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PubMed code 23142066

Compile data set for download or QSAR
Found 2 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM5447
PNG
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
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PC cid
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MMDB
Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Misr International University

Curated by ChEMBL


Assay Description
Inhibition of EGFR tyrosine kinase (unknown origin) using poly (Glu,Tyr) as substrate after 30 mins by ADP-GloTM assay


Eur J Med Chem 61: 132-45 (2013)


Article DOI: 10.1016/j.ejmech.2012.10.017
BindingDB Entry DOI: 10.7270/Q2B56M3H
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM50431333
PNG
(CHEMBL2347231)
Show SMILES NC(=O)Nc1ccc2ncnc(Nc3ccc(Cl)cc3)c2c1
Show InChI InChI=1S/C15H12ClN5O/c16-9-1-3-10(4-2-9)20-14-12-7-11(21-15(17)22)5-6-13(12)18-8-19-14/h1-8H,(H3,17,21,22)(H,18,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 61n/an/an/an/an/an/a



Misr International University

Curated by ChEMBL


Assay Description
Inhibition of EGFR tyrosine kinase (unknown origin) using poly (Glu,Tyr) as substrate after 30 mins by ADP-GloTM assay


Eur J Med Chem 61: 132-45 (2013)


Article DOI: 10.1016/j.ejmech.2012.10.017
BindingDB Entry DOI: 10.7270/Q2B56M3H
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%