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PubMed code 22364337

Compile data set for download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383333
PNG
(CHEMBL2029787)
Show SMILES COc1ccc(cc1)-c1ccn(CCC(C)C)c(=O)c1C#N
Show InChI InChI=1S/C18H20N2O2/c1-13(2)8-10-20-11-9-16(17(12-19)18(20)21)14-4-6-15(22-3)7-5-14/h4-7,9,11,13H,8,10H2,1-3H3
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n/an/an/an/a 1.15E+3n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383363
PNG
(CHEMBL2029818)
Show SMILES Cc1ncccc1Oc1ccc(cc1Cl)-c1ccn(CC2CC2)c(=O)c1C#N
Show InChI InChI=1S/C22H18ClN3O2/c1-14-20(3-2-9-25-14)28-21-7-6-16(11-19(21)23)17-8-10-26(13-15-4-5-15)22(27)18(17)12-24/h2-3,6-11,15H,4-5,13H2,1H3
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n/an/an/an/a 230n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383350
PNG
(CHEMBL2029812)
Show SMILES CCCCn1ccc(-c2ccc(Oc3ccc(C)nc3C)cc2)c(C#N)c1=O
Show InChI InChI=1S/C23H23N3O2/c1-4-5-13-26-14-12-20(21(15-24)23(26)27)18-7-9-19(10-8-18)28-22-11-6-16(2)25-17(22)3/h6-12,14H,4-5,13H2,1-3H3
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n/an/an/an/a 138n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383352
PNG
(CHEMBL2029814)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2ccn(CC3CC3)c(=O)c2C#N)c(C)n1
Show InChI InChI=1S/C23H21N3O2/c1-15-3-10-22(16(2)25-15)28-19-8-6-18(7-9-19)20-11-12-26(14-17-4-5-17)23(27)21(20)13-24/h3,6-12,17H,4-5,14H2,1-2H3
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n/an/an/an/a 263n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383335
PNG
(CHEMBL2029789)
Show SMILES COc1ccccc1-c1ccn(CCC(C)C)c(=O)c1C#N
Show InChI InChI=1S/C18H20N2O2/c1-13(2)8-10-20-11-9-14(16(12-19)18(20)21)15-6-4-5-7-17(15)22-3/h4-7,9,11,13H,8,10H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383343
PNG
(CHEMBL2029805)
Show SMILES CC(C)CCn1ccc(-c2ccc(Oc3ccnc(C)c3)cc2)c(C#N)c1=O
Show InChI InChI=1S/C23H23N3O2/c1-16(2)9-12-26-13-10-21(22(15-24)23(26)27)18-4-6-19(7-5-18)28-20-8-11-25-17(3)14-20/h4-8,10-11,13-14,16H,9,12H2,1-3H3
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n/an/an/an/a 447n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383349
PNG
(CHEMBL2029811)
Show SMILES Cc1ncccc1Oc1ccc(cc1)-c1ccn(CC2CC2)c(=O)c1C#N
Show InChI InChI=1S/C22H19N3O2/c1-15-21(3-2-11-24-15)27-18-8-6-17(7-9-18)19-10-12-25(14-16-4-5-16)22(26)20(19)13-23/h2-3,6-12,16H,4-5,14H2,1H3
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n/an/an/an/a 1.07E+3n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383357
PNG
(CHEMBL2029801)
Show SMILES CNc1ccc(cc1)-c1ccn(CCC(C)C)c(=O)c1C#N
Show InChI InChI=1S/C18H21N3O/c1-13(2)8-10-21-11-9-16(17(12-19)18(21)22)14-4-6-15(20-3)7-5-14/h4-7,9,11,13,20H,8,10H2,1-3H3
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n/an/an/an/a 460n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383365
PNG
(CHEMBL2029820)
Show SMILES Cc1ccc(Oc2ccc(cc2Cl)-c2ccn(CC3CC3)c(=O)c2C#N)c(C)n1
Show InChI InChI=1S/C23H20ClN3O2/c1-14-3-7-21(15(2)26-14)29-22-8-6-17(11-20(22)24)18-9-10-27(13-16-4-5-16)23(28)19(18)12-25/h3,6-11,16H,4-5,13H2,1-2H3
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n/an/an/an/a 64n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383334
PNG
(CHEMBL2029788)
Show SMILES COc1cccc(c1)-c1ccn(CCC(C)C)c(=O)c1C#N
Show InChI InChI=1S/C18H20N2O2/c1-13(2)7-9-20-10-8-16(17(12-19)18(20)21)14-5-4-6-15(11-14)22-3/h4-6,8,10-11,13H,7,9H2,1-3H3
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n/an/an/an/a 3.17E+3n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383342
PNG
(CHEMBL2029796)
Show SMILES CC(C)CCn1ccc(-c2ccc(OC3CCOCC3)c(Cl)c2)c(C#N)c1=O
Show InChI InChI=1S/C22H25ClN2O3/c1-15(2)5-9-25-10-6-18(19(14-24)22(25)26)16-3-4-21(20(23)13-16)28-17-7-11-27-12-8-17/h3-4,6,10,13,15,17H,5,7-9,11-12H2,1-2H3
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n/an/an/an/a 186n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383362
PNG
(CHEMBL2029817)
Show SMILES CCCCn1ccc(-c2ccc(Oc3cccnc3C)c(Cl)c2)c(C#N)c1=O
Show InChI InChI=1S/C22H20ClN3O2/c1-3-4-11-26-12-9-17(18(14-24)22(26)27)16-7-8-21(19(23)13-16)28-20-6-5-10-25-15(20)2/h5-10,12-13H,3-4,11H2,1-2H3
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n/an/an/an/a 100n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383364
PNG
(CHEMBL2029819)
Show SMILES CCCCn1ccc(-c2ccc(Oc3ccc(C)nc3C)c(Cl)c2)c(C#N)c1=O
Show InChI InChI=1S/C23H22ClN3O2/c1-4-5-11-27-12-10-18(19(14-25)23(27)28)17-7-9-22(20(24)13-17)29-21-8-6-15(2)26-16(21)3/h6-10,12-13H,4-5,11H2,1-3H3
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n/an/an/an/a 30n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383332
PNG
(CHEMBL2029786)
Show SMILES CC(C)CCn1ccc(-c2ccccc2)c(C#N)c1=O
Show InChI InChI=1S/C17H18N2O/c1-13(2)8-10-19-11-9-15(16(12-18)17(19)20)14-6-4-3-5-7-14/h3-7,9,11,13H,8,10H2,1-2H3
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n/an/an/an/a 8.51E+3n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383346
PNG
(CHEMBL2029808)
Show SMILES Cc1cc(Oc2ccc(cc2)-c2ccn(CC3CC3)c(=O)c2C#N)ccn1
Show InChI InChI=1S/C22H19N3O2/c1-15-12-19(8-10-24-15)27-18-6-4-17(5-7-18)20-9-11-25(14-16-2-3-16)22(26)21(20)13-23/h4-12,16H,2-3,14H2,1H3
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n/an/an/an/a 832n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383356
PNG
(CHEMBL2029800)
Show SMILES CC(C)CCn1ccc(-c2ccc(Oc3ccncc3)cc2)c(C#N)c1=O
Show InChI InChI=1S/C22H21N3O2/c1-16(2)9-13-25-14-10-20(21(15-23)22(25)26)17-3-5-18(6-4-17)27-19-7-11-24-12-8-19/h3-8,10-12,14,16H,9,13H2,1-2H3
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n/an/an/an/a 550n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383361
PNG
(CHEMBL2029816)
Show SMILES CCCCn1ccc(-c2ccc(Oc3ccnc(C)c3)cc2Cl)c(C#N)c1=O
Show InChI InChI=1S/C22H20ClN3O2/c1-3-4-10-26-11-8-18(20(14-24)22(26)27)19-6-5-16(13-21(19)23)28-17-7-9-25-15(2)12-17/h5-9,11-13H,3-4,10H2,1-2H3
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n/an/an/an/a 933n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383336
PNG
(CHEMBL2029790)
Show SMILES COc1ccc(cc1F)-c1ccn(CCC(C)C)c(=O)c1C#N
Show InChI InChI=1S/C18H19FN2O2/c1-12(2)6-8-21-9-7-14(15(11-20)18(21)22)13-4-5-17(23-3)16(19)10-13/h4-5,7,9-10,12H,6,8H2,1-3H3
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n/an/an/an/a 1.17E+3n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383338
PNG
(CHEMBL2029792)
Show SMILES COc1ccc(cc1OC)-c1ccn(CCC(C)C)c(=O)c1C#N
Show InChI InChI=1S/C19H22N2O3/c1-13(2)7-9-21-10-8-15(16(12-20)19(21)22)14-5-6-17(23-3)18(11-14)24-4/h5-6,8,10-11,13H,7,9H2,1-4H3
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n/an/an/an/a 260n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383358
PNG
(CHEMBL2029802)
Show SMILES CC(C)CCn1ccc(-c2ccc(NC3CCOCC3)c(Cl)c2)c(C#N)c1=O
Show InChI InChI=1S/C22H26ClN3O2/c1-15(2)5-9-26-10-6-18(19(14-24)22(26)27)16-3-4-21(20(23)13-16)25-17-7-11-28-12-8-17/h3-4,6,10,13,15,17,25H,5,7-9,11-12H2,1-2H3
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n/an/an/an/a 174n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383366
PNG
(CHEMBL2029821)
Show SMILES CCCCn1ccc(-c2ccc(Oc3ccnc(C)c3)c(F)c2)c(C#N)c1=O
Show InChI InChI=1S/C22H20FN3O2/c1-3-4-10-26-11-8-18(19(14-24)22(26)27)16-5-6-21(20(23)13-16)28-17-7-9-25-15(2)12-17/h5-9,11-13H,3-4,10H2,1-2H3
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n/an/an/an/a 316n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383337
PNG
(CHEMBL2029791)
Show SMILES COc1ccc(cc1Cl)-c1ccn(CCC(C)C)c(=O)c1C#N
Show InChI InChI=1S/C18H19ClN2O2/c1-12(2)6-8-21-9-7-14(15(11-20)18(21)22)13-4-5-17(23-3)16(19)10-13/h4-5,7,9-10,12H,6,8H2,1-3H3
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n/an/an/an/a 363n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383353
PNG
(CHEMBL2029815)
Show SMILES CCCCn1ccc(-c2ccc(Oc3ccnc(C)c3)c(Cl)c2)c(C#N)c1=O
Show InChI InChI=1S/C22H20ClN3O2/c1-3-4-10-26-11-8-18(19(14-24)22(26)27)16-5-6-21(20(23)13-16)28-17-7-9-25-15(2)12-17/h5-9,11-13H,3-4,10H2,1-2H3
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n/an/an/an/a 166n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383368
PNG
(CHEMBL2029823)
Show SMILES CCCCn1ccc(-c2ccc(Oc3cc(C)nc(C)c3)c(F)c2)c(C#N)c1=O
Show InChI InChI=1S/C23H22FN3O2/c1-4-5-9-27-10-8-19(20(14-25)23(27)28)17-6-7-22(21(24)13-17)29-18-11-15(2)26-16(3)12-18/h6-8,10-13H,4-5,9H2,1-3H3
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n/an/an/an/a 372n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383369
PNG
(CHEMBL2029797)
Show SMILES CC(C)CCn1ccc(-c2ccc(Oc3ccccc3)cc2)c(C#N)c1=O
Show InChI InChI=1S/C23H22N2O2/c1-17(2)12-14-25-15-13-21(22(16-24)23(25)26)18-8-10-20(11-9-18)27-19-6-4-3-5-7-19/h3-11,13,15,17H,12,14H2,1-2H3
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n/an/an/an/a 42n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383339
PNG
(CHEMBL2029793)
Show SMILES CC(C)CCn1ccc(-c2ccc(OCC3CC3)cc2)c(C#N)c1=O
Show InChI InChI=1S/C21H24N2O2/c1-15(2)9-11-23-12-10-19(20(13-22)21(23)24)17-5-7-18(8-6-17)25-14-16-3-4-16/h5-8,10,12,15-16H,3-4,9,11,14H2,1-2H3
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n/an/an/an/a 290n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383340
PNG
(CHEMBL2029794)
Show SMILES CC(C)CCn1ccc(-c2ccc(OCC3CC3)c(Cl)c2)c(C#N)c1=O
Show InChI InChI=1S/C21H23ClN2O2/c1-14(2)7-9-24-10-8-17(18(12-23)21(24)25)16-5-6-20(19(22)11-16)26-13-15-3-4-15/h5-6,8,10-11,14-15H,3-4,7,9,13H2,1-2H3
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n/an/an/an/a 110n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383341
PNG
(CHEMBL2029795)
Show SMILES CC(C)CCn1ccc(-c2ccc(OC3CCCC3)c(Cl)c2)c(C#N)c1=O
Show InChI InChI=1S/C22H25ClN2O2/c1-15(2)9-11-25-12-10-18(19(14-24)22(25)26)16-7-8-21(20(23)13-16)27-17-5-3-4-6-17/h7-8,10,12-13,15,17H,3-6,9,11H2,1-2H3
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n/an/an/an/a 100n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383345
PNG
(CHEMBL2029807)
Show SMILES CCCCn1ccc(-c2ccc(Oc3ccnc(C)c3)cc2)c(C#N)c1=O
Show InChI InChI=1S/C22H21N3O2/c1-3-4-12-25-13-10-20(21(15-23)22(25)26)17-5-7-18(8-6-17)27-19-9-11-24-16(2)14-19/h5-11,13-14H,3-4,12H2,1-2H3
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n/an/an/an/a 398n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383347
PNG
(CHEMBL2029809)
Show SMILES CCCCn1ccc(-c2ccc(Oc3cccnc3C)cc2)c(C#N)c1=O
Show InChI InChI=1S/C22H21N3O2/c1-3-4-13-25-14-11-19(20(15-23)22(25)26)17-7-9-18(10-8-17)27-21-6-5-12-24-16(21)2/h5-12,14H,3-4,13H2,1-2H3
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n/an/an/an/a 347n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383351
PNG
(CHEMBL2029813)
Show SMILES CC(C)CCn1ccc(-c2ccc(Oc3ccc(C)nc3C)cc2)c(C#N)c1=O
Show InChI InChI=1S/C24H25N3O2/c1-16(2)11-13-27-14-12-21(22(15-25)24(27)28)19-6-8-20(9-7-19)29-23-10-5-17(3)26-18(23)4/h5-10,12,14,16H,11,13H2,1-4H3
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n/an/an/an/a 100n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383354
PNG
(CHEMBL2029798)
Show SMILES CC(C)CCn1ccc(-c2ccc(Oc3ccccn3)cc2)c(C#N)c1=O
Show InChI InChI=1S/C22H21N3O2/c1-16(2)10-13-25-14-11-19(20(15-23)22(25)26)17-6-8-18(9-7-17)27-21-5-3-4-12-24-21/h3-9,11-12,14,16H,10,13H2,1-2H3
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n/an/an/an/a 646n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383355
PNG
(CHEMBL2029799)
Show SMILES CC(C)CCn1ccc(-c2ccc(Oc3cccnc3)cc2)c(C#N)c1=O
Show InChI InChI=1S/C22H21N3O2/c1-16(2)9-12-25-13-10-20(21(14-23)22(25)26)17-5-7-18(8-6-17)27-19-4-3-11-24-15-19/h3-8,10-11,13,15-16H,9,12H2,1-2H3
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n/an/an/an/a 479n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383360
PNG
(CHEMBL2029804)
Show SMILES CC(C)CCn1ccc(-c2ccc(Nc3ccncc3)cc2)c(C#N)c1=O
Show InChI InChI=1S/C22H22N4O/c1-16(2)9-13-26-14-10-20(21(15-23)22(26)27)17-3-5-18(6-4-17)25-19-7-11-24-12-8-19/h3-8,10-12,14,16H,9,13H2,1-2H3,(H,24,25)
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n/an/an/an/a 1.48E+3n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383367
PNG
(CHEMBL2029822)
Show SMILES CCCCn1ccc(-c2ccc(Oc3ccnc(C)c3)cc2F)c(C#N)c1=O
Show InChI InChI=1S/C22H20FN3O2/c1-3-4-10-26-11-8-18(20(14-24)22(26)27)19-6-5-16(13-21(19)23)28-17-7-9-25-15(2)12-17/h5-9,11-13H,3-4,10H2,1-2H3
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n/an/an/an/a 390n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383348
PNG
(CHEMBL2029810)
Show SMILES CC(C)CCn1ccc(-c2ccc(Oc3cccnc3C)cc2)c(C#N)c1=O
Show InChI InChI=1S/C23H23N3O2/c1-16(2)10-13-26-14-11-20(21(15-24)23(26)27)18-6-8-19(9-7-18)28-22-5-4-12-25-17(22)3/h4-9,11-12,14,16H,10,13H2,1-3H3
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n/an/an/an/a 275n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383359
PNG
(CHEMBL2029803)
Show SMILES CC(C)CCn1ccc(-c2ccc(cc2)N2CCOCC2)c(C#N)c1=O
Show InChI InChI=1S/C21H25N3O2/c1-16(2)7-9-24-10-8-19(20(15-22)21(24)25)17-3-5-18(6-4-17)23-11-13-26-14-12-23/h3-6,8,10,16H,7,9,11-14H2,1-2H3
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n/an/an/an/a 2.04E+3n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM50383344
PNG
(CHEMBL2029806)
Show SMILES Cc1cc(Oc2ccc(cc2)-c2ccn(CC3CCC3)c(=O)c2C#N)ccn1
Show InChI InChI=1S/C23H21N3O2/c1-16-13-20(9-11-25-16)28-19-7-5-18(6-8-19)21-10-12-26(15-17-3-2-4-17)23(27)22(21)14-24/h5-13,17H,2-4,15H2,1H3
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n/an/an/an/a 126n/an/an/an/a



Janssen-Cilag S.A.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...


J Med Chem 55: 2388-405 (2012)


Article DOI: 10.1021/jm2016864
BindingDB Entry DOI: 10.7270/Q22B9020
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%