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PubMed code 22542012

Compile data set for download or QSAR
Found 155 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385084
PNG
(CHEMBL2035636)
Show SMILES CN1C[C@@H]2CC[C@H]1CN2Cc1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C18H19BrN4O2/c1-22-7-12-4-3-11(22)8-23(12)9-15-20-16-13-6-10(19)2-5-14(13)25-17(16)18(24)21-15/h2,5-6,11-12H,3-4,7-9H2,1H3,(H,20,21,24)/t11-,12-/m0/s1
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385075
PNG
(CHEMBL2035626)
Show SMILES NCc1ccc(c(Cl)c1)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H11BrClN3O2/c18-9-2-4-13-11(6-9)14-15(24-13)17(23)22-16(21-14)10-3-1-8(7-20)5-12(10)19/h1-6H,7,20H2,(H,21,22,23)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385078
PNG
(CHEMBL2035629)
Show SMILES Clc1cc(NC(=O)CCN2CCCCC2)ccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C24H22BrClN4O3/c25-14-4-7-19-17(12-14)21-22(33-19)24(32)29-23(28-21)16-6-5-15(13-18(16)26)27-20(31)8-11-30-9-2-1-3-10-30/h4-7,12-13H,1-3,8-11H2,(H,27,31)(H,28,29,32)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385076
PNG
(CHEMBL2035627)
Show SMILES Clc1cc(ccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1)C(=O)NCCN1CCCCC1
Show InChI InChI=1S/C24H22BrClN4O3/c25-15-5-7-19-17(13-15)20-21(33-19)24(32)29-22(28-20)16-6-4-14(12-18(16)26)23(31)27-8-11-30-9-2-1-3-10-30/h4-7,12-13H,1-3,8-11H2,(H,27,31)(H,28,29,32)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385077
PNG
(CHEMBL2035628)
Show SMILES Clc1cc(CNC2CCNCC2)ccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C22H20BrClN4O2/c23-13-2-4-18-16(10-13)19-20(30-18)22(29)28-21(27-19)15-3-1-12(9-17(15)24)11-26-14-5-7-25-8-6-14/h1-4,9-10,14,25-26H,5-8,11H2,(H,27,28,29)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50383725
PNG
(CHEMBL2030386)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50383711
PNG
(CHEMBL2030387)
Show SMILES N[C@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H15BrN4O2/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)19-12(18-13)7-20-4-3-9(17)6-20/h1-2,5,9H,3-4,6-7,17H2,(H,18,19,21)/t9-/m0/s1
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50383725
PNG
(CHEMBL2030386)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385078
PNG
(CHEMBL2035629)
Show SMILES Clc1cc(NC(=O)CCN2CCCCC2)ccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C24H22BrClN4O3/c25-14-4-7-19-17(12-14)21-22(33-19)24(32)29-23(28-21)16-6-5-15(13-18(16)26)27-20(31)8-11-30-9-2-1-3-10-30/h4-7,12-13H,1-3,8-11H2,(H,27,31)(H,28,29,32)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50383726
PNG
(CHEMBL2030388)
Show SMILES N[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H15BrN4O2/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)19-12(18-13)7-20-4-3-9(17)6-20/h1-2,5,9H,3-4,6-7,17H2,(H,18,19,21)/t9-/m1/s1
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50383726
PNG
(CHEMBL2030388)
Show SMILES N[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H15BrN4O2/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)19-12(18-13)7-20-4-3-9(17)6-20/h1-2,5,9H,3-4,6-7,17H2,(H,18,19,21)/t9-/m1/s1
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385079
PNG
(CHEMBL2035630)
Show SMILES Brc1ccc2oc3c(nc([nH]c3=O)-c3ccc(NCC4CCNCC4)cc3)c2c1
Show InChI InChI=1S/C22H21BrN4O2/c23-15-3-6-18-17(11-15)19-20(29-18)22(28)27-21(26-19)14-1-4-16(5-2-14)25-12-13-7-9-24-10-8-13/h1-6,11,13,24-25H,7-10,12H2,(H,26,27,28)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385073
PNG
(CHEMBL2035623)
Show SMILES Clc1cccc(c1Cl)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrCl2N2O2/c17-7-4-5-11-9(6-7)13-14(23-11)16(22)21-15(20-13)8-2-1-3-10(18)12(8)19/h1-6H,(H,20,21,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385075
PNG
(CHEMBL2035626)
Show SMILES NCc1ccc(c(Cl)c1)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H11BrClN3O2/c18-9-2-4-13-11(6-9)14-15(24-13)17(23)22-16(21-14)10-3-1-8(7-20)5-12(10)19/h1-6H,7,20H2,(H,21,22,23)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385077
PNG
(CHEMBL2035628)
Show SMILES Clc1cc(CNC2CCNCC2)ccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C22H20BrClN4O2/c23-13-2-4-18-16(10-13)19-20(30-18)22(29)28-21(27-19)15-3-1-12(9-17(15)24)11-26-14-5-7-25-8-6-14/h1-4,9-10,14,25-26H,5-8,11H2,(H,27,28,29)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385079
PNG
(CHEMBL2035630)
Show SMILES Brc1ccc2oc3c(nc([nH]c3=O)-c3ccc(NCC4CCNCC4)cc3)c2c1
Show InChI InChI=1S/C22H21BrN4O2/c23-15-3-6-18-17(11-15)19-20(29-18)22(28)27-21(26-19)14-1-4-16(5-2-14)25-12-13-7-9-24-10-8-13/h1-6,11,13,24-25H,7-10,12H2,(H,26,27,28)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385073
PNG
(CHEMBL2035623)
Show SMILES Clc1cccc(c1Cl)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrCl2N2O2/c17-7-4-5-11-9(6-7)13-14(23-11)16(22)21-15(20-13)8-2-1-3-10(18)12(8)19/h1-6H,(H,20,21,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385081
PNG
(CHEMBL2035632)
Show SMILES Brc1ccc2oc3c(nc(CN4CCC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C14H12BrN3O2/c15-8-2-3-10-9(6-8)12-13(20-10)14(19)17-11(16-12)7-18-4-1-5-18/h2-3,6H,1,4-5,7H2,(H,16,17,19)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385083
PNG
(CHEMBL2035635)
Show SMILES CN1C[C@@H]2C[C@H]1CN2Cc1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H17BrN4O2/c1-21-6-11-5-10(21)7-22(11)8-14-19-15-12-4-9(18)2-3-13(12)24-16(15)17(23)20-14/h2-4,10-11H,5-8H2,1H3,(H,19,20,23)/t10-,11-/m0/s1
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50383715
PNG
(CHEMBL2030376)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385083
PNG
(CHEMBL2035635)
Show SMILES CN1C[C@@H]2C[C@H]1CN2Cc1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H17BrN4O2/c1-21-6-11-5-10(21)7-22(11)8-14-19-15-12-4-9(18)2-3-13(12)24-16(15)17(23)20-14/h2-4,10-11H,5-8H2,1H3,(H,19,20,23)/t10-,11-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385081
PNG
(CHEMBL2035632)
Show SMILES Brc1ccc2oc3c(nc(CN4CCC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C14H12BrN3O2/c15-8-2-3-10-9(6-8)12-13(20-10)14(19)17-11(16-12)7-18-4-1-5-18/h2-3,6H,1,4-5,7H2,(H,16,17,19)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385061
PNG
(CHEMBL2035638)
Show SMILES OC1CN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C14H12BrN3O3/c15-7-1-2-10-9(3-7)12-13(21-10)14(20)17-11(16-12)6-18-4-8(19)5-18/h1-3,8,19H,4-6H2,(H,16,17,20)
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n/an/a 10n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385060
PNG
(CHEMBL2035624)
Show SMILES Clc1ccc(c(Cl)c1)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrCl2N2O2/c17-7-1-4-12-10(5-7)13-14(23-12)16(22)21-15(20-13)9-3-2-8(18)6-11(9)19/h1-6H,(H,20,21,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385087
PNG
(CHEMBL2035640)
Show SMILES CN1CCN(Cc2nc3c4cc(I)ccc4oc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C16H17IN4O2/c1-20-4-6-21(7-5-20)9-13-18-14-11-8-10(17)2-3-12(11)23-15(14)16(22)19-13/h2-3,8H,4-7,9H2,1H3,(H,18,19,22)
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n/an/a 11n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50383715
PNG
(CHEMBL2030376)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m0/s1
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385082
PNG
(CHEMBL2035633)
Show SMILES CN1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C16H17BrN4O2/c1-20-4-6-21(7-5-20)9-13-18-14-11-8-10(17)2-3-12(11)23-15(14)16(22)19-13/h2-3,8H,4-7,9H2,1H3,(H,18,19,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385061
PNG
(CHEMBL2035638)
Show SMILES OC1CN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C14H12BrN3O3/c15-7-1-2-10-9(3-7)12-13(21-10)14(20)17-11(16-12)6-18-4-8(19)5-18/h1-3,8,19H,4-6H2,(H,16,17,20)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50383711
PNG
(CHEMBL2030387)
Show SMILES N[C@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H15BrN4O2/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)19-12(18-13)7-20-4-3-9(17)6-20/h1-2,5,9H,3-4,6-7,17H2,(H,18,19,21)/t9-/m0/s1
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50383727
PNG
(CHEMBL2030389)
Show SMILES Brc1ccc2oc3c(nc(CN4CCCC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C15H14BrN3O2/c16-9-3-4-11-10(7-9)13-14(21-11)15(20)18-12(17-13)8-19-5-1-2-6-19/h3-4,7H,1-2,5-6,8H2,(H,17,18,20)
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n/an/a 12n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50383727
PNG
(CHEMBL2030389)
Show SMILES Brc1ccc2oc3c(nc(CN4CCCC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C15H14BrN3O2/c16-9-3-4-11-10(7-9)13-14(21-11)15(20)18-12(17-13)8-19-5-1-2-6-19/h3-4,7H,1-2,5-6,8H2,(H,17,18,20)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385071
PNG
(CHEMBL2035621)
Show SMILES Fc1ccc(Cl)c(c1)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrClFN2O2/c17-7-1-4-12-10(5-7)13-14(23-12)16(22)21-15(20-13)9-6-8(19)2-3-11(9)18/h1-6H,(H,20,21,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385071
PNG
(CHEMBL2035621)
Show SMILES Fc1ccc(Cl)c(c1)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrClFN2O2/c17-7-1-4-12-10(5-7)13-14(23-12)16(22)21-15(20-13)9-6-8(19)2-3-11(9)18/h1-6H,(H,20,21,22)
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n/an/a 14n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385074
PNG
(CHEMBL2035625)
Show SMILES COc1cccc(c1Cl)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H10BrClN2O3/c1-23-12-4-2-3-9(13(12)19)16-20-14-10-7-8(18)5-6-11(10)24-15(14)17(22)21-16/h2-7H,1H3,(H,20,21,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385063
PNG
(CHEMBL2035634)
Show SMILES CC(N1CCN(C)CC1)c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H19BrN4O2/c1-10(22-7-5-21(2)6-8-22)16-19-14-12-9-11(18)3-4-13(12)24-15(14)17(23)20-16/h3-4,9-10H,5-8H2,1-2H3,(H,19,20,23)
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n/an/a 16n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385060
PNG
(CHEMBL2035624)
Show SMILES Clc1ccc(c(Cl)c1)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrCl2N2O2/c17-7-1-4-12-10(5-7)13-14(23-12)16(22)21-15(20-13)9-3-2-8(18)6-11(9)19/h1-6H,(H,20,21,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385090
PNG
(CHEMBL2035603)
Show SMILES Clc1ccccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H8BrClN2O2/c17-8-5-6-12-10(7-8)13-14(22-12)16(21)20-15(19-13)9-3-1-2-4-11(9)18/h1-7H,(H,19,20,21)
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n/an/a 17n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385085
PNG
(CHEMBL2035637)
Show SMILES CN1CCCC(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C17H18BrN3O2/c1-21-6-2-3-10(9-21)7-14-19-15-12-8-11(18)4-5-13(12)23-16(15)17(22)20-14/h4-5,8,10H,2-3,6-7,9H2,1H3,(H,19,20,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385084
PNG
(CHEMBL2035636)
Show SMILES CN1C[C@@H]2CC[C@H]1CN2Cc1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C18H19BrN4O2/c1-22-7-12-4-3-11(22)8-23(12)9-15-20-16-13-6-10(19)2-5-14(13)25-17(16)18(24)21-15/h2,5-6,11-12H,3-4,7-9H2,1H3,(H,20,21,24)/t11-,12-/m0/s1
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385090
PNG
(CHEMBL2035603)
Show SMILES Clc1ccccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H8BrClN2O2/c17-8-5-6-12-10(7-8)13-14(22-12)16(21)20-15(19-13)9-3-1-2-4-11(9)18/h1-7H,(H,19,20,21)
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n/an/a 18n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385076
PNG
(CHEMBL2035627)
Show SMILES Clc1cc(ccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1)C(=O)NCCN1CCCCC1
Show InChI InChI=1S/C24H22BrClN4O3/c25-15-5-7-19-17(13-15)20-21(33-19)24(32)29-22(28-20)16-6-4-14(12-18(16)26)23(31)27-8-11-30-9-2-1-3-10-30/h4-7,12-13H,1-3,8-11H2,(H,27,31)(H,28,29,32)
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n/an/a 20n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385074
PNG
(CHEMBL2035625)
Show SMILES COc1cccc(c1Cl)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H10BrClN2O3/c1-23-12-4-2-3-9(13(12)19)16-20-14-10-7-8(18)5-6-11(10)24-15(14)17(22)21-16/h2-7H,1H3,(H,20,21,22)
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n/an/a 21n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385070
PNG
(CHEMBL2035620)
Show SMILES Fc1ccc(c(Cl)c1)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrClFN2O2/c17-7-1-4-12-10(5-7)13-14(23-12)16(22)21-15(20-13)9-3-2-8(19)6-11(9)18/h1-6H,(H,20,21,22)
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n/an/a 23n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385098
PNG
(CHEMBL2035610)
Show SMILES FC(F)(F)c1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H8ClF3N2O2/c18-11-4-2-1-3-9(11)15-22-13-10-7-8(17(19,20)21)5-6-12(10)25-14(13)16(24)23-15/h1-7H,(H,22,23,24)
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n/an/a 23n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385072
PNG
(CHEMBL2035622)
Show SMILES Fc1cccc(Cl)c1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrClFN2O2/c17-7-4-5-11-8(6-7)13-14(23-11)16(22)21-15(20-13)12-9(18)2-1-3-10(12)19/h1-6H,(H,20,21,22)
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n/an/a 23n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385087
PNG
(CHEMBL2035640)
Show SMILES CN1CCN(Cc2nc3c4cc(I)ccc4oc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C16H17IN4O2/c1-20-4-6-21(7-5-20)9-13-18-14-11-8-10(17)2-3-12(11)23-15(14)16(22)19-13/h2-3,8H,4-7,9H2,1H3,(H,18,19,22)
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n/an/a 24n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385070
PNG
(CHEMBL2035620)
Show SMILES Fc1ccc(c(Cl)c1)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrClFN2O2/c17-7-1-4-12-10(5-7)13-14(23-12)16(22)21-15(20-13)9-3-2-8(19)6-11(9)18/h1-6H,(H,20,21,22)
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n/an/a 24n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385082
PNG
(CHEMBL2035633)
Show SMILES CN1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C16H17BrN4O2/c1-20-4-6-21(7-5-20)9-13-18-14-11-8-10(17)2-3-12(11)23-15(14)16(22)19-13/h2-3,8H,4-7,9H2,1H3,(H,18,19,22)
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n/an/a 27n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385092
PNG
(CHEMBL2035598)
Show SMILES Clc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C16H8Cl2N2O2/c17-8-5-6-12-10(7-8)13-14(22-12)16(21)20-15(19-13)9-3-1-2-4-11(9)18/h1-7H,(H,19,20,21)
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n/an/a 28n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385079
PNG
(CHEMBL2035630)
Show SMILES Brc1ccc2oc3c(nc([nH]c3=O)-c3ccc(NCC4CCNCC4)cc3)c2c1
Show InChI InChI=1S/C22H21BrN4O2/c23-15-3-6-18-17(11-15)19-20(29-18)22(28)27-21(26-19)14-1-4-16(5-2-14)25-12-13-7-9-24-10-8-13/h1-6,11,13,24-25H,7-10,12H2,(H,26,27,28)
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n/an/a 29n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385077
PNG
(CHEMBL2035628)
Show SMILES Clc1cc(CNC2CCNCC2)ccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C22H20BrClN4O2/c23-13-2-4-18-16(10-13)19-20(30-18)22(29)28-21(27-19)15-3-1-12(9-17(15)24)11-26-14-5-7-25-8-6-14/h1-4,9-10,14,25-26H,5-8,11H2,(H,27,28,29)
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n/an/a 29n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385092
PNG
(CHEMBL2035598)
Show SMILES Clc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C16H8Cl2N2O2/c17-8-5-6-12-10(7-8)13-14(22-12)16(21)20-15(19-13)9-3-1-2-4-11(9)18/h1-7H,(H,19,20,21)
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n/an/a 30n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385093
PNG
(CHEMBL2035605)
Show SMILES COc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H11ClN2O3/c1-22-9-6-7-13-11(8-9)14-15(23-13)17(21)20-16(19-14)10-4-2-3-5-12(10)18/h2-8H,1H3,(H,19,20,21)
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n/an/a 31n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385085
PNG
(CHEMBL2035637)
Show SMILES CN1CCCC(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C17H18BrN3O2/c1-21-6-2-3-10(9-21)7-14-19-15-12-8-11(18)4-5-13(12)23-16(15)17(22)20-14/h4-5,8,10H,2-3,6-7,9H2,1H3,(H,19,20,22)
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n/an/a 31n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385080
PNG
(CHEMBL2035631)
Show SMILES Brc1ccc2oc3c(nc(CN4CCCCC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C16H16BrN3O2/c17-10-4-5-12-11(8-10)14-15(22-12)16(21)19-13(18-14)9-20-6-2-1-3-7-20/h4-5,8H,1-3,6-7,9H2,(H,18,19,21)
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n/an/a 32n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385086
PNG
(CHEMBL2035639)
Show SMILES CN1CCN(Cc2nc3c4cc(Cl)ccc4oc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C16H17ClN4O2/c1-20-4-6-21(7-5-20)9-13-18-14-11-8-10(17)2-3-12(11)23-15(14)16(22)19-13/h2-3,8H,4-7,9H2,1H3,(H,18,19,22)
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n/an/a 34n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385072
PNG
(CHEMBL2035622)
Show SMILES Fc1cccc(Cl)c1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrClFN2O2/c17-7-4-5-11-8(6-7)13-14(23-11)16(22)21-15(20-13)12-9(18)2-1-3-10(12)19/h1-6H,(H,20,21,22)
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n/an/a 35n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385063
PNG
(CHEMBL2035634)
Show SMILES CC(N1CCN(C)CC1)c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H19BrN4O2/c1-10(22-7-5-21(2)6-8-22)16-19-14-12-9-11(18)3-4-13(12)24-15(14)17(23)20-16/h3-4,9-10H,5-8H2,1-2H3,(H,19,20,23)
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n/an/a 35n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385080
PNG
(CHEMBL2035631)
Show SMILES Brc1ccc2oc3c(nc(CN4CCCCC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C16H16BrN3O2/c17-10-4-5-12-11(8-10)14-15(22-12)16(21)19-13(18-14)9-20-6-2-1-3-7-20/h4-5,8H,1-3,6-7,9H2,(H,18,19,21)
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n/an/a 41n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50383711
PNG
(CHEMBL2030387)
Show SMILES N[C@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H15BrN4O2/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)19-12(18-13)7-20-4-3-9(17)6-20/h1-2,5,9H,3-4,6-7,17H2,(H,18,19,21)/t9-/m0/s1
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n/an/a 49n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385093
PNG
(CHEMBL2035605)
Show SMILES COc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H11ClN2O3/c1-22-9-6-7-13-11(8-9)14-15(23-13)17(21)20-16(19-14)10-4-2-3-5-12(10)18/h2-8H,1H3,(H,19,20,21)
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n/an/a 61n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385078
PNG
(CHEMBL2035629)
Show SMILES Clc1cc(NC(=O)CCN2CCCCC2)ccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C24H22BrClN4O3/c25-14-4-7-19-17(12-14)21-22(33-19)24(32)29-23(28-21)16-6-5-15(13-18(16)26)27-20(31)8-11-30-9-2-1-3-10-30/h4-7,12-13H,1-3,8-11H2,(H,27,31)(H,28,29,32)
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n/an/a 68n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50383725
PNG
(CHEMBL2030386)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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n/an/a 68n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385081
PNG
(CHEMBL2035632)
Show SMILES Brc1ccc2oc3c(nc(CN4CCC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C14H12BrN3O2/c15-8-2-3-10-9(6-8)12-13(20-10)14(19)17-11(16-12)7-18-4-1-5-18/h2-3,6H,1,4-5,7H2,(H,16,17,19)
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n/an/a 68n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385065
PNG
(CHEMBL2035614)
Show SMILES Oc1ccc2c(c1)oc1c2nc([nH]c1=O)-c1ccccc1Cl
Show InChI InChI=1S/C16H9ClN2O3/c17-11-4-2-1-3-9(11)15-18-13-10-6-5-8(20)7-12(10)22-14(13)16(21)19-15/h1-7,20H,(H,18,19,21)
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n/an/a 71n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50383726
PNG
(CHEMBL2030388)
Show SMILES N[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H15BrN4O2/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)19-12(18-13)7-20-4-3-9(17)6-20/h1-2,5,9H,3-4,6-7,17H2,(H,18,19,21)/t9-/m1/s1
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n/an/a 72n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385100
PNG
(CHEMBL2035602)
Show SMILES Cc1cc(ccc1O)-c1cc(nc(=O)[nH]1)-c1ccccc1Cl
Show InChI InChI=1S/C17H13ClN2O2/c1-10-8-11(6-7-16(10)21)14-9-15(20-17(22)19-14)12-4-2-3-5-13(12)18/h2-9,21H,1H3,(H,19,20,22)
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n/an/a 75n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of PIM1


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385086
PNG
(CHEMBL2035639)
Show SMILES CN1CCN(Cc2nc3c4cc(Cl)ccc4oc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C16H17ClN4O2/c1-20-4-6-21(7-5-20)9-13-18-14-11-8-10(17)2-3-12(11)23-15(14)16(22)19-13/h2-3,8H,4-7,9H2,1H3,(H,18,19,22)
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n/an/a 77n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385075
PNG
(CHEMBL2035626)
Show SMILES NCc1ccc(c(Cl)c1)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H11BrClN3O2/c18-9-2-4-13-11(6-9)14-15(24-13)17(23)22-16(21-14)10-3-1-8(7-20)5-12(10)19/h1-6H,7,20H2,(H,21,22,23)
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n/an/a 87n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385096
PNG
(CHEMBL2035608)
Show SMILES Clc1ccccc1-c1nc2c3cc(ccc3oc2c(=O)[nH]1)-c1ccccc1
Show InChI InChI=1S/C22H13ClN2O2/c23-17-9-5-4-8-15(17)21-24-19-16-12-14(13-6-2-1-3-7-13)10-11-18(16)27-20(19)22(26)25-21/h1-12H,(H,24,25,26)
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n/an/a 88n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385059
PNG
(CHEMBL2035604)
Show SMILES Cc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H11ClN2O2/c1-9-6-7-13-11(8-9)14-15(22-13)17(21)20-16(19-14)10-4-2-3-5-12(10)18/h2-8H,1H3,(H,19,20,21)
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n/an/a 99n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385098
PNG
(CHEMBL2035610)
Show SMILES FC(F)(F)c1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H8ClF3N2O2/c18-11-4-2-1-3-9(11)15-22-13-10-7-8(17(19,20)21)5-6-12(10)25-14(13)16(24)23-15/h1-7H,(H,22,23,24)
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n/an/a 102n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385059
PNG
(CHEMBL2035604)
Show SMILES Cc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H11ClN2O2/c1-9-6-7-13-11(8-9)14-15(22-13)17(21)20-16(19-14)10-4-2-3-5-12(10)18/h2-8H,1H3,(H,19,20,21)
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n/an/a 104n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385094
PNG
(CHEMBL2035606)
Show SMILES Oc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C16H9ClN2O3/c17-11-4-2-1-3-9(11)15-18-13-10-7-8(20)5-6-12(10)22-14(13)16(21)19-15/h1-7,20H,(H,18,19,21)
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n/an/a 106n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385083
PNG
(CHEMBL2035635)
Show SMILES CN1C[C@@H]2C[C@H]1CN2Cc1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H17BrN4O2/c1-21-6-11-5-10(21)7-22(11)8-14-19-15-12-4-9(18)2-3-13(12)24-16(15)17(23)20-14/h2-4,10-11H,5-8H2,1H3,(H,19,20,23)/t10-,11-/m0/s1
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50383715
PNG
(CHEMBL2030376)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m0/s1
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n/an/a 121n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385076
PNG
(CHEMBL2035627)
Show SMILES Clc1cc(ccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1)C(=O)NCCN1CCCCC1
Show InChI InChI=1S/C24H22BrClN4O3/c25-15-5-7-19-17(13-15)20-21(33-19)24(32)29-22(28-20)16-6-4-14(12-18(16)26)23(31)27-8-11-30-9-2-1-3-10-30/h4-7,12-13H,1-3,8-11H2,(H,27,31)(H,28,29,32)
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n/an/a 134n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385087
PNG
(CHEMBL2035640)
Show SMILES CN1CCN(Cc2nc3c4cc(I)ccc4oc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C16H17IN4O2/c1-20-4-6-21(7-5-20)9-13-18-14-11-8-10(17)2-3-12(11)23-15(14)16(22)19-13/h2-3,8H,4-7,9H2,1H3,(H,18,19,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385061
PNG
(CHEMBL2035638)
Show SMILES OC1CN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C14H12BrN3O3/c15-7-1-2-10-9(3-7)12-13(21-10)14(20)17-11(16-12)6-18-4-8(19)5-18/h1-3,8,19H,4-6H2,(H,16,17,20)
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n/an/a 142n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385088
PNG
(CHEMBL2035641)
Show SMILES CN1CCN(Cc2nc3c4cc(ccc4oc3c(=O)[nH]2)C2CC2)CC1
Show InChI InChI=1S/C19H22N4O2/c1-22-6-8-23(9-7-22)11-16-20-17-14-10-13(12-2-3-12)4-5-15(14)25-18(17)19(24)21-16/h4-5,10,12H,2-3,6-9,11H2,1H3,(H,20,21,24)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385084
PNG
(CHEMBL2035636)
Show SMILES CN1C[C@@H]2CC[C@H]1CN2Cc1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C18H19BrN4O2/c1-22-7-12-4-3-11(22)8-23(12)9-15-20-16-13-6-10(19)2-5-14(13)25-17(16)18(24)21-15/h2,5-6,11-12H,3-4,7-9H2,1H3,(H,20,21,24)/t11-,12-/m0/s1
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385067
PNG
(CHEMBL2035617)
Show SMILES Fc1cccc(Cl)c1-c1nc2c3cc(ccc3oc2c(=O)[nH]1)C1CC1
Show InChI InChI=1S/C19H12ClFN2O2/c20-12-2-1-3-13(21)15(12)18-22-16-11-8-10(9-4-5-9)6-7-14(11)25-17(16)19(24)23-18/h1-3,6-9H,4-5H2,(H,22,23,24)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50383727
PNG
(CHEMBL2030389)
Show SMILES Brc1ccc2oc3c(nc(CN4CCCC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C15H14BrN3O2/c16-9-3-4-11-10(7-9)13-14(21-11)15(20)18-12(17-13)8-19-5-1-2-6-19/h3-4,7H,1-2,5-6,8H2,(H,17,18,20)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385082
PNG
(CHEMBL2035633)
Show SMILES CN1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C16H17BrN4O2/c1-20-4-6-21(7-5-20)9-13-18-14-11-8-10(17)2-3-12(11)23-15(14)16(22)19-13/h2-3,8H,4-7,9H2,1H3,(H,18,19,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385095
PNG
(CHEMBL2035607)
Show SMILES Clc1ccccc1-c1nc2c3cc(ccc3oc2c(=O)[nH]1)C#N
Show InChI InChI=1S/C17H8ClN3O2/c18-12-4-2-1-3-10(12)16-20-14-11-7-9(8-19)5-6-13(11)23-15(14)17(22)21-16/h1-7H,(H,20,21,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385065
PNG
(CHEMBL2035614)
Show SMILES Oc1ccc2c(c1)oc1c2nc([nH]c1=O)-c1ccccc1Cl
Show InChI InChI=1S/C16H9ClN2O3/c17-11-4-2-1-3-9(11)15-18-13-10-6-5-8(20)7-12(10)22-14(13)16(21)19-15/h1-7,20H,(H,18,19,21)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385094
PNG
(CHEMBL2035606)
Show SMILES Oc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C16H9ClN2O3/c17-11-4-2-1-3-9(11)15-18-13-10-7-8(20)5-6-12(10)22-14(13)16(21)19-15/h1-7,20H,(H,18,19,21)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385089
PNG
(CHEMBL2035642)
Show SMILES CN1CCN(Cc2nc3c4cc(ccc4oc3c(=O)[nH]2)C(C)=O)CC1
Show InChI InChI=1S/C18H20N4O3/c1-11(23)12-3-4-14-13(9-12)16-17(25-14)18(24)20-15(19-16)10-22-7-5-21(2)6-8-22/h3-4,9H,5-8,10H2,1-2H3,(H,19,20,24)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385095
PNG
(CHEMBL2035607)
Show SMILES Clc1ccccc1-c1nc2c3cc(ccc3oc2c(=O)[nH]1)C#N
Show InChI InChI=1S/C17H8ClN3O2/c18-12-4-2-1-3-10(12)16-20-14-11-7-9(8-19)5-6-13(11)23-15(14)17(22)21-16/h1-7H,(H,20,21,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385097
PNG
(CHEMBL2035609)
Show SMILES FC(F)(F)Oc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H8ClF3N2O3/c18-11-4-2-1-3-9(11)15-22-13-10-7-8(26-17(19,20)21)5-6-12(10)25-14(13)16(24)23-15/h1-7H,(H,22,23,24)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385060
PNG
(CHEMBL2035624)
Show SMILES Clc1ccc(c(Cl)c1)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrCl2N2O2/c17-7-1-4-12-10(5-7)13-14(23-12)16(22)21-15(20-13)9-3-2-8(18)6-11(9)19/h1-6H,(H,20,21,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385097
PNG
(CHEMBL2035609)
Show SMILES FC(F)(F)Oc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H8ClF3N2O3/c18-11-4-2-1-3-9(11)15-22-13-10-7-8(26-17(19,20)21)5-6-12(10)25-14(13)16(24)23-15/h1-7H,(H,22,23,24)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50383716
PNG
(CHEMBL2030375)
Show SMILES Brc1ccc2oc3c(nc[nH]c3=O)c2c1
Show InChI InChI=1S/C10H5BrN2O2/c11-5-1-2-7-6(3-5)8-9(15-7)10(14)13-4-12-8/h1-4H,(H,12,13,14)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of PIM3


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385069
PNG
(CHEMBL2035619)
Show SMILES CC(C)c1ccccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C19H15BrN2O2/c1-10(2)12-5-3-4-6-13(12)18-21-16-14-9-11(20)7-8-15(14)24-17(16)19(23)22-18/h3-10H,1-2H3,(H,21,22,23)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385086
PNG
(CHEMBL2035639)
Show SMILES CN1CCN(Cc2nc3c4cc(Cl)ccc4oc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C16H17ClN4O2/c1-20-4-6-21(7-5-20)9-13-18-14-11-8-10(17)2-3-12(11)23-15(14)16(22)19-13/h2-3,8H,4-7,9H2,1H3,(H,18,19,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385067
PNG
(CHEMBL2035617)
Show SMILES Fc1cccc(Cl)c1-c1nc2c3cc(ccc3oc2c(=O)[nH]1)C1CC1
Show InChI InChI=1S/C19H12ClFN2O2/c20-12-2-1-3-13(21)15(12)18-22-16-11-8-10(9-4-5-9)6-7-14(11)25-17(16)19(24)23-18/h1-3,6-9H,4-5H2,(H,22,23,24)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385063
PNG
(CHEMBL2035634)
Show SMILES CC(N1CCN(C)CC1)c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H19BrN4O2/c1-10(22-7-5-21(2)6-8-22)16-19-14-12-9-11(18)3-4-13(12)24-15(14)17(23)20-16/h3-4,9-10H,5-8H2,1-2H3,(H,19,20,23)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50383716
PNG
(CHEMBL2030375)
Show SMILES Brc1ccc2oc3c(nc[nH]c3=O)c2c1
Show InChI InChI=1S/C10H5BrN2O2/c11-5-1-2-7-6(3-5)8-9(15-7)10(14)13-4-12-8/h1-4H,(H,12,13,14)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of PIM1


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385085
PNG
(CHEMBL2035637)
Show SMILES CN1CCCC(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C17H18BrN3O2/c1-21-6-2-3-10(9-21)7-14-19-15-12-8-11(18)4-5-13(12)23-16(15)17(22)20-14/h4-5,8,10H,2-3,6-7,9H2,1H3,(H,19,20,22)
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385088
PNG
(CHEMBL2035641)
Show SMILES CN1CCN(Cc2nc3c4cc(ccc4oc3c(=O)[nH]2)C2CC2)CC1
Show InChI InChI=1S/C19H22N4O2/c1-22-6-8-23(9-7-22)11-16-20-17-14-10-13(12-2-3-12)4-5-15(14)25-18(17)19(24)21-16/h4-5,10,12H,2-3,6-9,11H2,1H3,(H,20,21,24)
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n/an/a 580n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385073
PNG
(CHEMBL2035623)
Show SMILES Clc1cccc(c1Cl)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrCl2N2O2/c17-7-4-5-11-9(6-7)13-14(23-11)16(22)21-15(20-13)8-2-1-3-10(18)12(8)19/h1-6H,(H,20,21,22)
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n/an/a 598n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385089
PNG
(CHEMBL2035642)
Show SMILES CN1CCN(Cc2nc3c4cc(ccc4oc3c(=O)[nH]2)C(C)=O)CC1
Show InChI InChI=1S/C18H20N4O3/c1-11(23)12-3-4-14-13(9-12)16-17(25-14)18(24)20-15(19-16)10-22-7-5-21(2)6-8-22/h3-4,9H,5-8,10H2,1-2H3,(H,19,20,24)
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n/an/a 620n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385089
PNG
(CHEMBL2035642)
Show SMILES CN1CCN(Cc2nc3c4cc(ccc4oc3c(=O)[nH]2)C(C)=O)CC1
Show InChI InChI=1S/C18H20N4O3/c1-11(23)12-3-4-14-13(9-12)16-17(25-14)18(24)20-15(19-16)10-22-7-5-21(2)6-8-22/h3-4,9H,5-8,10H2,1-2H3,(H,19,20,24)
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n/an/a 640n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385071
PNG
(CHEMBL2035621)
Show SMILES Fc1ccc(Cl)c(c1)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrClFN2O2/c17-7-1-4-12-10(5-7)13-14(23-12)16(22)21-15(20-13)9-6-8(19)2-3-11(9)18/h1-6H,(H,20,21,22)
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n/an/a 653n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385080
PNG
(CHEMBL2035631)
Show SMILES Brc1ccc2oc3c(nc(CN4CCCCC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C16H16BrN3O2/c17-10-4-5-12-11(8-10)14-15(22-12)16(21)19-13(18-14)9-20-6-2-1-3-7-20/h4-5,8H,1-3,6-7,9H2,(H,18,19,21)
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n/an/a 730n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385090
PNG
(CHEMBL2035603)
Show SMILES Clc1ccccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H8BrClN2O2/c17-8-5-6-12-10(7-8)13-14(22-12)16(21)20-15(19-13)9-3-1-2-4-11(9)18/h1-7H,(H,19,20,21)
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n/an/a 781n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385069
PNG
(CHEMBL2035619)
Show SMILES CC(C)c1ccccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C19H15BrN2O2/c1-10(2)12-5-3-4-6-13(12)18-21-16-14-9-11(20)7-8-15(14)24-17(16)19(23)22-18/h3-10H,1-2H3,(H,21,22,23)
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n/an/a 810n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385088
PNG
(CHEMBL2035641)
Show SMILES CN1CCN(Cc2nc3c4cc(ccc4oc3c(=O)[nH]2)C2CC2)CC1
Show InChI InChI=1S/C19H22N4O2/c1-22-6-8-23(9-7-22)11-16-20-17-14-10-13(12-2-3-12)4-5-15(14)25-18(17)19(24)21-16/h4-5,10,12H,2-3,6-9,11H2,1H3,(H,20,21,24)
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n/an/a 840n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385070
PNG
(CHEMBL2035620)
Show SMILES Fc1ccc(c(Cl)c1)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrClFN2O2/c17-7-1-4-12-10(5-7)13-14(23-12)16(22)21-15(20-13)9-3-2-8(19)6-11(9)18/h1-6H,(H,20,21,22)
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n/an/a 850n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385062
PNG
(CHEMBL2035616)
Show SMILES COc1cccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c12
Show InChI InChI=1S/C17H11ClN2O3/c1-22-11-7-4-8-12-13(11)14-15(23-12)17(21)20-16(19-14)9-5-2-3-6-10(9)18/h2-8H,1H3,(H,19,20,21)
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n/an/a 850n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385092
PNG
(CHEMBL2035598)
Show SMILES Clc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C16H8Cl2N2O2/c17-8-5-6-12-10(7-8)13-14(22-12)16(21)20-15(19-13)9-3-1-2-4-11(9)18/h1-7H,(H,19,20,21)
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n/an/a 858n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385072
PNG
(CHEMBL2035622)
Show SMILES Fc1cccc(Cl)c1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H7BrClFN2O2/c17-7-4-5-11-8(6-7)13-14(23-11)16(22)21-15(20-13)12-9(18)2-1-3-10(12)19/h1-6H,(H,20,21,22)
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n/an/a 1.07E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385058
PNG
(CHEMBL2035613)
Show SMILES CC(=O)Nc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C18H12ClN3O3/c1-9(23)20-10-6-7-14-12(8-10)15-16(25-14)18(24)22-17(21-15)11-4-2-3-5-13(11)19/h2-8H,1H3,(H,20,23)(H,21,22,24)
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n/an/a 1.17E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385064
PNG
(CHEMBL2035612)
Show SMILES CNc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H12ClN3O2/c1-19-9-6-7-13-11(8-9)14-15(23-13)17(22)21-16(20-14)10-4-2-3-5-12(10)18/h2-8,19H,1H3,(H,20,21,22)
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n/an/a 1.24E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385093
PNG
(CHEMBL2035605)
Show SMILES COc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H11ClN2O3/c1-22-9-6-7-13-11(8-9)14-15(23-13)17(21)20-16(19-14)10-4-2-3-5-12(10)18/h2-8H,1H3,(H,19,20,21)
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n/an/a 1.45E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385074
PNG
(CHEMBL2035625)
Show SMILES COc1cccc(c1Cl)-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H10BrClN2O3/c1-23-12-4-2-3-9(13(12)19)16-20-14-10-7-8(18)5-6-11(10)24-15(14)17(22)21-16/h2-7H,1H3,(H,20,21,22)
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n/an/a 1.74E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385062
PNG
(CHEMBL2035616)
Show SMILES COc1cccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c12
Show InChI InChI=1S/C17H11ClN2O3/c1-22-11-7-4-8-12-13(11)14-15(23-12)17(21)20-16(19-14)9-5-2-3-6-10(9)18/h2-8H,1H3,(H,19,20,21)
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n/an/a 1.87E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385098
PNG
(CHEMBL2035610)
Show SMILES FC(F)(F)c1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H8ClF3N2O2/c18-11-4-2-1-3-9(11)15-22-13-10-7-8(17(19,20)21)5-6-12(10)25-14(13)16(24)23-15/h1-7H,(H,22,23,24)
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n/an/a 2.33E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385065
PNG
(CHEMBL2035614)
Show SMILES Oc1ccc2c(c1)oc1c2nc([nH]c1=O)-c1ccccc1Cl
Show InChI InChI=1S/C16H9ClN2O3/c17-11-4-2-1-3-9(11)15-18-13-10-6-5-8(20)7-12(10)22-14(13)16(21)19-15/h1-7,20H,(H,18,19,21)
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n/an/a 2.38E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50383716
PNG
(CHEMBL2030375)
Show SMILES Brc1ccc2oc3c(nc[nH]c3=O)c2c1
Show InChI InChI=1S/C10H5BrN2O2/c11-5-1-2-7-6(3-5)8-9(15-7)10(14)13-4-12-8/h1-4H,(H,12,13,14)
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n/an/a 2.96E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of PIM2


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385064
PNG
(CHEMBL2035612)
Show SMILES CNc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H12ClN3O2/c1-19-9-6-7-13-11(8-9)14-15(23-13)17(22)21-16(20-14)10-4-2-3-5-12(10)18/h2-8,19H,1H3,(H,20,21,22)
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n/an/a 2.98E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385067
PNG
(CHEMBL2035617)
Show SMILES Fc1cccc(Cl)c1-c1nc2c3cc(ccc3oc2c(=O)[nH]1)C1CC1
Show InChI InChI=1S/C19H12ClFN2O2/c20-12-2-1-3-13(21)15(12)18-22-16-11-8-10(9-4-5-9)6-7-14(11)25-17(16)19(24)23-18/h1-3,6-9H,4-5H2,(H,22,23,24)
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n/an/a 3.33E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385095
PNG
(CHEMBL2035607)
Show SMILES Clc1ccccc1-c1nc2c3cc(ccc3oc2c(=O)[nH]1)C#N
Show InChI InChI=1S/C17H8ClN3O2/c18-12-4-2-1-3-10(12)16-20-14-11-7-9(8-19)5-6-13(11)23-15(14)17(22)21-16/h1-7H,(H,20,21,22)
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n/an/a 3.43E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50383725
PNG
(CHEMBL2030386)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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n/an/a>3.60E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of Flt3


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50383725
PNG
(CHEMBL2030386)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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n/an/a>3.60E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of JAK2


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50383725
PNG
(CHEMBL2030386)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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n/an/a>3.60E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of KDR


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50383725
PNG
(CHEMBL2030386)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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n/an/a>3.60E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of c-Kit


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385094
PNG
(CHEMBL2035606)
Show SMILES Oc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C16H9ClN2O3/c17-11-4-2-1-3-9(11)15-18-13-10-7-8(20)5-6-12(10)22-14(13)16(21)19-15/h1-7,20H,(H,18,19,21)
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n/an/a 3.76E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385059
PNG
(CHEMBL2035604)
Show SMILES Cc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H11ClN2O2/c1-9-6-7-13-11(8-9)14-15(22-13)17(21)20-16(19-14)10-4-2-3-5-12(10)18/h2-8H,1H3,(H,19,20,21)
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n/an/a 3.93E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385096
PNG
(CHEMBL2035608)
Show SMILES Clc1ccccc1-c1nc2c3cc(ccc3oc2c(=O)[nH]1)-c1ccccc1
Show InChI InChI=1S/C22H13ClN2O2/c23-17-9-5-4-8-15(17)21-24-19-16-12-14(13-6-2-1-3-7-13)10-11-18(16)27-20(19)22(26)25-21/h1-12H,(H,24,25,26)
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n/an/a 3.96E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385099
PNG
(CHEMBL2035611)
Show SMILES Nc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C16H10ClN3O2/c17-11-4-2-1-3-9(11)15-19-13-10-7-8(18)5-6-12(10)22-14(13)16(21)20-15/h1-7H,18H2,(H,19,20,21)
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n/an/a 4.39E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385068
PNG
(CHEMBL2035618)
Show SMILES COc1ccccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H11BrN2O3/c1-22-12-5-3-2-4-10(12)16-19-14-11-8-9(18)6-7-13(11)23-15(14)17(21)20-16/h2-8H,1H3,(H,19,20,21)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385058
PNG
(CHEMBL2035613)
Show SMILES CC(=O)Nc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C18H12ClN3O3/c1-9(23)20-10-6-7-14-12(8-10)15-16(25-14)18(24)22-17(21-15)11-4-2-3-5-13(11)19/h2-8H,1H3,(H,20,23)(H,21,22,24)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385058
PNG
(CHEMBL2035613)
Show SMILES CC(=O)Nc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C18H12ClN3O3/c1-9(23)20-10-6-7-14-12(8-10)15-16(25-14)18(24)22-17(21-15)11-4-2-3-5-13(11)19/h2-8H,1H3,(H,20,23)(H,21,22,24)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385069
PNG
(CHEMBL2035619)
Show SMILES CC(C)c1ccccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C19H15BrN2O2/c1-10(2)12-5-3-4-6-13(12)18-21-16-14-9-11(20)7-8-15(14)24-17(16)19(23)22-18/h3-10H,1-2H3,(H,21,22,23)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385066
PNG
(CHEMBL2035615)
Show SMILES COc1ccc2c(c1)oc1c2nc([nH]c1=O)-c1ccccc1Cl
Show InChI InChI=1S/C17H11ClN2O3/c1-22-9-6-7-11-13(8-9)23-15-14(11)19-16(20-17(15)21)10-4-2-3-5-12(10)18/h2-8H,1H3,(H,19,20,21)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385068
PNG
(CHEMBL2035618)
Show SMILES COc1ccccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H11BrN2O3/c1-22-12-5-3-2-4-10(12)16-19-14-11-8-9(18)6-7-13(11)23-15(14)17(21)20-16/h2-8H,1H3,(H,19,20,21)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385091
PNG
(CHEMBL2035597)
Show SMILES Clc1ccccc1-c1nc2c3ccccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H9ClN2O2/c17-11-7-3-1-5-9(11)15-18-13-10-6-2-4-8-12(10)21-14(13)16(20)19-15/h1-8H,(H,18,19,20)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385064
PNG
(CHEMBL2035612)
Show SMILES CNc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H12ClN3O2/c1-19-9-6-7-13-11(8-9)14-15(23-13)17(22)21-16(20-14)10-4-2-3-5-12(10)18/h2-8,19H,1H3,(H,20,21,22)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385091
PNG
(CHEMBL2035597)
Show SMILES Clc1ccccc1-c1nc2c3ccccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H9ClN2O2/c17-11-7-3-1-5-9(11)15-18-13-10-6-2-4-8-12(10)21-14(13)16(20)19-15/h1-8H,(H,18,19,20)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385096
PNG
(CHEMBL2035608)
Show SMILES Clc1ccccc1-c1nc2c3cc(ccc3oc2c(=O)[nH]1)-c1ccccc1
Show InChI InChI=1S/C22H13ClN2O2/c23-17-9-5-4-8-15(17)21-24-19-16-12-14(13-6-2-1-3-7-13)10-11-18(16)27-20(19)22(26)25-21/h1-12H,(H,24,25,26)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385062
PNG
(CHEMBL2035616)
Show SMILES COc1cccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c12
Show InChI InChI=1S/C17H11ClN2O3/c1-22-11-7-4-8-12-13(11)14-15(23-12)17(21)20-16(19-14)9-5-2-3-6-10(9)18/h2-8H,1H3,(H,19,20,21)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385066
PNG
(CHEMBL2035615)
Show SMILES COc1ccc2c(c1)oc1c2nc([nH]c1=O)-c1ccccc1Cl
Show InChI InChI=1S/C17H11ClN2O3/c1-22-9-6-7-11-13(8-9)23-15-14(11)19-16(20-17(15)21)10-4-2-3-5-12(10)18/h2-8H,1H3,(H,19,20,21)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385066
PNG
(CHEMBL2035615)
Show SMILES COc1ccc2c(c1)oc1c2nc([nH]c1=O)-c1ccccc1Cl
Show InChI InChI=1S/C17H11ClN2O3/c1-22-9-6-7-11-13(8-9)23-15-14(11)19-16(20-17(15)21)10-4-2-3-5-12(10)18/h2-8H,1H3,(H,19,20,21)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385097
PNG
(CHEMBL2035609)
Show SMILES FC(F)(F)Oc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C17H8ClF3N2O3/c18-11-4-2-1-3-9(11)15-22-13-10-7-8(26-17(19,20)21)5-6-12(10)25-14(13)16(24)23-15/h1-7H,(H,22,23,24)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (human))
BDBM50385099
PNG
(CHEMBL2035611)
Show SMILES Nc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C16H10ClN3O2/c17-11-4-2-1-3-9(11)15-19-13-10-7-8(18)5-6-12(10)22-14(13)16(21)20-15/h1-7H,18H2,(H,19,20,21)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM2 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385091
PNG
(CHEMBL2035597)
Show SMILES Clc1ccccc1-c1nc2c3ccccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C16H9ClN2O2/c17-11-7-3-1-5-9(11)15-18-13-10-6-2-4-8-12(10)21-14(13)16(20)19-15/h1-8H,(H,18,19,20)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385099
PNG
(CHEMBL2035611)
Show SMILES Nc1ccc2oc3c(nc([nH]c3=O)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C16H10ClN3O2/c17-11-4-2-1-3-9(11)15-19-13-10-7-8(18)5-6-12(10)22-14(13)16(21)20-15/h1-7H,18H2,(H,19,20,21)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50385068
PNG
(CHEMBL2035618)
Show SMILES COc1ccccc1-c1nc2c3cc(Br)ccc3oc2c(=O)[nH]1
Show InChI InChI=1S/C17H11BrN2O3/c1-22-12-5-3-2-4-10(12)16-19-14-11-8-9(18)6-7-13(11)23-15(14)17(21)20-16/h2-8H,1H3,(H,19,20,21)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (human))
BDBM50383725
PNG
(CHEMBL2030386)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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n/an/a 5.10E+3n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50383725
PNG
(CHEMBL2030386)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (human))
BDBM50383725
PNG
(CHEMBL2030386)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50383725
PNG
(CHEMBL2030386)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (human))
BDBM50383725
PNG
(CHEMBL2030386)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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Exelixis

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
Cytochrome P450 2C8


(Homo sapiens (Human))
BDBM50383725
PNG
(CHEMBL2030386)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Br)ccc4oc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14BrN3O3/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Exelixis

Curated by ChEMBL


Assay Description
Inhibition of CYP2C8


Bioorg Med Chem Lett 22: 3732-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.025
BindingDB Entry DOI: 10.7270/Q2X34ZHV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%