Compile Data Set for Download or QSAR
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Found 9 Enz. Inhib. hit(s) with all data for entry = 50043727
TargetMuscarinic acetylcholine receptor M5(RAT)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50445222(CHEMBL3105228)
Affinity DataIC50:  790nMAssay Description:Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(RAT)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50445224(CHEMBL3105213)
Affinity DataIC50:  1.10E+3nMAssay Description:Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(RAT)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50445223(CHEMBL3105208)
Affinity DataIC50:  2.10E+3nMAssay Description:Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(RAT)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50445225(CHEMBL1459098)
Affinity DataIC50:  5.67E+3nMAssay Description:Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50445222(CHEMBL3105228)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 15 mins followed by NADPH addition measured after 8 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50445222(CHEMBL3105228)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 15 mins followed by NADPH addition measured after 8 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50445222(CHEMBL3105228)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 15 mins followed by NADPH addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(RAT)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50445222(CHEMBL3105228)
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of rat muscarinic acetylcholine receptor M4 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(RAT)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50445223(CHEMBL3105208)
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of rat muscarinic acetylcholine receptor M4 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed