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PubMed code 23944843

Compile data set for download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440904
PNG
(CHEMBL2431834)
Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cnn(C)c1
Show InChI InChI=1S/C19H16N8/c1-12(13-5-6-16-14(8-13)4-3-7-20-16)27-19-18(24-25-27)21-10-17(23-19)15-9-22-26(2)11-15/h3-12H,1-2H3/t12-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440905
PNG
(CHEMBL2431835)
Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cnn(CCO)c1
Show InChI InChI=1S/C20H18N8O/c1-13(14-4-5-17-15(9-14)3-2-6-21-17)28-20-19(25-26-28)22-11-18(24-20)16-10-23-27(12-16)7-8-29/h2-6,9-13,29H,7-8H2,1H3/t13-/m0/s1
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2.80n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440879
PNG
(CHEMBL2431824)
Show SMILES COc1ccc(cc1C)-c1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C24H21N5O/c1-15-13-19(7-10-22(15)30-3)21-9-11-23-26-27-24(29(23)28-21)16(2)17-6-8-20-18(14-17)5-4-12-25-20/h4-14,16H,1-3H3/t16-/m0/s1
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3n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440899
PNG
(CHEMBL2431829)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccc2OCCOc2c1)c1ccc2ncccc2c1
Show InChI InChI=1S/C24H19N5O2/c1-15(16-4-6-19-17(13-16)3-2-10-25-19)24-27-26-23-9-7-20(28-29(23)24)18-5-8-21-22(14-18)31-12-11-30-21/h2-10,13-15H,11-12H2,1H3/t15-/m0/s1
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4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440894
PNG
(CHEMBL2431823)
Show SMILES COc1ccc(cc1F)-c1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C23H18FN5O/c1-14(15-5-7-19-16(12-15)4-3-11-25-19)23-27-26-22-10-8-20(28-29(22)23)17-6-9-21(30-2)18(24)13-17/h3-14H,1-2H3/t14-/m0/s1
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4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440893
PNG
(CHEMBL2431822)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccc(F)c(F)c1)c1ccc2ncccc2c1
Show InChI InChI=1S/C22H15F2N5/c1-13(14-5-7-19-15(11-14)3-2-10-25-19)22-27-26-21-9-8-20(28-29(21)22)16-4-6-17(23)18(24)12-16/h2-13H,1H3/t13-/m0/s1
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4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440896
PNG
(CHEMBL2431826)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1cccc(c1)C#N)c1ccc2ncccc2c1
Show InChI InChI=1S/C23H16N6/c1-15(17-7-8-20-19(13-17)6-3-11-25-20)23-27-26-22-10-9-21(28-29(22)23)18-5-2-4-16(12-18)14-24/h2-13,15H,1H3/t15-/m0/s1
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4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440895
PNG
(CHEMBL2431825)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1cccc(C)c1)c1ccc2ncccc2c1
Show InChI InChI=1S/C23H19N5/c1-15-5-3-6-18(13-15)21-10-11-22-25-26-23(28(22)27-21)16(2)17-8-9-20-19(14-17)7-4-12-24-20/h3-14,16H,1-2H3/t16-/m0/s1
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5n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440898
PNG
(CHEMBL2431828)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccccc1C#N)c1ccc2ncccc2c1
Show InChI InChI=1S/C23H16N6/c1-15(16-8-9-20-17(13-16)6-4-12-25-20)23-27-26-22-11-10-21(28-29(22)23)19-7-3-2-5-18(19)14-24/h2-13,15H,1H3/t15-/m0/s1
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6n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396943
PNG
(CHEMBL2170816)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H14N8/c1-25-11-14(8-21-25)16-9-20-17-18(22-16)26(24-23-17)10-12-4-5-15-13(7-12)3-2-6-19-15/h2-9,11H,10H2,1H3
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6n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440880
PNG
(CHEMBL2431836)
Show SMILES CC(C)Nc1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H20N6/c1-12(2)21-17-8-9-18-22-23-19(25(18)24-17)13(3)14-6-7-16-15(11-14)5-4-10-20-16/h4-13H,1-3H3,(H,21,24)/t13-/m0/s1
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7n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440900
PNG
(CHEMBL2431830)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C24H20N6O/c1-15(18-9-10-20-19(14-18)4-3-13-26-20)23-28-27-22-12-11-21(29-30(22)23)16-5-7-17(8-6-16)24(31)25-2/h3-15H,1-2H3,(H,25,31)/t15-/m0/s1
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7n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440897
PNG
(CHEMBL2431827)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccc(cc1)C#N)c1ccc2ncccc2c1
Show InChI InChI=1S/C23H16N6/c1-15(18-8-9-20-19(13-18)3-2-12-25-20)23-27-26-22-11-10-21(28-29(22)23)17-6-4-16(14-24)5-7-17/h2-13,15H,1H3/t15-/m0/s1
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8n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440903
PNG
(CHEMBL2431833)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccc(nc1)N(C)C)c1ccc2ncccc2c1
Show InChI InChI=1S/C23H21N7/c1-15(16-6-8-19-17(13-16)5-4-12-24-19)23-27-26-22-11-9-20(28-30(22)23)18-7-10-21(25-14-18)29(2)3/h4-15H,1-3H3/t15-/m0/s1
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8n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440884
PNG
(CHEMBL2431816)
Show SMILES CC(C)Nc1ccc2nnc([C@@H](C)c3c[nH]c4ncccc34)n2n1
Show InChI InChI=1S/C17H19N7/c1-10(2)20-14-6-7-15-21-22-17(24(15)23-14)11(3)13-9-19-16-12(13)5-4-8-18-16/h4-11H,1-3H3,(H,18,19)(H,20,23)/t11-/m0/s1
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10n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440906
PNG
(CHEMBL2431819)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1cnn(C)c1)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H17N7/c1-13(14-5-6-17-15(10-14)4-3-9-21-17)20-24-23-19-8-7-18(25-27(19)20)16-11-22-26(2)12-16/h3-13H,1-2H3/t13-/m0/s1
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10n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440902
PNG
(CHEMBL2431832)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccc(cc1)S(C)(=O)=O)c1ccc2ncccc2c1
Show InChI InChI=1S/C23H19N5O2S/c1-15(17-7-10-20-18(14-17)4-3-13-24-20)23-26-25-22-12-11-21(27-28(22)23)16-5-8-19(9-6-16)31(2,29)30/h3-15H,1-2H3/t15-/m0/s1
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12n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440888
PNG
(CHEMBL2429888)
Show SMILES N#Cc1cccc(c1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C22H14N6/c23-14-16-3-1-4-18(12-16)20-8-9-21-25-26-22(28(21)27-20)13-15-6-7-19-17(11-15)5-2-10-24-19/h1-12H,13H2
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13n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440883
PNG
(CHEMBL2431815)
Show SMILES C[C@@H](c1c[nH]c2ncccc12)c1nnc2ccc(nn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C21H15N7/c1-13(17-12-24-20-16(17)3-2-10-23-20)21-26-25-19-9-8-18(27-28(19)21)15-6-4-14(11-22)5-7-15/h2-10,12-13H,1H3,(H,23,24)/t13-/m0/s1
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15n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396971
PNG
(CHEMBL2170953)
Show SMILES Nc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C14H11N7/c15-12-7-17-13-14(18-12)21(20-19-13)8-9-3-4-11-10(6-9)2-1-5-16-11/h1-7H,8H2,(H2,15,18)
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15n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440882
PNG
(CHEMBL2431838)
Show SMILES C[C@@H](c1c[nH]c2ncccc12)c1nnc2ccc(nn12)-c1cnn(C)c1
Show InChI InChI=1S/C18H16N8/c1-11(14-9-20-17-13(14)4-3-7-19-17)18-23-22-16-6-5-15(24-26(16)18)12-8-21-25(2)10-12/h3-11H,1-2H3,(H,19,20)/t11-/m0/s1
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16n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440885
PNG
(CHEMBL2431817)
Show SMILES CCNc1ccc2nnc([C@@H](C)c3c[nH]c4ncccc34)n2n1
Show InChI InChI=1S/C16H17N7/c1-3-17-13-6-7-14-20-21-16(23(14)22-13)10(2)12-9-19-15-11(12)5-4-8-18-15/h4-10H,3H2,1-2H3,(H,17,22)(H,18,19)/t10-/m0/s1
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17n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440901
PNG
(CHEMBL2431831)
Show SMILES CCS(=O)(=O)c1ccc(cc1)-c1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C24H21N5O2S/c1-3-32(30,31)20-9-6-17(7-10-20)22-12-13-23-26-27-24(29(23)28-22)16(2)18-8-11-21-19(15-18)5-4-14-25-21/h4-16H,3H2,1-2H3/t16-/m0/s1
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24n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440889
PNG
(CHEMBL2431840)
Show SMILES N#Cc1ccc(cc1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C22H14N6/c23-14-15-3-6-17(7-4-15)20-9-10-21-25-26-22(28(21)27-20)13-16-5-8-19-18(12-16)2-1-11-24-19/h1-12H,13H2
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24n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440887
PNG
(CHEMBL2431839)
Show SMILES Fc1ccc(cc1F)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C21H13F2N5/c22-16-5-4-15(12-17(16)23)19-7-8-20-25-26-21(28(20)27-19)11-13-3-6-18-14(10-13)2-1-9-24-18/h1-10,12H,11H2
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44n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440890
PNG
(CHEMBL2431841 | US9066954, 341)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H15N7/c1-25-12-15(11-21-25)17-6-7-18-22-23-19(26(18)24-17)10-13-4-5-16-14(9-13)3-2-8-20-16/h2-9,11-12H,10H2,1H3
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74n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440881
PNG
(CHEMBL2431837)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(Cc3c[nH]c4ncccc34)n2n1
Show InChI InChI=1S/C17H14N8/c1-24-10-12(9-20-24)14-4-5-15-21-22-16(25(15)23-14)7-11-8-19-17-13(11)3-2-6-18-17/h2-6,8-10H,7H2,1H3,(H,18,19)
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90n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440892
PNG
(CHEMBL2431821)
Show SMILES CN(C)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C17H16N6/c1-22(2)16-8-7-15-19-20-17(23(15)21-16)11-12-5-6-14-13(10-12)4-3-9-18-14/h3-10H,11H2,1-2H3
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250n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440886
PNG
(CHEMBL2431818)
Show SMILES Oc1ccc(Cc2nnc3ccc(nn23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H13FN4O/c19-14-5-3-13(4-6-14)16-9-10-17-20-21-18(23(17)22-16)11-12-1-7-15(24)8-2-12/h1-10,24H,11H2
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316n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440891
PNG
(CHEMBL2431820)
Show SMILES Nc1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C15H12N6/c16-13-5-6-14-18-19-15(21(14)20-13)9-10-3-4-12-11(8-10)2-1-7-17-12/h1-8H,9H2,(H2,16,20)
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379n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440905
PNG
(CHEMBL2431835)
Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cnn(CCO)c1
Show InChI InChI=1S/C20H18N8O/c1-13(14-4-5-17-15(9-14)3-2-6-21-17)28-20-19(25-26-28)22-11-18(24-20)16-10-23-27(12-16)7-8-29/h2-6,9-13,29H,7-8H2,1H3/t13-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440904
PNG
(CHEMBL2431834)
Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cnn(C)c1
Show InChI InChI=1S/C19H16N8/c1-12(13-5-6-16-14(8-13)4-3-7-20-16)27-19-18(24-25-27)21-10-17(23-19)15-9-22-26(2)11-15/h3-12H,1-2H3/t12-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396943
PNG
(CHEMBL2170816)
Show SMILES Cn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C18H14N8/c1-25-11-14(8-21-25)16-9-20-17-18(22-16)26(24-23-17)10-12-4-5-15-13(7-12)3-2-6-19-15/h2-9,11H,10H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440896
PNG
(CHEMBL2431826)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1cccc(c1)C#N)c1ccc2ncccc2c1
Show InChI InChI=1S/C23H16N6/c1-15(17-7-8-20-19(13-17)6-3-11-25-20)23-27-26-22-10-9-21(28-29(22)23)18-5-2-4-16(12-18)14-24/h2-13,15H,1H3/t15-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440898
PNG
(CHEMBL2431828)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccccc1C#N)c1ccc2ncccc2c1
Show InChI InChI=1S/C23H16N6/c1-15(16-8-9-20-17(13-16)6-4-12-25-20)23-27-26-22-11-10-21(28-29(22)23)19-7-3-2-5-18(19)14-24/h2-13,15H,1H3/t15-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440906
PNG
(CHEMBL2431819)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1cnn(C)c1)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H17N7/c1-13(14-5-6-17-15(10-14)4-3-9-21-17)20-24-23-19-8-7-18(25-27(19)20)16-11-22-26(2)12-16/h3-13H,1-2H3/t13-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440899
PNG
(CHEMBL2431829)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccc2OCCOc2c1)c1ccc2ncccc2c1
Show InChI InChI=1S/C24H19N5O2/c1-15(16-4-6-19-17(13-16)3-2-10-25-19)24-27-26-23-9-7-20(28-29(23)24)18-5-8-21-22(14-18)31-12-11-30-21/h2-10,13-15H,11-12H2,1H3/t15-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440894
PNG
(CHEMBL2431823)
Show SMILES COc1ccc(cc1F)-c1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C23H18FN5O/c1-14(15-5-7-19-16(12-15)4-3-11-25-19)23-27-26-22-10-8-20(28-29(22)23)17-6-9-21(30-2)18(24)13-17/h3-14H,1-2H3/t14-/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440879
PNG
(CHEMBL2431824)
Show SMILES COc1ccc(cc1C)-c1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C24H21N5O/c1-15-13-19(7-10-22(15)30-3)21-9-11-23-26-27-24(29(23)28-21)16(2)17-6-8-20-18(14-17)5-4-12-25-20/h4-14,16H,1-3H3/t16-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440895
PNG
(CHEMBL2431825)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1cccc(C)c1)c1ccc2ncccc2c1
Show InChI InChI=1S/C23H19N5/c1-15-5-3-6-18(13-15)21-10-11-22-25-26-23(28(22)27-21)16(2)17-8-9-20-19(14-17)7-4-12-24-20/h3-14,16H,1-2H3/t16-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440897
PNG
(CHEMBL2431827)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccc(cc1)C#N)c1ccc2ncccc2c1
Show InChI InChI=1S/C23H16N6/c1-15(18-8-9-20-19(13-18)3-2-12-25-20)23-27-26-22-11-10-21(28-29(22)23)17-6-4-16(14-24)5-7-17/h2-13,15H,1H3/t15-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440893
PNG
(CHEMBL2431822)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccc(F)c(F)c1)c1ccc2ncccc2c1
Show InChI InChI=1S/C22H15F2N5/c1-13(14-5-7-19-15(11-14)3-2-10-25-19)22-27-26-21-9-8-20(28-29(21)22)16-4-6-17(23)18(24)12-16/h2-13H,1H3/t13-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440900
PNG
(CHEMBL2431830)
Show SMILES CNC(=O)c1ccc(cc1)-c1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C24H20N6O/c1-15(18-9-10-20-19(14-18)4-3-13-26-20)23-28-27-22-12-11-21(29-30(22)23)16-5-7-17(8-6-16)24(31)25-2/h3-15H,1-2H3,(H,25,31)/t15-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440882
PNG
(CHEMBL2431838)
Show SMILES C[C@@H](c1c[nH]c2ncccc12)c1nnc2ccc(nn12)-c1cnn(C)c1
Show InChI InChI=1S/C18H16N8/c1-11(14-9-20-17-13(14)4-3-7-19-17)18-23-22-16-6-5-15(24-26(16)18)12-8-21-25(2)10-12/h3-11H,1-2H3,(H,19,20)/t11-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440884
PNG
(CHEMBL2431816)
Show SMILES CC(C)Nc1ccc2nnc([C@@H](C)c3c[nH]c4ncccc34)n2n1
Show InChI InChI=1S/C17H19N7/c1-10(2)20-14-6-7-15-21-22-17(24(15)23-14)11(3)13-9-19-16-12(13)5-4-8-18-16/h4-11H,1-3H3,(H,18,19)(H,20,23)/t11-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440888
PNG
(CHEMBL2429888)
Show SMILES N#Cc1cccc(c1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C22H14N6/c23-14-16-3-1-4-18(12-16)20-8-9-21-25-26-22(28(21)27-20)13-15-6-7-19-17(11-15)5-2-10-24-19/h1-12H,13H2
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n/an/a 19n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440880
PNG
(CHEMBL2431836)
Show SMILES CC(C)Nc1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H20N6/c1-12(2)21-17-8-9-18-22-23-19(25(18)24-17)13(3)14-6-7-16-15(11-14)5-4-10-20-16/h4-13H,1-3H3,(H,21,24)/t13-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440883
PNG
(CHEMBL2431815)
Show SMILES C[C@@H](c1c[nH]c2ncccc12)c1nnc2ccc(nn12)-c1ccc(cc1)C#N
Show InChI InChI=1S/C21H15N7/c1-13(17-12-24-20-16(17)3-2-10-23-20)21-26-25-19-9-8-18(27-28(19)21)15-6-4-14(11-22)5-7-15/h2-10,12-13H,1H3,(H,23,24)/t13-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440902
PNG
(CHEMBL2431832)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccc(cc1)S(C)(=O)=O)c1ccc2ncccc2c1
Show InChI InChI=1S/C23H19N5O2S/c1-15(17-7-10-20-18(14-17)4-3-13-24-20)23-26-25-22-12-11-21(27-28(22)23)16-5-8-19(9-6-16)31(2,29)30/h3-15H,1-2H3/t15-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440885
PNG
(CHEMBL2431817)
Show SMILES CCNc1ccc2nnc([C@@H](C)c3c[nH]c4ncccc34)n2n1
Show InChI InChI=1S/C16H17N7/c1-3-17-13-6-7-14-20-21-16(23(14)22-13)10(2)12-9-19-15-11(12)5-4-8-18-15/h4-10H,3H2,1-2H3,(H,17,22)(H,18,19)/t10-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440903
PNG
(CHEMBL2431833)
Show SMILES C[C@H](c1nnc2ccc(nn12)-c1ccc(nc1)N(C)C)c1ccc2ncccc2c1
Show InChI InChI=1S/C23H21N7/c1-15(16-6-8-19-17(13-16)5-4-12-24-19)23-27-26-22-11-9-20(28-30(22)23)18-7-10-21(25-14-18)29(2)3/h4-15H,1-3H3/t15-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50396971
PNG
(CHEMBL2170953)
Show SMILES Nc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C14H11N7/c15-12-7-17-13-14(18-12)21(20-19-13)8-9-3-4-11-10(6-9)2-1-5-16-11/h1-7H,8H2,(H2,15,18)
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n/an/a 34n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440901
PNG
(CHEMBL2431831)
Show SMILES CCS(=O)(=O)c1ccc(cc1)-c1ccc2nnc([C@@H](C)c3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C24H21N5O2S/c1-3-32(30,31)20-9-6-17(7-10-20)22-12-13-23-26-27-24(29(23)28-22)16(2)18-8-11-21-19(15-18)5-4-14-25-21/h4-16H,3H2,1-2H3/t16-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440890
PNG
(CHEMBL2431841 | US9066954, 341)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H15N7/c1-25-12-15(11-21-25)17-6-7-18-22-23-19(26(18)24-17)10-13-4-5-16-14(9-13)3-2-8-20-16/h2-9,11-12H,10H2,1H3
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n/an/a 44n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440889
PNG
(CHEMBL2431840)
Show SMILES N#Cc1ccc(cc1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C22H14N6/c23-14-15-3-6-17(7-4-15)20-9-10-21-25-26-22(28(21)27-20)13-16-5-8-19-18(12-16)2-1-11-24-19/h1-12H,13H2
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n/an/a 44n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440887
PNG
(CHEMBL2431839)
Show SMILES Fc1ccc(cc1F)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C21H13F2N5/c22-16-5-4-15(12-17(16)23)19-7-8-20-25-26-21(28(20)27-19)11-13-3-6-18-14(10-13)2-1-9-24-18/h1-10,12H,11H2
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n/an/a 48n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440881
PNG
(CHEMBL2431837)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(Cc3c[nH]c4ncccc34)n2n1
Show InChI InChI=1S/C17H14N8/c1-24-10-12(9-20-24)14-4-5-15-21-22-16(25(15)23-14)7-11-8-19-17-13(11)3-2-6-18-17/h2-6,8-10H,7H2,1H3,(H,18,19)
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n/an/a 209n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440892
PNG
(CHEMBL2431821)
Show SMILES CN(C)c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C17H16N6/c1-22(2)16-8-7-15-19-20-17(23(15)21-16)11-12-5-6-14-13(10-12)4-3-9-18-14/h3-10H,11H2,1-2H3
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n/an/a 349n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440886
PNG
(CHEMBL2431818)
Show SMILES Oc1ccc(Cc2nnc3ccc(nn23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C18H13FN4O/c19-14-5-3-13(4-6-14)16-9-10-17-20-21-18(23(17)22-16)11-12-1-7-15(24)8-2-12/h1-10,24H,11H2
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n/an/a 1.31E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440891
PNG
(CHEMBL2431820)
Show SMILES Nc1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C15H12N6/c16-13-5-6-14-18-19-15(21(14)20-13)9-10-3-4-12-11(8-10)2-1-7-17-12/h1-8H,9H2,(H2,16,20)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA


J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%