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PubMed code 23072958

Compile data set for download or QSAR
Found 24 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Excitatory amino acid transporter 1


(HUMAN)
BDBM50401540
PNG
(CHEMBL2207073)
Show SMILES CCN(CC)c1ccc2c(cc(=O)oc2c1)C1CC(=O)C2=C(C1)OC(=N)C(C#N)C2C
Show InChI InChI=1S/C24H25N3O4/c1-4-27(5-2)15-6-7-16-17(11-22(29)30-20(16)10-15)14-8-19(28)23-13(3)18(12-25)24(26)31-21(23)9-14/h6-7,10-11,13-14,18,26H,4-5,8-9H2,1-3H3
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT1 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(HUMAN)
BDBM50401540
PNG
(CHEMBL2207073)
Show SMILES CCN(CC)c1ccc2c(cc(=O)oc2c1)C1CC(=O)C2=C(C1)OC(=N)C(C#N)C2C
Show InChI InChI=1S/C24H25N3O4/c1-4-27(5-2)15-6-7-16-17(11-22(29)30-20(16)10-15)14-8-19(28)23-13(3)18(12-25)24(26)31-21(23)9-14/h6-7,10-11,13-14,18,26H,4-5,8-9H2,1-3H3
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n/an/a 1.41E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT1 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(HUMAN)
BDBM50401541
PNG
(CHEMBL2207074)
Show SMILES COc1ccc2c(cc(=O)oc2c1)C1CC(=O)C2=C(C1)OC(=N)C(C#N)C2C
Show InChI InChI=1S/C21H18N2O5/c1-10-15(9-22)21(23)28-18-6-11(5-16(24)20(10)18)14-8-19(25)27-17-7-12(26-2)3-4-13(14)17/h3-4,7-8,10-11,15,23H,5-6H2,1-2H3
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n/an/a 1.62E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT1 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(HUMAN)
BDBM50401541
PNG
(CHEMBL2207074)
Show SMILES COc1ccc2c(cc(=O)oc2c1)C1CC(=O)C2=C(C1)OC(=N)C(C#N)C2C
Show InChI InChI=1S/C21H18N2O5/c1-10-15(9-22)21(23)28-18-6-11(5-16(24)20(10)18)14-8-19(25)27-17-7-12(26-2)3-4-13(14)17/h3-4,7-8,10-11,15,23H,5-6H2,1-2H3
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n/an/a 1.70E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT1 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory Amino Acid EAAT2


()
BDBM50401541
PNG
(CHEMBL2207074)
Show SMILES COc1ccc2c(cc(=O)oc2c1)C1CC(=O)C2=C(C1)OC(=N)C(C#N)C2C
Show InChI InChI=1S/C21H18N2O5/c1-10-15(9-22)21(23)28-18-6-11(5-16(24)20(10)18)14-8-19(25)27-17-7-12(26-2)3-4-13(14)17/h3-4,7-8,10-11,15,23H,5-6H2,1-2H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT2 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory Amino Acid EAAT2


()
BDBM50401543
PNG
(CHEMBL2207076)
Show SMILES COc1ccc2c(C)c(-c3ccc(cc3)C3C(C#N)C(=N)OC4=C3C(=O)CC(C4)c3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C33H26N2O5/c1-18-24-13-12-23(38-2)16-27(24)40-33(37)29(18)20-8-10-21(11-9-20)30-25(17-34)32(35)39-28-15-22(14-26(36)31(28)30)19-6-4-3-5-7-19/h3-13,16,22,25,30,35H,14-15H2,1-2H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT2 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory Amino Acid EAAT2


()
BDBM50401545
PNG
(CHEMBL2207078)
Show SMILES COc1ccc2c(cc(=O)oc2c1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1S/C26H20N2O5/c1-31-16-7-8-17-18(12-23(30)32-21(17)11-16)24-19(13-27)26(28)33-22-10-15(9-20(29)25(22)24)14-5-3-2-4-6-14/h2-8,11-12,15,19,24,28H,9-10H2,1H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT2 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50401543
PNG
(CHEMBL2207076)
Show SMILES COc1ccc2c(C)c(-c3ccc(cc3)C3C(C#N)C(=N)OC4=C3C(=O)CC(C4)c3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C33H26N2O5/c1-18-24-13-12-23(38-2)16-27(24)40-33(37)29(18)20-8-10-21(11-9-20)30-25(17-34)32(35)39-28-15-22(14-26(36)31(28)30)19-6-4-3-5-7-19/h3-13,16,22,25,30,35H,14-15H2,1-2H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT3 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(HUMAN)
BDBM50401545
PNG
(CHEMBL2207078)
Show SMILES COc1ccc2c(cc(=O)oc2c1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1S/C26H20N2O5/c1-31-16-7-8-17-18(12-23(30)32-21(17)11-16)24-19(13-27)26(28)33-22-10-15(9-20(29)25(22)24)14-5-3-2-4-6-14/h2-8,11-12,15,19,24,28H,9-10H2,1H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT1 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(HUMAN)
BDBM50401544
PNG
(CHEMBL2207077)
Show SMILES CCN(CC)c1ccc2c(cc(=O)oc2c1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1S/C33H29N3O4/c1-3-36(4-2)21-12-13-24-25(17-30(38)39-28(24)16-21)31-26(18-34)33(35)40-29-15-20(14-27(37)32(29)31)23-11-7-9-19-8-5-6-10-22(19)23/h5-13,16-17,20,26,31,35H,3-4,14-15H2,1-2H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT1 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50401541
PNG
(CHEMBL2207074)
Show SMILES COc1ccc2c(cc(=O)oc2c1)C1CC(=O)C2=C(C1)OC(=N)C(C#N)C2C
Show InChI InChI=1S/C21H18N2O5/c1-10-15(9-22)21(23)28-18-6-11(5-16(24)20(10)18)14-8-19(25)27-17-7-12(26-2)3-4-13(14)17/h3-4,7-8,10-11,15,23H,5-6H2,1-2H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT3 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50401544
PNG
(CHEMBL2207077)
Show SMILES CCN(CC)c1ccc2c(cc(=O)oc2c1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1S/C33H29N3O4/c1-3-36(4-2)21-12-13-24-25(17-30(38)39-28(24)16-21)31-26(18-34)33(35)40-29-15-20(14-27(37)32(29)31)23-11-7-9-19-8-5-6-10-22(19)23/h5-13,16-17,20,26,31,35H,3-4,14-15H2,1-2H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT3 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory Amino Acid EAAT2


()
BDBM50401544
PNG
(CHEMBL2207077)
Show SMILES CCN(CC)c1ccc2c(cc(=O)oc2c1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1S/C33H29N3O4/c1-3-36(4-2)21-12-13-24-25(17-30(38)39-28(24)16-21)31-26(18-34)33(35)40-29-15-20(14-27(37)32(29)31)23-11-7-9-19-8-5-6-10-22(19)23/h5-13,16-17,20,26,31,35H,3-4,14-15H2,1-2H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT2 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory Amino Acid EAAT2


()
BDBM50401542
PNG
(CHEMBL2207075)
Show SMILES CCN(CC)c1ccc2c(C)c(-c3ccc(cc3)C3C(C#N)C(=N)OC4=C3C(=O)CC(C4)c3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C36H33N3O4/c1-4-39(5-2)26-15-16-27-21(3)32(36(41)43-30(27)19-26)23-11-13-24(14-12-23)33-28(20-37)35(38)42-31-18-25(17-29(40)34(31)33)22-9-7-6-8-10-22/h6-16,19,25,28,33,38H,4-5,17-18H2,1-3H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT2 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50401545
PNG
(CHEMBL2207078)
Show SMILES COc1ccc2c(cc(=O)oc2c1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1S/C26H20N2O5/c1-31-16-7-8-17-18(12-23(30)32-21(17)11-16)24-19(13-27)26(28)33-22-10-15(9-20(29)25(22)24)14-5-3-2-4-6-14/h2-8,11-12,15,19,24,28H,9-10H2,1H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT3 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(HUMAN)
BDBM50401543
PNG
(CHEMBL2207076)
Show SMILES COc1ccc2c(C)c(-c3ccc(cc3)C3C(C#N)C(=N)OC4=C3C(=O)CC(C4)c3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C33H26N2O5/c1-18-24-13-12-23(38-2)16-27(24)40-33(37)29(18)20-8-10-21(11-9-20)30-25(17-34)32(35)39-28-15-22(14-26(36)31(28)30)19-6-4-3-5-7-19/h3-13,16,22,25,30,35H,14-15H2,1-2H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT1 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50401540
PNG
(CHEMBL2207073)
Show SMILES CCN(CC)c1ccc2c(cc(=O)oc2c1)C1CC(=O)C2=C(C1)OC(=N)C(C#N)C2C
Show InChI InChI=1S/C24H25N3O4/c1-4-27(5-2)15-6-7-16-17(11-22(29)30-20(16)10-15)14-8-19(28)23-13(3)18(12-25)24(26)31-21(23)9-14/h6-7,10-11,13-14,18,26H,4-5,8-9H2,1-3H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT3 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 3


(HUMAN)
BDBM50401542
PNG
(CHEMBL2207075)
Show SMILES CCN(CC)c1ccc2c(C)c(-c3ccc(cc3)C3C(C#N)C(=N)OC4=C3C(=O)CC(C4)c3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C36H33N3O4/c1-4-39(5-2)26-15-16-27-21(3)32(36(41)43-30(27)19-26)23-11-13-24(14-12-23)33-28(20-37)35(38)42-31-18-25(17-29(40)34(31)33)22-9-7-6-8-10-22/h6-16,19,25,28,33,38H,4-5,17-18H2,1-3H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT3 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory Amino Acid EAAT2


()
BDBM50401540
PNG
(CHEMBL2207073)
Show SMILES CCN(CC)c1ccc2c(cc(=O)oc2c1)C1CC(=O)C2=C(C1)OC(=N)C(C#N)C2C
Show InChI InChI=1S/C24H25N3O4/c1-4-27(5-2)15-6-7-16-17(11-22(29)30-20(16)10-15)14-8-19(28)23-13(3)18(12-25)24(26)31-21(23)9-14/h6-7,10-11,13-14,18,26H,4-5,8-9H2,1-3H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT2 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(HUMAN)
BDBM50401542
PNG
(CHEMBL2207075)
Show SMILES CCN(CC)c1ccc2c(C)c(-c3ccc(cc3)C3C(C#N)C(=N)OC4=C3C(=O)CC(C4)c3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C36H33N3O4/c1-4-39(5-2)26-15-16-27-21(3)32(36(41)43-30(27)19-26)23-11-13-24(14-12-23)33-28(20-37)35(38)42-31-18-25(17-29(40)34(31)33)22-9-7-6-8-10-22/h6-16,19,25,28,33,38H,4-5,17-18H2,1-3H3
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT1 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(HUMAN)
BDBM50401545
PNG
(CHEMBL2207078)
Show SMILES COc1ccc2c(cc(=O)oc2c1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1
Show InChI InChI=1S/C26H20N2O5/c1-31-16-7-8-17-18(12-23(30)32-21(17)11-16)24-19(13-27)26(28)33-22-10-15(9-20(29)25(22)24)14-5-3-2-4-6-14/h2-8,11-12,15,19,24,28H,9-10H2,1H3
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n/an/a>3.16E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT1 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(HUMAN)
BDBM50401542
PNG
(CHEMBL2207075)
Show SMILES CCN(CC)c1ccc2c(C)c(-c3ccc(cc3)C3C(C#N)C(=N)OC4=C3C(=O)CC(C4)c3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C36H33N3O4/c1-4-39(5-2)26-15-16-27-21(3)32(36(41)43-30(27)19-26)23-11-13-24(14-12-23)33-28(20-37)35(38)42-31-18-25(17-29(40)34(31)33)22-9-7-6-8-10-22/h6-16,19,25,28,33,38H,4-5,17-18H2,1-3H3
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n/an/a>3.16E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT1 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(HUMAN)
BDBM50401543
PNG
(CHEMBL2207076)
Show SMILES COc1ccc2c(C)c(-c3ccc(cc3)C3C(C#N)C(=N)OC4=C3C(=O)CC(C4)c3ccccc3)c(=O)oc2c1
Show InChI InChI=1S/C33H26N2O5/c1-18-24-13-12-23(38-2)16-27(24)40-33(37)29(18)20-8-10-21(11-9-20)30-25(17-34)32(35)39-28-15-22(14-26(36)31(28)30)19-6-4-3-5-7-19/h3-13,16,22,25,30,35H,14-15H2,1-2H3
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n/an/a>3.16E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT1 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
Excitatory amino acid transporter 1


(HUMAN)
BDBM50401544
PNG
(CHEMBL2207077)
Show SMILES CCN(CC)c1ccc2c(cc(=O)oc2c1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1cccc2ccccc12
Show InChI InChI=1S/C33H29N3O4/c1-3-36(4-2)21-12-13-24-25(17-30(38)39-28(24)16-21)31-26(18-34)33(35)40-29-15-20(14-27(37)32(29)31)23-11-7-9-19-8-5-6-10-22(19)23/h5-13,16-17,20,26,31,35H,3-4,14-15H2,1-2H3
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n/an/a>3.16E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of [3H]-D-aspartate uptake at human EAAT1 expressed in HEK293 cells after 6 mins by scintillation counting


Bioorg Med Chem 20: 6831-9 (2012)


Article DOI: 10.1016/j.bmc.2012.09.049
BindingDB Entry DOI: 10.7270/Q25B03PT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%