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PubMed code 22924734

Compile data set for download or QSAR
Found 87 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396942
PNG
(CHEMBL2170818)
Show SMILES C(c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cn[nH]c1
Show InChI InChI=1S/C17H12N8/c1-2-12-6-11(3-4-14(12)18-5-1)10-25-17-16(23-24-25)19-9-15(22-17)13-7-20-21-8-13/h1-9H,10H2,(H,20,21)
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1n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396976
PNG
(CHEMBL2170969)
Show SMILES C[C@H](C(=O)NN=C1C(=O)Nc2c1c(Cl)ccc2C)c1ccc(O)cc1
Show InChI InChI=1S/C18H16ClN3O3/c1-9-3-8-13(19)14-15(9)20-18(25)16(14)21-22-17(24)10(2)11-4-6-12(23)7-5-11/h3-8,10,23H,1-2H3,(H,22,24)(H,20,21,25)/t10-/m0/s1
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1.30n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396954
PNG
(CHEMBL2170966)
Show SMILES CNc1snc(SCc2nnc3ncc(nn23)-c2ccc(F)cc2)c1C(N)=O
Show InChI InChI=1S/C16H13FN8OS2/c1-19-14-12(13(18)26)15(24-28-14)27-7-11-21-22-16-20-6-10(23-25(11)16)8-2-4-9(17)5-3-8/h2-6,19H,7H2,1H3,(H2,18,26)
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2n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396952
PNG
(CHEMBL2170968)
Show SMILES N#Cc1ccc(cc1)-c1cnc2nnc(Cc3c[nH]c4ncccc34)n2n1
Show InChI InChI=1S/C19H12N8/c20-9-12-3-5-13(6-4-12)16-11-23-19-25-24-17(27(19)26-16)8-14-10-22-18-15(14)2-1-7-21-18/h1-7,10-11H,8H2,(H,21,22)
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4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396970
PNG
(CHEMBL2170954)
Show SMILES CCNc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C16H15N7/c1-2-17-14-9-19-15-16(20-14)23(22-21-15)10-11-5-6-13-12(8-11)4-3-7-18-13/h3-9H,2,10H2,1H3,(H,17,20)
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4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396947
PNG
(CHEMBL2169896)
Show SMILES Fc1ccc(cc1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C20H13FN6/c21-16-6-4-14(5-7-16)18-11-23-19-20(24-18)27(26-25-19)12-13-3-8-17-15(10-13)2-1-9-22-17/h1-11H,12H2
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4.80n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396934
PNG
(CHEMBL2001019 | CHEMBL2170804 | US9062045, Compara...)
Show SMILES OCCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2
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5n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396953
PNG
(CHEMBL2170967)
Show SMILES Fc1ccc(cc1)-c1cnc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C20H13FN6/c21-16-6-4-14(5-7-16)18-12-23-20-25-24-19(27(20)26-18)11-13-3-8-17-15(10-13)2-1-9-22-17/h1-10,12H,11H2
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6n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396941
PNG
(CHEMBL2170819)
Show SMILES OC(=O)Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H14N8O2/c28-17(29)11-26-10-14(7-22-26)16-8-21-18-19(23-16)27(25-24-18)9-12-3-4-15-13(6-12)2-1-5-20-15/h1-8,10H,9,11H2,(H,28,29)
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6n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396943
PNG
(CHEMBL2170816)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H14N8/c1-25-11-14(8-21-25)16-9-20-17-18(22-16)26(24-23-17)10-12-4-5-15-13(7-12)3-2-6-19-15/h2-9,11H,10H2,1H3
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6n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396936
PNG
(CHEMBL2170949)
Show SMILES C(c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cnn(c1)[C@@H]1CCNC1
Show InChI InChI=1S/C21H19N9/c1-2-15-8-14(3-4-18(15)23-6-1)12-30-21-20(27-28-30)24-11-19(26-21)16-9-25-29(13-16)17-5-7-22-10-17/h1-4,6,8-9,11,13,17,22H,5,7,10,12H2/t17-/m1/s1
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6.14n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396967
PNG
(CHEMBL2170806)
Show SMILES N[C@@H]1CCN(C1)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H18N8/c19-14-5-7-25(11-14)16-9-21-17-18(22-16)26(24-23-17)10-12-3-4-15-13(8-12)2-1-6-20-15/h1-4,6,8-9,14H,5,7,10-11,19H2/t14-/m1/s1
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7n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396969
PNG
(CHEMBL2170955)
Show SMILES OCCNc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C16H15N7O/c24-7-6-18-14-9-19-15-16(20-14)23(22-21-15)10-11-3-4-13-12(8-11)2-1-5-17-13/h1-5,8-9,24H,6-7,10H2,(H,18,20)
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9n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396960
PNG
(CHEMBL2170957)
Show SMILES Oc1ccc(Cc2nnc3ncc(nn23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C17H12FN5O/c18-13-5-3-12(4-6-13)15-10-19-17-21-20-16(23(17)22-15)9-11-1-7-14(24)8-2-11/h1-8,10,24H,9H2
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11n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396935
PNG
(CHEMBL2170950)
Show SMILES C(c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H21N9/c1-2-16-10-15(3-4-19(16)24-7-1)13-31-22-21(28-29-31)25-12-20(27-22)17-11-26-30(14-17)18-5-8-23-9-6-18/h1-4,7,10-12,14,18,23H,5-6,8-9,13H2
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13.7n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396971
PNG
(CHEMBL2170953)
Show SMILES Nc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C14H11N7/c15-12-7-17-13-14(18-12)21(20-19-13)8-9-3-4-11-10(6-9)2-1-5-16-11/h1-7H,8H2,(H2,15,18)
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15n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396940
PNG
(CHEMBL2170820)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C21H20N8O/c1-21(2,30)13-28-12-16(9-24-28)18-10-23-19-20(25-18)29(27-26-19)11-14-5-6-17-15(8-14)4-3-7-22-17/h3-10,12,30H,11,13H2,1-2H3
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19n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396950
PNG
(CHEMBL2170810)
Show SMILES Oc1ccc(Cn2nnc3ncc(nc23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C17H12FN5O/c18-13-5-3-12(4-6-13)15-9-19-16-17(20-15)23(22-21-16)10-11-1-7-14(24)8-2-11/h1-9,24H,10H2
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19.8n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396939
PNG
(CHEMBL2170946)
Show SMILES CN(C)CCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C21H21N9/c1-28(2)8-9-29-14-17(11-24-29)19-12-23-20-21(25-19)30(27-26-20)13-15-5-6-18-16(10-15)4-3-7-22-18/h3-7,10-12,14H,8-9,13H2,1-2H3
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20n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396966
PNG
(CHEMBL2170807)
Show SMILES OC1CCN(C1)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H17N7O/c26-14-5-7-24(11-14)16-9-20-17-18(21-16)25(23-22-17)10-12-3-4-15-13(8-12)2-1-6-19-15/h1-4,6,8-9,14,26H,5,7,10-11H2
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20.9n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396972
PNG
(CHEMBL2170952)
Show SMILES Cc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C15H12N6/c1-10-8-17-14-15(18-10)21(20-19-14)9-11-4-5-13-12(7-11)3-2-6-16-13/h2-8H,9H2,1H3
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34n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396944
PNG
(CHEMBL2170815)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4OCCOc4c3)c2n1
Show InChI InChI=1S/C17H15N7O2/c1-23-10-12(7-19-23)13-8-18-16-17(20-13)24(22-21-16)9-11-2-3-14-15(6-11)26-5-4-25-14/h2-3,6-8,10H,4-5,9H2,1H3
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35n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396965
PNG
(CHEMBL2170808)
Show SMILES CN1CCN(CC1)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H20N8/c1-25-7-9-26(10-8-25)17-12-21-18-19(22-17)27(24-23-18)13-14-4-5-16-15(11-14)3-2-6-20-16/h2-6,11-12H,7-10,13H2,1H3
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37.3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396938
PNG
(CHEMBL2170947)
Show SMILES C(Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1)N1CCCC1
Show InChI InChI=1S/C23H23N9/c1-2-9-30(8-1)10-11-31-16-19(13-26-31)21-14-25-22-23(27-21)32(29-28-22)15-17-5-6-20-18(12-17)4-3-7-24-20/h3-7,12-14,16H,1-2,8-11,15H2
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43.2n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396951
PNG
(CHEMBL2170817)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncncc4c3)c2n1
Show InChI InChI=1S/C17H13N9/c1-25-9-13(6-21-25)15-7-19-16-17(22-15)26(24-23-16)8-11-2-3-14-12(4-11)5-18-10-20-14/h2-7,9-10H,8H2,1H3
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44n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396958
PNG
(CHEMBL2170961)
Show SMILES Oc1ccc(Cc2nnc3ncc(nn23)-c2ccc(F)cc2)cc1Cl
Show InChI InChI=1S/C17H11ClFN5O/c18-13-7-10(1-6-15(13)25)8-16-21-22-17-20-9-14(23-24(16)17)11-2-4-12(19)5-3-11/h1-7,9,25H,8H2
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51.8n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396945
PNG
(CHEMBL2170814)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4OCCc4c3)c2n1
Show InChI InChI=1S/C17H15N7O/c1-23-10-13(7-19-23)14-8-18-16-17(20-14)24(22-21-16)9-11-2-3-15-12(6-11)4-5-25-15/h2-3,6-8,10H,4-5,9H2,1H3
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58.6n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396937
PNG
(CHEMBL2170948)
Show SMILES O=C1CCCN1CCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C23H21N9O/c33-21-4-2-8-30(21)9-10-31-15-18(12-26-31)20-13-25-22-23(27-20)32(29-28-22)14-16-5-6-19-17(11-16)3-1-7-24-19/h1,3,5-7,11-13,15H,2,4,8-10,14H2
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61.7n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396973
PNG
(CHEMBL2170951)
Show SMILES C(c1ccc2ncccc2c1)n1nnc2nccnc12
Show InChI InChI=1S/C14H10N6/c1-2-11-8-10(3-4-12(11)15-5-1)9-20-14-13(18-19-20)16-6-7-17-14/h1-8H,9H2
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68n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396959
PNG
(CHEMBL2170959)
Show SMILES COc1ccc(Cc2nnc3ncc(nn23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H14FN5O/c1-25-15-8-2-12(3-9-15)10-17-21-22-18-20-11-16(23-24(17)18)13-4-6-14(19)7-5-13/h2-9,11H,10H2,1H3
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69n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396949
PNG
(CHEMBL2170811)
Show SMILES COc1ccc(Cn2nnc3ncc(nc23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H14FN5O/c1-25-15-8-2-12(3-9-15)11-24-18-17(22-23-24)20-10-16(21-18)13-4-6-14(19)7-5-13/h2-10H,11H2,1H3
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73n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396946
PNG
(CHEMBL2170813)
Show SMILES COc1ccc(Cn2nnc3ncc(nc23)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C16H15N7O/c1-22-10-12(7-18-22)14-8-17-15-16(19-14)23(21-20-15)9-11-3-5-13(24-2)6-4-11/h3-8,10H,9H2,1-2H3
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82n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396964
PNG
(CHEMBL2170809)
Show SMILES CN(C)CCOc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H19N7O/c1-24(2)8-9-26-16-11-20-17-18(21-16)25(23-22-17)12-13-5-6-15-14(10-13)4-3-7-19-15/h3-7,10-11H,8-9,12H2,1-2H3
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106n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396975
PNG
(CHEMBL2170956)
Show SMILES Cc1ccc(Cl)c2c3nn4c(Cc5ccc(O)cc5)nnc4nc3[nH]c12
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107n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396968
PNG
(CHEMBL2170805)
Show SMILES CN(C)CCNc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H20N8/c1-25(2)9-8-20-16-11-21-17-18(22-16)26(24-23-17)12-13-5-6-15-14(10-13)4-3-7-19-15/h3-7,10-11H,8-9,12H2,1-2H3,(H,20,22)
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140n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396955
PNG
(CHEMBL2170965)
Show SMILES Fc1ccc(cc1)-c1cnc2nnc(CSc3ncnc4n[nH]cc34)n2n1
Show InChI InChI=1S/C16H10FN9S/c17-10-3-1-9(2-4-10)12-6-18-16-24-22-13(26(16)25-12)7-27-15-11-5-21-23-14(11)19-8-20-15/h1-6,8H,7H2,(H,19,20,21,23)
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188n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396962
PNG
(CHEMBL2170960)
Show SMILES Fc1ccc(Cc2nnc3ncc(nn23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C17H11F2N5/c18-13-5-1-11(2-6-13)9-16-21-22-17-20-10-15(23-24(16)17)12-3-7-14(19)8-4-12/h1-8,10H,9H2
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379n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396956
PNG
(CHEMBL2170964)
Show SMILES Fc1ccc(cc1)-c1cnc2nnc(COc3ccnc4ccsc34)n2n1
Show InChI InChI=1S/C18H11FN6OS/c19-12-3-1-11(2-4-12)14-9-21-18-23-22-16(25(18)24-14)10-26-15-5-7-20-13-6-8-27-17(13)15/h1-9H,10H2
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425n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396948
PNG
(CHEMBL2170812)
Show SMILES Fc1ccc(Cn2nnc3ncc(nc23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C17H11F2N5/c18-13-5-1-11(2-6-13)10-24-17-16(22-23-24)20-9-15(21-17)12-3-7-14(19)8-4-12/h1-9H,10H2
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653n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396957
PNG
(CHEMBL2170962)
Show SMILES Fc1ccc(cc1)-c1cnc2nnc(Cn3ccc(=O)cc3)n2n1
Show InChI InChI=1S/C16H11FN6O/c17-12-3-1-11(2-4-12)14-9-18-16-20-19-15(23(16)21-14)10-22-7-5-13(24)6-8-22/h1-9H,10H2
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6.51E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396961
PNG
(CHEMBL2170963)
Show SMILES Fc1ccc(cc1)-c1cnc2nnc(COc3cccnc3)n2n1
Show InChI InChI=1S/C16H11FN6O/c17-12-5-3-11(4-6-12)14-9-19-16-21-20-15(23(16)22-14)10-24-13-2-1-7-18-8-13/h1-9H,10H2
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7.39E+3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396963
PNG
(CHEMBL2170958)
Show SMILES Cc1nnc2ncc(nn12)-c1ccc(F)cc1
Show InChI InChI=1S/C11H8FN5/c1-7-14-15-11-13-6-10(16-17(7)11)8-2-4-9(12)5-3-8/h2-6H,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of N-terminal His6-tagged recombinant human c-MET (974 to 1390 amino acids) by spectrophotometry


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396943
PNG
(CHEMBL2170816)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H14N8/c1-25-11-14(8-21-25)16-9-20-17-18(22-16)26(24-23-17)10-12-4-5-15-13(7-12)3-2-6-19-15/h2-9,11H,10H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396954
PNG
(CHEMBL2170966)
Show SMILES CNc1snc(SCc2nnc3ncc(nn23)-c2ccc(F)cc2)c1C(N)=O
Show InChI InChI=1S/C16H13FN8OS2/c1-19-14-12(13(18)26)15(24-28-14)27-7-11-21-22-16-20-6-10(23-25(11)16)8-2-4-9(17)5-3-8/h2-6,19H,7H2,1H3,(H2,18,26)
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n/an/a 3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396934
PNG
(CHEMBL2001019 | CHEMBL2170804 | US9062045, Compara...)
Show SMILES OCCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2
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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396953
PNG
(CHEMBL2170967)
Show SMILES Fc1ccc(cc1)-c1cnc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C20H13FN6/c21-16-6-4-14(5-7-16)18-12-23-20-25-24-19(27(20)26-18)11-13-3-8-17-15(10-13)2-1-9-22-17/h1-10,12H,11H2
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n/an/a 5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396970
PNG
(CHEMBL2170954)
Show SMILES CCNc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C16H15N7/c1-2-17-14-9-19-15-16(20-14)23(22-21-15)10-11-5-6-13-12(8-11)4-3-7-18-13/h3-9H,2,10H2,1H3,(H,17,20)
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n/an/a 5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396942
PNG
(CHEMBL2170818)
Show SMILES C(c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cn[nH]c1
Show InChI InChI=1S/C17H12N8/c1-2-12-6-11(3-4-14(12)18-5-1)10-25-17-16(23-24-25)19-9-15(22-17)13-7-20-21-8-13/h1-9H,10H2,(H,20,21)
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n/an/a 6n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396976
PNG
(CHEMBL2170969)
Show SMILES C[C@H](C(=O)NN=C1C(=O)Nc2c1c(Cl)ccc2C)c1ccc(O)cc1
Show InChI InChI=1S/C18H16ClN3O3/c1-9-3-8-13(19)14-15(9)20-18(25)16(14)21-22-17(24)10(2)11-4-6-12(23)7-5-11/h3-8,10,23H,1-2H3,(H,22,24)(H,20,21,25)/t10-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396975
PNG
(CHEMBL2170956)
Show SMILES Cc1ccc(Cl)c2c3nn4c(Cc5ccc(O)cc5)nnc4nc3[nH]c12
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n/an/a 7n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396960
PNG
(CHEMBL2170957)
Show SMILES Oc1ccc(Cc2nnc3ncc(nn23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C17H12FN5O/c18-13-5-3-12(4-6-13)15-10-19-17-21-20-16(23(17)22-15)9-11-1-7-14(24)8-2-11/h1-8,10,24H,9H2
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n/an/a 7n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396967
PNG
(CHEMBL2170806)
Show SMILES N[C@@H]1CCN(C1)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H18N8/c19-14-5-7-25(11-14)16-9-21-17-18(22-16)26(24-23-17)10-12-3-4-15-13(8-12)2-1-6-20-15/h1-4,6,8-9,14H,5,7,10-11,19H2/t14-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396936
PNG
(CHEMBL2170949)
Show SMILES C(c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cnn(c1)[C@@H]1CCNC1
Show InChI InChI=1S/C21H19N9/c1-2-15-8-14(3-4-18(15)23-6-1)12-30-21-20(27-28-30)24-11-19(26-21)16-9-25-29(13-16)17-5-7-22-10-17/h1-4,6,8-9,11,13,17,22H,5,7,10,12H2/t17-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396938
PNG
(CHEMBL2170947)
Show SMILES C(Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1)N1CCCC1
Show InChI InChI=1S/C23H23N9/c1-2-9-30(8-1)10-11-31-16-19(13-26-31)21-14-25-22-23(27-21)32(29-28-22)15-17-5-6-20-18(12-17)4-3-7-24-20/h3-7,12-14,16H,1-2,8-11,15H2
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n/an/a 16n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396952
PNG
(CHEMBL2170968)
Show SMILES N#Cc1ccc(cc1)-c1cnc2nnc(Cc3c[nH]c4ncccc34)n2n1
Show InChI InChI=1S/C19H12N8/c20-9-12-3-5-13(6-4-12)16-11-23-19-25-24-17(27(19)26-16)8-14-10-22-18-15(14)2-1-7-21-18/h1-7,10-11H,8H2,(H,21,22)
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n/an/a 16n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396940
PNG
(CHEMBL2170820)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C21H20N8O/c1-21(2,30)13-28-12-16(9-24-28)18-10-23-19-20(25-18)29(27-26-19)11-14-5-6-17-15(8-14)4-3-7-22-17/h3-10,12,30H,11,13H2,1-2H3
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n/an/a 17n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396965
PNG
(CHEMBL2170808)
Show SMILES CN1CCN(CC1)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H20N8/c1-25-7-9-26(10-8-25)17-12-21-18-19(22-17)27(24-23-18)13-14-4-5-16-15(11-14)3-2-6-20-16/h2-6,11-12H,7-10,13H2,1H3
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396941
PNG
(CHEMBL2170819)
Show SMILES OC(=O)Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H14N8O2/c28-17(29)11-26-10-14(7-22-26)16-8-21-18-19(23-16)27(25-24-18)9-12-3-4-15-13(6-12)2-1-5-20-15/h1-8,10H,9,11H2,(H,28,29)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396969
PNG
(CHEMBL2170955)
Show SMILES OCCNc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C16H15N7O/c24-7-6-18-14-9-19-15-16(20-14)23(22-21-15)10-11-3-4-13-12(8-11)2-1-5-17-13/h1-5,8-9,24H,6-7,10H2,(H,18,20)
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n/an/a 27n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396939
PNG
(CHEMBL2170946)
Show SMILES CN(C)CCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C21H21N9/c1-28(2)8-9-29-14-17(11-24-29)19-12-23-20-21(25-19)30(27-26-20)13-15-5-6-18-16(10-15)4-3-7-22-18/h3-7,10-12,14H,8-9,13H2,1-2H3
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n/an/a 27n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396935
PNG
(CHEMBL2170950)
Show SMILES C(c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H21N9/c1-2-16-10-15(3-4-19(16)24-7-1)13-31-22-21(28-29-31)25-12-20(27-22)17-11-26-30(14-17)18-5-8-23-9-6-18/h1-4,7,10-12,14,18,23H,5-6,8-9,13H2
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n/an/a 33n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396971
PNG
(CHEMBL2170953)
Show SMILES Nc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C14H11N7/c15-12-7-17-13-14(18-12)21(20-19-13)8-9-3-4-11-10(6-9)2-1-5-16-11/h1-7H,8H2,(H2,15,18)
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396945
PNG
(CHEMBL2170814)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4OCCc4c3)c2n1
Show InChI InChI=1S/C17H15N7O/c1-23-10-13(7-19-23)14-8-18-16-17(20-14)24(22-21-16)9-11-2-3-15-12(6-11)4-5-25-15/h2-3,6-8,10H,4-5,9H2,1H3
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n/an/a 35.6n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396947
PNG
(CHEMBL2169896)
Show SMILES Fc1ccc(cc1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C20H13FN6/c21-16-6-4-14(5-7-16)18-11-23-19-20(24-18)27(26-25-19)12-13-3-8-17-15(10-13)2-1-9-22-17/h1-11H,12H2
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n/an/a 48n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396946
PNG
(CHEMBL2170813)
Show SMILES COc1ccc(Cn2nnc3ncc(nc23)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C16H15N7O/c1-22-10-12(7-18-22)14-8-17-15-16(19-14)23(21-20-15)9-11-3-5-13(24-2)6-4-11/h3-8,10H,9H2,1-2H3
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n/an/a 51n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396966
PNG
(CHEMBL2170807)
Show SMILES OC1CCN(C1)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H17N7O/c26-14-5-7-24(11-14)16-9-20-17-18(21-16)25(23-22-17)10-12-3-4-15-13(8-12)2-1-6-19-15/h1-4,6,8-9,14,26H,5,7,10-11H2
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n/an/a 53n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396972
PNG
(CHEMBL2170952)
Show SMILES Cc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C15H12N6/c1-10-8-17-14-15(18-10)21(20-19-14)9-11-4-5-13-12(7-11)3-2-6-16-13/h2-8H,9H2,1H3
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n/an/a 82n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396937
PNG
(CHEMBL2170948)
Show SMILES O=C1CCCN1CCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C23H21N9O/c33-21-4-2-8-30(21)9-10-31-15-18(12-26-31)20-13-25-22-23(27-20)32(29-28-22)14-16-5-6-19-17(11-16)3-1-7-24-19/h1,3,5-7,11-13,15H,2,4,8-10,14H2
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n/an/a 91n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396959
PNG
(CHEMBL2170959)
Show SMILES COc1ccc(Cc2nnc3ncc(nn23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H14FN5O/c1-25-15-8-2-12(3-9-15)10-17-21-22-18-20-11-16(23-24(17)18)13-4-6-14(19)7-5-13/h2-9,11H,10H2,1H3
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n/an/a 113n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396950
PNG
(CHEMBL2170810)
Show SMILES Oc1ccc(Cn2nnc3ncc(nc23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C17H12FN5O/c18-13-5-3-12(4-6-13)15-9-19-16-17(20-15)23(22-21-16)10-11-1-7-14(24)8-2-11/h1-9,24H,10H2
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n/an/a 141n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396944
PNG
(CHEMBL2170815)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4OCCOc4c3)c2n1
Show InChI InChI=1S/C17H15N7O2/c1-23-10-12(7-19-23)13-8-18-16-17(20-13)24(22-21-16)9-11-2-3-14-15(6-11)26-5-4-25-14/h2-3,6-8,10H,4-5,9H2,1H3
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n/an/a 146n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396968
PNG
(CHEMBL2170805)
Show SMILES CN(C)CCNc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H20N8/c1-25(2)9-8-20-16-11-21-17-18(22-16)26(24-23-17)12-13-5-6-15-14(10-13)4-3-7-19-15/h3-7,10-11H,8-9,12H2,1-2H3,(H,20,22)
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n/an/a 165n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396964
PNG
(CHEMBL2170809)
Show SMILES CN(C)CCOc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H19N7O/c1-24(2)8-9-26-16-11-20-17-18(21-16)25(23-22-17)12-13-5-6-15-14(10-13)4-3-7-19-15/h3-7,10-11H,8-9,12H2,1-2H3
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n/an/a 166n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396958
PNG
(CHEMBL2170961)
Show SMILES Oc1ccc(Cc2nnc3ncc(nn23)-c2ccc(F)cc2)cc1Cl
Show InChI InChI=1S/C17H11ClFN5O/c18-13-7-10(1-6-15(13)25)8-16-21-22-17-20-9-14(23-24(16)17)11-2-4-12(19)5-3-11/h1-7,9,25H,8H2
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n/an/a 189n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396973
PNG
(CHEMBL2170951)
Show SMILES C(c1ccc2ncccc2c1)n1nnc2nccnc12
Show InChI InChI=1S/C14H10N6/c1-2-11-8-10(3-4-12(11)15-5-1)9-20-14-13(18-19-20)16-6-7-17-14/h1-8H,9H2
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n/an/a 253n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396955
PNG
(CHEMBL2170965)
Show SMILES Fc1ccc(cc1)-c1cnc2nnc(CSc3ncnc4n[nH]cc34)n2n1
Show InChI InChI=1S/C16H10FN9S/c17-10-3-1-9(2-4-10)12-6-18-16-24-22-13(26(16)25-12)7-27-15-11-5-21-23-14(11)19-8-20-15/h1-6,8H,7H2,(H,19,20,21,23)
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n/an/a 520n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396956
PNG
(CHEMBL2170964)
Show SMILES Fc1ccc(cc1)-c1cnc2nnc(COc3ccnc4ccsc34)n2n1
Show InChI InChI=1S/C18H11FN6OS/c19-12-3-1-11(2-4-12)14-9-21-18-23-22-16(25(18)24-14)10-26-15-5-7-20-13-6-8-27-17(13)15/h1-9H,10H2
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n/an/a>2.50E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396949
PNG
(CHEMBL2170811)
Show SMILES COc1ccc(Cn2nnc3ncc(nc23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H14FN5O/c1-25-15-8-2-12(3-9-15)11-24-18-17(22-23-24)20-10-16(21-18)13-4-6-14(19)7-5-13/h2-10H,11H2,1H3
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n/an/a 2.92E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50396934
PNG
(CHEMBL2001019 | CHEMBL2170804 | US9062045, Compara...)
Show SMILES OCCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2
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n/an/a 5.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9 in human liver microsomes


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396948
PNG
(CHEMBL2170812)
Show SMILES Fc1ccc(Cn2nnc3ncc(nc23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C17H11F2N5/c18-13-5-1-11(2-6-13)10-24-17-16(22-23-24)20-9-15(21-17)12-3-7-14(19)8-4-12/h1-9H,10H2
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396957
PNG
(CHEMBL2170962)
Show SMILES Fc1ccc(cc1)-c1cnc2nnc(Cn3ccc(=O)cc3)n2n1
Show InChI InChI=1S/C16H11FN6O/c17-12-3-1-11(2-4-12)14-9-18-16-20-19-15(23(16)21-14)10-22-7-5-13(24)6-8-22/h1-9H,10H2
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at c-MET receptor in human A549 cells assessed as inhibition of autophosphorylation after 1 hr by ELISA


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (human))
BDBM50396934
PNG
(CHEMBL2001019 | CHEMBL2170804 | US9062045, Compara...)
Show SMILES OCCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4 in human liver microsomes


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50396934
PNG
(CHEMBL2001019 | CHEMBL2170804 | US9062045, Compara...)
Show SMILES OCCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6 in human liver microsomes


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (human))
BDBM50396934
PNG
(CHEMBL2001019 | CHEMBL2170804 | US9062045, Compara...)
Show SMILES OCCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19 in human liver microsomes


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (human))
BDBM50396934
PNG
(CHEMBL2001019 | CHEMBL2170804 | US9062045, Compara...)
Show SMILES OCCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2 in human liver microsomes


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Cytochrome P450 2C8


(Homo sapiens (Human))
BDBM50396934
PNG
(CHEMBL2001019 | CHEMBL2170804 | US9062045, Compara...)
Show SMILES OCCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2C8 in human liver microsomes


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50396934
PNG
(CHEMBL2001019 | CHEMBL2170804 | US9062045, Compara...)
Show SMILES OCCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp technique


J Med Chem 55: 8091-109 (2012)


Article DOI: 10.1021/jm300967g
BindingDB Entry DOI: 10.7270/Q2Z60Q59
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%