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PubMed code 24071445

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442480
PNG
(CHEMBL2440380)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)20-18(25)19(26)21(28-20)17(24)11-23/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19-,20+,21-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442482
PNG
(CHEMBL2440377)
Show SMILES OC[C@@H](O)[C@H]1O[C@H]([C@H](O)[C@H]1O)c1ccc(Cl)c(Cc2ccc(Oc3ccccc3)cc2)c1
Show InChI InChI=1/C25H25ClO6/c26-20-11-8-16(24-22(29)23(30)25(32-24)21(28)14-27)13-17(20)12-15-6-9-19(10-7-15)31-18-4-2-1-3-5-18/h1-11,13,21-25,27-30H,12,14H2/t21-,22-,23-,24+,25-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442475
PNG
(CHEMBL2440366)
Show SMILES CC(C)c1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C23H30O5/c1-13(2)16-8-5-15(6-9-16)10-18-11-17(7-4-14(18)3)22-20(26)21(27)23(28-22)19(25)12-24/h4-9,11,13,19-27H,10,12H2,1-3H3/t19-,20-,21-,22+,23-/s2
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n/an/an/an/a 1.10E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442474
PNG
(CHEMBL2440367)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C22H28O5/c1-3-14-5-7-15(8-6-14)10-17-11-16(9-4-13(17)2)21-19(25)20(26)22(27-21)18(24)12-23/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20-,21+,22-/s2
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n/an/an/an/a 2.50E+3n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442487
PNG
(CHEMBL2440370)
Show SMILES CCc1ccc(Cc2cc([C@@H]3O[C@H]([C@H](O)CO)[C@H](O)[C@H]3O)c(OC)cc2Cl)cc1
Show InChI InChI=1/C22H27ClO6/c1-3-12-4-6-13(7-5-12)8-14-9-15(18(28-2)10-16(14)23)21-19(26)20(27)22(29-21)17(25)11-24/h4-7,9-10,17,19-22,24-27H,3,8,11H2,1-2H3/t17-,19-,20-,21+,22-/s2
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n/an/an/an/a 620n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 77n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50442474
PNG
(CHEMBL2440367)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C22H28O5/c1-3-14-5-7-15(8-6-14)10-17-11-16(9-4-13(17)2)21-19(25)20(26)22(27-21)18(24)12-23/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20-,21+,22-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442481
PNG
(CHEMBL2440379)
Show SMILES OC[C@@H](O)[C@H]1O[C@H]([C@H](O)[C@H]1O)c1ccc(Cl)c(Cc2ccc3OCOc3c2)c1
Show InChI InChI=1/C20H21ClO7/c21-13-3-2-11(19-17(24)18(25)20(28-19)14(23)8-22)7-12(13)5-10-1-4-15-16(6-10)27-9-26-15/h1-4,6-7,14,17-20,22-25H,5,8-9H2/t14-,17-,18-,19+,20-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442485
PNG
(CHEMBL2440372)
Show SMILES COc1cccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)c1
Show InChI InChI=1/C20H23ClO6/c1-26-14-4-2-3-11(8-14)7-13-9-12(5-6-15(13)21)19-17(24)18(25)20(27-19)16(23)10-22/h2-6,8-9,16-20,22-25H,7,10H2,1H3/t16-,17-,18-,19+,20-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442473
PNG
(CHEMBL2440368)
Show SMILES CCOc1ccc(Cc2cc([C@@H]3O[C@H]([C@H](O)CO)[C@H](O)[C@H]3O)c(OC)cc2Cl)cc1
Show InChI InChI=1/C22H27ClO7/c1-3-29-14-6-4-12(5-7-14)8-13-9-15(18(28-2)10-16(13)23)21-19(26)20(27)22(30-21)17(25)11-24/h4-7,9-10,17,19-22,24-27H,3,8,11H2,1-2H3/t17-,19-,20-,21+,22-/s2
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n/an/an/an/a 4.60E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442477
PNG
(CHEMBL2440378)
Show SMILES COc1ccc2cc(Cc3cc(ccc3Cl)[C@@H]3O[C@H]([C@H](O)CO)[C@H](O)[C@H]3O)ccc2c1
Show InChI InChI=1/C24H25ClO6/c1-30-18-6-4-14-8-13(2-3-15(14)11-18)9-17-10-16(5-7-19(17)25)23-21(28)22(29)24(31-23)20(27)12-26/h2-8,10-11,20-24,26-29H,9,12H2,1H3/t20-,21-,22-,23+,24-/s2
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n/an/an/an/a 5.10E+3n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50442473
PNG
(CHEMBL2440368)
Show SMILES CCOc1ccc(Cc2cc([C@@H]3O[C@H]([C@H](O)CO)[C@H](O)[C@H]3O)c(OC)cc2Cl)cc1
Show InChI InChI=1/C22H27ClO7/c1-3-29-14-6-4-12(5-7-14)8-13-9-15(18(28-2)10-16(13)23)21-19(26)20(27)22(30-21)17(25)11-24/h4-7,9-10,17,19-22,24-27H,3,8,11H2,1-2H3/t17-,19-,20-,21+,22-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442483
PNG
(CHEMBL2440375)
Show SMILES OC[C@@H](O)[C@H]1O[C@H]([C@H](O)[C@H]1O)c1ccc(Cl)c(Cc2ccc(F)cc2)c1
Show InChI InChI=1/C19H20ClFO5/c20-14-6-3-11(8-12(14)7-10-1-4-13(21)5-2-10)18-16(24)17(25)19(26-18)15(23)9-22/h1-6,8,15-19,22-25H,7,9H2/t15-,16-,17-,18+,19-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50442472
PNG
(CHEMBL2440369)
Show SMILES COc1cc(Cl)c(Cc2ccc(cc2)C(C)C)cc1[C@@H]1O[C@H]([C@H](O)CO)[C@H](O)[C@H]1O
Show InChI InChI=1/C23H29ClO6/c1-12(2)14-6-4-13(5-7-14)8-15-9-16(19(29-3)10-17(15)24)22-20(27)21(28)23(30-22)18(26)11-25/h4-7,9-10,12,18,20-23,25-28H,8,11H2,1-3H3/t18-,20-,21-,22+,23-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50442477
PNG
(CHEMBL2440378)
Show SMILES COc1ccc2cc(Cc3cc(ccc3Cl)[C@@H]3O[C@H]([C@H](O)CO)[C@H](O)[C@H]3O)ccc2c1
Show InChI InChI=1/C24H25ClO6/c1-30-18-6-4-14-8-13(2-3-15(14)11-18)9-17-10-16(5-7-19(17)25)23-21(28)22(29)24(31-23)20(27)12-26/h2-8,10-11,20-24,26-29H,9,12H2,1H3/t20-,21-,22-,23+,24-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442479
PNG
(CHEMBL2440371)
Show SMILES COc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C20H23ClO6/c1-26-14-5-2-11(3-6-14)8-13-9-12(4-7-15(13)21)19-17(24)18(25)20(27-19)16(23)10-22/h2-7,9,16-20,22-25H,8,10H2,1H3/t16-,17-,18-,19+,20-/s2
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n/an/an/an/a 3.50E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442476
PNG
(CHEMBL2440365)
Show SMILES CCOc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C22H28O6/c1-3-27-17-8-5-14(6-9-17)10-16-11-15(7-4-13(16)2)21-19(25)20(26)22(28-21)18(24)12-23/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20-,21+,22-/s2
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n/an/an/an/a 3.40E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50442487
PNG
(CHEMBL2440370)
Show SMILES CCc1ccc(Cc2cc([C@@H]3O[C@H]([C@H](O)CO)[C@H](O)[C@H]3O)c(OC)cc2Cl)cc1
Show InChI InChI=1/C22H27ClO6/c1-3-12-4-6-13(7-5-12)8-14-9-15(18(28-2)10-16(14)23)21-19(26)20(27)22(29-21)17(25)11-24/h4-7,9-10,17,19-22,24-27H,3,8,11H2,1-2H3/t17-,19-,20-,21+,22-/s2
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n/an/an/an/a 2.90E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442488
PNG
(CHEMBL2440374)
Show SMILES CC(C)(C)c1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C23H29ClO5/c1-23(2,3)16-7-4-13(5-8-16)10-15-11-14(6-9-17(15)24)21-19(27)20(28)22(29-21)18(26)12-25/h4-9,11,18-22,25-28H,10,12H2,1-3H3/t18-,19-,20-,21+,22-/s2
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n/an/an/an/a 2.40E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 120n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50442475
PNG
(CHEMBL2440366)
Show SMILES CC(C)c1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C23H30O5/c1-13(2)16-8-5-15(6-9-16)10-18-11-17(7-4-14(18)3)22-20(26)21(27)23(28-22)19(25)12-24/h4-9,11,13,19-27H,10,12H2,1-3H3/t19-,20-,21-,22+,23-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50442486
PNG
(CHEMBL2440381)
Show SMILES CC(C)c1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C22H27ClO5/c1-12(2)14-5-3-13(4-6-14)9-16-10-15(7-8-17(16)23)21-19(26)20(27)22(28-21)18(25)11-24/h3-8,10,12,18-22,24-27H,9,11H2,1-2H3/t18-,19-,20-,21+,22-/s2
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n/an/an/an/a 4.70E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442472
PNG
(CHEMBL2440369)
Show SMILES COc1cc(Cl)c(Cc2ccc(cc2)C(C)C)cc1[C@@H]1O[C@H]([C@H](O)CO)[C@H](O)[C@H]1O
Show InChI InChI=1/C23H29ClO6/c1-12(2)14-6-4-13(5-7-14)8-15-9-16(19(29-3)10-17(15)24)22-20(27)21(28)23(30-22)18(26)11-25/h4-7,9-10,12,18,20-23,25-28H,8,11H2,1-3H3/t18-,20-,21-,22+,23-/s2
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n/an/an/an/a 2.10E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50442478
PNG
(CHEMBL2440376)
Show SMILES CSc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C20H23ClO5S/c1-27-14-5-2-11(3-6-14)8-13-9-12(4-7-15(13)21)19-17(24)18(25)20(26-19)16(23)10-22/h2-7,9,16-20,22-25H,8,10H2,1H3/t16-,17-,18-,19+,20-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442484
PNG
(CHEMBL2440373)
Show SMILES COc1ccccc1Cc1cc(ccc1Cl)[C@@H]1O[C@H]([C@H](O)CO)[C@H](O)[C@H]1O
Show InChI InChI=1/C20H23ClO6/c1-26-16-5-3-2-4-11(16)8-13-9-12(6-7-14(13)21)19-17(24)18(25)20(27-19)15(23)10-22/h2-7,9,15,17-20,22-25H,8,10H2,1H3/t15-,17-,18-,19+,20-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50442488
PNG
(CHEMBL2440374)
Show SMILES CC(C)(C)c1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C23H29ClO5/c1-23(2,3)16-7-4-13(5-8-16)10-15-11-14(6-9-17(15)24)21-19(27)20(28)22(29-21)18(26)12-25/h4-9,11,18-22,25-28H,10,12H2,1-3H3/t18-,19-,20-,21+,22-/s2
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n/an/an/an/a 2.40E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442478
PNG
(CHEMBL2440376)
Show SMILES CSc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C20H23ClO5S/c1-27-14-5-2-11(3-6-14)8-13-9-12(4-7-15(13)21)19-17(24)18(25)20(26-19)16(23)10-22/h2-7,9,16-20,22-25H,8,10H2,1H3/t16-,17-,18-,19+,20-/s2
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n/an/an/an/a 3.70E+3n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50442476
PNG
(CHEMBL2440365)
Show SMILES CCOc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C22H28O6/c1-3-27-17-8-5-14(6-9-17)10-16-11-15(7-4-13(16)2)21-19(25)20(26)22(28-21)18(24)12-23/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20-,21+,22-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50442479
PNG
(CHEMBL2440371)
Show SMILES COc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C20H23ClO6/c1-26-14-5-2-11(3-6-14)8-13-9-12(4-7-15(13)21)19-17(24)18(25)20(27-19)16(23)10-22/h2-7,9,16-20,22-25H,8,10H2,1H3/t16-,17-,18-,19+,20-/s2
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442486
PNG
(CHEMBL2440381)
Show SMILES CC(C)c1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1/C22H27ClO5/c1-12(2)14-5-3-13(4-6-14)9-16-10-15(7-8-17(16)23)21-19(26)20(27)22(28-21)18(25)11-24/h3-8,10,12,18-22,24-27H,9,11H2,1-2H3/t18-,19-,20-,21+,22-/s2
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n/an/an/an/a 3.30E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%