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PubMed code 22325948

Compile data set for download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365592
PNG
(CHEMBL1957805)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccc3ccnn23)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-5-4-15(18(22)14-16)7-9-24-10-12-25(13-11-24)20(27)19-3-1-2-17-6-8-23-26(17)19/h1-6,8,14H,7,9-13H2
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0.400n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365589
PNG
(CHEMBL1957802)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2nn3ccccc3c2Cl)c(F)c1
Show InChI InChI=1S/C20H19ClF2N4O/c21-18-17-3-1-2-7-27(17)24-19(18)20(28)26-11-9-25(10-12-26)8-6-14-4-5-15(22)13-16(14)23/h1-5,7,13H,6,8-12H2
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0.600n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365586
PNG
(CHEMBL1957801)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2nn3ccccc3c2Br)c(F)c1
Show InChI InChI=1S/C20H19BrF2N4O/c21-18-17-3-1-2-7-27(17)24-19(18)20(28)26-11-9-25(10-12-26)8-6-14-4-5-15(22)13-16(14)23/h1-5,7,13H,6,8-12H2
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0.800n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50324551
PNG
((4-Bromo-1-methyl-1H-pyrazol-3-yl)-{4-[2-(2,4-difl...)
Show SMILES Cn1cc(Br)c(n1)C(=O)N1CCN(CCc2ccc(F)cc2F)CC1
Show InChI InChI=1S/C17H19BrF2N4O/c1-22-11-14(18)16(21-22)17(25)24-8-6-23(7-9-24)5-4-12-2-3-13(19)10-15(12)20/h2-3,10-11H,4-9H2,1H3
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1.10n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365595
PNG
(CHEMBL1957812)
Show SMILES Nc1cccc2nc(cn12)C(=O)N1CCN(CCc2ccc(F)cc2F)CC1
Show InChI InChI=1S/C20H21F2N5O/c21-15-5-4-14(16(22)12-15)6-7-25-8-10-26(11-9-25)20(28)17-13-27-18(23)2-1-3-19(27)24-17/h1-5,12-13H,6-11,23H2
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1.40n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365590
PNG
(CHEMBL1957818)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3cc(Cl)nc23)c(F)c1
Show InChI InChI=1S/C20H19ClF2N4O/c21-18-13-27-6-1-2-16(19(27)24-18)20(28)26-10-8-25(9-11-26)7-5-14-3-4-15(22)12-17(14)23/h1-4,6,12-13H,5,7-11H2
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1.5n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365585
PNG
(CHEMBL1957816)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3ccnc23)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-4-3-15(18(22)14-16)5-8-24-10-12-26(13-11-24)20(27)17-2-1-7-25-9-6-23-19(17)25/h1-4,6-7,9,14H,5,8,10-13H2
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1.60n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365579
PNG
(CHEMBL1957814)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cnc3ccccn23)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-5-4-15(17(22)13-16)6-8-24-9-11-25(12-10-24)20(27)18-14-23-19-3-1-2-7-26(18)19/h1-5,7,13-14H,6,8-12H2
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1.70n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365581
PNG
(CHEMBL1957817)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3cc(Br)nc23)c(F)c1
Show InChI InChI=1S/C20H19BrF2N4O/c21-18-13-27-6-1-2-16(19(27)24-18)20(28)26-10-8-25(9-11-26)7-5-14-3-4-15(22)12-17(14)23/h1-4,6,12-13H,5,7-11H2
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1.70n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365591
PNG
(CHEMBL1957803)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cnn3ccccc23)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-5-4-15(18(22)13-16)6-8-24-9-11-25(12-10-24)20(27)17-14-23-26-7-2-1-3-19(17)26/h1-5,7,13-14H,6,8-12H2
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1.80n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365583
PNG
(CHEMBL1957811)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2nc3ccccn3c2Br)c(F)c1
Show InChI InChI=1S/C20H19BrF2N4O/c21-19-18(24-17-3-1-2-7-27(17)19)20(28)26-11-9-25(10-12-26)8-6-14-4-5-15(22)13-16(14)23/h1-5,7,13H,6,8-12H2
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1.90n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365580
PNG
(CHEMBL1957808)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cc3CCCCn3n2)c(F)c1
Show InChI InChI=1S/C20H24F2N4O/c21-16-5-4-15(18(22)13-16)6-8-24-9-11-25(12-10-24)20(27)19-14-17-3-1-2-7-26(17)23-19/h4-5,13-14H,1-3,6-12H2
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2.60n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365593
PNG
(CHEMBL1957813)
Show SMILES Nc1cccn2cc(nc12)C(=O)N1CCN(CCc2ccc(F)cc2F)CC1
Show InChI InChI=1S/C20H21F2N5O/c21-15-4-3-14(16(22)12-15)5-7-25-8-10-26(11-9-25)20(28)18-13-27-6-1-2-17(23)19(27)24-18/h1-4,6,12-13H,5,7-11,23H2
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2.70n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365574
PNG
(CHEMBL1957819)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3cc(nc23)C#N)c(F)c1
Show InChI InChI=1S/C21H19F2N5O/c22-16-4-3-15(19(23)12-16)5-7-26-8-10-27(11-9-26)21(29)18-2-1-6-28-14-17(13-24)25-20(18)28/h1-4,6,12,14H,5,7-11H2
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2.80n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365577
PNG
(CHEMBL1957815)
Show SMILES Cc1nc2ccccn2c1C(=O)N1CCN(CCc2ccc(F)cc2F)CC1
Show InChI InChI=1S/C21H22F2N4O/c1-15-20(27-8-3-2-4-19(27)24-15)21(28)26-12-10-25(11-13-26)9-7-16-5-6-17(22)14-18(16)23/h2-6,8,14H,7,9-13H2,1H3
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3.5n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365594
PNG
(CHEMBL1957821)
Show SMILES Cc1cc(C)n2ccnc2c1C(=O)N1CCN(CCc2ccc(F)cc2F)CC1
Show InChI InChI=1S/C22H24F2N4O/c1-15-13-16(2)28-8-6-25-21(28)20(15)22(29)27-11-9-26(10-12-27)7-5-17-3-4-18(23)14-19(17)24/h3-4,6,8,13-14H,5,7,9-12H2,1-2H3
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3.60n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365578
PNG
(CHEMBL1957807)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cnn3cccnc23)c(F)c1
Show InChI InChI=1S/C19H19F2N5O/c20-15-3-2-14(17(21)12-15)4-7-24-8-10-25(11-9-24)19(27)16-13-23-26-6-1-5-22-18(16)26/h1-3,5-6,12-13H,4,7-11H2
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3.80n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365582
PNG
(CHEMBL1957810)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cn3ccccc3n2)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-5-4-15(17(22)13-16)6-8-24-9-11-25(12-10-24)20(27)18-14-26-7-2-1-3-19(26)23-18/h1-5,7,13-14H,6,8-12H2
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4.30n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365587
PNG
(CHEMBL1957820)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cc(Br)cn3ccnc23)c(F)c1
Show InChI InChI=1S/C20H19BrF2N4O/c21-15-11-17(19-24-4-6-27(19)13-15)20(28)26-9-7-25(8-10-26)5-3-14-1-2-16(22)12-18(14)23/h1-2,4,6,11-13H,3,5,7-10H2
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5n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365576
PNG
(CHEMBL1957806)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cc3ncccn3n2)c(F)c1
Show InChI InChI=1S/C19H19F2N5O/c20-15-3-2-14(16(21)12-15)4-7-24-8-10-25(11-9-24)19(27)17-13-18-22-5-1-6-26(18)23-17/h1-3,5-6,12-13H,4,7-11H2
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5.60n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365588
PNG
(CHEMBL1957800)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cc3ccccn3n2)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-5-4-15(18(22)13-16)6-8-24-9-11-25(12-10-24)20(27)19-14-17-3-1-2-7-26(17)23-19/h1-5,7,13-14H,6,8-12H2
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PubMed
5.70n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365584
PNG
(CHEMBL1957804)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cnn3cc(Cl)ccc23)c(F)c1
Show InChI InChI=1S/C20H19ClF2N4O/c21-15-2-4-19-17(12-24-27(19)13-15)20(28)26-9-7-25(8-10-26)6-5-14-1-3-16(22)11-18(14)23/h1-4,11-13H,5-10H2
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5.90n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50365575
PNG
(CHEMBL1957809)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cnn3CCCCc23)c(F)c1
Show InChI InChI=1S/C20H24F2N4O/c21-16-5-4-15(18(22)13-16)6-8-24-9-11-25(12-10-24)20(27)17-14-23-26-7-2-1-3-19(17)26/h4-5,13-14H,1-3,6-12H2
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18n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2A receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365595
PNG
(CHEMBL1957812)
Show SMILES Nc1cccc2nc(cn12)C(=O)N1CCN(CCc2ccc(F)cc2F)CC1
Show InChI InChI=1S/C20H21F2N5O/c21-15-5-4-14(16(22)12-15)6-7-25-8-10-26(11-9-25)20(28)17-13-27-18(23)2-1-3-19(27)24-17/h1-5,12-13H,6-11,23H2
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PubMed
152n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365594
PNG
(CHEMBL1957821)
Show SMILES Cc1cc(C)n2ccnc2c1C(=O)N1CCN(CCc2ccc(F)cc2F)CC1
Show InChI InChI=1S/C22H24F2N4O/c1-15-13-16(2)28-8-6-25-21(28)20(15)22(29)27-11-9-26(10-12-27)7-5-17-3-4-18(23)14-19(17)24/h3-4,6,8,13-14H,5,7,9-12H2,1-2H3
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153n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365593
PNG
(CHEMBL1957813)
Show SMILES Nc1cccn2cc(nc12)C(=O)N1CCN(CCc2ccc(F)cc2F)CC1
Show InChI InChI=1S/C20H21F2N5O/c21-15-4-3-14(16(22)12-15)5-7-25-8-10-26(11-9-25)20(28)18-13-27-6-1-2-17(23)19(27)24-18/h1-4,6,12-13H,5,7-11,23H2
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190n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365592
PNG
(CHEMBL1957805)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccc3ccnn23)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-5-4-15(18(22)14-16)7-9-24-10-12-25(13-11-24)20(27)19-3-1-2-17-6-8-23-26(17)19/h1-6,8,14H,7,9-13H2
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194n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365591
PNG
(CHEMBL1957803)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cnn3ccccc23)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-5-4-15(18(22)13-16)6-8-24-9-11-25(12-10-24)20(27)17-14-23-26-7-2-1-3-19(17)26/h1-5,7,13-14H,6,8-12H2
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246n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365590
PNG
(CHEMBL1957818)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3cc(Cl)nc23)c(F)c1
Show InChI InChI=1S/C20H19ClF2N4O/c21-18-13-27-6-1-2-16(19(27)24-18)20(28)26-10-8-25(9-11-26)7-5-14-3-4-15(22)12-17(14)23/h1-4,6,12-13H,5,7-11H2
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391n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365589
PNG
(CHEMBL1957802)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2nn3ccccc3c2Cl)c(F)c1
Show InChI InChI=1S/C20H19ClF2N4O/c21-18-17-3-1-2-7-27(17)24-19(18)20(28)26-11-9-25(10-12-26)8-6-14-4-5-15(22)13-16(14)23/h1-5,7,13H,6,8-12H2
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394n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365588
PNG
(CHEMBL1957800)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cc3ccccn3n2)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-5-4-15(18(22)13-16)6-8-24-9-11-25(12-10-24)20(27)19-14-17-3-1-2-7-26(17)23-19/h1-5,7,13-14H,6,8-12H2
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467n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365587
PNG
(CHEMBL1957820)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cc(Br)cn3ccnc23)c(F)c1
Show InChI InChI=1S/C20H19BrF2N4O/c21-15-11-17(19-24-4-6-27(19)13-15)20(28)26-9-7-25(8-10-26)5-3-14-1-2-16(22)12-18(14)23/h1-2,4,6,11-13H,3,5,7-10H2
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474n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365586
PNG
(CHEMBL1957801)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2nn3ccccc3c2Br)c(F)c1
Show InChI InChI=1S/C20H19BrF2N4O/c21-18-17-3-1-2-7-27(17)24-19(18)20(28)26-11-9-25(10-12-26)8-6-14-4-5-15(22)13-16(14)23/h1-5,7,13H,6,8-12H2
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496n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365585
PNG
(CHEMBL1957816)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3ccnc23)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-4-3-15(18(22)14-16)5-8-24-10-12-26(13-11-24)20(27)17-2-1-7-25-9-6-23-19(17)25/h1-4,6-7,9,14H,5,8,10-13H2
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524n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365584
PNG
(CHEMBL1957804)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cnn3cc(Cl)ccc23)c(F)c1
Show InChI InChI=1S/C20H19ClF2N4O/c21-15-2-4-19-17(12-24-27(19)13-15)20(28)26-9-7-25(8-10-26)6-5-14-1-3-16(22)11-18(14)23/h1-4,11-13H,5-10H2
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575n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365583
PNG
(CHEMBL1957811)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2nc3ccccn3c2Br)c(F)c1
Show InChI InChI=1S/C20H19BrF2N4O/c21-19-18(24-17-3-1-2-7-27(17)19)20(28)26-11-9-25(10-12-26)8-6-14-4-5-15(22)13-16(14)23/h1-5,7,13H,6,8-12H2
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581n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365582
PNG
(CHEMBL1957810)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cn3ccccc3n2)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-5-4-15(17(22)13-16)6-8-24-9-11-25(12-10-24)20(27)18-14-26-7-2-1-3-19(26)23-18/h1-5,7,13-14H,6,8-12H2
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596n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365581
PNG
(CHEMBL1957817)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3cc(Br)nc23)c(F)c1
Show InChI InChI=1S/C20H19BrF2N4O/c21-18-13-27-6-1-2-16(19(27)24-18)20(28)26-10-8-25(9-11-26)7-5-14-3-4-15(22)12-17(14)23/h1-4,6,12-13H,5,7-11H2
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682n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365580
PNG
(CHEMBL1957808)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cc3CCCCn3n2)c(F)c1
Show InChI InChI=1S/C20H24F2N4O/c21-16-5-4-15(18(22)13-16)6-8-24-9-11-25(12-10-24)20(27)19-14-17-3-1-2-7-26(17)23-19/h4-5,13-14H,1-3,6-12H2
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717n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365579
PNG
(CHEMBL1957814)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cnc3ccccn23)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-5-4-15(17(22)13-16)6-8-24-9-11-25(12-10-24)20(27)18-14-23-19-3-1-2-7-26(18)19/h1-5,7,13-14H,6,8-12H2
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739n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365578
PNG
(CHEMBL1957807)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cnn3cccnc23)c(F)c1
Show InChI InChI=1S/C19H19F2N5O/c20-15-3-2-14(17(21)12-15)4-7-24-8-10-25(11-9-24)19(27)16-13-23-26-6-1-5-22-18(16)26/h1-3,5-6,12-13H,4,7-11H2
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910n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365577
PNG
(CHEMBL1957815)
Show SMILES Cc1nc2ccccn2c1C(=O)N1CCN(CCc2ccc(F)cc2F)CC1
Show InChI InChI=1S/C21H22F2N4O/c1-15-20(27-8-3-2-4-19(27)24-15)21(28)26-12-10-25(11-13-26)9-7-16-5-6-17(22)14-18(16)23/h2-6,8,14H,7,9-13H2,1H3
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997n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365576
PNG
(CHEMBL1957806)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cc3ncccn3n2)c(F)c1
Show InChI InChI=1S/C19H19F2N5O/c20-15-3-2-14(16(21)12-15)4-7-24-8-10-25(11-9-24)19(27)17-13-18-22-5-1-6-26(18)23-17/h1-3,5-6,12-13H,4,7-11H2
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1.36E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50324551
PNG
((4-Bromo-1-methyl-1H-pyrazol-3-yl)-{4-[2-(2,4-difl...)
Show SMILES Cn1cc(Br)c(n1)C(=O)N1CCN(CCc2ccc(F)cc2F)CC1
Show InChI InChI=1S/C17H19BrF2N4O/c1-22-11-14(18)16(21-22)17(25)24-8-6-23(7-9-24)5-4-12-2-3-13(19)10-15(12)20/h2-3,10-11H,4-9H2,1H3
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2.82E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365575
PNG
(CHEMBL1957809)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cnn3CCCCc23)c(F)c1
Show InChI InChI=1S/C20H24F2N4O/c21-16-5-4-15(18(22)13-16)6-8-24-9-11-25(12-10-24)20(27)17-14-23-26-7-2-1-3-19(17)26/h4-5,13-14H,1-3,6-12H2
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2.88E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 2C (5-HT2C)


(Homo sapiens (human))
BDBM50365574
PNG
(CHEMBL1957819)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3cc(nc23)C#N)c(F)c1
Show InChI InChI=1S/C21H19F2N5O/c22-16-4-3-15(19(23)12-16)5-7-26-8-10-27(11-9-26)21(29)18-2-1-6-28-14-17(13-24)25-20(18)28/h1-4,6,12,14H,5,7-11H2
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6.90E+3n/an/an/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-DOI from recombinant human 5HT2C receptor


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50365585
PNG
(CHEMBL1957816)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3ccnc23)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-4-3-15(18(22)14-16)5-8-24-10-12-26(13-11-24)20(27)17-2-1-7-25-9-6-23-19(17)25/h1-4,6-7,9,14H,5,8,10-13H2
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n/an/a 1.90E+3n/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch-clamp assay


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50365585
PNG
(CHEMBL1957816)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3ccnc23)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-4-3-15(18(22)14-16)5-8-24-10-12-26(13-11-24)20(27)17-2-1-7-25-9-6-23-19(17)25/h1-4,6-7,9,14H,5,8,10-13H2
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n/an/a>4.00E+4n/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9 in human liver microsomes


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (human))
BDBM50365585
PNG
(CHEMBL1957816)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3ccnc23)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-4-3-15(18(22)14-16)5-8-24-10-12-26(13-11-24)20(27)17-2-1-7-25-9-6-23-19(17)25/h1-4,6-7,9,14H,5,8,10-13H2
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n/an/a>4.00E+4n/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP219 in human liver microsomes


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (human))
BDBM50365585
PNG
(CHEMBL1957816)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3ccnc23)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-4-3-15(18(22)14-16)5-8-24-10-12-26(13-11-24)20(27)17-2-1-7-25-9-6-23-19(17)25/h1-4,6-7,9,14H,5,8,10-13H2
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n/an/a>4.00E+4n/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2 in human liver microsomes


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50365585
PNG
(CHEMBL1957816)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3ccnc23)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-4-3-15(18(22)14-16)5-8-24-10-12-26(13-11-24)20(27)17-2-1-7-25-9-6-23-19(17)25/h1-4,6-7,9,14H,5,8,10-13H2
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n/an/a>4.00E+4n/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6 in human liver microsomes


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (human))
BDBM50365585
PNG
(CHEMBL1957816)
Show SMILES Fc1ccc(CCN2CCN(CC2)C(=O)c2cccn3ccnc23)c(F)c1
Show InChI InChI=1S/C20H20F2N4O/c21-16-4-3-15(18(22)14-16)5-8-24-10-12-26(13-11-24)20(27)17-2-1-7-25-9-6-23-19(17)25/h1-4,6-7,9,14H,5,8,10-13H2
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n/an/a>4.00E+4n/an/an/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4 in human liver microsomes


Bioorg Med Chem Lett 22: 1870-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.080
BindingDB Entry DOI: 10.7270/Q2XP75D0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%