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PubMed code 22824762

Compile data set for download or QSAR
Found 39 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388112
PNG
(CHEMBL2058971)
Show SMILES FC(F)(F)c1cc(N2CCN(CC2)[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)c2ccccc2n1
Show InChI InChI=1S/C22H26F3N5OS/c23-22(24,25)20-12-19(16-3-1-2-4-17(16)27-20)29-7-5-28(6-8-29)15-11-18(26-13-15)21(31)30-9-10-32-14-30/h1-4,12,15,18,26H,5-11,13-14H2/t15-,18-/m0/s1
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n/an/a 0.370n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388123
PNG
(CHEMBL2058762)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1nc2ccc(cc2[nH]1)C#N)N1CCSC1
Show InChI InChI=1S/C20H25N7OS/c21-11-14-1-2-16-17(9-14)24-20(23-16)26-5-3-25(4-6-26)15-10-18(22-12-15)19(28)27-7-8-29-13-27/h1-2,9,15,18,22H,3-8,10,12-13H2,(H,23,24)/t15-,18-/m0/s1
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n/an/a 0.390n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388127
PNG
(CHEMBL2058758)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1nc2cc(ccc2s1)C#N)N1CCSC1
Show InChI InChI=1S/C20H24N6OS2/c21-11-14-1-2-18-16(9-14)23-20(29-18)25-5-3-24(4-6-25)15-10-17(22-12-15)19(27)26-7-8-28-13-26/h1-2,9,15,17,22H,3-8,10,12-13H2/t15-,17-/m0/s1
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n/an/a 0.420n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388125
PNG
(CHEMBL2058756)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1nc2cc(ccc2o1)C#N)N1CCSC1
Show InChI InChI=1S/C20H24N6O2S/c21-11-14-1-2-18-16(9-14)23-20(28-18)25-5-3-24(4-6-25)15-10-17(22-12-15)19(27)26-7-8-29-13-26/h1-2,9,15,17,22H,3-8,10,12-13H2/t15-,17-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388115
PNG
(CHEMBL2058975)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1ncc(C#N)c2ccccc12)N1CCSC1
Show InChI InChI=1S/C22H26N6OS/c23-12-16-13-25-21(19-4-2-1-3-18(16)19)27-7-5-26(6-8-27)17-11-20(24-14-17)22(29)28-9-10-30-15-28/h1-4,13,17,20,24H,5-11,14-15H2/t17-,20-/m0/s1
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n/an/a 0.510n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388126
PNG
(CHEMBL2058757)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1nc2ccccc2s1)N1CCSC1
Show InChI InChI=1S/C19H25N5OS2/c25-18(24-9-10-26-13-24)16-11-14(12-20-16)22-5-7-23(8-6-22)19-21-15-3-1-2-4-17(15)27-19/h1-4,14,16,20H,5-13H2/t14-,16-/m0/s1
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n/an/a 0.550n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388115
PNG
(CHEMBL2058975)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1ncc(C#N)c2ccccc12)N1CCSC1
Show InChI InChI=1S/C22H26N6OS/c23-12-16-13-25-21(19-4-2-1-3-18(16)19)27-7-5-26(6-8-27)17-11-20(24-14-17)22(29)28-9-10-30-15-28/h1-4,13,17,20,24H,5-11,14-15H2/t17-,20-/m0/s1
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n/an/a 0.560n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388118
PNG
(CHEMBL2058970)
Show SMILES Cc1cc(N2CCN(CC2)[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)c2ccccc2n1
Show InChI InChI=1S/C22H29N5OS/c1-16-12-21(18-4-2-3-5-19(18)24-16)26-8-6-25(7-9-26)17-13-20(23-14-17)22(28)27-10-11-29-15-27/h2-5,12,17,20,23H,6-11,13-15H2,1H3/t17-,20-/m0/s1
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n/an/a 0.560n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388122
PNG
(CHEMBL2058761)
Show SMILES Clc1ccc2nc([nH]c2c1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C19H25ClN6OS/c20-13-1-2-15-16(9-13)23-19(22-15)25-5-3-24(4-6-25)14-10-17(21-11-14)18(27)26-7-8-28-12-26/h1-2,9,14,17,21H,3-8,10-12H2,(H,22,23)/t14-,17-/m0/s1
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n/an/a 0.590n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388112
PNG
(CHEMBL2058971)
Show SMILES FC(F)(F)c1cc(N2CCN(CC2)[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)c2ccccc2n1
Show InChI InChI=1S/C22H26F3N5OS/c23-22(24,25)20-12-19(16-3-1-2-4-17(16)27-20)29-7-5-28(6-8-29)15-11-18(26-13-15)21(31)30-9-10-32-14-30/h1-4,12,15,18,26H,5-11,13-14H2/t15-,18-/m0/s1
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n/an/a 0.590n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388113
PNG
(CHEMBL2058973)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1nccc2ccccc12)N1CCSC1
Show InChI InChI=1S/C21H27N5OS/c27-21(26-11-12-28-15-26)19-13-17(14-23-19)24-7-9-25(10-8-24)20-18-4-2-1-3-16(18)5-6-22-20/h1-6,17,19,23H,7-15H2/t17-,19-/m0/s1
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n/an/a 0.610n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388123
PNG
(CHEMBL2058762)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1nc2ccc(cc2[nH]1)C#N)N1CCSC1
Show InChI InChI=1S/C20H25N7OS/c21-11-14-1-2-16-17(9-14)24-20(23-16)26-5-3-25(4-6-26)15-10-18(22-12-15)19(28)27-7-8-29-13-27/h1-2,9,15,18,22H,3-8,10,12-13H2,(H,23,24)/t15-,18-/m0/s1
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n/an/a 0.610n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388119
PNG
(CHEMBL2058972)
Show SMILES Clc1ccc2c(ccnc2c1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C21H26ClN5OS/c22-15-1-2-17-18(11-15)23-4-3-20(17)26-7-5-25(6-8-26)16-12-19(24-13-16)21(28)27-9-10-29-14-27/h1-4,11,16,19,24H,5-10,12-14H2/t16-,19-/m0/s1
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n/an/a 0.610n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388119
PNG
(CHEMBL2058972)
Show SMILES Clc1ccc2c(ccnc2c1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C21H26ClN5OS/c22-15-1-2-17-18(11-15)23-4-3-20(17)26-7-5-25(6-8-26)16-12-19(24-13-16)21(28)27-9-10-29-14-27/h1-4,11,16,19,24H,5-10,12-14H2/t16-,19-/m0/s1
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n/an/a 0.620n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388127
PNG
(CHEMBL2058758)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1nc2cc(ccc2s1)C#N)N1CCSC1
Show InChI InChI=1S/C20H24N6OS2/c21-11-14-1-2-18-16(9-14)23-20(29-18)25-5-3-24(4-6-25)15-10-17(22-12-15)19(27)26-7-8-28-13-26/h1-2,9,15,17,22H,3-8,10,12-13H2/t15-,17-/m0/s1
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n/an/a 0.690n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388125
PNG
(CHEMBL2058756)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1nc2cc(ccc2o1)C#N)N1CCSC1
Show InChI InChI=1S/C20H24N6O2S/c21-11-14-1-2-18-16(9-14)23-20(28-18)25-5-3-24(4-6-25)15-10-17(22-12-15)19(27)26-7-8-29-13-26/h1-2,9,15,17,22H,3-8,10,12-13H2/t15-,17-/m0/s1
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n/an/a 0.720n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388114
PNG
(CHEMBL2058974)
Show SMILES Clc1cnc(N2CCN(CC2)[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)c2ccccc12
Show InChI InChI=1S/C21H26ClN5OS/c22-18-13-24-20(17-4-2-1-3-16(17)18)26-7-5-25(6-8-26)15-11-19(23-12-15)21(28)27-9-10-29-14-27/h1-4,13,15,19,23H,5-12,14H2/t15-,19-/m0/s1
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n/an/a 0.730n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388126
PNG
(CHEMBL2058757)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1nc2ccccc2s1)N1CCSC1
Show InChI InChI=1S/C19H25N5OS2/c25-18(24-9-10-26-13-24)16-11-14(12-20-16)22-5-7-23(8-6-22)19-21-15-3-1-2-4-17(15)27-19/h1-4,14,16,20H,5-13H2/t14-,16-/m0/s1
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n/an/a 0.770n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388114
PNG
(CHEMBL2058974)
Show SMILES Clc1cnc(N2CCN(CC2)[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)c2ccccc12
Show InChI InChI=1S/C21H26ClN5OS/c22-18-13-24-20(17-4-2-1-3-16(17)18)26-7-5-25(6-8-26)15-11-19(23-12-15)21(28)27-9-10-29-14-27/h1-4,13,15,19,23H,5-12,14H2/t15-,19-/m0/s1
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Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388121
PNG
(CHEMBL2058760)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1nc2ccccc2[nH]1)N1CCSC1
Show InChI InChI=1S/C19H26N6OS/c26-18(25-9-10-27-13-25)17-11-14(12-20-17)23-5-7-24(8-6-23)19-21-15-3-1-2-4-16(15)22-19/h1-4,14,17,20H,5-13H2,(H,21,22)/t14-,17-/m0/s1
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Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388113
PNG
(CHEMBL2058973)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1nccc2ccccc12)N1CCSC1
Show InChI InChI=1S/C21H27N5OS/c27-21(26-11-12-28-15-26)19-13-17(14-23-19)24-7-9-25(10-8-24)20-18-4-2-1-3-16(18)5-6-22-20/h1-6,17,19,23H,7-15H2/t17-,19-/m0/s1
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Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50206043
PNG
(((2S,4S)-4-(4-(5-nitropyridin-2-yl)piperazin-1-yl)...)
Show SMILES [O-][N+](=O)c1ccc(nc1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C17H24N6O3S/c24-17(22-7-8-27-12-22)15-9-14(11-18-15)20-3-5-21(6-4-20)16-2-1-13(10-19-16)23(25)26/h1-2,10,14-15,18H,3-9,11-12H2/t14-,15-/m0/s1
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Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388117
PNG
(CHEMBL2058969)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1ccnc2ccccc12)N1CCSC1
Show InChI InChI=1S/C21H27N5OS/c27-21(26-11-12-28-15-26)19-13-16(14-23-19)24-7-9-25(10-8-24)20-5-6-22-18-4-2-1-3-17(18)20/h1-6,16,19,23H,7-15H2/t16-,19-/m0/s1
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n/an/a 0.950n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388117
PNG
(CHEMBL2058969)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1ccnc2ccccc12)N1CCSC1
Show InChI InChI=1S/C21H27N5OS/c27-21(26-11-12-28-15-26)19-13-16(14-23-19)24-7-9-25(10-8-24)20-5-6-22-18-4-2-1-3-17(18)20/h1-6,16,19,23H,7-15H2/t16-,19-/m0/s1
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Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388122
PNG
(CHEMBL2058761)
Show SMILES Clc1ccc2nc([nH]c2c1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C19H25ClN6OS/c20-13-1-2-15-16(9-13)23-19(22-15)25-5-3-24(4-6-25)14-10-17(21-11-14)18(27)26-7-8-28-12-26/h1-2,9,14,17,21H,3-8,10-12H2,(H,22,23)/t14-,17-/m0/s1
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Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388121
PNG
(CHEMBL2058760)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1nc2ccccc2[nH]1)N1CCSC1
Show InChI InChI=1S/C19H26N6OS/c26-18(25-9-10-27-13-25)17-11-14(12-20-17)23-5-7-24(8-6-23)19-21-15-3-1-2-4-16(15)22-19/h1-4,14,17,20H,5-13H2,(H,21,22)/t14-,17-/m0/s1
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Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50206043
PNG
(((2S,4S)-4-(4-(5-nitropyridin-2-yl)piperazin-1-yl)...)
Show SMILES [O-][N+](=O)c1ccc(nc1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C17H24N6O3S/c24-17(22-7-8-27-12-22)15-9-14(11-18-15)20-3-5-21(6-4-20)16-2-1-13(10-19-16)23(25)26/h1-2,10,14-15,18H,3-9,11-12H2/t14-,15-/m0/s1
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Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388124
PNG
(CHEMBL2058967)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1nc2ccccc2o1)N1CCSC1
Show InChI InChI=1S/C19H25N5O2S/c25-18(24-9-10-27-13-24)16-11-14(12-20-16)22-5-7-23(8-6-22)19-21-15-3-1-2-4-17(15)26-19/h1-4,14,16,20H,5-13H2/t14-,16-/m0/s1
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Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388120
PNG
(CHEMBL2058759)
Show SMILES FC(F)(F)c1ccc2c(ccnc2c1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C22H26F3N5OS/c23-22(24,25)15-1-2-17-18(11-15)26-4-3-20(17)29-7-5-28(6-8-29)16-12-19(27-13-16)21(31)30-9-10-32-14-30/h1-4,11,16,19,27H,5-10,12-14H2/t16-,19-/m0/s1
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Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388118
PNG
(CHEMBL2058970)
Show SMILES Cc1cc(N2CCN(CC2)[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)c2ccccc2n1
Show InChI InChI=1S/C22H29N5OS/c1-16-12-21(18-4-2-3-5-19(18)24-16)26-8-6-25(7-9-26)17-13-20(23-14-17)22(28)27-10-11-29-15-27/h2-5,12,17,20,23H,6-11,13-15H2,1H3/t17-,20-/m0/s1
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Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388124
PNG
(CHEMBL2058967)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1nc2ccccc2o1)N1CCSC1
Show InChI InChI=1S/C19H25N5O2S/c25-18(24-9-10-27-13-24)16-11-14(12-20-16)22-5-7-23(8-6-22)19-21-15-3-1-2-4-17(15)26-19/h1-4,14,16,20H,5-13H2/t14-,16-/m0/s1
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Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50206038
PNG
(((2S,4S)-4-(4-(4-nitrophenyl)piperazin-1-yl)pyrrol...)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C18H25N5O3S/c24-18(22-9-10-27-13-22)17-11-16(12-19-17)21-7-5-20(6-8-21)14-1-3-15(4-2-14)23(25)26/h1-4,16-17,19H,5-13H2/t16-,17-/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388120
PNG
(CHEMBL2058759)
Show SMILES FC(F)(F)c1ccc2c(ccnc2c1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C22H26F3N5OS/c23-22(24,25)15-1-2-17-18(11-15)26-4-3-20(17)29-7-5-28(6-8-29)16-12-19(27-13-16)21(31)30-9-10-32-14-30/h1-4,11,16,19,27H,5-10,12-14H2/t16-,19-/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4 (DPP4)


(Homo sapiens (human))
BDBM50388116
PNG
(CHEMBL2058968)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1ccc2ccccc2n1)N1CCSC1
Show InChI InChI=1S/C21H27N5OS/c27-21(26-11-12-28-15-26)19-13-17(14-22-19)24-7-9-25(10-8-24)20-6-5-16-3-1-2-4-18(16)23-20/h1-6,17,19,22H,7-15H2/t17-,19-/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IV


(Rattus norvegicus (rat))
BDBM50388116
PNG
(CHEMBL2058968)
Show SMILES O=C([C@@H]1C[C@@H](CN1)N1CCN(CC1)c1ccc2ccccc2n1)N1CCSC1
Show InChI InChI=1S/C21H27N5OS/c27-21(26-11-12-28-15-26)19-13-17(14-22-19)24-7-9-25(10-8-24)20-6-5-16-3-1-2-4-18(16)23-20/h1-6,17,19,22H,7-15H2/t17-,19-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat DPP4 using Gly-Pro-MCA as substrate after 60 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50206038
PNG
(((2S,4S)-4-(4-(4-nitrophenyl)piperazin-1-yl)pyrrol...)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C18H25N5O3S/c24-18(22-9-10-27-13-22)17-11-16(12-19-17)21-7-5-20(6-8-21)14-1-3-15(4-2-14)23(25)26/h1-4,16-17,19H,5-13H2/t16-,17-/m0/s1
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n/an/a 12.2n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP8 using Gly-Pro-MCA as substrate after 30 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50206038
PNG
(((2S,4S)-4-(4-(4-nitrophenyl)piperazin-1-yl)pyrrol...)
Show SMILES [O-][N+](=O)c1ccc(cc1)N1CCN(CC1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1
Show InChI InChI=1S/C18H25N5O3S/c24-18(22-9-10-27-13-22)17-11-16(12-19-17)21-7-5-20(6-8-21)14-1-3-15(4-2-14)23(25)26/h1-4,16-17,19H,5-13H2/t16-,17-/m0/s1
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n/an/a 30.2n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP9 using Gly-Pro-MCA as substrate after 30 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM50388112
PNG
(CHEMBL2058971)
Show SMILES FC(F)(F)c1cc(N2CCN(CC2)[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)c2ccccc2n1
Show InChI InChI=1S/C22H26F3N5OS/c23-22(24,25)20-12-19(16-3-1-2-4-17(16)27-20)29-7-5-28(6-8-29)15-11-18(26-13-15)21(31)30-9-10-32-14-30/h1-4,12,15,18,26H,5-11,13-14H2/t15-,18-/m0/s1
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n/an/a 72.4n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP8 using Gly-Pro-MCA as substrate after 30 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM50388112
PNG
(CHEMBL2058971)
Show SMILES FC(F)(F)c1cc(N2CCN(CC2)[C@@H]2CN[C@@H](C2)C(=O)N2CCSC2)c2ccccc2n1
Show InChI InChI=1S/C22H26F3N5OS/c23-22(24,25)20-12-19(16-3-1-2-4-17(16)27-20)29-7-5-28(6-8-29)15-11-18(26-13-15)21(31)30-9-10-32-14-30/h1-4,12,15,18,26H,5-11,13-14H2/t15-,18-/m0/s1
PDB

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UniProtKB/SwissProt

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Article
PubMed
n/an/a 105n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP9 using Gly-Pro-MCA as substrate after 30 mins by fluorometry


Bioorg Med Chem 20: 5033-41 (2012)


Article DOI: 10.1016/j.bmc.2012.06.033
BindingDB Entry DOI: 10.7270/Q20Z74B2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%