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PubMed code 22524426

Compile Data Set for Download or QSAR

Found 281 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389047
PNG
(CHEMBL2064328)
Show SMILES CC(Nc1ccccc1)c1cc(C)cc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C22H24N2O3/c1-15-12-18(16(2)23-17-6-4-3-5-7-17)22-19(13-15)20(25)14-21(27-22)24-8-10-26-11-9-24/h3-7,12-14,16,23H,8-11H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389047
PNG
(CHEMBL2064328)
Show SMILES CC(Nc1ccccc1)c1cc(C)cc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C22H24N2O3/c1-15-12-18(16(2)23-17-6-4-3-5-7-17)22-19(13-15)20(25)14-21(27-22)24-8-10-26-11-9-24/h3-7,12-14,16,23H,8-11H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at T308 residue expressed in PTEN-deficient human PC3 cells after 2 hrs by Western blot ana...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50365890
PNG
(CHEMBL1957875)
Show SMILES C[C@@H](Nc1ccccc1)c1cc(C)cn2c1nc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C21H24N4O2/c1-15-12-18(16(2)22-17-6-4-3-5-7-17)21-23-19(13-20(26)25(21)14-15)24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3/t16-/m1/s1
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at T308 residue expressed in PTEN-deficient human PC3 cells after 2 hrs by Western blot ana...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389048
PNG
(CHEMBL2064417)
Show SMILES Fc1ccc2oc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)nc2c1-c1ccccc1
Show InChI InChI=1S/C22H19FN4O3/c23-15-6-7-16-22(21(15)14-4-2-1-3-5-14)26-20(30-16)12-17-24-18(13-19(28)25-17)27-8-10-29-11-9-27/h1-7,13H,8-12H2,(H,24,25,28)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389048
PNG
(CHEMBL2064417)
Show SMILES Fc1ccc2oc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)nc2c1-c1ccccc1
Show InChI InChI=1S/C22H19FN4O3/c23-15-6-7-16-22(21(15)14-4-2-1-3-5-14)26-20(30-16)12-17-24-18(13-19(28)25-17)27-8-10-29-11-9-27/h1-7,13H,8-12H2,(H,24,25,28)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389069
PNG
(CHEMBL2064344)
Show SMILES O=c1cc(nc(Cc2nc3ccccc3n2-c2ccccc2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C22H21N5O2/c28-22-15-20(26-10-12-29-13-11-26)24-19(25-22)14-21-23-17-8-4-5-9-18(17)27(21)16-6-2-1-3-7-16/h1-9,15H,10-14H2,(H,24,25,28)
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n/an/a 8n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389072
PNG
(CHEMBL2064341)
Show SMILES Fc1ccc2n(C3CC3)c(Cc3nc(cc(=O)[nH]3)N3CCOCC3)nc2c1
Show InChI InChI=1S/C19H20FN5O2/c20-12-1-4-15-14(9-12)21-18(25(15)13-2-3-13)10-16-22-17(11-19(26)23-16)24-5-7-27-8-6-24/h1,4,9,11,13H,2-3,5-8,10H2,(H,22,23,26)
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n/an/a 9n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389067
PNG
(CHEMBL2064346)
Show SMILES O=c1cc(nc(Cc2nc3c(cccc3[nH]2)-c2ccccc2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C22H21N5O2/c28-21-14-20(27-9-11-29-12-10-27)24-19(25-21)13-18-23-17-8-4-7-16(22(17)26-18)15-5-2-1-3-6-15/h1-8,14H,9-13H2,(H,23,26)(H,24,25,28)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50365890
PNG
(CHEMBL1957875)
Show SMILES C[C@@H](Nc1ccccc1)c1cc(C)cn2c1nc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C21H24N4O2/c1-15-12-18(16(2)22-17-6-4-3-5-7-17)21-23-19(13-20(26)25(21)14-15)24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3/t16-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50365890
PNG
(CHEMBL1957875)
Show SMILES C[C@@H](Nc1ccccc1)c1cc(C)cn2c1nc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C21H24N4O2/c1-15-12-18(16(2)22-17-6-4-3-5-7-17)21-23-19(13-20(26)25(21)14-15)24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3/t16-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in mouse MEF-3T3 cells after 0.5 to 2 hrs by Western blot analy...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389054
PNG
(CHEMBL2064411)
Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2ccccc2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C22H20N4O3/c27-20-14-19(26-9-11-28-12-10-26)23-18(24-20)13-21-25-22-16(7-4-8-17(22)29-21)15-5-2-1-3-6-15/h1-8,14H,9-13H2,(H,23,24,27)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389041
PNG
(CHEMBL2064333)
Show SMILES Cn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2cc(F)ccc12
Show InChI InChI=1S/C17H18FN5O2/c1-22-13-3-2-11(18)8-12(13)19-15(22)9-14-20-16(10-17(24)21-14)23-4-6-25-7-5-23/h2-3,8,10H,4-7,9H2,1H3,(H,20,21,24)
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n/an/a 16n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389065
PNG
(CHEMBL2064348)
Show SMILES Cn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2cccc(-c3ccccc3)c12
Show InChI InChI=1S/C23H23N5O2/c1-27-20(14-19-25-21(15-22(29)26-19)28-10-12-30-13-11-28)24-18-9-5-8-17(23(18)27)16-6-3-2-4-7-16/h2-9,15H,10-14H2,1H3,(H,25,26,29)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389054
PNG
(CHEMBL2064411)
Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2ccccc2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C22H20N4O3/c27-20-14-19(26-9-11-28-12-10-26)23-18(24-20)13-21-25-22-16(7-4-8-17(22)29-21)15-5-2-1-3-6-15/h1-8,14H,9-13H2,(H,23,24,27)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50389070
PNG
(CHEMBL2064343)
Show SMILES O=c1cc(nc(Cc2nc3ccccc3n2C2CCCCC2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C22H27N5O2/c28-22-15-20(26-10-12-29-13-11-26)24-19(25-22)14-21-23-17-8-4-5-9-18(17)27(21)16-6-2-1-3-7-16/h4-5,8-9,15-16H,1-3,6-7,10-14H2,(H,24,25,28)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate p...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389052
PNG
(CHEMBL2064413)
Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2cccs2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C20H18N4O3S/c25-18-12-17(24-6-8-26-9-7-24)21-16(22-18)11-19-23-20-13(15-5-2-10-28-15)3-1-4-14(20)27-19/h1-5,10,12H,6-9,11H2,(H,21,22,25)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389066
PNG
(CHEMBL2064347)
Show SMILES Cn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2c(cccc12)-c1ccccc1
Show InChI InChI=1S/C23H23N5O2/c1-27-18-9-5-8-17(16-6-3-2-4-7-16)23(18)26-20(27)14-19-24-21(15-22(29)25-19)28-10-12-30-13-11-28/h2-9,15H,10-14H2,1H3,(H,24,25,29)
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n/an/a 26n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389073
PNG
(CHEMBL2064340)
Show SMILES CCn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2ccccc12
Show InChI InChI=1S/C18H21N5O2/c1-2-23-14-6-4-3-5-13(14)19-17(23)11-15-20-16(12-18(24)21-15)22-7-9-25-10-8-22/h3-6,12H,2,7-11H2,1H3,(H,20,21,24)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389062
PNG
(CHEMBL2064352)
Show SMILES Fc1ccc2oc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)nc2c1
Show InChI InChI=1S/C16H15FN4O3/c17-10-1-2-12-11(7-10)18-16(24-12)8-13-19-14(9-15(22)20-13)21-3-5-23-6-4-21/h1-2,7,9H,3-6,8H2,(H,19,20,22)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389047
PNG
(CHEMBL2064328)
Show SMILES CC(Nc1ccccc1)c1cc(C)cc2c1oc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C22H24N2O3/c1-15-12-18(16(2)23-17-6-4-3-5-7-17)22-19(13-15)20(25)14-21(27-22)24-8-10-26-11-9-24/h3-7,12-14,16,23H,8-11H2,1-2H3
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n/an/a 28n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389072
PNG
(CHEMBL2064341)
Show SMILES Fc1ccc2n(C3CC3)c(Cc3nc(cc(=O)[nH]3)N3CCOCC3)nc2c1
Show InChI InChI=1S/C19H20FN5O2/c20-12-1-4-15-14(9-12)21-18(25(15)13-2-3-13)10-16-22-17(11-19(26)23-16)24-5-7-27-8-6-24/h1,4,9,11,13H,2-3,5-8,10H2,(H,22,23,26)
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n/an/a 29n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50365890
PNG
(CHEMBL1957875)
Show SMILES C[C@@H](Nc1ccccc1)c1cc(C)cn2c1nc(cc2=O)N1CCOCC1
Show InChI InChI=1S/C21H24N4O2/c1-15-12-18(16(2)22-17-6-4-3-5-7-17)21-23-19(13-20(26)25(21)14-15)24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3/t16-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389042
PNG
(CHEMBL2064331)
Show SMILES Fc1ccc2nc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)[nH]c2c1
Show InChI InChI=1S/C16H16FN5O2/c17-10-1-2-11-12(7-10)19-13(18-11)8-14-20-15(9-16(23)21-14)22-3-5-24-6-4-22/h1-2,7,9H,3-6,8H2,(H,18,19)(H,20,21,23)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389046
PNG
(CHEMBL2064327)
Show SMILES Cc1cc(F)ccc1Oc1cccc2c(O)cc(nc12)N1CCOCC1
Show InChI InChI=1S/C20H19FN2O3/c1-13-11-14(21)5-6-17(13)26-18-4-2-3-15-16(24)12-19(22-20(15)18)23-7-9-25-10-8-23/h2-6,11-12H,7-10H2,1H3,(H,22,24)
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n/an/a 32n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50389072
PNG
(CHEMBL2064341)
Show SMILES Fc1ccc2n(C3CC3)c(Cc3nc(cc(=O)[nH]3)N3CCOCC3)nc2c1
Show InChI InChI=1S/C19H20FN5O2/c20-12-1-4-15-14(9-12)21-18(25(15)13-2-3-13)10-16-22-17(11-19(26)23-16)24-5-7-27-8-6-24/h1,4,9,11,13H,2-3,5-8,10H2,(H,22,23,26)
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n/an/a 36n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate p...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50389069
PNG
(CHEMBL2064344)
Show SMILES O=c1cc(nc(Cc2nc3ccccc3n2-c2ccccc2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C22H21N5O2/c28-22-15-20(26-10-12-29-13-11-26)24-19(25-22)14-21-23-17-8-4-5-9-18(17)27(21)16-6-2-1-3-7-16/h1-9,15H,10-14H2,(H,24,25,28)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate p...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389042
PNG
(CHEMBL2064331)
Show SMILES Fc1ccc2nc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)[nH]c2c1
Show InChI InChI=1S/C16H16FN5O2/c17-10-1-2-11-12(7-10)19-13(18-11)8-14-20-15(9-16(23)21-14)22-3-5-24-6-4-22/h1-2,7,9H,3-6,8H2,(H,18,19)(H,20,21,23)
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n/an/a 41n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389035
PNG
(CHEMBL2064419)
Show SMILES O=C(Cc1nc(cc(=O)[nH]1)N1CCOCC1)Nc1ccccc1
Show InChI InChI=1S/C16H18N4O3/c21-15(17-12-4-2-1-3-5-12)10-13-18-14(11-16(22)19-13)20-6-8-23-9-7-20/h1-5,11H,6-10H2,(H,17,21)(H,18,19,22)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389050
PNG
(CHEMBL2064415)
Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2cccnc2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C21H19N5O3/c27-19-12-18(26-7-9-28-10-8-26)23-17(24-19)11-20-25-21-15(4-1-5-16(21)29-20)14-3-2-6-22-13-14/h1-6,12-13H,7-11H2,(H,23,24,27)
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n/an/a 44n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389052
PNG
(CHEMBL2064413)
Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2cccs2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C20H18N4O3S/c25-18-12-17(24-6-8-26-9-7-24)21-16(22-18)11-19-23-20-13(15-5-2-10-28-15)3-1-4-14(20)27-19/h1-5,10,12H,6-9,11H2,(H,21,22,25)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389062
PNG
(CHEMBL2064352)
Show SMILES Fc1ccc2oc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)nc2c1
Show InChI InChI=1S/C16H15FN4O3/c17-10-1-2-12-11(7-10)18-16(24-12)8-13-19-14(9-15(22)20-13)21-3-5-23-6-4-21/h1-2,7,9H,3-6,8H2,(H,19,20,22)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389049
PNG
(CHEMBL2064416)
Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2ccncc2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C21H19N5O3/c27-19-13-18(26-8-10-28-11-9-26)23-17(24-19)12-20-25-21-15(2-1-3-16(21)29-20)14-4-6-22-7-5-14/h1-7,13H,8-12H2,(H,23,24,27)
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n/an/a 47n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389061
PNG
(CHEMBL2064353)
Show SMILES Fc1ccc2nc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)oc2c1
Show InChI InChI=1S/C16H15FN4O3/c17-10-1-2-11-12(7-10)24-16(18-11)8-13-19-14(9-15(22)20-13)21-3-5-23-6-4-21/h1-2,7,9H,3-6,8H2,(H,19,20,22)
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n/an/a 49n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389066
PNG
(CHEMBL2064347)
Show SMILES Cn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2c(cccc12)-c1ccccc1
Show InChI InChI=1S/C23H23N5O2/c1-27-18-9-5-8-17(16-6-3-2-4-7-16)23(18)26-20(27)14-19-24-21(15-22(29)25-19)28-10-12-30-13-11-28/h2-9,15H,10-14H2,1H3,(H,24,25,29)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389065
PNG
(CHEMBL2064348)
Show SMILES Cn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2cccc(-c3ccccc3)c12
Show InChI InChI=1S/C23H23N5O2/c1-27-20(14-19-25-21(15-22(29)26-19)28-10-12-30-13-11-28)24-18-9-5-8-17(23(18)27)16-6-3-2-4-7-16/h2-9,15H,10-14H2,1H3,(H,25,26,29)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389044
PNG
(CHEMBL2064418)
Show SMILES O=c1cc(nc(Cc2nc3ccccc3o2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C16H16N4O3/c21-15-10-14(20-5-7-22-8-6-20)18-13(19-15)9-16-17-11-3-1-2-4-12(11)23-16/h1-4,10H,5-9H2,(H,18,19,21)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389076
PNG
(CHEMBL2064336)
Show SMILES Clc1ccc2nc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)[nH]c2c1
Show InChI InChI=1S/C16H16ClN5O2/c17-10-1-2-11-12(7-10)19-13(18-11)8-14-20-15(9-16(23)21-14)22-3-5-24-6-4-22/h1-2,7,9H,3-6,8H2,(H,18,19)(H,20,21,23)
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Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389067
PNG
(CHEMBL2064346)
Show SMILES O=c1cc(nc(Cc2nc3c(cccc3[nH]2)-c2ccccc2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C22H21N5O2/c28-21-14-20(27-9-11-29-12-10-27)24-19(25-21)13-18-23-17-8-4-7-16(22(17)26-18)15-5-2-1-3-6-15/h1-8,14H,9-13H2,(H,23,26)(H,24,25,28)
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n/an/a 65n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389046
PNG
(CHEMBL2064327)
Show SMILES Cc1cc(F)ccc1Oc1cccc2c(O)cc(nc12)N1CCOCC1
Show InChI InChI=1S/C20H19FN2O3/c1-13-11-14(21)5-6-17(13)26-18-4-2-3-15-16(24)12-19(22-20(15)18)23-7-9-25-10-8-23/h2-6,11-12H,7-10H2,1H3,(H,22,24)
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n/an/a 72n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389073
PNG
(CHEMBL2064340)
Show SMILES CCn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2ccccc12
Show InChI InChI=1S/C18H21N5O2/c1-2-23-14-6-4-3-5-13(14)19-17(23)11-15-20-16(12-18(24)21-15)22-7-9-25-10-8-22/h3-6,12H,2,7-11H2,1H3,(H,20,21,24)
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n/an/a 72n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389038
PNG
(CHEMBL2064406)
Show SMILES Cc1cccc2oc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)nc12
Show InChI InChI=1S/C17H18N4O3/c1-11-3-2-4-12-17(11)20-16(24-12)9-13-18-14(10-15(22)19-13)21-5-7-23-8-6-21/h2-4,10H,5-9H2,1H3,(H,18,19,22)
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n/an/a 75n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389069
PNG
(CHEMBL2064344)
Show SMILES O=c1cc(nc(Cc2nc3ccccc3n2-c2ccccc2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C22H21N5O2/c28-22-15-20(26-10-12-29-13-11-26)24-19(25-22)14-21-23-17-8-4-5-9-18(17)27(21)16-6-2-1-3-7-16/h1-9,15H,10-14H2,(H,24,25,28)
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n/an/a 75n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389043
PNG
(CHEMBL2064330)
Show SMILES Cn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2ccccc12
Show InChI InChI=1S/C17H19N5O2/c1-21-13-5-3-2-4-12(13)18-15(21)10-14-19-16(11-17(23)20-14)22-6-8-24-9-7-22/h2-5,11H,6-10H2,1H3,(H,19,20,23)
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n/an/a 76n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389044
PNG
(CHEMBL2064418)
Show SMILES O=c1cc(nc(Cc2nc3ccccc3o2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C16H16N4O3/c21-15-10-14(20-5-7-22-8-6-20)18-13(19-15)9-16-17-11-3-1-2-4-12(11)23-16/h1-4,10H,5-9H2,(H,18,19,21)
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n/an/a 82n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389041
PNG
(CHEMBL2064333)
Show SMILES Cn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2cc(F)ccc12
Show InChI InChI=1S/C17H18FN5O2/c1-22-13-3-2-11(18)8-12(13)19-15(22)9-14-20-16(10-17(24)21-14)23-4-6-25-7-5-23/h2-3,8,10H,4-7,9H2,1H3,(H,20,21,24)
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n/an/a 82n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50389068
PNG
(CHEMBL2064345)
Show SMILES O=c1cc(nc(Cc2nc3ccccc3n2Cc2ccccc2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C23H23N5O2/c29-23-15-21(27-10-12-30-13-11-27)25-20(26-23)14-22-24-18-8-4-5-9-19(18)28(22)16-17-6-2-1-3-7-17/h1-9,15H,10-14,16H2,(H,25,26,29)
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n/an/a 84n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate p...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389077
PNG
(CHEMBL2064335)
Show SMILES Brc1ccc2nc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)[nH]c2c1
Show InChI InChI=1S/C16H16BrN5O2/c17-10-1-2-11-12(7-10)19-13(18-11)8-14-20-15(9-16(23)21-14)22-3-5-24-6-4-22/h1-2,7,9H,3-6,8H2,(H,18,19)(H,20,21,23)
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n/an/a 85n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389043
PNG
(CHEMBL2064330)
Show SMILES Cn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2ccccc12
Show InChI InChI=1S/C17H19N5O2/c1-21-13-5-3-2-4-12(13)18-15(21)10-14-19-16(11-17(23)20-14)22-6-8-24-9-7-22/h2-5,11H,6-10H2,1H3,(H,19,20,23)
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n/an/a 86n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in mouse MEF-3T3 cells after 0.5 to 2 hrs by Western blot analy...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389060
PNG
(CHEMBL2064354)
Show SMILES Fc1cccc2nc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)oc12
Show InChI InChI=1S/C16H15FN4O3/c17-10-2-1-3-11-16(10)24-15(18-11)8-12-19-13(9-14(22)20-12)21-4-6-23-7-5-21/h1-3,9H,4-8H2,(H,19,20,22)
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n/an/a 88n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50389070
PNG
(CHEMBL2064343)
Show SMILES O=c1cc(nc(Cc2nc3ccccc3n2C2CCCCC2)[nH]1)N1CCOCC1
Show InChI InChI=1S/C22H27N5O2/c28-22-15-20(26-10-12-29-13-11-26)24-19(25-22)14-21-23-17-8-4-5-9-18(17)27(21)16-6-2-1-3-7-16/h4-5,8-9,15-16H,1-3,6-7,10-14H2,(H,24,25,28)
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n/an/a 90n/an/an/an/an/an/a



Sanofi Research& Development

Curated by ChEMBL


Assay Description
Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s...


J Med Chem 55: 4788-805 (2012)


Article DOI: 10.1021/jm300241b
BindingDB Entry DOI: 10.7270/Q2R78G88
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%