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PubMed code 22369181

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peroxisome proliferator-activated receptor delta


(Mus musculus)
BDBM50383371
PNG
(CHEMBL2030550)
Show SMILES CN1CCN(CC1)c1ccc(\C=C(/C#N)c2ccccc2Br)cc1
Show InChI InChI=1S/C20H20BrN3/c1-23-10-12-24(13-11-23)18-8-6-16(7-9-18)14-17(15-22)19-4-2-3-5-20(19)21/h2-9,14H,10-13H2,1H3/b17-14+
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PC sid
UniChem
Article
PubMed
n/an/a 9.5n/an/an/an/an/an/a



Philipps University

Curated by ChEMBL


Assay Description
Inverse agonist activity at PPARbeta/delta in mouse C2C12 cells assessed as inhibition of Angptl4 expression after 24 hrs by RT-qPCR analysis


J Med Chem 55: 2858-68 (2012)


Article DOI: 10.1021/jm2017122
BindingDB Entry DOI: 10.7270/Q2XK8GK9
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Mus musculus)
BDBM50383371
PNG
(CHEMBL2030550)
Show SMILES CN1CCN(CC1)c1ccc(\C=C(/C#N)c2ccccc2Br)cc1
Show InChI InChI=1S/C20H20BrN3/c1-23-10-12-24(13-11-23)18-8-6-16(7-9-18)14-17(15-22)19-4-2-3-5-20(19)21/h2-9,14H,10-13H2,1H3/b17-14+
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PC sid
UniChem
Article
PubMed
n/an/a 26.9n/an/an/an/an/an/a



Philipps University

Curated by ChEMBL


Assay Description
Displacement of fluormone Pan-PPAR Green from mouse recombinant GST-tagged PPARbeta/delta LBD after 60 mins by TR-FRET assay


J Med Chem 55: 2858-68 (2012)


Article DOI: 10.1021/jm2017122
BindingDB Entry DOI: 10.7270/Q2XK8GK9
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Mus musculus)
BDBM50383373
PNG
(CHEMBL592652 | GSK0660)
Show SMILES COC(=O)c1sccc1S(=O)(=O)Nc1ccc(Nc2ccccc2)cc1OC
Show InChI InChI=1S/C19H18N2O5S2/c1-25-16-12-14(20-13-6-4-3-5-7-13)8-9-15(16)21-28(23,24)17-10-11-27-18(17)19(22)26-2/h3-12,20-21H,1-2H3
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PC sid
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n/an/a 48n/an/an/an/an/an/a



Philipps University

Curated by ChEMBL


Assay Description
Inverse agonist activity at PPARbeta/delta in mouse C2C12 cells assessed as inhibition of Angptl4 expression after 24 hrs by RT-qPCR analysis


J Med Chem 55: 2858-68 (2012)


Article DOI: 10.1021/jm2017122
BindingDB Entry DOI: 10.7270/Q2XK8GK9
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Mus musculus)
BDBM50383370
PNG
(CHEMBL2030543)
Show SMILES CN(C)c1ccc(\C=C(/C#N)c2ccccc2Cl)cc1
Show InChI InChI=1S/C17H15ClN2/c1-20(2)15-9-7-13(8-10-15)11-14(12-19)16-5-3-4-6-17(16)18/h3-11H,1-2H3/b14-11+
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n/an/a 52n/an/an/an/an/an/a



Philipps University

Curated by ChEMBL


Assay Description
Inverse agonist activity at PPARbeta/delta in mouse C2C12 cells assessed as inhibition of Angptl4 expression after 24 hrs by RT-qPCR analysis


J Med Chem 55: 2858-68 (2012)


Article DOI: 10.1021/jm2017122
BindingDB Entry DOI: 10.7270/Q2XK8GK9
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Mus musculus)
BDBM50383370
PNG
(CHEMBL2030543)
Show SMILES CN(C)c1ccc(\C=C(/C#N)c2ccccc2Cl)cc1
Show InChI InChI=1S/C17H15ClN2/c1-20(2)15-9-7-13(8-10-15)11-14(12-19)16-5-3-4-6-17(16)18/h3-11H,1-2H3/b14-11+
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Philipps University

Curated by ChEMBL


Assay Description
Displacement of fluormone Pan-PPAR Green from mouse recombinant GST-tagged PPARbeta/delta LBD after 60 mins by TR-FRET assay


J Med Chem 55: 2858-68 (2012)


Article DOI: 10.1021/jm2017122
BindingDB Entry DOI: 10.7270/Q2XK8GK9
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Mus musculus)
BDBM50383372
PNG
(CHEMBL1998001)
Show SMILES CN(C)c1ccc(\C=C(/C#N)c2ccccc2)cc1
Show InChI InChI=1S/C17H16N2/c1-19(2)17-10-8-14(9-11-17)12-16(13-18)15-6-4-3-5-7-15/h3-12H,1-2H3/b16-12+
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PC cid
PC sid
UniChem
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PubMed
n/an/a>500n/an/an/an/an/an/a



Philipps University

Curated by ChEMBL


Assay Description
Inverse agonist activity at PPARbeta/delta in mouse C2C12 cells assessed as inhibition of Angptl4 expression after 24 hrs by RT-qPCR analysis


J Med Chem 55: 2858-68 (2012)


Article DOI: 10.1021/jm2017122
BindingDB Entry DOI: 10.7270/Q2XK8GK9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%