BindingDB logo
myBDB logout

PubMed code 22985853

Compile data set for download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391660
PNG
(CHEMBL2148143)
Show SMILES [O-][N+](=O)c1cccc(CNc2nc(nc3ncc(cc23)-c2cnn(c2)C2CCNCC2)C(F)(F)F)c1
Show InChI InChI=1S/C23H21F3N8O2/c24-23(25,26)22-31-20(28-10-14-2-1-3-18(8-14)34(35)36)19-9-15(11-29-21(19)32-22)16-12-30-33(13-16)17-4-6-27-7-5-17/h1-3,8-9,11-13,17,27H,4-7,10H2,(H,28,29,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 6.5n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391669
PNG
(CHEMBL2148141)
Show SMILES C[C@@H](Oc1nc(nc2ncc(cc12)-c1cnn(CCO)c1)C(F)(F)F)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H15Cl2F4N5O2/c1-10(16-14(22)2-3-15(24)17(16)23)34-19-13-6-11(12-8-29-32(9-12)4-5-33)7-28-18(13)30-20(31-19)21(25,26)27/h2-3,6-10,33H,4-5H2,1H3/t10-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>10n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391656
PNG
(CHEMBL2148139)
Show SMILES C[C@@H](Oc1nc(nc2ncc(cc12)-c1cnn(c1)C1CCNCC1)C(F)(F)F)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C24H20Cl2F4N6O/c1-12(19-17(25)2-3-18(27)20(19)26)37-22-16-8-13(9-32-21(16)34-23(35-22)24(28,29)30)14-10-33-36(11-14)15-4-6-31-7-5-15/h2-3,8-12,15,31H,4-7H2,1H3/t12-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>10n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391661
PNG
(CHEMBL2148140)
Show SMILES C[C@@H](Oc1nc(nc2ncc(cc12)-c1cnn(C)c1)C(F)(F)F)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H13Cl2F4N5O/c1-9(15-13(21)3-4-14(23)16(15)22)32-18-12-5-10(11-7-28-31(2)8-11)6-27-17(12)29-19(30-18)20(24,25)26/h3-9H,1-2H3/t9-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>10n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391664
PNG
(CHEMBL2148133)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3nnc4ccc(nn34)-c3cccc(Cl)c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C26H23ClF3N9/c1-37-7-9-38(10-8-37)23-14-31-20-12-17(26(28,29)30)13-21(25(20)33-23)32-15-24-35-34-22-6-5-19(36-39(22)24)16-3-2-4-18(27)11-16/h2-6,11-14,32H,7-10,15H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 257n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391659
PNG
(CHEMBL2148136)
Show SMILES CC(=O)N1CCN(CC1)c1cnc2cc(cc(NCc3nnc4ccc(nn34)-c3ccc(F)cc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C27H23F4N9O/c1-16(41)38-8-10-39(11-9-38)24-14-32-21-12-18(27(29,30)31)13-22(26(21)34-24)33-15-25-36-35-23-7-6-20(37-40(23)25)17-2-4-19(28)5-3-17/h2-7,12-14,33H,8-11,15H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 309n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391668
PNG
(CHEMBL2148145)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3nnc4cccnn34)c2c1)C(F)(F)F
Show InChI InChI=1S/C21H21F3N8/c1-30-5-7-31(8-6-30)15-11-16-17(25-12-15)9-14(21(22,23)24)10-18(16)26-13-20-29-28-19-3-2-4-27-32(19)20/h2-4,9-12,26H,5-8,13H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 330n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391671
PNG
(CHEMBL2148132)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3nnc4ccc(nn34)-c3cccc(F)c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C26H23F4N9/c1-37-7-9-38(10-8-37)23-14-31-20-12-17(26(28,29)30)13-21(25(20)33-23)32-15-24-35-34-22-6-5-19(36-39(22)24)16-3-2-4-18(27)11-16/h2-6,11-14,32H,7-10,15H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 385n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391658
PNG
(CHEMBL2148129)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3nnc4ccc(nn34)-c3ccco3)c2n1)C(F)(F)F
Show InChI InChI=1S/C24H22F3N9O/c1-34-6-8-35(9-7-34)21-13-28-17-11-15(24(25,26)27)12-18(23(17)30-21)29-14-22-32-31-20-5-4-16(33-36(20)22)19-3-2-10-37-19/h2-5,10-13,29H,6-9,14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 409n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391654
PNG
(CHEMBL2148128)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3nnc4ccc(nn34)-c3ccsc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C24H22F3N9S/c1-34-5-7-35(8-6-34)21-12-28-18-10-16(24(25,26)27)11-19(23(18)30-21)29-13-22-32-31-20-3-2-17(33-36(20)22)15-4-9-37-14-15/h2-4,9-12,14,29H,5-8,13H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 441n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391657
PNG
(CHEMBL2148142)
Show SMILES Fc1ccc(Cl)c(CNc2nc(nc3ncc(cc23)-c2cnn(c2)C2CCNCC2)C(F)(F)F)c1Cl
Show InChI InChI=1S/C23H19Cl2F4N7/c24-17-1-2-18(26)19(25)16(17)10-32-21-15-7-12(8-31-20(15)34-22(35-21)23(27,28)29)13-9-33-36(11-13)14-3-5-30-6-4-14/h1-2,7-9,11,14,30H,3-6,10H2,(H,31,32,34,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 441n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391666
PNG
(CHEMBL2148135)
Show SMILES Fc1ccc(cc1)-c1ccc2nnc(CNc3cc(cc4ncc(nc34)N3CCOCC3)C(F)(F)F)n2n1
Show InChI InChI=1S/C25H20F4N8O/c26-17-3-1-15(2-4-17)18-5-6-21-33-34-23(37(21)35-18)14-31-20-12-16(25(27,28)29)11-19-24(20)32-22(13-30-19)36-7-9-38-10-8-36/h1-6,11-13,31H,7-10,14H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 485n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391672
PNG
(CHEMBL2148125)
Show SMILES Fc1ccc(cc1)-c1ccc2nnc(CNc3cc(cc4ncc(nc34)N3CCN(CC3)C(=O)C3CC3)C(F)(F)F)n2n1
Show InChI InChI=1S/C29H25F4N9O/c30-20-5-3-17(4-6-20)21-7-8-24-37-38-26(42(24)39-21)16-35-23-14-19(29(31,32)33)13-22-27(23)36-25(15-34-22)40-9-11-41(12-10-40)28(43)18-1-2-18/h3-8,13-15,18,35H,1-2,9-12,16H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 486n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391667
PNG
(CHEMBL2148137)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1cnc2cc(cc(NCc3nnc4ccc(nn34)-c3ccc(F)cc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C27H24F4N8O/c1-15-13-38(14-16(2)40-15)24-11-32-21-9-18(27(29,30)31)10-22(26(21)34-24)33-12-25-36-35-23-8-7-20(37-39(23)25)17-3-5-19(28)6-4-17/h3-11,15-16,33H,12-14H2,1-2H3/t15-,16+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 539n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391670
PNG
(CHEMBL2148131)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3nnc4ccc(nn34)-c3ccc(F)cc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C26H23F4N9/c1-37-8-10-38(11-9-37)23-14-31-20-12-17(26(28,29)30)13-21(25(20)33-23)32-15-24-35-34-22-7-6-19(36-39(22)24)16-2-4-18(27)5-3-16/h2-7,12-14,32H,8-11,15H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 626n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391651
PNG
(CHEMBL2148127)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3nnc4ccc(nn34)-c3cccs3)c2n1)C(F)(F)F
Show InChI InChI=1S/C24H22F3N9S/c1-34-6-8-35(9-7-34)21-13-28-17-11-15(24(25,26)27)12-18(23(17)30-21)29-14-22-32-31-20-5-4-16(33-36(20)22)19-3-2-10-37-19/h2-5,10-13,29H,6-9,14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 659n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391655
PNG
(CHEMBL2148138)
Show SMILES COC1CCN(CC1)c1cnc2cc(cc(NCc3nnc4ccc(nn34)-c3ccc(F)cc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C27H24F4N8O/c1-40-19-8-10-38(11-9-19)24-14-32-21-12-17(27(29,30)31)13-22(26(21)34-24)33-15-25-36-35-23-7-6-20(37-39(23)25)16-2-4-18(28)5-3-16/h2-7,12-14,19,33H,8-11,15H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 879n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391665
PNG
(CHEMBL2148134)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3nnc4ccc(nn34)-c3cnn(C)c3)c2n1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N11/c1-35-5-7-37(8-6-35)21-12-28-18-9-16(24(25,26)27)10-19(23(18)31-21)29-13-22-33-32-20-4-3-17(34-38(20)22)15-11-30-36(2)14-15/h3-4,9-12,14,29H,5-8,13H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 924n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391662
PNG
(CHEMBL2148144)
Show SMILES FC(F)(F)c1nc(NCc2cccc(c2)C#N)c2cc(cnc2n1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C24H21F3N8/c25-24(26,27)23-33-21(30-11-16-3-1-2-15(8-16)10-28)20-9-17(12-31-22(20)34-23)18-13-32-35(14-18)19-4-6-29-7-5-19/h1-3,8-9,12-14,19,29H,4-7,11H2,(H,30,31,33,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391663
PNG
(CHEMBL2148130)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3nnc4ccc(nn34)-c3ccccc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C26H24F3N9/c1-36-9-11-37(12-10-36)23-15-30-20-13-18(26(27,28)29)14-21(25(20)32-23)31-16-24-34-33-22-8-7-19(35-38(22)24)17-5-3-2-4-6-17/h2-8,13-15,31H,9-12,16H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.98E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391652
PNG
(CHEMBL2148072)
Show SMILES CN1CCN(CC1)c1cnc2cc(cc(NCc3nnc4cccnn34)c2n1)C(F)(F)F
Show InChI InChI=1S/C20H20F3N9/c1-30-5-7-31(8-6-30)17-11-24-14-9-13(20(21,22)23)10-15(19(14)27-17)25-12-18-29-28-16-3-2-4-26-32(16)18/h2-4,9-11,25H,5-8,12H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50391653
PNG
(CHEMBL2148126)
Show SMILES COc1ccc2nnc(CNc3cc(cc4ncc(nc34)N3CCN(C)CC3)C(F)(F)F)n2n1
Show InChI InChI=1S/C21H22F3N9O/c1-31-5-7-32(8-6-31)17-11-25-14-9-13(21(22,23)24)10-15(20(14)27-17)26-12-18-29-28-16-3-4-19(34-2)30-33(16)18/h3-4,9-11,26H,5-8,12H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.70E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met kinase domain using poly(Glu,Tyr) as substrate after 60 mins by ELISA


Bioorg Med Chem Lett 22: 6368-72 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.075
BindingDB Entry DOI: 10.7270/Q2X0684C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%