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PubMed code 23672185

Compile data set for download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Inhibition of HDAC3 (unknown origin) after 60 mins by fluorescence assay


J Med Chem 56: 4816-20 (2013)


Article DOI: 10.1021/jm400390r
BindingDB Entry DOI: 10.7270/Q27H1M0S
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM50434125
PNG
(CHEMBL2381524)
Show SMILES ONC(=O)c1cccc(\C=C\C(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C16H14N2O3/c19-15(17-14-7-2-1-3-8-14)10-9-12-5-4-6-13(11-12)16(20)18-21/h1-11,21H,(H,17,19)(H,18,20)/b10-9+
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PubMed
n/an/a 1.80E+4n/an/an/an/an/an/a



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Inhibition of HDAC3 (unknown origin) after 60 mins by fluorescence assay


J Med Chem 56: 4816-20 (2013)


Article DOI: 10.1021/jm400390r
BindingDB Entry DOI: 10.7270/Q27H1M0S
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM50434126
PNG
(CHEMBL2381517)
Show SMILES ONC(=O)c1cccc(c1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C16H16N2O3/c19-15(17-10-9-12-5-2-1-3-6-12)13-7-4-8-14(11-13)16(20)18-21/h1-8,11,21H,9-10H2,(H,17,19)(H,18,20)
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PC cid
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Article
PubMed
n/an/a 2.30E+4n/an/an/an/an/an/a



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Inhibition of HDAC3 (unknown origin) after 60 mins by fluorescence assay


J Med Chem 56: 4816-20 (2013)


Article DOI: 10.1021/jm400390r
BindingDB Entry DOI: 10.7270/Q27H1M0S
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%