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PubMed code 22884989

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390627
PNG
(CHEMBL2069598)
Show SMILES CCc1cc2c(ccc(C(C)O)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C16H20N4O2/c1-5-10-8-13-11(14-16(3,4)15(22)18-17-14)6-7-12(9(2)21)20(13)19-10/h6-9,21H,5H2,1-4H3,(H,18,22)
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n/an/a 3.40n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390628
PNG
(CHEMBL2069599)
Show SMILES CCc1cc2c(ccc(C(C)=O)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C16H18N4O2/c1-5-10-8-13-11(14-16(3,4)15(22)18-17-14)6-7-12(9(2)21)20(13)19-10/h6-8H,5H2,1-4H3,(H,18,22)
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n/an/a 7.5n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390625
PNG
(CHEMBL2069596)
Show SMILES CCc1cc2c(ccc(NC)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C15H19N5O/c1-5-9-8-11-10(6-7-12(16-4)20(11)19-9)13-15(2,3)14(21)18-17-13/h6-8,16H,5H2,1-4H3,(H,18,21)
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n/an/a 15n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390622
PNG
(CHEMBL2069593)
Show SMILES CCc1cc2c(ccc(CC)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C16H20N4O/c1-5-10-9-13-12(8-7-11(6-2)20(13)19-10)14-16(3,4)15(21)18-17-14/h7-9H,5-6H2,1-4H3,(H,18,21)
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n/an/a 17n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390626
PNG
(CHEMBL2069597)
Show SMILES CCc1cc2c(ccc(CO)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C15H18N4O2/c1-4-9-7-12-11(6-5-10(8-20)19(12)18-9)13-15(2,3)14(21)17-16-13/h5-7,20H,4,8H2,1-3H3,(H,17,21)
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n/an/a 35n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390629
PNG
(CHEMBL2069600)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O2/c1-7-5-11(22)18-19-13(7)8-3-4-12(23-2)21-9(8)6-10(20-21)14(15,16)17/h3-4,6-7H,5H2,1-2H3,(H,18,22)
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n/an/a 42n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390612
PNG
(CHEMBL2069603)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2cc(nn12)C(F)F
Show InChI InChI=1S/C14H14F2N4O2/c1-14(2)11(17-18-13(14)21)7-4-5-10(22-3)20-9(7)6-8(19-20)12(15)16/h4-6,12H,1-3H3,(H,18,21)
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n/an/a 50n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390615
PNG
(CHEMBL2069607)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2sc(nc12)C(F)(F)F
Show InChI InChI=1S/C14H12F3N3O2S/c1-13(2)10(19-20-11(13)21)6-4-5-7(22-3)8-9(6)23-12(18-8)14(15,16)17/h4-5H,1-3H3,(H,20,21)
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n/an/a 63n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390624
PNG
(CHEMBL2069595)
Show SMILES CCc1cc2c(ccc(SC)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C15H18N4OS/c1-5-9-8-11-10(6-7-12(21-4)19(11)18-9)13-15(2,3)14(20)17-16-13/h6-8H,5H2,1-4H3,(H,17,20)
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n/an/a 79n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390613
PNG
(CHEMBL2069604)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O2/c1-13(2)11(18-19-12(13)22)7-4-5-10(23-3)21-8(7)6-9(20-21)14(15,16)17/h4-6H,1-3H3,(H,19,22)
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n/an/a 110n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390617
PNG
(CHEMBL2069609)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)n2cc(nc12)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O2/c1-13(2)10(19-20-12(13)22)7-4-5-8(23-3)11-18-9(6-21(7)11)14(15,16)17/h4-6H,1-3H3,(H,20,22)
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n/an/a 140n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390617
PNG
(CHEMBL2069609)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)n2cc(nc12)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O2/c1-13(2)10(19-20-12(13)22)7-4-5-8(23-3)11-18-9(6-21(7)11)14(15,16)17/h4-6H,1-3H3,(H,20,22)
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n/an/a 150n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390631
PNG
(CHEMBL2069602)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2cc(nn12)C1CC1
Show InChI InChI=1S/C16H18N4O2/c1-16(2)14(17-18-15(16)21)10-6-7-13(22-3)20-12(10)8-11(19-20)9-4-5-9/h6-9H,4-5H2,1-3H3,(H,18,21)
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Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390621
PNG
(CHEMBL2069592)
Show SMILES CCc1cc2c(ccc(C)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C15H18N4O/c1-5-10-8-12-11(7-6-9(2)19(12)18-10)13-15(3,4)14(20)17-16-13/h6-8H,5H2,1-4H3,(H,17,20)
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n/an/a 160n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390616
PNG
(CHEMBL2069608)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2[nH]c(nc12)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O2/c1-13(2)10(20-21-12(13)22)6-4-5-7(23-3)9-8(6)18-11(19-9)14(15,16)17/h4-5H,1-3H3,(H,18,19)(H,21,22)
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n/an/a 200n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390629
PNG
(CHEMBL2069600)
Show SMILES COc1ccc(C2=NNC(=O)CC2C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O2/c1-7-5-11(22)18-19-13(7)8-3-4-12(23-2)21-9(8)6-10(20-21)14(15,16)17/h3-4,6-7H,5H2,1-2H3,(H,18,22)
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n/an/a 360n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390632
PNG
(CHEMBL2069605)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2cc(oc12)C(F)(F)F
Show InChI InChI=1S/C15H13F3N2O3/c1-14(2)12(19-20-13(14)21)7-4-5-9(22-3)11-8(7)6-10(23-11)15(16,17)18/h4-6H,1-3H3,(H,20,21)
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Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390623
PNG
(CHEMBL2069594)
Show SMILES CCc1cc2c(ccc(OC)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C15H18N4O2/c1-5-9-8-11-10(6-7-12(21-4)19(11)18-9)13-15(2,3)14(20)17-16-13/h6-8H,5H2,1-4H3,(H,17,20)
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Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390620
PNG
(CHEMBL2069591)
Show SMILES CCc1cc2c(ccc(OC)n2n1)C1=NNC(=O)CC1C
Show InChI InChI=1S/C15H18N4O2/c1-4-10-8-12-11(5-6-14(21-3)19(12)18-10)15-9(2)7-13(20)16-17-15/h5-6,8-9H,4,7H2,1-3H3,(H,16,20)
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Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390615
PNG
(CHEMBL2069607)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2sc(nc12)C(F)(F)F
Show InChI InChI=1S/C14H12F3N3O2S/c1-13(2)10(19-20-11(13)21)6-4-5-7(22-3)8-9(6)23-12(18-8)14(15,16)17/h4-5H,1-3H3,(H,20,21)
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Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390614
PNG
(CHEMBL2069606)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2cc(sc12)C(F)(F)F
Show InChI InChI=1S/C15H13F3N2O2S/c1-14(2)12(19-20-13(14)21)7-4-5-9(22-3)11-8(7)6-10(23-11)15(16,17)18/h4-6H,1-3H3,(H,20,21)
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n/an/a 690n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390619
PNG
(CHEMBL2069611)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2ccc(nc12)C(F)(F)F
Show InChI InChI=1S/C16H14F3N3O2/c1-15(2)13(21-22-14(15)23)9-4-6-10(24-3)12-8(9)5-7-11(20-12)16(17,18)19/h4-7H,1-3H3,(H,22,23)
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Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390632
PNG
(CHEMBL2069605)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2cc(oc12)C(F)(F)F
Show InChI InChI=1S/C15H13F3N2O3/c1-14(2)12(19-20-13(14)21)7-4-5-9(22-3)11-8(7)6-10(23-11)15(16,17)18/h4-6H,1-3H3,(H,20,21)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390626
PNG
(CHEMBL2069597)
Show SMILES CCc1cc2c(ccc(CO)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C15H18N4O2/c1-4-9-7-12-11(6-5-10(8-20)19(12)18-9)13-15(2,3)14(21)17-16-13/h5-7,20H,4,8H2,1-3H3,(H,17,21)
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n/an/a 1.59E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390627
PNG
(CHEMBL2069598)
Show SMILES CCc1cc2c(ccc(C(C)O)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C16H20N4O2/c1-5-10-8-13-11(14-16(3,4)15(22)18-17-14)6-7-12(9(2)21)20(13)19-10/h6-9,21H,5H2,1-4H3,(H,18,22)
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n/an/a 1.63E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390622
PNG
(CHEMBL2069593)
Show SMILES CCc1cc2c(ccc(CC)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C16H20N4O/c1-5-10-9-13-12(8-7-11(6-2)20(13)19-10)14-16(3,4)15(21)18-17-14/h7-9H,5-6H2,1-4H3,(H,18,21)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390621
PNG
(CHEMBL2069592)
Show SMILES CCc1cc2c(ccc(C)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C15H18N4O/c1-5-10-8-12-11(7-6-9(2)19(12)18-10)13-15(3,4)14(20)17-16-13/h6-8H,5H2,1-4H3,(H,17,20)
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n/an/a 2.37E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390628
PNG
(CHEMBL2069599)
Show SMILES CCc1cc2c(ccc(C(C)=O)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C16H18N4O2/c1-5-10-8-13-11(14-16(3,4)15(22)18-17-14)6-7-12(9(2)21)20(13)19-10/h6-8H,5H2,1-4H3,(H,18,22)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390618
PNG
(CHEMBL2069610)
Show SMILES CCc1ccc2c(ccc(OC)c2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C17H19N3O2/c1-5-10-6-7-11-12(8-9-13(22-4)14(11)18-10)15-17(2,3)16(21)20-19-15/h6-9H,5H2,1-4H3,(H,20,21)
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n/an/a 2.58E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50390630
PNG
(CHEMBL2069601)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2ccnn12
Show InChI InChI=1S/C13H14N4O2/c1-13(2)11(15-16-12(13)18)8-4-5-10(19-3)17-9(8)6-7-14-17/h4-7H,1-3H3,(H,16,18)
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n/an/a 2.93E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE4B


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390612
PNG
(CHEMBL2069603)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2cc(nn12)C(F)F
Show InChI InChI=1S/C14H14F2N4O2/c1-14(2)11(17-18-13(14)21)7-4-5-10(22-3)20-9(7)6-8(19-20)12(15)16/h4-6,12H,1-3H3,(H,18,21)
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n/an/a 3.28E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390613
PNG
(CHEMBL2069604)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2cc(nn12)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O2/c1-13(2)11(18-19-12(13)22)7-4-5-10(23-3)21-8(7)6-9(20-21)14(15,16)17/h4-6H,1-3H3,(H,19,22)
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n/an/a 4.13E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390614
PNG
(CHEMBL2069606)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2cc(sc12)C(F)(F)F
Show InChI InChI=1S/C15H13F3N2O2S/c1-14(2)12(19-20-13(14)21)7-4-5-9(22-3)11-8(7)6-10(23-11)15(16,17)18/h4-6H,1-3H3,(H,20,21)
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n/an/a 5.36E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390631
PNG
(CHEMBL2069602)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2cc(nn12)C1CC1
Show InChI InChI=1S/C16H18N4O2/c1-16(2)14(17-18-15(16)21)10-6-7-13(22-3)20-12(10)8-11(19-20)9-4-5-9/h6-9H,4-5H2,1-3H3,(H,18,21)
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n/an/a 6.17E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390619
PNG
(CHEMBL2069611)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2ccc(nc12)C(F)(F)F
Show InChI InChI=1S/C16H14F3N3O2/c1-15(2)13(21-22-14(15)23)9-4-6-10(24-3)12-8(9)5-7-11(20-12)16(17,18)19/h4-7H,1-3H3,(H,22,23)
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n/an/a 6.65E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390624
PNG
(CHEMBL2069595)
Show SMILES CCc1cc2c(ccc(SC)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C15H18N4OS/c1-5-9-8-11-10(6-7-12(21-4)19(11)18-9)13-15(2,3)14(20)17-16-13/h6-8H,5H2,1-4H3,(H,17,20)
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n/an/a 9.01E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390623
PNG
(CHEMBL2069594)
Show SMILES CCc1cc2c(ccc(OC)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C15H18N4O2/c1-5-9-8-11-10(6-7-12(21-4)19(11)18-9)13-15(2,3)14(20)17-16-13/h6-8H,5H2,1-4H3,(H,17,20)
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n/an/a 9.21E+3n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390618
PNG
(CHEMBL2069610)
Show SMILES CCc1ccc2c(ccc(OC)c2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C17H19N3O2/c1-5-10-6-7-11-12(8-9-13(22-4)14(11)18-10)15-17(2,3)16(21)20-19-15/h6-9H,5H2,1-4H3,(H,20,21)
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n/an/a 1.01E+4n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390630
PNG
(CHEMBL2069601)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2ccnn12
Show InChI InChI=1S/C13H14N4O2/c1-13(2)11(15-16-12(13)18)8-4-5-10(19-3)17-9(8)6-7-14-17/h4-7H,1-3H3,(H,16,18)
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n/an/a 1.08E+4n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390620
PNG
(CHEMBL2069591)
Show SMILES CCc1cc2c(ccc(OC)n2n1)C1=NNC(=O)CC1C
Show InChI InChI=1S/C15H18N4O2/c1-4-10-8-12-11(5-6-14(21-3)19(12)18-10)15-9(2)7-13(20)16-17-15/h5-6,8-9H,4,7H2,1-3H3,(H,16,20)
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n/an/a 1.13E+4n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390616
PNG
(CHEMBL2069608)
Show SMILES COc1ccc(C2=NNC(=O)C2(C)C)c2[nH]c(nc12)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O2/c1-13(2)10(20-21-12(13)22)6-4-5-7(23-3)9-8(6)18-11(19-9)14(15,16)17/h4-5H,1-3H3,(H,18,19)(H,21,22)
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n/an/a 1.41E+4n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
Phosphodiesterase 3 (PDE3)


(Homo sapiens (human))
BDBM50390625
PNG
(CHEMBL2069596)
Show SMILES CCc1cc2c(ccc(NC)n2n1)C1=NNC(=O)C1(C)C
Show InChI InChI=1S/C15H19N5O/c1-5-9-8-11-10(6-7-12(16-4)20(11)19-9)13-15(2,3)14(21)18-17-13/h6-8,16H,5H2,1-4H3,(H,18,21)
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n/an/a 7.56E+4n/an/an/an/an/an/a



Kyorin Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of core catalytic domain of PDE3A


Bioorg Med Chem Lett 22: 5833-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.088
BindingDB Entry DOI: 10.7270/Q2QR4Z6H
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%