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PubMed code 24055078

Compile data set for download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bacterial leucyl aminopeptidase


(Vibrio proteolyticus)
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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PubMed
1.60n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of Aeromonas proteolytica leucyl aminopeptidase using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by...


Bioorg Med Chem 21: 6447-55 (2013)


Article DOI: 10.1016/j.bmc.2013.08.044
BindingDB Entry DOI: 10.7270/Q2PR7XF2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bacterial leucyl aminopeptidase


(Vibrio proteolyticus)
BDBM50442434
PNG
(CHEMBL2443111)
Show SMILES N[C@H]1Cc2ccccc2CC(=O)[C@H]1O
Show InChI InChI=1S/C11H13NO2/c12-9-5-7-3-1-2-4-8(7)6-10(13)11(9)14/h1-4,9,11,14H,5-6,12H2/t9-,11-/m0/s1
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10n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of Aeromonas proteolytica leucyl aminopeptidase using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by...


Bioorg Med Chem 21: 6447-55 (2013)


Article DOI: 10.1016/j.bmc.2013.08.044
BindingDB Entry DOI: 10.7270/Q2PR7XF2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50336495
PNG
(7-Amino-5,7,8,9-tetrahydro-benzocyclohepten-6-one,...)
Show SMILES NC1CCc2ccccc2CC1=O
Show InChI InChI=1S/C11H13NO/c12-10-6-5-8-3-1-2-4-9(8)7-11(10)13/h1-4,10H,5-7,12H2
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1.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney APN using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by Dixon plot analysis


Bioorg Med Chem 21: 6447-55 (2013)


Article DOI: 10.1016/j.bmc.2013.08.044
BindingDB Entry DOI: 10.7270/Q2PR7XF2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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3.50E+3n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney APN using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by Dixon plot analysis


Bioorg Med Chem 21: 6447-55 (2013)


Article DOI: 10.1016/j.bmc.2013.08.044
BindingDB Entry DOI: 10.7270/Q2PR7XF2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bacterial leucyl aminopeptidase


(Vibrio proteolyticus)
BDBM50442436
PNG
(CHEMBL2443109)
Show SMILES N[C@H]1Cc2ccccc2C[C@@H](O)C1=O
Show InChI InChI=1S/C11H13NO2/c12-9-5-7-3-1-2-4-8(7)6-10(13)11(9)14/h1-4,9-10,13H,5-6,12H2/t9-,10+/m0/s1
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PubMed
4.00E+3n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of Aeromonas proteolytica leucyl aminopeptidase using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by...


Bioorg Med Chem 21: 6447-55 (2013)


Article DOI: 10.1016/j.bmc.2013.08.044
BindingDB Entry DOI: 10.7270/Q2PR7XF2
More data for this
Ligand-Target Pair
Bacterial leucyl aminopeptidase


(Vibrio proteolyticus)
BDBM50442435
PNG
(CHEMBL2443110)
Show SMILES N[C@H]1Cc2ccccc2C[C@H](O)C1=O
Show InChI InChI=1S/C11H13NO2/c12-9-5-7-3-1-2-4-8(7)6-10(13)11(9)14/h1-4,9-10,13H,5-6,12H2/t9-,10-/m0/s1
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PubMed
2.40E+4n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of Aeromonas proteolytica leucyl aminopeptidase using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by...


Bioorg Med Chem 21: 6447-55 (2013)


Article DOI: 10.1016/j.bmc.2013.08.044
BindingDB Entry DOI: 10.7270/Q2PR7XF2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50442435
PNG
(CHEMBL2443110)
Show SMILES N[C@H]1Cc2ccccc2C[C@H](O)C1=O
Show InChI InChI=1S/C11H13NO2/c12-9-5-7-3-1-2-4-8(7)6-10(13)11(9)14/h1-4,9-10,13H,5-6,12H2/t9-,10-/m0/s1
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4.20E+4n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney APN using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by Dixon plot analysis


Bioorg Med Chem 21: 6447-55 (2013)


Article DOI: 10.1016/j.bmc.2013.08.044
BindingDB Entry DOI: 10.7270/Q2PR7XF2
More data for this
Ligand-Target Pair
Bacterial leucyl aminopeptidase


(Vibrio proteolyticus)
BDBM50442433
PNG
(CHEMBL2443107)
Show SMILES N[C@H]1[C@@H](O)Cc2ccccc2C[C@H]1O
Show InChI InChI=1S/C11H15NO2/c12-11-9(13)5-7-3-1-2-4-8(7)6-10(11)14/h1-4,9-11,13-14H,5-6,12H2/t9-,10+,11-
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7.80E+4n/an/an/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of Aeromonas proteolytica leucyl aminopeptidase using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by...


Bioorg Med Chem 21: 6447-55 (2013)


Article DOI: 10.1016/j.bmc.2013.08.044
BindingDB Entry DOI: 10.7270/Q2PR7XF2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50442436
PNG
(CHEMBL2443109)
Show SMILES N[C@H]1Cc2ccccc2C[C@@H](O)C1=O
Show InChI InChI=1S/C11H13NO2/c12-9-5-7-3-1-2-4-8(7)6-10(13)11(9)14/h1-4,9-10,13H,5-6,12H2/t9-,10+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney APN using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by Dixon plot analysis


Bioorg Med Chem 21: 6447-55 (2013)


Article DOI: 10.1016/j.bmc.2013.08.044
BindingDB Entry DOI: 10.7270/Q2PR7XF2
More data for this
Ligand-Target Pair
Bacterial leucyl aminopeptidase


(Vibrio proteolyticus)
BDBM50336495
PNG
(7-Amino-5,7,8,9-tetrahydro-benzocyclohepten-6-one,...)
Show SMILES NC1CCc2ccccc2CC1=O
Show InChI InChI=1S/C11H13NO/c12-10-6-5-8-3-1-2-4-9(8)7-11(10)13/h1-4,10H,5-7,12H2
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n/an/a 9.00E+5n/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of Aeromonas proteolytica leucyl aminopeptidase using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by...


Bioorg Med Chem 21: 6447-55 (2013)


Article DOI: 10.1016/j.bmc.2013.08.044
BindingDB Entry DOI: 10.7270/Q2PR7XF2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50442432
PNG
(CHEMBL2443108)
Show SMILES N[C@H]1[C@@H](O)Cc2ccccc2CC1=O
Show InChI InChI=1S/C11H13NO2/c12-11-9(13)5-7-3-1-2-4-8(7)6-10(11)14/h1-4,9,11,13H,5-6,12H2/t9-,11-/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney APN using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by Dixon plot analysis


Bioorg Med Chem 21: 6447-55 (2013)


Article DOI: 10.1016/j.bmc.2013.08.044
BindingDB Entry DOI: 10.7270/Q2PR7XF2
More data for this
Ligand-Target Pair
Bacterial leucyl aminopeptidase


(Vibrio proteolyticus)
BDBM50442432
PNG
(CHEMBL2443108)
Show SMILES N[C@H]1[C@@H](O)Cc2ccccc2CC1=O
Show InChI InChI=1S/C11H13NO2/c12-11-9(13)5-7-3-1-2-4-8(7)6-10(11)14/h1-4,9,11,13H,5-6,12H2/t9-,11-/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of Aeromonas proteolytica leucyl aminopeptidase using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by...


Bioorg Med Chem 21: 6447-55 (2013)


Article DOI: 10.1016/j.bmc.2013.08.044
BindingDB Entry DOI: 10.7270/Q2PR7XF2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50442433
PNG
(CHEMBL2443107)
Show SMILES N[C@H]1[C@@H](O)Cc2ccccc2C[C@H]1O
Show InChI InChI=1S/C11H15NO2/c12-11-9(13)5-7-3-1-2-4-8(7)6-10(11)14/h1-4,9-11,13-14H,5-6,12H2/t9-,10+,11-
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n/an/a>1.00E+6n/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney APN using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by Dixon plot analysis


Bioorg Med Chem 21: 6447-55 (2013)


Article DOI: 10.1016/j.bmc.2013.08.044
BindingDB Entry DOI: 10.7270/Q2PR7XF2
More data for this
Ligand-Target Pair
Aminopeptidase N


(Sus scrofa (Pig))
BDBM50442434
PNG
(CHEMBL2443111)
Show SMILES N[C@H]1Cc2ccccc2CC(=O)[C@H]1O
Show InChI InChI=1S/C11H13NO2/c12-9-5-7-3-1-2-4-8(7)6-10(13)11(9)14/h1-4,9,11,14H,5-6,12H2/t9-,11-/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Universit£ de Haute Alsace

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney APN using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by Dixon plot analysis


Bioorg Med Chem 21: 6447-55 (2013)


Article DOI: 10.1016/j.bmc.2013.08.044
BindingDB Entry DOI: 10.7270/Q2PR7XF2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%