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PubMed code 23474386

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432878
PNG
(CHEMBL2376640)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)NC1CCOCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C19H19Cl2FN2O4/c1-10(16-14(20)2-3-15(22)17(16)21)28-12-8-13(18(25)23-9-12)19(26)24-11-4-6-27-7-5-11/h2-3,8-11H,4-7H2,1H3,(H,23,25)(H,24,26)/t10-/m1/s1
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n/an/a 0.320n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432894
PNG
(CHEMBL2376648 | US9126947, 1)
Show SMILES C[C@@H](Oc1cc(nnc1N)C(=O)Nc1ccc(cc1)C(=O)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C25H25Cl2FN6O3/c1-14(21-17(26)7-8-18(28)22(21)27)37-20-13-19(31-32-23(20)29)24(35)30-16-5-3-15(4-6-16)25(36)34-11-9-33(2)10-12-34/h3-8,13-14H,9-12H2,1-2H3,(H2,29,32)(H,30,35)/t14-/m1/s1
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n/an/a 0.690n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin)


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432892
PNG
(CHEMBL2376650)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1ccc(cc1)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C25H25Cl2FN4O3/c1-15(22-20(26)7-8-21(28)23(22)27)35-18-13-19(24(33)29-14-18)25(34)30-16-3-5-17(6-4-16)32-11-9-31(2)10-12-32/h3-8,13-15H,9-12H2,1-2H3,(H,29,33)(H,30,34)/t15-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432879
PNG
(CHEMBL2376638)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C22H22Cl2FN5O3/c1-12(19-17(23)2-3-18(25)20(19)24)33-15-8-16(21(31)27-10-15)22(32)29-13-9-28-30(11-13)14-4-6-26-7-5-14/h2-3,8-12,14,26H,4-7H2,1H3,(H,27,31)(H,29,32)/t12-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432884
PNG
(CHEMBL2376659)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1ccc2C(=O)N(CCN(C)C)Cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C26H25Cl2FN4O4/c1-14(22-20(27)6-7-21(29)23(22)28)37-17-11-19(24(34)30-12-17)25(35)31-16-4-5-18-15(10-16)13-33(26(18)36)9-8-32(2)3/h4-7,10-12,14H,8-9,13H2,1-3H3,(H,30,34)(H,31,35)/t14-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432889
PNG
(CHEMBL2376654)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1ccc(CN2CCN(C)CC2)cc1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C26H27Cl2FN4O3/c1-16(23-21(27)7-8-22(29)24(23)28)36-19-13-20(25(34)30-14-19)26(35)31-18-5-3-17(4-6-18)15-33-11-9-32(2)10-12-33/h3-8,13-14,16H,9-12,15H2,1-2H3,(H,30,34)(H,31,35)/t16-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432882
PNG
(CHEMBL2376635)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1ccc(OCCN2CCOCC2)cc1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C26H26Cl2FN3O5/c1-16(23-21(27)6-7-22(29)24(23)28)37-19-14-20(25(33)30-15-19)26(34)31-17-2-4-18(5-3-17)36-13-10-32-8-11-35-12-9-32/h2-7,14-16H,8-13H2,1H3,(H,30,33)(H,31,34)/t16-/m1/s1
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n/an/a 27n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432880
PNG
(CHEMBL2376637)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1cnn(CCO)c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C19H17Cl2FN4O4/c1-10(16-14(20)2-3-15(22)17(16)21)30-12-6-13(18(28)23-8-12)19(29)25-11-7-24-26(9-11)4-5-27/h2-3,6-10,27H,4-5H2,1H3,(H,23,28)(H,25,29)/t10-/m1/s1
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n/an/a 27n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432881
PNG
(CHEMBL2376636)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1cnn(C)c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C18H15Cl2FN4O3/c1-9(15-13(19)3-4-14(21)16(15)20)28-11-5-12(17(26)22-7-11)18(27)24-10-6-23-25(2)8-10/h3-9H,1-2H3,(H,22,26)(H,24,27)/t9-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432891
PNG
(CHEMBL2376651)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1ccc(nc1)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C24H24Cl2FN5O3/c1-14(21-18(25)4-5-19(27)22(21)26)35-16-11-17(23(33)29-13-16)24(34)30-15-3-6-20(28-12-15)32-9-7-31(2)8-10-32/h3-6,11-14H,7-10H2,1-2H3,(H,29,33)(H,30,34)/t14-/m1/s1
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n/an/a 31n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432886
PNG
(CHEMBL2376657)
Show SMILES CNC(=O)c1ccc(NC(=O)c2cc(O[C@H](C)c3c(Cl)ccc(F)c3Cl)c[nH]c2=O)cc1
Show InChI InChI=1S/C22H18Cl2FN3O4/c1-11(18-16(23)7-8-17(25)19(18)24)32-14-9-15(21(30)27-10-14)22(31)28-13-5-3-12(4-6-13)20(29)26-2/h3-11H,1-2H3,(H,26,29)(H,27,30)(H,28,31)/t11-/m1/s1
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n/an/a 48n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432883
PNG
(CHEMBL2376634)
Show SMILES CCN1c2ccc(NC(=O)c3cc(O[C@H](C)c4c(Cl)ccc(F)c4Cl)c[nH]c3=O)cc2CCCC1=O
Show InChI InChI=1S/C26H24Cl2FN3O4/c1-3-32-21-10-7-16(11-15(21)5-4-6-22(32)33)31-26(35)18-12-17(13-30-25(18)34)36-14(2)23-19(27)8-9-20(29)24(23)28/h7-14H,3-6H2,1-2H3,(H,30,34)(H,31,35)/t14-/m1/s1
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n/an/a 75n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432887
PNG
(CHEMBL2376656)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1cccc(CN2CCCCC2)c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C26H26Cl2FN3O3/c1-16(23-21(27)8-9-22(29)24(23)28)35-19-13-20(25(33)30-14-19)26(34)31-18-7-5-6-17(12-18)15-32-10-3-2-4-11-32/h5-9,12-14,16H,2-4,10-11,15H2,1H3,(H,30,33)(H,31,34)/t16-/m1/s1
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n/an/a 76n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432890
PNG
(CHEMBL2376652)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1ccc(nc1)N1CCOCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C23H21Cl2FN4O4/c1-13(20-17(24)3-4-18(26)21(20)25)34-15-10-16(22(31)28-12-15)23(32)29-14-2-5-19(27-11-14)30-6-8-33-9-7-30/h2-5,10-13H,6-9H2,1H3,(H,28,31)(H,29,32)/t13-/m1/s1
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n/an/a 78n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432877
PNG
(CHEMBL2376644)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)-c1nc2ccc(cc2[nH]1)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C25H24Cl2FN5O2/c1-14(22-18(26)4-5-19(28)23(22)27)35-16-12-17(25(34)29-13-16)24-30-20-6-3-15(11-21(20)31-24)33-9-7-32(2)8-10-33/h3-6,11-14H,7-10H2,1-2H3,(H,29,34)(H,30,31)/t14-/m1/s1
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n/an/a 130n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432876
PNG
(CHEMBL2376645)
Show SMILES CNC(=O)c1ccc2nc([nH]c2c1)-c1cc(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c[nH]c1=O
Show InChI InChI=1S/C22H17Cl2FN4O3/c1-10(18-14(23)4-5-15(25)19(18)24)32-12-8-13(22(31)27-9-12)20-28-16-6-3-11(21(30)26-2)7-17(16)29-20/h3-10H,1-2H3,(H,26,30)(H,27,31)(H,28,29)/t10-/m1/s1
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n/an/a 140n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432885
PNG
(CHEMBL2376658)
Show SMILES CNC(=O)c1ccc(NC(=O)c2cc(O[C@H](C)c3c(Cl)ccc(F)c3Cl)c[nH]c2=O)cc1F
Show InChI InChI=1S/C22H17Cl2F2N3O4/c1-10(18-15(23)5-6-16(25)19(18)24)33-12-8-14(21(31)28-9-12)22(32)29-11-3-4-13(17(26)7-11)20(30)27-2/h3-10H,1-2H3,(H,27,30)(H,28,31)(H,29,32)/t10-/m1/s1
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n/an/a 142n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432888
PNG
(CHEMBL2376655)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1ccc(CN2CCN(C)CC2)c(c1)C(F)(F)F)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C27H26Cl2F4N4O3/c1-15(23-21(28)5-6-22(30)24(23)29)40-18-12-19(25(38)34-13-18)26(39)35-17-4-3-16(20(11-17)27(31,32)33)14-37-9-7-36(2)8-10-37/h3-6,11-13,15H,7-10,14H2,1-2H3,(H,34,38)(H,35,39)/t15-/m1/s1
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n/an/a 152n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50432892
PNG
(CHEMBL2376650)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1ccc(cc1)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C25H25Cl2FN4O3/c1-15(22-20(26)7-8-21(28)23(22)27)35-18-13-19(24(33)29-14-18)25(34)30-16-3-5-17(6-4-16)32-11-9-31(2)10-12-32/h3-8,13-15H,9-12H2,1-2H3,(H,29,33)(H,30,34)/t15-/m1/s1
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n/an/a 281n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of ABL (unknown origin)


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432875
PNG
(CHEMBL2376646)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)-c1nc2ccc(cc2[nH]1)C(=O)NCCN(C)C)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C25H24Cl2FN5O3/c1-13(21-17(26)5-6-18(28)22(21)27)36-15-11-16(25(35)30-12-15)23-31-19-7-4-14(10-20(19)32-23)24(34)29-8-9-33(2)3/h4-7,10-13H,8-9H2,1-3H3,(H,29,34)(H,30,35)(H,31,32)/t13-/m1/s1
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n/an/a 330n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432874
PNG
(CHEMBL2376647)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)-c1nc2ccc(cc2[nH]1)C(=O)NCCN1CCOCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C27H26Cl2FN5O4/c1-15(23-19(28)3-4-20(30)24(23)29)39-17-13-18(27(37)32-14-17)25-33-21-5-2-16(12-22(21)34-25)26(36)31-6-7-35-8-10-38-11-9-35/h2-5,12-15H,6-11H2,1H3,(H,31,36)(H,32,37)(H,33,34)/t15-/m1/s1
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n/an/a 360n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50432892
PNG
(CHEMBL2376650)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1ccc(cc1)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C25H25Cl2FN4O3/c1-15(22-20(26)7-8-21(28)23(22)27)35-18-13-19(24(33)29-14-18)25(34)30-16-3-5-17(6-4-16)32-11-9-31(2)10-12-32/h3-8,13-15H,9-12H2,1-2H3,(H,29,33)(H,30,34)/t15-/m1/s1
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n/an/a 446n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin)


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Re


(Homo sapiens (Human))
BDBM50432892
PNG
(CHEMBL2376650)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1ccc(cc1)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C25H25Cl2FN4O3/c1-15(22-20(26)7-8-21(28)23(22)27)35-18-13-19(24(33)29-14-18)25(34)30-16-3-5-17(6-4-16)32-11-9-31(2)10-12-32/h3-8,13-15H,9-12H2,1-2H3,(H,29,33)(H,30,34)/t15-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RET (unknown origin)


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM50432892
PNG
(CHEMBL2376650)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1ccc(cc1)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C25H25Cl2FN4O3/c1-15(22-20(26)7-8-21(28)23(22)27)35-18-13-19(24(33)29-14-18)25(34)30-16-3-5-17(6-4-16)32-11-9-31(2)10-12-32/h3-8,13-15H,9-12H2,1-2H3,(H,29,33)(H,30,34)/t15-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of TYRO3 (unknown origin)


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50432892
PNG
(CHEMBL2376650)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1ccc(cc1)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C25H25Cl2FN4O3/c1-15(22-20(26)7-8-21(28)23(22)27)35-18-13-19(24(33)29-14-18)25(34)30-16-3-5-17(6-4-16)32-11-9-31(2)10-12-32/h3-8,13-15H,9-12H2,1-2H3,(H,29,33)(H,30,34)/t15-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of PDGFRalpha (unknown origin)


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50432893
PNG
(CHEMBL2376649)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)Nc1ccccc1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O3/c1-11(17-15(21)7-8-16(23)18(17)22)28-13-9-14(19(26)24-10-13)20(27)25-12-5-3-2-4-6-12/h2-11H,1H3,(H,24,26)(H,25,27)/t11-/m1/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA


Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%