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PubMed code 23867390

Compile data set for download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438658
PNG
(CHEMBL1188560)
Show SMILES OC(CCc1ccc(I)cc1)Cn1ccnc1
Show InChI InChI=1S/C13H15IN2O/c14-12-4-1-11(2-5-12)3-6-13(17)9-16-8-7-15-10-16/h1-2,4-5,7-8,10,13,17H,3,6,9H2
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n/an/a 60n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438651
PNG
(CHEMBL2414454)
Show SMILES Ic1ccc(OCCCCn2ccnc2)cc1
Show InChI InChI=1S/C13H15IN2O/c14-12-3-5-13(6-4-12)17-10-2-1-8-16-9-7-15-11-16/h3-7,9,11H,1-2,8,10H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50438658
PNG
(CHEMBL1188560)
Show SMILES OC(CCc1ccc(I)cc1)Cn1ccnc1
Show InChI InChI=1S/C13H15IN2O/c14-12-4-1-11(2-5-12)3-6-13(17)9-16-8-7-15-10-16/h1-2,4-5,7-8,10,13,17H,3,6,9H2
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50271549
PNG
(1-(4-(3-bromophenoxy)butyl)-1H-imidazole | CHEMBL4...)
Show SMILES Brc1cccc(OCCCCn2ccnc2)c1
Show InChI InChI=1S/C13H15BrN2O/c14-12-4-3-5-13(10-12)17-9-2-1-7-16-8-6-15-11-16/h3-6,8,10-11H,1-2,7,9H2
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n/an/a 2.10E+3n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50271549
PNG
(1-(4-(3-bromophenoxy)butyl)-1H-imidazole | CHEMBL4...)
Show SMILES Brc1cccc(OCCCCn2ccnc2)c1
Show InChI InChI=1S/C13H15BrN2O/c14-12-4-3-5-13(10-12)17-9-2-1-7-16-8-6-15-11-16/h3-6,8,10-11H,1-2,7,9H2
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50240895
PNG
(2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone | 2...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Cn1ccnc1
Show InChI InChI=1S/C11H9N3O3/c15-11(7-13-6-5-12-8-13)9-1-3-10(4-2-9)14(16)17/h1-6,8H,7H2
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n/an/a 2.50E+3n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM84805
PNG
(1-azolyl-4-phenyl-2-butanone, 7)
Show SMILES O=C(CCc1ccccc1)Cn1cncn1
Show InChI InChI=1S/C12H13N3O/c16-12(8-15-10-13-9-14-15)7-6-11-4-2-1-3-5-11/h1-5,9-10H,6-8H2
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50044424
PNG
(4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...)
Show SMILES Nc1ccc(SC[C@@H]2CO[C@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1
Show InChI InChI=1S/C22H24ClN3O2S/c23-18-3-1-17(2-4-18)9-10-22(15-26-12-11-25-16-26)27-13-20(28-22)14-29-21-7-5-19(24)6-8-21/h1-8,11-12,16,20H,9-10,13-15,24H2/t20-,22-/m0/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50438651
PNG
(CHEMBL2414454)
Show SMILES Ic1ccc(OCCCCn2ccnc2)cc1
Show InChI InChI=1S/C13H15IN2O/c14-12-3-5-13(6-4-12)17-10-2-1-8-16-9-7-15-11-16/h3-7,9,11H,1-2,8,10H2
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438656
PNG
(CHEMBL2414445)
Show SMILES C(CCn1ccnc1)COc1ccccc1
Show InChI InChI=1S/C13H16N2O/c1-2-6-13(7-3-1)16-11-5-4-9-15-10-8-14-12-15/h1-3,6-8,10,12H,4-5,9,11H2
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n/an/a 2.10E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50438654
PNG
(CHEMBL2414448)
Show SMILES [O-][N+](=O)c1ccc(OCCCCn2ccnc2)cc1
Show InChI InChI=1S/C13H15N3O3/c17-16(18)12-3-5-13(6-4-12)19-10-2-1-8-15-9-7-14-11-15/h3-7,9,11H,1-2,8,10H2
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n/an/a 2.10E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50271548
PNG
(1-(4-(2-bromophenoxy)butyl)-1H-imidazole | CHEMBL5...)
Show SMILES Brc1ccccc1OCCCCn1ccnc1
Show InChI InChI=1S/C13H15BrN2O/c14-12-5-1-2-6-13(12)17-10-4-3-8-16-9-7-15-11-16/h1-2,5-7,9,11H,3-4,8,10H2
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n/an/a 2.40E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50044424
PNG
(4-(((2S,4S)-2-((1H-imidazol-1-yl)methyl)-2-(4-chlo...)
Show SMILES Nc1ccc(SC[C@@H]2CO[C@](CCc3ccc(Cl)cc3)(Cn3ccnc3)O2)cc1
Show InChI InChI=1S/C22H24ClN3O2S/c23-18-3-1-17(2-4-18)9-10-22(15-26-12-11-25-16-26)27-13-20(28-22)14-29-21-7-5-19(24)6-8-21/h1-8,11-12,16,20H,9-10,13-15,24H2/t20-,22-/m0/s1
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n/an/a 2.45E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50438655
PNG
(CHEMBL2414446)
Show SMILES C(CCn1cncn1)COc1ccccc1
Show InChI InChI=1S/C12H15N3O/c1-2-6-12(7-3-1)16-9-5-4-8-15-11-13-10-14-15/h1-3,6-7,10-11H,4-5,8-9H2
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n/an/a 2.70E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50438656
PNG
(CHEMBL2414445)
Show SMILES C(CCn1ccnc1)COc1ccccc1
Show InChI InChI=1S/C13H16N2O/c1-2-6-13(7-3-1)16-11-5-4-9-15-10-8-14-12-15/h1-3,6-8,10,12H,4-5,9,11H2
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n/an/a 3.00E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438657
PNG
(CHEMBL1363752)
Show SMILES C(COc1ccccc1)Cn1ccnc1
Show InChI InChI=1S/C12H14N2O/c1-2-5-12(6-3-1)15-10-4-8-14-9-7-13-11-14/h1-3,5-7,9,11H,4,8,10H2
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n/an/a 3.10E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50271513
PNG
(1-(4-(4-bromophenoxy)butyl)-1H-imidazole | CHEMBL4...)
Show SMILES Brc1ccc(OCCCCn2ccnc2)cc1
Show InChI InChI=1S/C13H15BrN2O/c14-12-3-5-13(6-4-12)17-10-2-1-8-16-9-7-15-11-16/h3-7,9,11H,1-2,8,10H2
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n/an/a 3.10E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM84805
PNG
(1-azolyl-4-phenyl-2-butanone, 7)
Show SMILES O=C(CCc1ccccc1)Cn1cncn1
Show InChI InChI=1S/C12H13N3O/c16-12(8-15-10-13-9-14-15)7-6-11-4-2-1-3-5-11/h1-5,9-10H,6-8H2
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n/an/a 3.40E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438650
PNG
(CHEMBL2414455)
Show SMILES Ic1ccc(OCCCCn2cncn2)cc1
Show InChI InChI=1S/C12H14IN3O/c13-11-3-5-12(6-4-11)17-8-2-1-7-16-10-14-9-15-16/h3-6,9-10H,1-2,7-8H2
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n/an/a 3.80E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50271548
PNG
(1-(4-(2-bromophenoxy)butyl)-1H-imidazole | CHEMBL5...)
Show SMILES Brc1ccccc1OCCCCn1ccnc1
Show InChI InChI=1S/C13H15BrN2O/c14-12-5-1-2-6-13(12)17-10-4-3-8-16-9-7-15-11-16/h1-2,5-7,9,11H,3-4,8,10H2
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n/an/a 5.30E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438654
PNG
(CHEMBL2414448)
Show SMILES [O-][N+](=O)c1ccc(OCCCCn2ccnc2)cc1
Show InChI InChI=1S/C13H15N3O3/c17-16(18)12-3-5-13(6-4-12)19-10-2-1-8-15-9-7-14-11-15/h3-7,9,11H,1-2,8,10H2
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n/an/a 5.60E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438653
PNG
(CHEMBL2414450)
Show SMILES Brc1cccc(OCCCn2ccnc2)c1
Show InChI InChI=1S/C12H13BrN2O/c13-11-3-1-4-12(9-11)16-8-2-6-15-7-5-14-10-15/h1,3-5,7,9-10H,2,6,8H2
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PubMed
n/an/a 6.90E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50438650
PNG
(CHEMBL2414455)
Show SMILES Ic1ccc(OCCCCn2cncn2)cc1
Show InChI InChI=1S/C12H14IN3O/c13-11-3-5-12(6-4-11)17-8-2-1-7-16-10-14-9-15-16/h3-6,9-10H,1-2,7-8H2
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PubMed
n/an/a 7.00E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50271513
PNG
(1-(4-(4-bromophenoxy)butyl)-1H-imidazole | CHEMBL4...)
Show SMILES Brc1ccc(OCCCCn2ccnc2)cc1
Show InChI InChI=1S/C13H15BrN2O/c14-12-3-5-13(6-4-12)17-10-2-1-8-16-9-7-15-11-16/h3-7,9,11H,1-2,8,10H2
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PubMed
n/an/a 7.50E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438652
PNG
(CHEMBL2414453)
Show SMILES Ic1ccc(OCCCn2cncn2)cc1
Show InChI InChI=1S/C11H12IN3O/c12-10-2-4-11(5-3-10)16-7-1-6-15-9-13-8-14-15/h2-5,8-9H,1,6-7H2
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PubMed
n/an/a 7.50E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50438652
PNG
(CHEMBL2414453)
Show SMILES Ic1ccc(OCCCn2cncn2)cc1
Show InChI InChI=1S/C11H12IN3O/c12-10-2-4-11(5-3-10)16-7-1-6-15-9-13-8-14-15/h2-5,8-9H,1,6-7H2
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PubMed
n/an/a 9.00E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438655
PNG
(CHEMBL2414446)
Show SMILES C(CCn1cncn1)COc1ccccc1
Show InChI InChI=1S/C12H15N3O/c1-2-6-12(7-3-1)16-9-5-4-8-15-11-13-10-14-15/h1-3,6-7,10-11H,4-5,8-9H2
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PubMed
n/an/a 9.20E+4n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438661
PNG
(CHEMBL2414451)
Show SMILES Brc1cccc(OCCCn2cncn2)c1
Show InChI InChI=1S/C11H12BrN3O/c12-10-3-1-4-11(7-10)16-6-2-5-15-9-13-8-14-15/h1,3-4,7-9H,2,5-6H2
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PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50438657
PNG
(CHEMBL1363752)
Show SMILES C(COc1ccccc1)Cn1ccnc1
Show InChI InChI=1S/C12H14N2O/c1-2-5-12(6-3-1)15-10-4-8-14-9-7-13-11-14/h1-3,5-7,9,11H,4,8,10H2
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PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438662
PNG
(CHEMBL2414449)
Show SMILES [O-][N+](=O)c1ccc(OCCCCn2cncn2)cc1
Show InChI InChI=1S/C12H14N4O3/c17-16(18)11-3-5-12(6-4-11)19-8-2-1-7-15-10-13-9-14-15/h3-6,9-10H,1-2,7-8H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50438653
PNG
(CHEMBL2414450)
Show SMILES Brc1cccc(OCCCn2ccnc2)c1
Show InChI InChI=1S/C12H13BrN2O/c13-11-3-1-4-12(9-11)16-8-2-6-15-7-5-14-10-15/h1,3-5,7,9-10H,2,6,8H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438664
PNG
(CHEMBL2414447)
Show SMILES [O-][N+](=O)c1ccc(OCCCn2ccnc2)cc1
Show InChI InChI=1S/C12H13N3O3/c16-15(17)11-2-4-12(5-3-11)18-9-1-7-14-8-6-13-10-14/h2-6,8,10H,1,7,9H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438665
PNG
(CHEMBL2414444)
Show SMILES C(COc1ccccc1)Cn1cncn1
Show InChI InChI=1S/C11H13N3O/c1-2-5-11(6-3-1)15-8-4-7-14-10-12-9-13-14/h1-3,5-6,9-10H,4,7-8H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438659
PNG
(CHEMBL2414452)
Show SMILES Ic1ccc(OCCCn2ccnc2)cc1
Show InChI InChI=1S/C12H13IN2O/c13-11-2-4-12(5-3-11)16-9-1-7-15-8-6-14-10-15/h2-6,8,10H,1,7,9H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438663
PNG
(CHEMBL1452451)
Show SMILES [O-][N+](=O)c1ccc(OCCCn2cncn2)cc1
Show InChI InChI=1S/C11H12N4O3/c16-15(17)10-2-4-11(5-3-10)18-7-1-6-14-9-12-8-13-14/h2-5,8-9H,1,6-7H2
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PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 1 (HO-1)


(Rattus norvegicus (rat))
BDBM50438660
PNG
(CHEMBL1404869)
Show SMILES Brc1cccc(OCCCCn2cncn2)c1
Show InChI InChI=1S/C12H14BrN3O/c13-11-4-3-5-12(8-11)17-7-2-1-6-16-10-14-9-15-16/h3-5,8-10H,1-2,6-7H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
Heme Oxygenase 2 (HO-2)


(Rattus norvegicus (rat))
BDBM50240895
PNG
(2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone | 2...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Cn1ccnc1
Show InChI InChI=1S/C11H9N3O3/c15-11(7-13-6-5-12-8-13)9-1-3-10(4-2-9)14(16)17/h1-6,8H,7H2
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PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Catania

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis


Bioorg Med Chem 21: 5145-53 (2013)


Article DOI: 10.1016/j.bmc.2013.06.040
BindingDB Entry DOI: 10.7270/Q2FF3TSH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%