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PubMed code 23773865

Compile data set for download or QSAR
Found 49 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase B


(Homo sapiens (Human))
BDBM50437161
PNG
(CHEMBL2401832)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H19Cl2FN4O3/c1-10(16-14(22)2-3-15(24)17(16)23)31-19-18-12(8-27-20(19)25)13(9-30-18)11-4-6-28(7-5-11)21(26)29/h2-4,8-10H,5-7H2,1H3,(H2,25,27)(H2,26,29)/t10-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of aurora-B (unknown origin) autophosphorylation


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50437161
PNG
(CHEMBL2401832)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H19Cl2FN4O3/c1-10(16-14(22)2-3-15(24)17(16)23)31-19-18-12(8-27-20(19)25)13(9-30-18)11-4-6-28(7-5-11)21(26)29/h2-4,8-10H,5-7H2,1H3,(H2,25,27)(H2,26,29)/t10-/m1/s1
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n/an/a 25n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) autophosphorylation


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437161
PNG
(CHEMBL2401832)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H19Cl2FN4O3/c1-10(16-14(22)2-3-15(24)17(16)23)31-19-18-12(8-27-20(19)25)13(9-30-18)11-4-6-28(7-5-11)21(26)29/h2-4,8-10H,5-7H2,1H3,(H2,25,27)(H2,26,29)/t10-/m1/s1
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437186
PNG
(CHEMBL2401825)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H18Cl2FN3O2/c1-10(16-14(21)2-3-15(23)17(16)22)28-19-18-12(8-26-20(19)24)13(9-27-18)11-4-6-25-7-5-11/h2-4,8-10,25H,5-7H2,1H3,(H2,24,26)/t10-/m1/s1
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50437161
PNG
(CHEMBL2401832)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H19Cl2FN4O3/c1-10(16-14(22)2-3-15(24)17(16)23)31-19-18-12(8-27-20(19)25)13(9-30-18)11-4-6-28(7-5-11)21(26)29/h2-4,8-10H,5-7H2,1H3,(H2,25,27)(H2,26,29)/t10-/m1/s1
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of ALK (unknown origin) autophosphorylation


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437185
PNG
(CHEMBL2401810)
Show SMILES CC(Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)c(F)cc(F)c1Cl
Show InChI InChI=1S/C23H21Cl2F2N5O2/c1-11(18-19(24)16(26)6-17(27)20(18)25)34-22-21-14(8-30-23(22)28)15(10-33-21)12-7-31-32(9-12)13-2-4-29-5-3-13/h6-11,13,29H,2-5H2,1H3,(H2,28,30)
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437161
PNG
(CHEMBL2401832)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H19Cl2FN4O3/c1-10(16-14(22)2-3-15(24)17(16)23)31-19-18-12(8-27-20(19)25)13(9-30-18)11-4-6-28(7-5-11)21(26)29/h2-4,8-10H,5-7H2,1H3,(H2,25,27)(H2,26,29)/t10-/m1/s1
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437171
PNG
(CHEMBL2401813)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C23H22Cl2FN5O2/c1-12(19-17(24)2-3-18(26)20(19)25)33-22-21-15(9-29-23(22)27)16(11-32-21)13-8-30-31(10-13)14-4-6-28-7-5-14/h2-3,8-12,14,28H,4-7H2,1H3,(H2,27,29)/t12-/m1/s1
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n/an/a 47n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437168
PNG
(CHEMBL2401818)
Show SMILES Nc1ncc2c(coc2c1OC(CC#C)c1c(Cl)ccc(F)c1Cl)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H22Cl2FN5O2/c1-2-3-20(21-18(26)4-5-19(28)22(21)27)35-24-23-16(11-31-25(24)29)17(13-34-23)14-10-32-33(12-14)15-6-8-30-9-7-15/h1,4-5,10-13,15,20,30H,3,6-9H2,(H2,29,31)
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437157
PNG
(CHEMBL2401814)
Show SMILES C[C@H](Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C23H22Cl2FN5O2/c1-12(19-17(24)2-3-18(26)20(19)25)33-22-21-15(9-29-23(22)27)16(11-32-21)13-8-30-31(10-13)14-4-6-28-7-5-14/h2-3,8-12,14,28H,4-7H2,1H3,(H2,27,29)/t12-/m0/s1
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437184
PNG
(CHEMBL2401811)
Show SMILES CC(Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Br)ccc(F)c1Cl
Show InChI InChI=1S/C23H22BrClFN5O2/c1-12(19-17(24)2-3-18(26)20(19)25)33-22-21-15(9-29-23(22)27)16(11-32-21)13-8-30-31(10-13)14-4-6-28-7-5-14/h2-3,8-12,14,28H,4-7H2,1H3,(H2,27,29)
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437158
PNG
(CHEMBL2401740)
Show SMILES CCC(Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C24H24Cl2FN5O2/c1-2-19(20-17(25)3-4-18(27)21(20)26)34-23-22-15(10-30-24(23)28)16(12-33-22)13-9-31-32(11-13)14-5-7-29-8-6-14/h3-4,9-12,14,19,29H,2,5-8H2,1H3,(H2,28,30)
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n/an/a 92n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437183
PNG
(CHEMBL2401808)
Show SMILES CC(Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(Cl)c1Cl
Show InChI InChI=1S/C23H22Cl3N5O2/c1-12(19-17(24)2-3-18(25)20(19)26)33-22-21-15(9-29-23(22)27)16(11-32-21)13-8-30-31(10-13)14-4-6-28-7-5-14/h2-3,8-12,14,28H,4-7H2,1H3,(H2,27,29)
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437159
PNG
(CHEMBL2401817)
Show SMILES Nc1ncc2c(coc2c1OC(CC=C)c1c(Cl)ccc(F)c1Cl)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H24Cl2FN5O2/c1-2-3-20(21-18(26)4-5-19(28)22(21)27)35-24-23-16(11-31-25(24)29)17(13-34-23)14-10-32-33(12-14)15-6-8-30-9-7-15/h2,4-5,10-13,15,20,30H,1,3,6-9H2,(H2,29,31)
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437182
PNG
(CHEMBL2401812)
Show SMILES CC(Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)cc(Cl)cc1Cl
Show InChI InChI=1S/C23H22Cl3N5O2/c1-12(20-18(25)6-14(24)7-19(20)26)33-22-21-16(9-29-23(22)27)17(11-32-21)13-8-30-31(10-13)15-2-4-28-5-3-15/h6-12,15,28H,2-5H2,1H3,(H2,27,29)
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50437157
PNG
(CHEMBL2401814)
Show SMILES C[C@H](Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C23H22Cl2FN5O2/c1-12(19-17(24)2-3-18(26)20(19)25)33-22-21-15(9-29-23(22)27)16(11-32-21)13-8-30-31(10-13)14-4-6-28-7-5-14/h2-3,8-12,14,28H,4-7H2,1H3,(H2,27,29)/t12-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrs


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437181
PNG
(CHEMBL2401816)
Show SMILES CCCC(Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C25H26Cl2FN5O2/c1-2-3-20(21-18(26)4-5-19(28)22(21)27)35-24-23-16(11-31-25(24)29)17(13-34-23)14-10-32-33(12-14)15-6-8-30-9-7-15/h4-5,10-13,15,20,30H,2-3,6-9H2,1H3,(H2,29,31)
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n/an/a 130n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437180
PNG
(CHEMBL2401820)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)-c1cn[nH]c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C18H13Cl2FN4O2/c1-8(14-12(19)2-3-13(21)15(14)20)27-17-16-10(6-23-18(17)22)11(7-26-16)9-4-24-25-5-9/h2-8H,1H3,(H2,22,23)(H,24,25)/t8-/m1/s1
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50437161
PNG
(CHEMBL2401832)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H19Cl2FN4O3/c1-10(16-14(22)2-3-15(24)17(16)23)31-19-18-12(8-27-20(19)25)13(9-30-18)11-4-6-28(7-5-11)21(26)29/h2-4,8-10H,5-7H2,1H3,(H2,25,27)(H2,26,29)/t10-/m1/s1
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n/an/a 200n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrs


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437179
PNG
(CHEMBL2401826)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H20Cl2FN3O2/c1-10(16-14(21)2-3-15(23)17(16)22)28-19-18-12(8-26-20(19)24)13(9-27-18)11-4-6-25-7-5-11/h2-3,8-11,25H,4-7H2,1H3,(H2,24,26)/t10-/m1/s1
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n/an/a 200n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437178
PNG
(CHEMBL2401835)
Show SMILES CC(Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H23Cl2N5O2/c1-13(20-18(24)3-2-4-19(20)25)32-22-21-16(10-28-23(22)26)17(12-31-21)14-9-29-30(11-14)15-5-7-27-8-6-15/h2-4,9-13,15,27H,5-8H2,1H3,(H2,26,28)
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437177
PNG
(CHEMBL2401824)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)-c1ccncc1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H14Cl2FN3O2/c1-10(16-14(21)2-3-15(23)17(16)22)28-19-18-12(8-26-20(19)24)13(9-27-18)11-4-6-25-7-5-11/h2-10H,1H3,(H2,24,26)/t10-/m1/s1
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437176
PNG
(CHEMBL2401831)
Show SMILES CNC(=O)N1CCC(=CC1)c1coc2c(O[C@H](C)c3c(Cl)ccc(F)c3Cl)c(N)ncc12
Show InChI InChI=1S/C22H21Cl2FN4O3/c1-11(17-15(23)3-4-16(25)18(17)24)32-20-19-13(9-28-21(20)26)14(10-31-19)12-5-7-29(8-6-12)22(30)27-2/h3-5,9-11H,6-8H2,1-2H3,(H2,26,28)(H,27,30)/t11-/m1/s1
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437175
PNG
(CHEMBL2401806)
Show SMILES CC(Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1cc(F)ccc1Cl
Show InChI InChI=1S/C23H23ClFN5O2/c1-13(17-8-15(25)2-3-20(17)24)32-22-21-18(10-28-23(22)26)19(12-31-21)14-9-29-30(11-14)16-4-6-27-7-5-16/h2-3,8-13,16,27H,4-7H2,1H3,(H2,26,28)
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437174
PNG
(CHEMBL2401828)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(C)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C22H20Cl2FN3O3/c1-11(18-16(23)3-4-17(25)19(18)24)31-21-20-14(9-27-22(21)26)15(10-30-20)13-5-7-28(8-6-13)12(2)29/h3-5,9-11H,6-8H2,1-2H3,(H2,26,27)/t11-/m1/s1
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437173
PNG
(CHEMBL2401809)
Show SMILES COc1ccc(Cl)c([C@@H](C)Oc2c(N)ncc3c(coc23)-c2cnn(c2)C2CCNCC2)c1Cl
Show InChI InChI=1S/C24H25Cl2N5O3/c1-13(20-18(25)3-4-19(32-2)21(20)26)34-23-22-16(10-29-24(23)27)17(12-33-22)14-9-30-31(11-14)15-5-7-28-8-6-15/h3-4,9-13,15,28H,5-8H2,1-2H3,(H2,27,29)/t13-/m1/s1
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437172
PNG
(CHEMBL2401807)
Show SMILES CC(Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1cccc(F)c1Cl
Show InChI InChI=1S/C23H23ClFN5O2/c1-13(16-3-2-4-19(25)20(16)24)32-22-21-17(10-28-23(22)26)18(12-31-21)14-9-29-30(11-14)15-5-7-27-8-6-15/h2-4,9-13,15,27H,5-8H2,1H3,(H2,26,28)
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437171
PNG
(CHEMBL2401813)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C23H22Cl2FN5O2/c1-12(19-17(24)2-3-18(26)20(19)25)33-22-21-15(9-29-23(22)27)16(11-32-21)13-8-30-31(10-13)14-4-6-28-7-5-14/h2-3,8-12,14,28H,4-7H2,1H3,(H2,27,29)/t12-/m1/s1
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n/an/a 410n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437170
PNG
(CHEMBL2401815)
Show SMILES Nc1ncc2c(coc2c1OCc1c(Cl)ccc(F)c1Cl)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H20Cl2FN5O2/c23-17-1-2-18(25)19(24)16(17)11-32-21-20-14(8-28-22(21)26)15(10-31-20)12-7-29-30(9-12)13-3-5-27-6-4-13/h1-2,7-10,13,27H,3-6,11H2,(H2,26,28)
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n/an/a 430n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50437161
PNG
(CHEMBL2401832)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H19Cl2FN4O3/c1-10(16-14(22)2-3-15(24)17(16)23)31-19-18-12(8-27-20(19)25)13(9-30-18)11-4-6-28(7-5-11)21(26)29/h2-4,8-10H,5-7H2,1H3,(H2,25,27)(H2,26,29)/t10-/m1/s1
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n/an/a 500n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of ALK autophosphorylation in human Karpas-299 cells


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437169
PNG
(CHEMBL2401823)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)-c1cccnc1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H14Cl2FN3O2/c1-10(16-14(21)4-5-15(23)17(16)22)28-19-18-12(8-26-20(19)24)13(9-27-18)11-3-2-6-25-7-11/h2-10H,1H3,(H2,24,26)/t10-/m1/s1
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n/an/a 520n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437162
PNG
(CHEMBL2401833)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)S(N)(=O)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H19Cl2FN4O4S/c1-10(16-14(21)2-3-15(23)17(16)22)31-19-18-12(8-26-20(19)24)13(9-30-18)11-4-6-27(7-5-11)32(25,28)29/h2-4,8-10H,5-7H2,1H3,(H2,24,26)(H2,25,28,29)/t10-/m1/s1
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n/an/a 550n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437168
PNG
(CHEMBL2401818)
Show SMILES Nc1ncc2c(coc2c1OC(CC#C)c1c(Cl)ccc(F)c1Cl)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H22Cl2FN5O2/c1-2-3-20(21-18(26)4-5-19(28)22(21)27)35-24-23-16(11-31-25(24)29)17(13-34-23)14-10-32-33(12-14)15-6-8-30-9-7-15/h1,4-5,10-13,15,20,30H,3,6-9H2,(H2,29,31)
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n/an/a 560n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437157
PNG
(CHEMBL2401814)
Show SMILES C[C@H](Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C23H22Cl2FN5O2/c1-12(19-17(24)2-3-18(26)20(19)25)33-22-21-15(9-29-23(22)27)16(11-32-21)13-8-30-31(10-13)14-4-6-28-7-5-14/h2-3,8-12,14,28H,4-7H2,1H3,(H2,27,29)/t12-/m0/s1
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n/an/a 560n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437167
PNG
(CHEMBL2401830)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(=O)N(C)C)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C23H23Cl2FN4O3/c1-12(18-16(24)4-5-17(26)19(18)25)33-21-20-14(10-28-22(21)27)15(11-32-20)13-6-8-30(9-7-13)23(31)29(2)3/h4-6,10-12H,7-9H2,1-3H3,(H2,27,28)/t12-/m1/s1
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n/an/a 580n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437166
PNG
(CHEMBL2401821)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)-c1ccccc1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H15Cl2FN2O2/c1-11(17-15(22)7-8-16(24)18(17)23)28-20-19-13(9-26-21(20)25)14(10-27-19)12-5-3-2-4-6-12/h2-11H,1H3,(H2,25,26)/t11-/m1/s1
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437165
PNG
(CHEMBL2401827)
Show SMILES CNC(=O)c1coc2c(O[C@H](C)c3c(Cl)ccc(F)c3Cl)c(N)ncc12
Show InChI InChI=1S/C17H14Cl2FN3O3/c1-7(12-10(18)3-4-11(20)13(12)19)26-15-14-8(5-23-16(15)21)9(6-25-14)17(24)22-2/h3-7H,1-2H3,(H2,21,23)(H,22,24)/t7-/m1/s1
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OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437161
PNG
(CHEMBL2401832)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H19Cl2FN4O3/c1-10(16-14(22)2-3-15(24)17(16)23)31-19-18-12(8-27-20(19)25)13(9-30-18)11-4-6-28(7-5-11)21(26)29/h2-4,8-10H,5-7H2,1H3,(H2,25,27)(H2,26,29)/t10-/m1/s1
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n/an/a 600n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs in presence of mouse plasma


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437157
PNG
(CHEMBL2401814)
Show SMILES C[C@H](Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C23H22Cl2FN5O2/c1-12(19-17(24)2-3-18(26)20(19)25)33-22-21-15(9-29-23(22)27)16(11-32-21)13-8-30-31(10-13)14-4-6-28-7-5-14/h2-3,8-12,14,28H,4-7H2,1H3,(H2,27,29)/t12-/m0/s1
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n/an/a 660n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437164
PNG
(CHEMBL2401829)
Show SMILES COC(=O)N1CCC(=CC1)c1coc2c(O[C@H](C)c3c(Cl)ccc(F)c3Cl)c(N)ncc12
Show InChI InChI=1S/C22H20Cl2FN3O4/c1-11(17-15(23)3-4-16(25)18(17)24)32-20-19-13(9-27-21(20)26)14(10-31-19)12-5-7-28(8-6-12)22(29)30-2/h3-5,9-11H,6-8H2,1-2H3,(H2,26,27)/t11-/m1/s1
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n/an/a 780n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437163
PNG
(CHEMBL2401819)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCN(CC1)C(C)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C25H24Cl2FN5O3/c1-13(21-19(26)3-4-20(28)22(21)27)36-24-23-17(10-30-25(24)29)18(12-35-23)15-9-31-33(11-15)16-5-7-32(8-6-16)14(2)34/h3-4,9-13,16H,5-8H2,1-2H3,(H2,29,30)/t13-/m1/s1
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n/an/a 950n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50437161
PNG
(CHEMBL2401832)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H19Cl2FN4O3/c1-10(16-14(22)2-3-15(24)17(16)23)31-19-18-12(8-27-20(19)25)13(9-30-18)11-4-6-28(7-5-11)21(26)29/h2-4,8-10H,5-7H2,1H3,(H2,25,27)(H2,26,29)/t10-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of aurora-B in human HT-29 cells assessed as phosphorylation of histone H3 at Ser10


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437162
PNG
(CHEMBL2401833)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)S(N)(=O)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H19Cl2FN4O4S/c1-10(16-14(21)2-3-15(23)17(16)22)31-19-18-12(8-26-20(19)24)13(9-30-18)11-4-6-27(7-5-11)32(25,28)29/h2-4,8-10H,5-7H2,1H3,(H2,24,26)(H2,25,28,29)/t10-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437160
PNG
(CHEMBL2401822)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)-c1ccccn1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H14Cl2FN3O2/c1-10(16-13(21)5-6-14(23)17(16)22)28-19-18-11(8-26-20(19)24)12(9-27-18)15-4-2-3-7-25-15/h2-10H,1H3,(H2,24,26)/t10-/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 mins


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437159
PNG
(CHEMBL2401817)
Show SMILES Nc1ncc2c(coc2c1OC(CC=C)c1c(Cl)ccc(F)c1Cl)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C25H24Cl2FN5O2/c1-2-3-20(21-18(26)4-5-19(28)22(21)27)35-24-23-16(11-31-25(24)29)17(13-34-23)14-10-32-33(12-14)15-6-8-30-9-7-15/h2,4-5,10-13,15,20,30H,1,3,6-9H2,(H2,29,31)
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n/an/a 2.10E+3n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437158
PNG
(CHEMBL2401740)
Show SMILES CCC(Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C24H24Cl2FN5O2/c1-2-19(20-17(25)3-4-18(27)21(20)26)34-23-22-15(10-30-24(23)28)16(12-33-22)13-9-31-32(11-13)14-5-7-29-8-6-14/h3-4,9-12,14,19,29H,2,5-8H2,1H3,(H2,28,30)
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n/an/a 2.20E+3n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437157
PNG
(CHEMBL2401814)
Show SMILES C[C@H](Oc1c(N)ncc2c(coc12)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C23H22Cl2FN5O2/c1-12(19-17(24)2-3-18(26)20(19)25)33-22-21-15(9-29-23(22)27)16(11-32-21)13-8-30-31(10-13)14-4-6-28-7-5-14/h2-3,8-12,14,28H,4-7H2,1H3,(H2,27,29)/t12-/m0/s1
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n/an/a 7.40E+3n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50437161
PNG
(CHEMBL2401832)
Show SMILES C[C@@H](Oc1c(N)ncc2c(coc12)C1=CCN(CC1)C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H19Cl2FN4O3/c1-10(16-14(22)2-3-15(24)17(16)23)31-19-18-12(8-27-20(19)25)13(9-30-18)11-4-6-28(7-5-11)21(26)29/h2-4,8-10H,5-7H2,1H3,(H2,25,27)(H2,26,29)/t10-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of aurora-B in human HT-29 cells assessed as phosphorylation of histone H3 at Ser10 in presence of mouse plasma


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50437170
PNG
(CHEMBL2401815)
Show SMILES Nc1ncc2c(coc2c1OCc1c(Cl)ccc(F)c1Cl)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H20Cl2FN5O2/c23-17-1-2-18(25)19(24)16(17)11-32-21-20-14(8-28-22(21)26)15(10-31-20)12-7-29-30(9-12)13-3-5-27-6-4-13/h1-2,7-10,13,27H,3-6,11H2,(H2,26,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



OSI Pharmaceuticals, LLC

Curated by ChEMBL


Assay Description
Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs


Bioorg Med Chem Lett 23: 4381-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.074
BindingDB Entry DOI: 10.7270/Q2RB7601
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%