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PubMed code 23692872

Compile data set for download or QSAR
Found 98 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437479
PNG
(CHEMBL2409491)
Show SMILES C[C@@H]1C[C@@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C12H20N2O/c1-8-2-11(8)12(15)14-6-9-3-10(7-14)5-13-4-9/h8-11,13H,2-7H2,1H3/t8-,9?,10?,11+/s2
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0.200n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437496
PNG
(CHEMBL3037927)
Show SMILES O=C(C1CC1)[C@@H]1C[C@@H]2CNC[C@@H]2C1
Show InChI InChI=1/C11H17NO/c13-11(7-1-2-7)8-3-9-5-12-6-10(9)4-8/h7-10,12H,1-6H2/t8-,9-,10+
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0.5n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437481
PNG
(CHEMBL2409482)
Show SMILES C[C@@H]1C[C@@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H18N2O/c1-7-2-10(7)11(14)13-5-8-3-12-4-9(8)6-13/h7-10,12H,2-6H2,1H3/t7-,8?,9?,10+/s2
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1n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50397903
PNG
(CHEMBL2179962)
Show SMILES O=C(C1CC1)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H18N2O/c14-11(10-1-2-10)13-6-8-3-9(7-13)5-12-4-8/h8-10,12H,1-7H2
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1n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437471
PNG
(CHEMBL2409489)
Show SMILES C[C@@H]1C[C@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C12H20N2O/c1-8-2-11(8)12(15)14-6-9-3-10(7-14)5-13-4-9/h8-11,13H,2-7H2,1H3/t8-,9?,10?,11-/s2
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1n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437491
PNG
(CHEMBL2409487)
Show SMILES F[C@@H]1C[C@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H17FN2O/c12-10-2-9(10)11(15)14-5-7-1-8(6-14)4-13-3-7/h7-10,13H,1-6H2/t7?,8?,9-,10-/s2
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1n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437473
PNG
(CHEMBL2409486)
Show SMILES F[C@@H]1C[C@@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H17FN2O/c12-10-2-9(10)11(15)14-5-7-1-8(6-14)4-13-3-7/h7-10,13H,1-6H2/t7?,8?,9-,10+/s2
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1.40n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437478
PNG
(CHEMBL2409475)
Show SMILES CNC(=O)[C@@H]1C[C@H]2CNC[C@H](C2)C1
Show InChI InChI=1/C10H18N2O/c1-11-10(13)9-3-7-2-8(4-9)6-12-5-7/h7-9,12H,2-6H2,1H3,(H,11,13)/t7-,8+,9+
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1.90n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM82070
PNG
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Show SMILES CN1CCC[C@H]1c1cccnc1
Show InChI InChI=1/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/s2
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2n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437499
PNG
(CHEMBL2409492)
Show SMILES C[C@H]1C[C@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C12H20N2O/c1-8-2-11(8)12(15)14-6-9-3-10(7-14)5-13-4-9/h8-11,13H,2-7H2,1H3/t8-,9?,10?,11+/s2
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2.90n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50397904
PNG
(CHEMBL2179961)
Show SMILES O=C(C1CC1)N1CC2CNCC2C1
Show InChI InChI=1/C10H16N2O/c13-10(7-1-2-7)12-5-8-3-11-4-9(8)6-12/h7-9,11H,1-6H2
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4n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437480
PNG
(CHEMBL2409483)
Show SMILES C[C@@H]1C[C@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H18N2O/c1-7-2-10(7)11(14)13-5-8-3-12-4-9(8)6-13/h7-10,12H,2-6H2,1H3/t7-,8?,9?,10-/s2
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4n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437487
PNG
(CHEMBL2409478)
Show SMILES F[C@@H]1C[C@@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C10H15FN2O/c11-9-1-8(9)10(14)13-4-6-2-12-3-7(6)5-13/h6-9,12H,1-5H2/t6?,7?,8-,9+/s2
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5n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437479
PNG
(CHEMBL2409491)
Show SMILES C[C@@H]1C[C@@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C12H20N2O/c1-8-2-11(8)12(15)14-6-9-3-10(7-14)5-13-4-9/h8-11,13H,2-7H2,1H3/t8-,9?,10?,11+/s2
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5n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437482
PNG
(CHEMBL2409485)
Show SMILES F[C@H]1C[C@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H17FN2O/c12-10-2-9(10)11(15)14-5-7-1-8(6-14)4-13-3-7/h7-10,13H,1-6H2/t7?,8?,9-,10+/s2
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5.20n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437486
PNG
(CHEMBL2409476)
Show SMILES CCCNC(=O)[C@@H]1C[C@H]2CNC[C@H](C2)C1
Show InChI InChI=1/C12H22N2O/c1-2-3-14-12(15)11-5-9-4-10(6-11)8-13-7-9/h9-11,13H,2-8H2,1H3,(H,14,15)/t9-,10+,11+
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6n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437483
PNG
(CHEMBL2409488)
Show SMILES F[C@H]1C[C@@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H17FN2O/c12-10-2-9(10)11(15)14-5-7-1-8(6-14)4-13-3-7/h7-10,13H,1-6H2/t7?,8?,9-,10-/s2
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7.30n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437490
PNG
(CHEMBL3037929)
Show SMILES COC(=O)[C@@H]1C[C@@H]2CNC[C@@H]2C1
Show InChI InChI=1/C9H15NO2/c1-12-9(11)6-2-7-4-10-5-8(7)3-6/h6-8,10H,2-5H2,1H3/t6-,7-,8+
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8n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437493
PNG
(CHEMBL2409496)
Show SMILES CCC(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C10H18N2O/c1-2-10(13)12-6-8-3-9(7-12)5-11-4-8/h8-9,11H,2-7H2,1H3
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8n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437495
PNG
(CHEMBL2409480)
Show SMILES F[C@@H]1C[C@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C10H15FN2O/c11-9-1-8(9)10(14)13-4-6-2-12-3-7(6)5-13/h6-9,12H,1-5H2/t6?,7?,8-,9-/s2
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9n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437491
PNG
(CHEMBL2409487)
Show SMILES F[C@@H]1C[C@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H17FN2O/c12-10-2-9(10)11(15)14-5-7-1-8(6-14)4-13-3-7/h7-10,13H,1-6H2/t7?,8?,9-,10-/s2
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10n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437488
PNG
(CHEMBL2409494)
Show SMILES CCC(=O)N1CC2CNCC2C1
Show InChI InChI=1/C9H16N2O/c1-2-9(12)11-5-7-3-10-4-8(7)6-11/h7-8,10H,2-6H2,1H3
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12n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437485
PNG
(CHEMBL3037928)
Show SMILES O=C([C@@H]1C[C@@H]2CNC[C@@H]2C1)c1ccco1
Show InChI InChI=1/C12H15NO2/c14-12(11-2-1-3-15-11)8-4-9-6-13-7-10(9)5-8/h1-3,8-10,13H,4-7H2/t8-,9-,10+
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13n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437489
PNG
(CHEMBL2409477)
Show SMILES F[C@H]1C[C@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C10H15FN2O/c11-9-1-8(9)10(14)13-4-6-2-12-3-7(6)5-13/h6-9,12H,1-5H2/t6?,7?,8-,9+/s2
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17n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437470
PNG
(CHEMBL2409481)
Show SMILES C[C@H]1C[C@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H18N2O/c1-7-2-10(7)11(14)13-5-8-3-12-4-9(8)6-13/h7-10,12H,2-6H2,1H3/t7-,8?,9?,10+/s2
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18n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50397903
PNG
(CHEMBL2179962)
Show SMILES O=C(C1CC1)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H18N2O/c14-11(10-1-2-10)13-6-8-3-9(7-13)5-12-4-8/h8-10,12H,1-7H2
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20n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437484
PNG
(CHEMBL2409495)
Show SMILES CC(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C9H16N2O/c1-7(12)11-5-8-2-9(6-11)4-10-3-8/h8-10H,2-6H2,1H3
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20n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437476
PNG
(CHEMBL2409497)
Show SMILES COC(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C9H16N2O2/c1-13-9(12)11-5-7-2-8(6-11)4-10-3-7/h7-8,10H,2-6H2,1H3
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20n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437500
PNG
(CHEMBL2409498)
Show SMILES COC(=O)N1CC2CNCC2C1
Show InChI InChI=1/C8H14N2O2/c1-12-8(11)10-4-6-2-9-3-7(6)5-10/h6-7,9H,2-5H2,1H3
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23n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437492
PNG
(CHEMBL2407115)
Show SMILES CC(C)NC(=O)[C@@H]1C[C@H]2CNC[C@H](C2)C1
Show InChI InChI=1/C12H22N2O/c1-8(2)14-12(15)11-4-9-3-10(5-11)7-13-6-9/h8-11,13H,3-7H2,1-2H3,(H,14,15)/t9-,10+,11+
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23n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437472
PNG
(CHEMBL2409490)
Show SMILES C[C@H]1C[C@@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C12H20N2O/c1-8-2-11(8)12(15)14-6-9-3-10(7-14)5-13-4-9/h8-11,13H,2-7H2,1H3/t8-,9?,10?,11-/s2
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28n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437494
PNG
(CHEMBL2409479)
Show SMILES F[C@H]1C[C@@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C10H15FN2O/c11-9-1-8(9)10(14)13-4-6-2-12-3-7(6)5-13/h6-9,12H,1-5H2/t6?,7?,8-,9-/s2
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30n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50397890
PNG
(CHEMBL2179529)
Show SMILES Clc1ccc(o1)C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H13ClN2O2/c12-10-2-1-9(16-10)11(15)14-5-7-3-13-4-8(7)6-14/h1-2,7-8,13H,3-6H2
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30n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437471
PNG
(CHEMBL2409489)
Show SMILES C[C@@H]1C[C@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C12H20N2O/c1-8-2-11(8)12(15)14-6-9-3-10(7-14)5-13-4-9/h8-11,13H,2-7H2,1H3/t8-,9?,10?,11-/s2
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30n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437477
PNG
(CHEMBL2409493)
Show SMILES CC(=O)N1CC2CNCC2C1
Show InChI InChI=1/C8H14N2O/c1-6(11)10-4-7-2-9-3-8(7)5-10/h7-9H,2-5H2,1H3
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38n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437475
PNG
(CHEMBL2409484)
Show SMILES C[C@H]1C[C@@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H18N2O/c1-7-2-10(7)11(14)13-5-8-3-12-4-9(8)6-13/h7-10,12H,2-6H2,1H3/t7-,8?,9?,10-/s2
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43n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437474
PNG
(CHEMBL2409472)
Show SMILES O=C(C1CC1)[C@@H]1C[C@H]2CNC[C@H](C2)C1
Show InChI InChI=1/C12H19NO/c14-12(10-1-2-10)11-4-8-3-9(5-11)7-13-6-8/h8-11,13H,1-7H2/t8-,9+,11+
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43n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437473
PNG
(CHEMBL2409486)
Show SMILES F[C@@H]1C[C@@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H17FN2O/c12-10-2-9(10)11(15)14-5-7-1-8(6-14)4-13-3-7/h7-10,13H,1-6H2/t7?,8?,9-,10+/s2
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100n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437499
PNG
(CHEMBL2409492)
Show SMILES C[C@H]1C[C@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C12H20N2O/c1-8-2-11(8)12(15)14-6-9-3-10(7-14)5-13-4-9/h8-11,13H,2-7H2,1H3/t8-,9?,10?,11+/s2
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100n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437498
PNG
(CHEMBL2409473)
Show SMILES O=C([C@@H]1C[C@H]2CNC[C@H](C2)C1)c1ccco1
Show InChI InChI=1/C13H17NO2/c15-13(12-2-1-3-16-12)11-5-9-4-10(6-11)8-14-7-9/h1-3,9-11,14H,4-8H2/t9-,10+,11+
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110n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437496
PNG
(CHEMBL3037927)
Show SMILES O=C(C1CC1)[C@@H]1C[C@@H]2CNC[C@@H]2C1
Show InChI InChI=1/C11H17NO/c13-11(7-1-2-7)8-3-9-5-12-6-10(9)4-8/h7-10,12H,1-6H2/t8-,9-,10+
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140n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437497
PNG
(CHEMBL3037926)
Show SMILES CNC(=O)[C@@H]1C[C@@H]2CNC[C@@H]2C1
Show InChI InChI=1/C9H16N2O/c1-10-9(12)6-2-7-4-11-5-8(7)3-6/h6-8,11H,2-5H2,1H3,(H,10,12)/t6-,7-,8+
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180n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437482
PNG
(CHEMBL2409485)
Show SMILES F[C@H]1C[C@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H17FN2O/c12-10-2-9(10)11(15)14-5-7-1-8(6-14)4-13-3-7/h7-10,13H,1-6H2/t7?,8?,9-,10+/s2
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300n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437472
PNG
(CHEMBL2409490)
Show SMILES C[C@H]1C[C@@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C12H20N2O/c1-8-2-11(8)12(15)14-6-9-3-10(7-14)5-13-4-9/h8-11,13H,2-7H2,1H3/t8-,9?,10?,11-/s2
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300n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437481
PNG
(CHEMBL2409482)
Show SMILES C[C@@H]1C[C@@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H18N2O/c1-7-2-10(7)11(14)13-5-8-3-12-4-9(8)6-13/h7-10,12H,2-6H2,1H3/t7-,8?,9?,10+/s2
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350n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437483
PNG
(CHEMBL2409488)
Show SMILES F[C@H]1C[C@@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H17FN2O/c12-10-2-9(10)11(15)14-5-7-1-8(6-14)4-13-3-7/h7-10,13H,1-6H2/t7?,8?,9-,10-/s2
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400n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50397904
PNG
(CHEMBL2179961)
Show SMILES O=C(C1CC1)N1CC2CNCC2C1
Show InChI InChI=1/C10H16N2O/c13-10(7-1-2-7)12-5-8-3-11-4-9(8)6-12/h7-9,11H,1-6H2
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840n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437495
PNG
(CHEMBL2409480)
Show SMILES F[C@@H]1C[C@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C10H15FN2O/c11-9-1-8(9)10(14)13-4-6-2-12-3-7(6)5-13/h6-9,12H,1-5H2/t6?,7?,8-,9-/s2
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990n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437487
PNG
(CHEMBL2409478)
Show SMILES F[C@@H]1C[C@@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C10H15FN2O/c11-9-1-8(9)10(14)13-4-6-2-12-3-7(6)5-13/h6-9,12H,1-5H2/t6?,7?,8-,9+/s2
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1.40E+3n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437493
PNG
(CHEMBL2409496)
Show SMILES CCC(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C10H18N2O/c1-2-10(13)12-6-8-3-9(7-12)5-11-4-8/h8-9,11H,2-7H2,1H3
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1.60E+3n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437480
PNG
(CHEMBL2409483)
Show SMILES C[C@@H]1C[C@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H18N2O/c1-7-2-10(7)11(14)13-5-8-3-12-4-9(8)6-13/h7-10,12H,2-6H2,1H3/t7-,8?,9?,10-/s2
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1.90E+3n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437501
PNG
(CHEMBL2409474)
Show SMILES COC(=O)C1CC2CNCC(C2)C1
Show InChI InChI=1/C10H17NO2/c1-13-10(12)9-3-7-2-8(4-9)6-11-5-7/h7-9,11H,2-6H2,1H3
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2.40E+3n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Nicotine from alpha4beta2 nACHR in human SHEP1 cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437494
PNG
(CHEMBL2409479)
Show SMILES F[C@H]1C[C@@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C10H15FN2O/c11-9-1-8(9)10(14)13-4-6-2-12-3-7(6)5-13/h6-9,12H,1-5H2/t6?,7?,8-,9-/s2
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2.70E+3n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM82070
PNG
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Show SMILES CN1CCC[C@H]1c1cccnc1
Show InChI InChI=1/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/s2
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3.00E+3n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437484
PNG
(CHEMBL2409495)
Show SMILES CC(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C9H16N2O/c1-7(12)11-5-8-2-9(6-11)4-10-3-8/h8-10H,2-6H2,1H3
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3.30E+3n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437485
PNG
(CHEMBL3037928)
Show SMILES O=C([C@@H]1C[C@@H]2CNC[C@@H]2C1)c1ccco1
Show InChI InChI=1/C12H15NO2/c14-12(11-2-1-3-15-11)8-4-9-6-13-7-10(9)5-8/h1-3,8-10,13H,4-7H2/t8-,9-,10+
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3.40E+3n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437488
PNG
(CHEMBL2409494)
Show SMILES CCC(=O)N1CC2CNCC2C1
Show InChI InChI=1/C9H16N2O/c1-2-9(12)11-5-7-3-10-4-8(7)6-11/h7-8,10H,2-6H2,1H3
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4.00E+3n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437470
PNG
(CHEMBL2409481)
Show SMILES C[C@H]1C[C@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H18N2O/c1-7-2-10(7)11(14)13-5-8-3-12-4-9(8)6-13/h7-10,12H,2-6H2,1H3/t7-,8?,9?,10+/s2
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4.50E+3n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50397890
PNG
(CHEMBL2179529)
Show SMILES Clc1ccc(o1)C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H13ClN2O2/c12-10-2-1-9(16-10)11(15)14-5-7-3-13-4-8(7)6-14/h1-2,7-8,13H,3-6H2
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6.70E+3n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437489
PNG
(CHEMBL2409477)
Show SMILES F[C@H]1C[C@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C10H15FN2O/c11-9-1-8(9)10(14)13-4-6-2-12-3-7(6)5-13/h6-9,12H,1-5H2/t6?,7?,8-,9+/s2
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6.90E+3n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437486
PNG
(CHEMBL2409476)
Show SMILES CCCNC(=O)[C@@H]1C[C@H]2CNC[C@H](C2)C1
Show InChI InChI=1/C12H22N2O/c1-2-3-14-12(15)11-5-9-4-10(6-11)8-13-7-9/h9-11,13H,2-8H2,1H3,(H,14,15)/t9-,10+,11+
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1.00E+4n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437492
PNG
(CHEMBL2407115)
Show SMILES CC(C)NC(=O)[C@@H]1C[C@H]2CNC[C@H](C2)C1
Show InChI InChI=1/C12H22N2O/c1-8(2)14-12(15)11-4-9-3-10(5-11)7-13-6-9/h8-11,13H,3-7H2,1-2H3,(H,14,15)/t9-,10+,11+
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1.10E+4n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437490
PNG
(CHEMBL3037929)
Show SMILES COC(=O)[C@@H]1C[C@@H]2CNC[C@@H]2C1
Show InChI InChI=1/C9H15NO2/c1-12-9(11)6-2-7-4-10-5-8(7)3-6/h6-8,10H,2-5H2,1H3/t6-,7-,8+
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1.30E+4n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437498
PNG
(CHEMBL2409473)
Show SMILES O=C([C@@H]1C[C@H]2CNC[C@H](C2)C1)c1ccco1
Show InChI InChI=1/C13H17NO2/c15-13(12-2-1-3-16-12)11-5-9-4-10(6-11)8-14-7-9/h1-3,9-11,14H,4-8H2/t9-,10+,11+
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1.50E+4n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437497
PNG
(CHEMBL3037926)
Show SMILES CNC(=O)[C@@H]1C[C@@H]2CNC[C@@H]2C1
Show InChI InChI=1/C9H16N2O/c1-10-9(12)6-2-7-4-11-5-8(7)3-6/h6-8,11H,2-5H2,1H3,(H,10,12)/t6-,7-,8+
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2.70E+4n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM50437475
PNG
(CHEMBL2409484)
Show SMILES C[C@H]1C[C@@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H18N2O/c1-7-2-10(7)11(14)13-5-8-3-12-4-9(8)6-13/h7-10,12H,2-6H2,1H3/t7-,8?,9?,10-/s2
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1.00E+5n/an/an/an/an/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Displacement of [3H]Epibatidine from human alpha7 nACHR expressed in CHO cell membranes after 2 hrs by liquid scintillation counting analysis


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437479
PNG
(CHEMBL2409491)
Show SMILES C[C@@H]1C[C@@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C12H20N2O/c1-8-2-11(8)12(15)14-6-9-3-10(7-14)5-13-4-9/h8-11,13H,2-7H2,1H3/t8-,9?,10?,11+/s2
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n/an/an/an/a 1.90E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM82070
PNG
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Show SMILES CN1CCC[C@H]1c1cccnc1
Show InChI InChI=1/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/s2
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n/an/an/an/a 3.00E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437477
PNG
(CHEMBL2409493)
Show SMILES CC(=O)N1CC2CNCC2C1
Show InChI InChI=1/C8H14N2O/c1-6(11)10-4-7-2-9-3-8(7)5-10/h7-9H,2-5H2,1H3
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n/an/an/an/a 2.60E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437493
PNG
(CHEMBL2409496)
Show SMILES CCC(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C10H18N2O/c1-2-10(13)12-6-8-3-9(7-12)5-11-4-8/h8-9,11H,2-7H2,1H3
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n/an/an/an/a 1.90E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437476
PNG
(CHEMBL2409497)
Show SMILES COC(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C9H16N2O2/c1-13-9(12)11-5-7-2-8(6-11)4-10-3-7/h7-8,10H,2-6H2,1H3
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n/an/an/an/a 5.20E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437474
PNG
(CHEMBL2409472)
Show SMILES O=C(C1CC1)[C@@H]1C[C@H]2CNC[C@H](C2)C1
Show InChI InChI=1/C12H19NO/c14-12(10-1-2-10)11-4-8-3-9(5-11)7-13-6-8/h8-11,13H,1-7H2/t8-,9+,11+
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n/an/an/an/a 7.10E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437472
PNG
(CHEMBL2409490)
Show SMILES C[C@H]1C[C@@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C12H20N2O/c1-8-2-11(8)12(15)14-6-9-3-10(7-14)5-13-4-9/h8-11,13H,2-7H2,1H3/t8-,9?,10?,11-/s2
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n/an/an/an/a 1.00E+4n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437471
PNG
(CHEMBL2409489)
Show SMILES C[C@@H]1C[C@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C12H20N2O/c1-8-2-11(8)12(15)14-6-9-3-10(7-14)5-13-4-9/h8-11,13H,2-7H2,1H3/t8-,9?,10?,11-/s2
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n/an/an/an/a 1.20E+4n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437495
PNG
(CHEMBL2409480)
Show SMILES F[C@@H]1C[C@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C10H15FN2O/c11-9-1-8(9)10(14)13-4-6-2-12-3-7(6)5-13/h6-9,12H,1-5H2/t6?,7?,8-,9-/s2
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n/an/an/an/a 190n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437485
PNG
(CHEMBL3037928)
Show SMILES O=C([C@@H]1C[C@@H]2CNC[C@@H]2C1)c1ccco1
Show InChI InChI=1/C12H15NO2/c14-12(11-2-1-3-15-11)8-4-9-6-13-7-10(9)5-8/h1-3,8-10,13H,4-7H2/t8-,9-,10+
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n/an/an/an/a 1.60E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437494
PNG
(CHEMBL2409479)
Show SMILES F[C@H]1C[C@@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C10H15FN2O/c11-9-1-8(9)10(14)13-4-6-2-12-3-7(6)5-13/h6-9,12H,1-5H2/t6?,7?,8-,9-/s2
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n/an/an/an/a 900n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437492
PNG
(CHEMBL2407115)
Show SMILES CC(C)NC(=O)[C@@H]1C[C@H]2CNC[C@H](C2)C1
Show InChI InChI=1/C12H22N2O/c1-8(2)14-12(15)11-4-9-3-10(5-11)7-13-6-9/h8-11,13H,3-7H2,1-2H3,(H,14,15)/t9-,10+,11+
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n/an/an/an/a 1.90E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437491
PNG
(CHEMBL2409487)
Show SMILES F[C@@H]1C[C@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H17FN2O/c12-10-2-9(10)11(15)14-5-7-1-8(6-14)4-13-3-7/h7-10,13H,1-6H2/t7?,8?,9-,10-/s2
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n/an/an/an/a 430n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437489
PNG
(CHEMBL2409477)
Show SMILES F[C@H]1C[C@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C10H15FN2O/c11-9-1-8(9)10(14)13-4-6-2-12-3-7(6)5-13/h6-9,12H,1-5H2/t6?,7?,8-,9+/s2
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n/an/an/an/a 930n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437484
PNG
(CHEMBL2409495)
Show SMILES CC(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C9H16N2O/c1-7(12)11-5-8-2-9(6-11)4-10-3-8/h8-10H,2-6H2,1H3
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n/an/an/an/a 9.90E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50397890
PNG
(CHEMBL2179529)
Show SMILES Clc1ccc(o1)C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H13ClN2O2/c12-10-2-1-9(16-10)11(15)14-5-7-3-13-4-8(7)6-14/h1-2,7-8,13H,3-6H2
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n/an/an/an/a 4.90E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437483
PNG
(CHEMBL2409488)
Show SMILES F[C@H]1C[C@@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H17FN2O/c12-10-2-9(10)11(15)14-5-7-1-8(6-14)4-13-3-7/h7-10,13H,1-6H2/t7?,8?,9-,10-/s2
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n/an/an/an/a 2.70E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437480
PNG
(CHEMBL2409483)
Show SMILES C[C@@H]1C[C@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H18N2O/c1-7-2-10(7)11(14)13-5-8-3-12-4-9(8)6-13/h7-10,12H,2-6H2,1H3/t7-,8?,9?,10-/s2
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n/an/an/an/a 1.70E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437475
PNG
(CHEMBL2409484)
Show SMILES C[C@H]1C[C@@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H18N2O/c1-7-2-10(7)11(14)13-5-8-3-12-4-9(8)6-13/h7-10,12H,2-6H2,1H3/t7-,8?,9?,10-/s2
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n/an/an/an/a 5.60E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437496
PNG
(CHEMBL3037927)
Show SMILES O=C(C1CC1)[C@@H]1C[C@@H]2CNC[C@@H]2C1
Show InChI InChI=1/C11H17NO/c13-11(7-1-2-7)8-3-9-5-12-6-10(9)4-8/h7-10,12H,1-6H2/t8-,9-,10+
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n/an/an/an/a 18n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50397903
PNG
(CHEMBL2179962)
Show SMILES O=C(C1CC1)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H18N2O/c14-11(10-1-2-10)13-6-8-3-9(7-13)5-12-4-8/h8-10,12H,1-7H2
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n/an/an/an/a 850n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437490
PNG
(CHEMBL3037929)
Show SMILES COC(=O)[C@@H]1C[C@@H]2CNC[C@@H]2C1
Show InChI InChI=1/C9H15NO2/c1-12-9(11)6-2-7-4-10-5-8(7)3-6/h6-8,10H,2-5H2,1H3/t6-,7-,8+
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n/an/an/an/a 1.20E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437487
PNG
(CHEMBL2409478)
Show SMILES F[C@@H]1C[C@@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C10H15FN2O/c11-9-1-8(9)10(14)13-4-6-2-12-3-7(6)5-13/h6-9,12H,1-5H2/t6?,7?,8-,9+/s2
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n/an/an/an/a 1.00E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437478
PNG
(CHEMBL2409475)
Show SMILES CNC(=O)[C@@H]1C[C@H]2CNC[C@H](C2)C1
Show InChI InChI=1/C10H18N2O/c1-11-10(13)9-3-7-2-8(4-9)6-12-5-7/h7-9,12H,2-6H2,1H3,(H,11,13)/t7-,8+,9+
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n/an/an/an/a 2.00E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437473
PNG
(CHEMBL2409486)
Show SMILES F[C@@H]1C[C@@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H17FN2O/c12-10-2-9(10)11(15)14-5-7-1-8(6-14)4-13-3-7/h7-10,13H,1-6H2/t7?,8?,9-,10+/s2
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n/an/an/an/a 9.20E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437499
PNG
(CHEMBL2409492)
Show SMILES C[C@H]1C[C@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C12H20N2O/c1-8-2-11(8)12(15)14-6-9-3-10(7-14)5-13-4-9/h8-11,13H,2-7H2,1H3/t8-,9?,10?,11+/s2
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n/an/an/an/a 1.00E+5n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437488
PNG
(CHEMBL2409494)
Show SMILES CCC(=O)N1CC2CNCC2C1
Show InChI InChI=1/C9H16N2O/c1-2-9(12)11-5-7-3-10-4-8(7)6-11/h7-8,10H,2-6H2,1H3
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n/an/an/an/a 1.30E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437486
PNG
(CHEMBL2409476)
Show SMILES CCCNC(=O)[C@@H]1C[C@H]2CNC[C@H](C2)C1
Show InChI InChI=1/C12H22N2O/c1-2-3-14-12(15)11-5-9-4-10(6-11)8-13-7-9/h9-11,13H,2-8H2,1H3,(H,14,15)/t9-,10+,11+
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n/an/an/an/a 2.40E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437482
PNG
(CHEMBL2409485)
Show SMILES F[C@H]1C[C@H]1C(=O)N1CC2CNCC(C2)C1
Show InChI InChI=1/C11H17FN2O/c12-10-2-9(10)11(15)14-5-7-1-8(6-14)4-13-3-7/h7-10,13H,1-6H2/t7?,8?,9-,10+/s2
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n/an/an/an/a 400n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437481
PNG
(CHEMBL2409482)
Show SMILES C[C@@H]1C[C@@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H18N2O/c1-7-2-10(7)11(14)13-5-8-3-12-4-9(8)6-13/h7-10,12H,2-6H2,1H3/t7-,8?,9?,10+/s2
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n/an/an/an/a 1.20E+3n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50437470
PNG
(CHEMBL2409481)
Show SMILES C[C@H]1C[C@H]1C(=O)N1CC2CNCC2C1
Show InChI InChI=1/C11H18N2O/c1-7-2-10(7)11(14)13-5-8-3-12-4-9(8)6-13/h7-10,12H,2-6H2,1H3/t7-,8?,9?,10+/s2
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n/an/an/an/a 1.90E+4n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2


(Homo sapiens (Human))
BDBM50397904
PNG
(CHEMBL2179961)
Show SMILES O=C(C1CC1)N1CC2CNCC2C1
Show InChI InChI=1/C10H16N2O/c13-10(7-1-2-7)12-5-8-3-11-4-9(8)6-12/h7-9,11H,1-6H2
PDB
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n/an/an/an/a 470n/an/an/an/a



Targacept Inc

Curated by ChEMBL


Assay Description
Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay


Bioorg Med Chem Lett 23: 3927-34 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.058
BindingDB Entry DOI: 10.7270/Q279462S
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%