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PubMed code 23085105

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM50391210
PNG
(CHEMBL2088840)
Show SMILES NS(=O)(=O)c1cccc(Nc2nccc(n2)-n2ncc3ccccc23)c1
Show InChI InChI=1S/C17H14N6O2S/c18-26(24,25)14-6-3-5-13(10-14)21-17-19-9-8-16(22-17)23-15-7-2-1-4-12(15)11-20-23/h1-11H,(H2,18,24,25)(H,19,21,22)
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17n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin-T1 by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM50391209
PNG
(CHEMBL2088839)
Show SMILES NS(=O)(=O)c1ccc(Nc2nccc(n2)-n2ncc3ccccc23)cc1
Show InChI InChI=1S/C17H14N6O2S/c18-26(24,25)14-7-5-13(6-8-14)21-17-19-10-9-16(22-17)23-15-4-2-1-3-12(15)11-20-23/h1-11H,(H2,18,24,25)(H,19,21,22)
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28n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM50391210
PNG
(CHEMBL2088840)
Show SMILES NS(=O)(=O)c1cccc(Nc2nccc(n2)-n2ncc3ccccc23)c1
Show InChI InChI=1S/C17H14N6O2S/c18-26(24,25)14-6-3-5-13(10-14)21-17-19-9-8-16(22-17)23-15-7-2-1-4-12(15)11-20-23/h1-11H,(H2,18,24,25)(H,19,21,22)
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53n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM50391213
PNG
(CHEMBL2088828)
Show SMILES CCn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C19H18N6O2S/c1-2-25-17-6-4-3-5-15(17)18(24-25)16-11-12-21-19(23-16)22-13-7-9-14(10-8-13)28(20,26)27/h3-12H,2H2,1H3,(H2,20,26,27)(H,21,22,23)
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55n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM50391212
PNG
(CHEMBL2088827)
Show SMILES Cn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C18H16N6O2S/c1-24-16-8-3-2-7-14(16)17(23-24)15-9-10-20-18(22-15)21-12-5-4-6-13(11-12)27(19,25)26/h2-11H,1H3,(H2,19,25,26)(H,20,21,22)
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61n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM50391209
PNG
(CHEMBL2088839)
Show SMILES NS(=O)(=O)c1ccc(Nc2nccc(n2)-n2ncc3ccccc23)cc1
Show InChI InChI=1S/C17H14N6O2S/c18-26(24,25)14-7-5-13(6-8-14)21-17-19-10-9-16(22-17)23-15-4-2-1-3-12(15)11-20-23/h1-11H,(H2,18,24,25)(H,19,21,22)
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91n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin-T1 by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM50391211
PNG
(CHEMBL2088826)
Show SMILES Cn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C18H16N6O2S/c1-24-16-5-3-2-4-14(16)17(23-24)15-10-11-20-18(22-15)21-12-6-8-13(9-7-12)27(19,25)26/h2-11H,1H3,(H2,19,25,26)(H,20,21,22)
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96n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM50391212
PNG
(CHEMBL2088827)
Show SMILES Cn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C18H16N6O2S/c1-24-16-8-3-2-7-14(16)17(23-24)15-9-10-20-18(22-15)21-12-5-4-6-13(11-12)27(19,25)26/h2-11H,1H3,(H2,19,25,26)(H,20,21,22)
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98n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin-T1 by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM50391215
PNG
(CHEMBL2088835)
Show SMILES CCCn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C20H20N6O2S/c1-2-13-26-18-6-4-3-5-16(18)19(25-26)17-11-12-22-20(24-17)23-14-7-9-15(10-8-14)29(21,27)28/h3-12H,2,13H2,1H3,(H2,21,27,28)(H,22,23,24)
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127n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM50391211
PNG
(CHEMBL2088826)
Show SMILES Cn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C18H16N6O2S/c1-24-16-5-3-2-4-14(16)17(23-24)15-10-11-20-18(22-15)21-12-6-8-13(9-7-12)27(19,25)26/h2-11H,1H3,(H2,19,25,26)(H,20,21,22)
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140n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin-T1 by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM50391214
PNG
(CHEMBL2088829)
Show SMILES CCn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C19H18N6O2S/c1-2-25-17-9-4-3-8-15(17)18(24-25)16-10-11-21-19(23-16)22-13-6-5-7-14(12-13)28(20,26)27/h3-12H,2H2,1H3,(H2,20,26,27)(H,21,22,23)
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154n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin-T1 by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM50391215
PNG
(CHEMBL2088835)
Show SMILES CCCn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C20H20N6O2S/c1-2-13-26-18-6-4-3-5-16(18)19(25-26)17-11-12-22-20(24-17)23-14-7-9-15(10-8-14)29(21,27)28/h3-12H,2,13H2,1H3,(H2,21,27,28)(H,22,23,24)
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176n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin-T1 by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM50391217
PNG
(CHEMBL2088837)
Show SMILES NS(=O)(=O)c1ccc(Nc2nccc(n2)-c2nn(Cc3cccnc3)c3ccccc23)cc1
Show InChI InChI=1S/C23H19N7O2S/c24-33(31,32)18-9-7-17(8-10-18)27-23-26-13-11-20(28-23)22-19-5-1-2-6-21(19)30(29-22)15-16-4-3-12-25-14-16/h1-14H,15H2,(H2,24,31,32)(H,26,27,28)
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207n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin-T1 by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM50391213
PNG
(CHEMBL2088828)
Show SMILES CCn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C19H18N6O2S/c1-2-25-17-6-4-3-5-15(17)18(24-25)16-11-12-21-19(23-16)22-13-7-9-14(10-8-13)28(20,26)27/h3-12H,2H2,1H3,(H2,20,26,27)(H,21,22,23)
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253n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin-T1 by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM50391216
PNG
(CHEMBL2088836)
Show SMILES CCCn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C20H20N6O2S/c1-2-12-26-18-9-4-3-8-16(18)19(25-26)17-10-11-22-20(24-17)23-14-6-5-7-15(13-14)29(21,27)28/h3-11,13H,2,12H2,1H3,(H2,21,27,28)(H,22,23,24)
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285n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin-T1 by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM50391217
PNG
(CHEMBL2088837)
Show SMILES NS(=O)(=O)c1ccc(Nc2nccc(n2)-c2nn(Cc3cccnc3)c3ccccc23)cc1
Show InChI InChI=1S/C23H19N7O2S/c24-33(31,32)18-9-7-17(8-10-18)27-23-26-13-11-20(28-23)22-19-5-1-2-6-21(19)30(29-22)15-16-4-3-12-25-14-16/h1-14H,15H2,(H2,24,31,32)(H,26,27,28)
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287n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 9 (CDK9)


(Homo sapiens (human))
BDBM50391218
PNG
(CHEMBL2088838)
Show SMILES NS(=O)(=O)c1cccc(Nc2nccc(n2)-c2nn(Cc3cccnc3)c3ccccc23)c1
Show InChI InChI=1S/C23H19N7O2S/c24-33(31,32)18-7-3-6-17(13-18)27-23-26-12-10-20(28-23)22-19-8-1-2-9-21(19)30(29-22)15-16-5-4-11-25-14-16/h1-14H,15H2,(H2,24,31,32)(H,26,27,28)
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314n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK9/cyclin-T1 by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM50391209
PNG
(CHEMBL2088839)
Show SMILES NS(=O)(=O)c1ccc(Nc2nccc(n2)-n2ncc3ccccc23)cc1
Show InChI InChI=1S/C17H14N6O2S/c18-26(24,25)14-7-5-13(6-8-14)21-17-19-10-9-16(22-17)23-15-4-2-1-3-12(15)11-20-23/h1-11H,(H2,18,24,25)(H,19,21,22)
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328n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK7/cyclin-H by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM50391214
PNG
(CHEMBL2088829)
Show SMILES CCn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C19H18N6O2S/c1-2-25-17-9-4-3-8-15(17)18(24-25)16-10-11-21-19(23-16)22-13-6-5-7-14(12-13)28(20,26)27/h3-12H,2H2,1H3,(H2,20,26,27)(H,21,22,23)
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471n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM50391216
PNG
(CHEMBL2088836)
Show SMILES CCCn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C20H20N6O2S/c1-2-12-26-18-9-4-3-8-16(18)19(25-26)17-10-11-22-20(24-17)23-14-6-5-7-15(13-14)29(21,27)28/h3-11,13H,2,12H2,1H3,(H2,21,27,28)(H,22,23,24)
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945n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM50391218
PNG
(CHEMBL2088838)
Show SMILES NS(=O)(=O)c1cccc(Nc2nccc(n2)-c2nn(Cc3cccnc3)c3ccccc23)c1
Show InChI InChI=1S/C23H19N7O2S/c24-33(31,32)18-7-3-6-17(13-18)27-23-26-12-10-20(28-23)22-19-8-1-2-9-21(19)30(29-22)15-16-5-4-11-25-14-16/h1-14H,15H2,(H2,24,31,32)(H,26,27,28)
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PubMed
4.53E+3n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK1/cyclin B by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM50391211
PNG
(CHEMBL2088826)
Show SMILES Cn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C18H16N6O2S/c1-24-16-5-3-2-4-14(16)17(23-24)15-10-11-20-18(22-15)21-12-6-8-13(9-7-12)27(19,25)26/h2-11H,1H3,(H2,19,25,26)(H,20,21,22)
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>5.00E+3n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK7/cyclin-H by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM50391218
PNG
(CHEMBL2088838)
Show SMILES NS(=O)(=O)c1cccc(Nc2nccc(n2)-c2nn(Cc3cccnc3)c3ccccc23)c1
Show InChI InChI=1S/C23H19N7O2S/c24-33(31,32)18-7-3-6-17(13-18)27-23-26-12-10-20(28-23)22-19-8-1-2-9-21(19)30(29-22)15-16-5-4-11-25-14-16/h1-14H,15H2,(H2,24,31,32)(H,26,27,28)
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>5.00E+3n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK7/cyclin-H by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM50391217
PNG
(CHEMBL2088837)
Show SMILES NS(=O)(=O)c1ccc(Nc2nccc(n2)-c2nn(Cc3cccnc3)c3ccccc23)cc1
Show InChI InChI=1S/C23H19N7O2S/c24-33(31,32)18-9-7-17(8-10-18)27-23-26-13-11-20(28-23)22-19-5-1-2-6-21(19)30(29-22)15-16-4-3-12-25-14-16/h1-14H,15H2,(H2,24,31,32)(H,26,27,28)
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>5.00E+3n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK7/cyclin-H by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM50391212
PNG
(CHEMBL2088827)
Show SMILES Cn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C18H16N6O2S/c1-24-16-8-3-2-7-14(16)17(23-24)15-9-10-20-18(22-15)21-12-5-4-6-13(11-12)27(19,25)26/h2-11H,1H3,(H2,19,25,26)(H,20,21,22)
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>5.00E+3n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK7/cyclin-H by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM50391210
PNG
(CHEMBL2088840)
Show SMILES NS(=O)(=O)c1cccc(Nc2nccc(n2)-n2ncc3ccccc23)c1
Show InChI InChI=1S/C17H14N6O2S/c18-26(24,25)14-6-3-5-13(10-14)21-17-19-9-8-16(22-17)23-15-7-2-1-4-12(15)11-20-23/h1-11H,(H2,18,24,25)(H,19,21,22)
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>5.00E+3n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK7/cyclin-H by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM50391215
PNG
(CHEMBL2088835)
Show SMILES CCCn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C20H20N6O2S/c1-2-13-26-18-6-4-3-5-16(18)19(25-26)17-11-12-22-20(24-17)23-14-7-9-15(10-8-14)29(21,27)28/h3-12H,2,13H2,1H3,(H2,21,27,28)(H,22,23,24)
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>5.00E+3n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK7/cyclin-H by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM50391214
PNG
(CHEMBL2088829)
Show SMILES CCn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C19H18N6O2S/c1-2-25-17-9-4-3-8-15(17)18(24-25)16-10-11-21-19(23-16)22-13-6-5-7-14(12-13)28(20,26)27/h3-12H,2H2,1H3,(H2,20,26,27)(H,21,22,23)
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>5.00E+3n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK7/cyclin-H by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM50391216
PNG
(CHEMBL2088836)
Show SMILES CCCn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C20H20N6O2S/c1-2-12-26-18-9-4-3-8-16(18)19(25-26)17-10-11-22-20(24-17)23-14-6-5-7-15(13-14)29(21,27)28/h3-11,13H,2,12H2,1H3,(H2,21,27,28)(H,22,23,24)
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>5.00E+3n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK7/cyclin-H by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM50391213
PNG
(CHEMBL2088828)
Show SMILES CCn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12
Show InChI InChI=1S/C19H18N6O2S/c1-2-25-17-6-4-3-5-15(17)18(24-25)16-11-12-21-19(23-16)22-13-7-9-14(10-8-13)28(20,26)27/h3-12H,2H2,1H3,(H2,20,26,27)(H,21,22,23)
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>5.00E+3n/an/an/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of CDK7/cyclin-H by radiometric assay


Eur J Med Chem 57: 311-22 (2012)


Article DOI: 10.1016/j.ejmech.2012.09.034
BindingDB Entry DOI: 10.7270/Q2GX4CNV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%