMBL2031871)
Show SMILES O=C(NC1CC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C25H29N3O2/c29-24(26-22-8-9-22)19-5-3-18(4-6-19)20-7-10-23-21(17-20)11-14-28(25(23)30)16-15-27-12-1-2-13-27/h3-7,10,17,22H,1-2,8-9,11-16H2,(H,26,29)
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2.70n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383166
PNG
(CHEMBL2031882)
Show SMILES CN(C)C(=O)c1ccc(c(F)c1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H28FN3O2/c1-26(2)23(29)19-6-7-20(22(25)16-19)17-5-8-21-18(15-17)9-12-28(24(21)30)14-13-27-10-3-4-11-27/h5-8,15-16H,3-4,9-14H2,1-2H3
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3.10n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383157
PNG
(CHEMBL2031878)
Show SMILES Fc1cc(ccc1-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1)C(=O)N1CCCC1
Show InChI InChI=1S/C26H30FN3O2/c27-24-18-21(25(31)29-12-3-4-13-29)6-7-22(24)19-5-8-23-20(17-19)9-14-30(26(23)32)16-15-28-10-1-2-11-28/h5-8,17-18H,1-4,9-16H2
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3.20n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383123
PNG
(CHEMBL2031746)
Show SMILES O=C1N(CCN2CCCC2)CCc2cc(ccc12)-c1cccc(c1)C#N
Show InChI InChI=1S/C22H23N3O/c23-16-17-4-3-5-18(14-17)19-6-7-21-20(15-19)8-11-25(22(21)26)13-12-24-9-1-2-10-24/h3-7,14-15H,1-2,8-13H2
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3.40n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383124
PNG
(CHEMBL2031747)
Show SMILES O=C1N(CCN2CCCC2)CCc2cc(ccc12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H23N3O/c23-16-17-3-5-18(6-4-17)19-7-8-21-20(15-19)9-12-25(22(21)26)14-13-24-10-1-2-11-24/h3-8,15H,1-2,9-14H2
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3.90n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383134
PNG
(CHEMBL2031758)
Show SMILES Fc1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCCCC3)CCc2c1
Show InChI InChI=1S/C23H27FN2O/c24-21-8-5-18(6-9-21)19-7-10-22-20(17-19)11-14-26(23(22)27)16-15-25-12-3-1-2-4-13-25/h5-10,17H,1-4,11-16H2
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5.70n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383138
PNG
(CHEMBL2031762)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H25N3O/c1-17-3-2-11-25(17)13-14-26-12-10-21-15-20(8-9-22(21)23(26)27)19-6-4-18(16-24)5-7-19/h4-9,15,17H,2-3,10-14H2,1H3/t17-/m1/s1
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5.80n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383147
PNG
(CHEMBL2031867)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C22H25N3O2/c23-21(26)17-5-3-16(4-6-17)18-7-8-20-19(15-18)9-12-25(22(20)27)14-13-24-10-1-2-11-24/h3-8,15H,1-2,9-14H2,(H2,23,26)
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6n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383146
PNG
(CHEMBL2031866)
Show SMILES O=C(C1CC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C25H28N2O2/c28-24(20-7-8-20)19-5-3-18(4-6-19)21-9-10-23-22(17-21)11-14-27(25(23)29)16-15-26-12-1-2-13-26/h3-6,9-10,17,20H,1-2,7-8,11-16H2
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6n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383125
PNG
(CHEMBL2031748)
Show SMILES FC(F)(F)c1cccc(c1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C22H23F3N2O/c23-22(24,25)19-5-3-4-16(15-19)17-6-7-20-18(14-17)8-11-27(21(20)28)13-12-26-9-1-2-10-26/h3-7,14-15H,1-2,8-13H2
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6.40n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383132
PNG
(CHEMBL2031755)
Show SMILES O=C1N(CCCN2CCCC2)CCc2cc(ccc12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H25N3O/c24-17-18-4-6-19(7-5-18)20-8-9-22-21(16-20)10-15-26(23(22)27)14-3-13-25-11-1-2-12-25/h4-9,16H,1-3,10-15H2
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6.90n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383130
PNG
(CHEMBL2031753)
Show SMILES Fc1ccc(cc1F)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C21H22F2N2O/c22-19-6-4-16(14-20(19)23)15-3-5-18-17(13-15)7-10-25(21(18)26)12-11-24-8-1-2-9-24/h3-6,13-14H,1-2,7-12H2
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7.70n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383145
PNG
(CHEMBL2031865)
Show SMILES O=C1N(CCN2CCCC2)CCc2cc(ccc12)-c1ccncc1
Show InChI InChI=1S/C20H23N3O/c24-20-19-4-3-17(16-5-8-21-9-6-16)15-18(19)7-12-23(20)14-13-22-10-1-2-11-22/h3-6,8-9,15H,1-2,7,10-14H2
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7.80n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383133
PNG
(CHEMBL2031757)
Show SMILES Fc1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCCC3)CCc2c1
Show InChI InChI=1S/C22H25FN2O/c23-20-7-4-17(5-8-20)18-6-9-21-19(16-18)10-13-25(22(21)26)15-14-24-11-2-1-3-12-24/h4-9,16H,1-3,10-15H2
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7.80n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383129
PNG
(CHEMBL2031752)
Show SMILES Fc1ccc(c(F)c1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C21H22F2N2O/c22-17-4-6-18(20(23)14-17)15-3-5-19-16(13-15)7-10-25(21(19)26)12-11-24-8-1-2-9-24/h3-6,13-14H,1-2,7-12H2
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8.10n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383131
PNG
(CHEMBL2031754)
Show SMILES Fc1cc(F)cc(c1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C21H22F2N2O/c22-18-12-17(13-19(23)14-18)15-3-4-20-16(11-15)5-8-25(21(20)26)10-9-24-6-1-2-7-24/h3-4,11-14H,1-2,5-10H2
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9n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383126
PNG
(CHEMBL2031749)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C22H23F3N2O/c23-22(24,25)19-6-3-16(4-7-19)17-5-8-20-18(15-17)9-12-27(21(20)28)14-13-26-10-1-2-11-26/h3-8,15H,1-2,9-14H2
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9.30n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383122
PNG
(CHEMBL2031745)
Show SMILES Fc1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C21H23FN2O/c22-19-6-3-16(4-7-19)17-5-8-20-18(15-17)9-12-24(21(20)25)14-13-23-10-1-2-11-23/h3-8,15H,1-2,9-14H2
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11n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383119
PNG
(CHEMBL2031742)
Show SMILES O=C1N(CCN2CCCC2)CCc2cc(ccc12)-c1ccccc1
Show InChI InChI=1S/C21H24N2O/c24-21-20-9-8-18(17-6-2-1-3-7-17)16-19(20)10-13-23(21)15-14-22-11-4-5-12-22/h1-3,6-9,16H,4-5,10-15H2
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11.4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383121
PNG
(CHEMBL2031744)
Show SMILES Fc1cccc(c1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C21H23FN2O/c22-19-5-3-4-16(15-19)17-6-7-20-18(14-17)8-11-24(21(20)25)13-12-23-9-1-2-10-23/h3-7,14-15H,1-2,8-13H2
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11.6n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383135
PNG
(CHEMBL2031759)
Show SMILES C[C@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C22H25FN2O/c1-16-3-2-11-24(16)13-14-25-12-10-19-15-18(6-9-21(19)22(25)26)17-4-7-20(23)8-5-17/h4-9,15-16H,2-3,10-14H2,1H3/t16-/m0/s1
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12.7n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383120
PNG
(CHEMBL2031743)
Show SMILES Fc1ccccc1-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C21H23FN2O/c22-20-6-2-1-5-18(20)16-7-8-19-17(15-16)9-12-24(21(19)25)14-13-23-10-3-4-11-23/h1-2,5-8,15H,3-4,9-14H2
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14.1n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383128
PNG
(CHEMBL2031751)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C22H23F3N2O2/c23-22(24,25)29-19-6-3-16(4-7-19)17-5-8-20-18(15-17)9-12-27(21(20)28)14-13-26-10-1-2-11-26/h3-8,15H,1-2,9-14H2
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14.9n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383164
PNG
(CHEMBL2031756)
Show SMILES O=C1N(CCCN2CCCCC2)CCc2cc(ccc12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H27N3O/c25-18-19-5-7-20(8-6-19)21-9-10-23-22(17-21)11-16-27(24(23)28)15-4-14-26-12-2-1-3-13-26/h5-10,17H,1-4,11-16H2
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18n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383139
PNG
(CHEMBL2031763)
Show SMILES C[C@@H]1CCCN1CCN1CCc2c(cccc2-c2ccc(cc2)C#N)C1=O
Show InChI InChI=1S/C23H25N3O/c1-17-4-3-12-25(17)14-15-26-13-11-21-20(5-2-6-22(21)23(26)27)19-9-7-18(16-24)8-10-19/h2,5-10,17H,3-4,11-15H2,1H3/t17-/m1/s1
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21.7n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383136
PNG
(CHEMBL2031760)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C22H25FN2O/c1-16-3-2-11-24(16)13-14-25-12-10-19-15-18(6-9-21(19)22(25)26)17-4-7-20(23)8-5-17/h4-9,15-16H,2-3,10-14H2,1H3/t16-/m1/s1
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23n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383141
PNG
(CHEMBL2031861)
Show SMILES C[C@@H]1CCCN1CCN1Cc2c(cccc2-c2ccc(cc2)C#N)C1=O
Show InChI InChI=1S/C22H23N3O/c1-16-4-3-11-24(16)12-13-25-15-21-19(5-2-6-20(21)22(25)26)18-9-7-17(14-23)8-10-18/h2,5-10,16H,3-4,11-13,15H2,1H3/t16-/m1/s1
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23.8n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383124
PNG
(CHEMBL2031747)
Show SMILES O=C1N(CCN2CCCC2)CCc2cc(ccc12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H23N3O/c23-16-17-3-5-18(6-4-17)19-7-8-21-20(15-19)9-12-25(22(21)26)14-13-24-10-1-2-11-24/h3-8,15H,1-2,9-14H2
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25n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383127
PNG
(CHEMBL2031750)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C22H23F3N2O2/c23-22(24,25)29-19-5-3-4-16(15-19)17-6-7-20-18(14-17)8-11-27(21(20)28)13-12-26-9-1-2-10-26/h3-7,14-15H,1-2,8-13H2
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28.4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383134
PNG
(CHEMBL2031758)
Show SMILES Fc1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCCCC3)CCc2c1
Show InChI InChI=1S/C23H27FN2O/c24-21-8-5-18(6-9-21)19-7-10-22-20(17-19)11-14-26(23(22)27)16-15-25-12-3-1-2-4-13-25/h5-10,17H,1-4,11-16H2
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47n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383137
PNG
(CHEMBL2031761)
Show SMILES C[C@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H25N3O/c1-17-3-2-11-25(17)13-14-26-12-10-21-15-20(8-9-22(21)23(26)27)19-6-4-18(16-24)5-7-19/h4-9,15,17H,2-3,10-14H2,1H3/t17-/m0/s1
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49n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383123
PNG
(CHEMBL2031746)
Show SMILES O=C1N(CCN2CCCC2)CCc2cc(ccc12)-c1cccc(c1)C#N
Show InChI InChI=1S/C22H23N3O/c23-16-17-4-3-5-18(14-17)19-6-7-21-20(15-19)8-11-25(22(21)26)13-12-24-9-1-2-10-24/h3-7,14-15H,1-2,8-13H2
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73n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383130
PNG
(CHEMBL2031753)
Show SMILES Fc1ccc(cc1F)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C21H22F2N2O/c22-19-6-4-16(14-20(19)23)15-3-5-18-17(13-15)7-10-25(21(18)26)12-11-24-8-1-2-9-24/h3-6,13-14H,1-2,7-12H2
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82n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383122
PNG
(CHEMBL2031745)
Show SMILES Fc1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C21H23FN2O/c22-19-6-3-16(4-7-19)17-5-8-20-18(15-17)9-12-24(21(20)25)14-13-23-10-1-2-11-23/h3-8,15H,1-2,9-14H2
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86n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383126
PNG
(CHEMBL2031749)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C22H23F3N2O/c23-22(24,25)19-6-3-16(4-7-19)17-5-8-20-18(15-17)9-12-27(21(20)28)14-13-26-10-1-2-11-26/h3-8,15H,1-2,9-14H2
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101n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383135
PNG
(CHEMBL2031759)
Show SMILES C[C@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C22H25FN2O/c1-16-3-2-11-24(16)13-14-25-12-10-19-15-18(6-9-21(19)22(25)26)17-4-7-20(23)8-5-17/h4-9,15-16H,2-3,10-14H2,1H3/t16-/m0/s1
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110n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383119
PNG
(CHEMBL2031742)
Show SMILES O=C1N(CCN2CCCC2)CCc2cc(ccc12)-c1ccccc1
Show InChI InChI=1S/C21H24N2O/c24-21-20-9-8-18(17-6-2-1-3-7-17)16-19(20)10-13-23(21)15-14-22-11-4-5-12-22/h1-3,6-9,16H,4-5,10-15H2
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145n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383131
PNG
(CHEMBL2031754)
Show SMILES Fc1cc(F)cc(c1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C21H22F2N2O/c22-18-12-17(13-19(23)14-18)15-3-4-20-16(11-15)5-8-25(21(20)26)10-9-24-6-1-2-7-24/h3-4,11-14H,1-2,5-10H2
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146n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383129
PNG
(CHEMBL2031752)
Show SMILES Fc1ccc(c(F)c1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C21H22F2N2O/c22-17-4-6-18(20(23)14-17)15-3-5-19-16(13-15)7-10-25(21(19)26)12-11-24-8-1-2-9-24/h3-6,13-14H,1-2,7-12H2
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153n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383164
PNG
(CHEMBL2031756)
Show SMILES O=C1N(CCCN2CCCCC2)CCc2cc(ccc12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H27N3O/c25-18-19-5-7-20(8-6-19)21-9-10-23-22(17-21)11-16-27(24(23)28)15-4-14-26-12-2-1-3-13-26/h5-10,17H,1-4,11-16H2
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153n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383121
PNG
(CHEMBL2031744)
Show SMILES Fc1cccc(c1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C21H23FN2O/c22-19-5-3-4-16(15-19)17-6-7-20-18(14-17)8-11-24(21(20)25)13-12-23-9-1-2-10-23/h3-7,14-15H,1-2,8-13H2
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164n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50383152
PNG
(CHEMBL2031873)
Show SMILES O=C(NC1CCCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c31-26(28-24-5-1-2-6-24)21-9-7-20(8-10-21)22-11-12-25-23(19-22)13-16-30(27(25)32)18-17-29-14-3-4-15-29/h7-12,19,24H,1-6,13-18H2,(H,28,31)
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170n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT transporter


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383120
PNG
(CHEMBL2031743)
Show SMILES Fc1ccccc1-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C21H23FN2O/c22-20-6-2-1-5-18(20)16-7-8-19-17(15-16)9-12-24(21(19)25)14-13-23-10-3-4-11-23/h1-2,5-8,15H,3-4,9-14H2
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174n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383167
PNG
(CHEMBL2031741)
Show SMILES O=C1N(CCN2CCCC2)CCc2cc(ccc12)-n1cnc2ccccc12
Show InChI InChI=1S/C22H24N4O/c27-22-19-8-7-18(26-16-23-20-5-1-2-6-21(20)26)15-17(19)9-12-25(22)14-13-24-10-3-4-11-24/h1-2,5-8,15-16H,3-4,9-14H2
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174n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383128
PNG
(CHEMBL2031751)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C22H23F3N2O2/c23-22(24,25)29-19-6-3-16(4-7-19)17-5-8-20-18(15-17)9-12-27(21(20)28)14-13-26-10-1-2-11-26/h3-8,15H,1-2,9-14H2
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178n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383125
PNG
(CHEMBL2031748)
Show SMILES FC(F)(F)c1cccc(c1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C22H23F3N2O/c23-22(24,25)19-5-3-4-16(15-19)17-6-7-20-18(14-17)8-11-27(21(20)28)13-12-26-9-1-2-10-26/h3-7,14-15H,1-2,8-13H2
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182n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383132
PNG
(CHEMBL2031755)
Show SMILES O=C1N(CCCN2CCCC2)CCc2cc(ccc12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H25N3O/c24-17-18-4-6-19(7-5-18)20-8-9-22-21(16-20)10-15-26(23(22)27)14-3-13-25-11-1-2-12-25/h4-9,16H,1-3,10-15H2
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270n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50383127
PNG
(CHEMBL2031750)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C22H23F3N2O2/c23-22(24,25)29-19-5-3-4-16(15-19)17-6-7-20-18(14-17)8-11-27(21(20)28)13-12-26-9-1-2-10-26/h3-7,14-15H,1-2,8-13H2
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276n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-(R)-alpha-methylhistamine from rat H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50383162
PNG
(CHEMBL2031884)
Show SMILES CCNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCC[C@H]3C)CCc2c1
Show InChI InChI=1S/C25H31N3O2/c1-3-26-24(29)20-8-6-19(7-9-20)21-10-11-23-22(17-21)12-14-28(25(23)30)16-15-27-13-4-5-18(27)2/h6-11,17-18H,3-5,12-16H2,1-2H3,(H,26,29)/t18-/m1/s1
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300n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT transporter


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50383155
PNG
(CHEMBL2031876)
Show SMILES C[C@@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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320n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT transporter


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50383156
PNG
(CHEMBL2031877)
Show SMILES C[C@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m0/s1
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390n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT transporter


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50383163
PNG
(CHEMBL2031885)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-28(20)17-18-30-16-12-24-19-23(10-11-25(24)27(30)32)21-6-8-22(9-7-21)26(31)29-13-2-3-14-29/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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810n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT transporter


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50383153
PNG
(CHEMBL2031874)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-25(2)23(28)19-7-5-18(6-8-19)20-9-10-22-21(17-20)11-14-27(24(22)29)16-15-26-12-3-4-13-26/h5-10,17H,3-4,11-16H2,1-2H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2A receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50383156
PNG
(CHEMBL2031877)
Show SMILES C[C@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m0/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2A receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50383163
PNG
(CHEMBL2031885)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-28(20)17-18-30-16-12-24-19-23(10-11-25(24)27(30)32)21-6-8-22(9-7-21)26(31)29-13-2-3-14-29/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2A receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50383152
PNG
(CHEMBL2031873)
Show SMILES O=C(NC1CCCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c31-26(28-24-5-1-2-6-24)21-9-7-20(8-10-21)22-11-12-25-23(19-22)13-16-30(27(25)32)18-17-29-14-3-4-15-29/h7-12,19,24H,1-6,13-18H2,(H,28,31)
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>3.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2A receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Serotonin and norepinephrine transporters (SERT/NET)


(Homo sapiens (human))
BDBM50383153
PNG
(CHEMBL2031874)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-25(2)23(28)19-7-5-18(6-8-19)20-9-10-22-21(17-20)11-14-27(24(22)29)16-15-26-12-3-4-13-26/h5-10,17H,3-4,11-16H2,1-2H3
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>3.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT transporter


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50383162
PNG
(CHEMBL2031884)
Show SMILES CCNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCC[C@H]3C)CCc2c1
Show InChI InChI=1S/C25H31N3O2/c1-3-26-24(29)20-8-6-19(7-9-20)21-10-11-23-22(17-21)12-14-28(25(23)30)16-15-27-13-4-5-18(27)2/h6-11,17-18H,3-5,12-16H2,1-2H3,(H,26,29)/t18-/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2A receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50383155
PNG
(CHEMBL2031876)
Show SMILES C[C@@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to alpha-2A receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50383156
PNG
(CHEMBL2031877)
Show SMILES C[C@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m0/s1
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7.01E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to H1 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50383162
PNG
(CHEMBL2031884)
Show SMILES CCNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCC[C@H]3C)CCc2c1
Show InChI InChI=1S/C25H31N3O2/c1-3-26-24(29)20-8-6-19(7-9-20)21-10-11-23-22(17-21)12-14-28(25(23)30)16-15-27-13-4-5-18(27)2/h6-11,17-18H,3-5,12-16H2,1-2H3,(H,26,29)/t18-/m1/s1
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7.23E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to H1 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50383153
PNG
(CHEMBL2031874)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-25(2)23(28)19-7-5-18(6-8-19)20-9-10-22-21(17-20)11-14-27(24(22)29)16-15-26-12-3-4-13-26/h5-10,17H,3-4,11-16H2,1-2H3
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8.67E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1A receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50383152
PNG
(CHEMBL2031873)
Show SMILES O=C(NC1CCCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c31-26(28-24-5-1-2-6-24)21-9-7-20(8-10-21)22-11-12-25-23(19-22)13-16-30(27(25)32)18-17-29-14-3-4-15-29/h7-12,19,24H,1-6,13-18H2,(H,28,31)
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8.72E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1A receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50383163
PNG
(CHEMBL2031885)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-28(20)17-18-30-16-12-24-19-23(10-11-25(24)27(30)32)21-6-8-22(9-7-21)26(31)29-13-2-3-14-29/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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8.75E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to H1 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50383156
PNG
(CHEMBL2031877)
Show SMILES C[C@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m0/s1
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9.04E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1A receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50383152
PNG
(CHEMBL2031873)
Show SMILES O=C(NC1CCCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c31-26(28-24-5-1-2-6-24)21-9-7-20(8-10-21)22-11-12-25-23(19-22)13-16-30(27(25)32)18-17-29-14-3-4-15-29/h7-12,19,24H,1-6,13-18H2,(H,28,31)
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9.62E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to H1 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50383155
PNG
(CHEMBL2031876)
Show SMILES C[C@@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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9.72E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1A receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (human))
BDBM50383155
PNG
(CHEMBL2031876)
Show SMILES C[C@@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT2B receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM50383162
PNG
(CHEMBL2031884)
Show SMILES CCNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCC[C@H]3C)CCc2c1
Show InChI InChI=1S/C25H31N3O2/c1-3-26-24(29)20-8-6-19(7-9-20)21-10-11-23-22(17-21)12-14-28(25(23)30)16-15-27-13-4-5-18(27)2/h6-11,17-18H,3-5,12-16H2,1-2H3,(H,26,29)/t18-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to DAT


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50383156
PNG
(CHEMBL2031877)
Show SMILES C[C@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to D2 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (human))
BDBM50383162
PNG
(CHEMBL2031884)
Show SMILES CCNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCC[C@H]3C)CCc2c1
Show InChI InChI=1S/C25H31N3O2/c1-3-26-24(29)20-8-6-19(7-9-20)21-10-11-23-22(17-21)12-14-28(25(23)30)16-15-27-13-4-5-18(27)2/h6-11,17-18H,3-5,12-16H2,1-2H3,(H,26,29)/t18-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to H2 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (human))
BDBM50383156
PNG
(CHEMBL2031877)
Show SMILES C[C@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT2B receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50383163
PNG
(CHEMBL2031885)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-28(20)17-18-30-16-12-24-19-23(10-11-25(24)27(30)32)21-6-8-22(9-7-21)26(31)29-13-2-3-14-29/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to D2 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM50383163
PNG
(CHEMBL2031885)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-28(20)17-18-30-16-12-24-19-23(10-11-25(24)27(30)32)21-6-8-22(9-7-21)26(31)29-13-2-3-14-29/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to DAT


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM50383152
PNG
(CHEMBL2031873)
Show SMILES O=C(NC1CCCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c31-26(28-24-5-1-2-6-24)21-9-7-20(8-10-21)22-11-12-25-23(19-22)13-16-30(27(25)32)18-17-29-14-3-4-15-29/h7-12,19,24H,1-6,13-18H2,(H,28,31)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to DAT


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (human))
BDBM50383155
PNG
(CHEMBL2031876)
Show SMILES C[C@@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to H2 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (human))
BDBM50383156
PNG
(CHEMBL2031877)
Show SMILES C[C@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to H2 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (human))
BDBM50383152
PNG
(CHEMBL2031873)
Show SMILES O=C(NC1CCCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c31-26(28-24-5-1-2-6-24)21-9-7-20(8-10-21)22-11-12-25-23(19-22)13-16-30(27(25)32)18-17-29-14-3-4-15-29/h7-12,19,24H,1-6,13-18H2,(H,28,31)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT2B receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50383156
PNG
(CHEMBL2031877)
Show SMILES C[C@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT6 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50383163
PNG
(CHEMBL2031885)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-28(20)17-18-30-16-12-24-19-23(10-11-25(24)27(30)32)21-6-8-22(9-7-21)26(31)29-13-2-3-14-29/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT6 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50383155
PNG
(CHEMBL2031876)
Show SMILES C[C@@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to D2 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50383153
PNG
(CHEMBL2031874)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-25(2)23(28)19-7-5-18(6-8-19)20-9-10-22-21(17-20)11-14-27(24(22)29)16-15-26-12-3-4-13-26/h5-10,17H,3-4,11-16H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to H1 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50383155
PNG
(CHEMBL2031876)
Show SMILES C[C@@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT6 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50383152
PNG
(CHEMBL2031873)
Show SMILES O=C(NC1CCCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c31-26(28-24-5-1-2-6-24)21-9-7-20(8-10-21)22-11-12-25-23(19-22)13-16-30(27(25)32)18-17-29-14-3-4-15-29/h7-12,19,24H,1-6,13-18H2,(H,28,31)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to D2 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (human))
BDBM50383163
PNG
(CHEMBL2031885)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-28(20)17-18-30-16-12-24-19-23(10-11-25(24)27(30)32)21-6-8-22(9-7-21)26(31)29-13-2-3-14-29/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to H2 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (human))
BDBM50383162
PNG
(CHEMBL2031884)
Show SMILES CCNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCC[C@H]3C)CCc2c1
Show InChI InChI=1S/C25H31N3O2/c1-3-26-24(29)20-8-6-19(7-9-20)21-10-11-23-22(17-21)12-14-28(25(23)30)16-15-27-13-4-5-18(27)2/h6-11,17-18H,3-5,12-16H2,1-2H3,(H,26,29)/t18-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT2B receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50383152
PNG
(CHEMBL2031873)
Show SMILES O=C(NC1CCCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c31-26(28-24-5-1-2-6-24)21-9-7-20(8-10-21)22-11-12-25-23(19-22)13-16-30(27(25)32)18-17-29-14-3-4-15-29/h7-12,19,24H,1-6,13-18H2,(H,28,31)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT6 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM50383153
PNG
(CHEMBL2031874)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-25(2)23(28)19-7-5-18(6-8-19)20-9-10-22-21(17-20)11-14-27(24(22)29)16-15-26-12-3-4-13-26/h5-10,17H,3-4,11-16H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to DAT


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM50383155
PNG
(CHEMBL2031876)
Show SMILES C[C@@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to DAT


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50383162
PNG
(CHEMBL2031884)
Show SMILES CCNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCC[C@H]3C)CCc2c1
Show InChI InChI=1S/C25H31N3O2/c1-3-26-24(29)20-8-6-19(7-9-20)21-10-11-23-22(17-21)12-14-28(25(23)30)16-15-27-13-4-5-18(27)2/h6-11,17-18H,3-5,12-16H2,1-2H3,(H,26,29)/t18-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT6 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (human))
BDBM50383155
PNG
(CHEMBL2031876)
Show SMILES C[C@@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to H1 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (human))
BDBM50383153
PNG
(CHEMBL2031874)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-25(2)23(28)19-7-5-18(6-8-19)20-9-10-22-21(17-20)11-14-27(24(22)29)16-15-26-12-3-4-13-26/h5-10,17H,3-4,11-16H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT2B receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50383162
PNG
(CHEMBL2031884)
Show SMILES CCNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCC[C@H]3C)CCc2c1
Show InChI InChI=1S/C25H31N3O2/c1-3-26-24(29)20-8-6-19(7-9-20)21-10-11-23-22(17-21)12-14-28(25(23)30)16-15-27-13-4-5-18(27)2/h6-11,17-18H,3-5,12-16H2,1-2H3,(H,26,29)/t18-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to D2 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (human))
BDBM50383156
PNG
(CHEMBL2031877)
Show SMILES C[C@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to DAT


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (human))
BDBM50383152
PNG
(CHEMBL2031873)
Show SMILES O=C(NC1CCCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c31-26(28-24-5-1-2-6-24)21-9-7-20(8-10-21)22-11-12-25-23(19-22)13-16-30(27(25)32)18-17-29-14-3-4-15-29/h7-12,19,24H,1-6,13-18H2,(H,28,31)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to H2 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Serotonin receptor (2b and 2c)


(Homo sapiens (human))
BDBM50383163
PNG
(CHEMBL2031885)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-28(20)17-18-30-16-12-24-19-23(10-11-25(24)27(30)32)21-6-8-22(9-7-21)26(31)29-13-2-3-14-29/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT2B receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50383153
PNG
(CHEMBL2031874)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-25(2)23(28)19-7-5-18(6-8-19)20-9-10-22-21(17-20)11-14-27(24(22)29)16-15-26-12-3-4-13-26/h5-10,17H,3-4,11-16H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT6 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50383153
PNG
(CHEMBL2031874)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-25(2)23(28)19-7-5-18(6-8-19)20-9-10-22-21(17-20)11-14-27(24(22)29)16-15-26-12-3-4-13-26/h5-10,17H,3-4,11-16H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to D2 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50383162
PNG
(CHEMBL2031884)
Show SMILES CCNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCC[C@H]3C)CCc2c1
Show InChI InChI=1S/C25H31N3O2/c1-3-26-24(29)20-8-6-19(7-9-20)21-10-11-23-22(17-21)12-14-28(25(23)30)16-15-27-13-4-5-18(27)2/h6-11,17-18H,3-5,12-16H2,1-2H3,(H,26,29)/t18-/m1/s1
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1.01E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1A receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50383163
PNG
(CHEMBL2031885)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-28(20)17-18-30-16-12-24-19-23(10-11-25(24)27(30)32)21-6-8-22(9-7-21)26(31)29-13-2-3-14-29/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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1.22E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to 5-HT1A receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (human))
BDBM50383153
PNG
(CHEMBL2031874)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-25(2)23(28)19-7-5-18(6-8-19)20-9-10-22-21(17-20)11-14-27(24(22)29)16-15-26-12-3-4-13-26/h5-10,17H,3-4,11-16H2,1-2H3
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>5.50E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to H2 receptor


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383138
PNG
(CHEMBL2031762)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H25N3O/c1-17-3-2-11-25(17)13-14-26-12-10-21-15-20(8-9-22(21)23(26)27)19-6-4-18(16-24)5-7-19/h4-9,15,17H,2-3,10-14H2,1H3/t17-/m1/s1
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n/an/a 140n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383136
PNG
(CHEMBL2031760)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C22H25FN2O/c1-16-3-2-11-24(16)13-14-25-12-10-19-15-18(6-9-21(19)22(25)26)17-4-7-20(23)8-5-17/h4-9,15-16H,2-3,10-14H2,1H3/t16-/m1/s1
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n/an/a 300n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383151
PNG
(CHEMBL2031872)
Show SMILES O=C(NC1CCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C26H31N3O2/c30-25(27-23-4-3-5-23)20-8-6-19(7-9-20)21-10-11-24-22(18-21)12-15-29(26(24)31)17-16-28-13-1-2-14-28/h6-11,18,23H,1-5,12-17H2,(H,27,30)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383160
PNG
(CHEMBL2031881)
Show SMILES CNC(=O)c1ccc(c(F)c1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C23H26FN3O2/c1-25-22(28)18-5-6-19(21(24)15-18)16-4-7-20-17(14-16)8-11-27(23(20)29)13-12-26-9-2-3-10-26/h4-7,14-15H,2-3,8-13H2,1H3,(H,25,28)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383165
PNG
(CHEMBL2031870)
Show SMILES CC(C)NC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C25H31N3O2/c1-18(2)26-24(29)20-7-5-19(6-8-20)21-9-10-23-22(17-21)11-14-28(25(23)30)16-15-27-12-3-4-13-27/h5-10,17-18H,3-4,11-16H2,1-2H3,(H,26,29)
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n/an/a 6.20E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383162
PNG
(CHEMBL2031884)
Show SMILES CCNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCC[C@H]3C)CCc2c1
Show InChI InChI=1S/C25H31N3O2/c1-3-26-24(29)20-8-6-19(7-9-20)21-10-11-23-22(17-21)12-14-28(25(23)30)16-15-27-13-4-5-18(27)2/h6-11,17-18H,3-5,12-16H2,1-2H3,(H,26,29)/t18-/m1/s1
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n/an/a 7.40E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383152
PNG
(CHEMBL2031873)
Show SMILES O=C(NC1CCCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c31-26(28-24-5-1-2-6-24)21-9-7-20(8-10-21)22-11-12-25-23(19-22)13-16-30(27(25)32)18-17-29-14-3-4-15-29/h7-12,19,24H,1-6,13-18H2,(H,28,31)
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n/an/a 8.20E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383158
PNG
(CHEMBL2031879)
Show SMILES Fc1cc(ccc1C(=O)N1CCCC1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C26H30FN3O2/c27-24-18-20(6-8-23(24)26(32)29-12-3-4-13-29)19-5-7-22-21(17-19)9-14-30(25(22)31)16-15-28-10-1-2-11-28/h5-8,17-18H,1-4,9-16H2
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n/an/a 8.80E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383154
PNG
(CHEMBL2031875)
Show SMILES O=C(N1CCCC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C26H31N3O2/c30-25(28-14-3-4-15-28)21-7-5-20(6-8-21)22-9-10-24-23(19-22)11-16-29(26(24)31)18-17-27-12-1-2-13-27/h5-10,19H,1-4,11-18H2
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n/an/a 8.80E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383159
PNG
(CHEMBL2031880)
Show SMILES Clc1cc(ccc1C(=O)N1CCCC1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C26H30ClN3O2/c27-24-18-20(6-8-23(24)26(32)29-12-3-4-13-29)19-5-7-22-21(17-19)9-14-30(25(22)31)16-15-28-10-1-2-11-28/h5-8,17-18H,1-4,9-16H2
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n/an/a 9.30E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383163
PNG
(CHEMBL2031885)
Show SMILES C[C@@H]1CCCN1CCN1CCc2cc(ccc2C1=O)-c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-28(20)17-18-30-16-12-24-19-23(10-11-25(24)27(30)32)21-6-8-22(9-7-21)26(31)29-13-2-3-14-29/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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n/an/a 9.60E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383155
PNG
(CHEMBL2031876)
Show SMILES C[C@@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m1/s1
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n/an/a 1.05E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383153
PNG
(CHEMBL2031874)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-25(2)23(28)19-7-5-18(6-8-19)20-9-10-22-21(17-20)11-14-27(24(22)29)16-15-26-12-3-4-13-26/h5-10,17H,3-4,11-16H2,1-2H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383150
PNG
(CHEMBL2031871)
Show SMILES O=C(NC1CC1)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C25H29N3O2/c29-24(26-22-8-9-22)19-5-3-18(4-6-19)20-7-10-23-21(17-20)11-14-28(25(23)30)16-15-27-12-1-2-13-27/h3-7,10,17,22H,1-2,8-9,11-16H2,(H,26,29)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383157
PNG
(CHEMBL2031878)
Show SMILES Fc1cc(ccc1-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1)C(=O)N1CCCC1
Show InChI InChI=1S/C26H30FN3O2/c27-24-18-21(25(31)29-12-3-4-13-29)6-7-22(24)19-5-8-23-20(17-19)9-14-30(26(23)32)16-15-28-10-1-2-11-28/h5-8,17-18H,1-4,9-16H2
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n/an/a 1.13E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383156
PNG
(CHEMBL2031877)
Show SMILES C[C@H]1CCCN1C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C27H33N3O2/c1-20-5-4-15-30(20)26(31)22-8-6-21(7-9-22)23-10-11-25-24(19-23)12-16-29(27(25)32)18-17-28-13-2-3-14-28/h6-11,19-20H,2-5,12-18H2,1H3/t20-/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383149
PNG
(CHEMBL2031869)
Show SMILES CCNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-2-25-23(28)19-7-5-18(6-8-19)20-9-10-22-21(17-20)11-14-27(24(22)29)16-15-26-12-3-4-13-26/h5-10,17H,2-4,11-16H2,1H3,(H,25,28)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383161
PNG
(CHEMBL2031883)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCC[C@H]3C)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-17-4-3-12-26(17)14-15-27-13-11-21-16-20(9-10-22(21)24(27)29)18-5-7-19(8-6-18)23(28)25-2/h5-10,16-17H,3-4,11-15H2,1-2H3,(H,25,28)/t17-/m1/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383148
PNG
(CHEMBL2031868)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C23H27N3O2/c1-24-22(27)18-6-4-17(5-7-18)19-8-9-21-20(16-19)10-13-26(23(21)28)15-14-25-11-2-3-12-25/h4-9,16H,2-3,10-15H2,1H3,(H,24,27)
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n/an/a 2.90E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50383166
PNG
(CHEMBL2031882)
Show SMILES CN(C)C(=O)c1ccc(c(F)c1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H28FN3O2/c1-26(2)23(29)19-6-7-20(22(25)16-19)17-5-8-21-18(15-17)9-12-28(24(21)30)14-13-27-10-3-4-11-27/h5-8,15-16H,3-4,9-14H2,1-2H3
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n/an/a 3.25E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by IonWorks assay


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50383153
PNG
(CHEMBL2031874)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1ccc2C(=O)N(CCN3CCCC3)CCc2c1
Show InChI InChI=1S/C24H29N3O2/c1-25(2)23(28)19-7-5-18(6-8-19)20-9-10-22-21(17-20)11-14-27(24(22)29)16-15-26-12-3-4-13-26/h5-10,17H,3-4,11-16H2,1-2H3
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n/an/an/an/a 10.7n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inverse agonist activity at human H3 receptor expressed in HEK293T cells assessed as inhibition of {35S]GTPgamma binding


J Med Chem 55: 2452-68 (2012)


Article DOI: 10.1021/jm300011d
BindingDB Entry DOI: 10.7270/Q2736RZR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%