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Found 13 Enz. Inhib. hit(s) with all data for entry = 50043752
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50445691(CHEMBL243677)
Affinity DataKi:  1.80E+4nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7461(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...)
Affinity DataKi:  1.94E+4nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50157555(2-(3,4-dihydroxyphenyl)-4H-chromen-4-one | 3',4'-d...)
Affinity DataKi:  8.45E+4nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50445690(CHEMBL457821)
Affinity DataKi:  9.54E+4nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50312650(5,4'-dihydroxyflavone | 5-hydroxy-2-(4-hydroxyphen...)
Affinity DataKi:  1.03E+5nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataKi:  1.07E+5nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataKi:  1.22E+5nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7458(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataKi:  1.78E+5nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50157555(2-(3,4-dihydroxyphenyl)-4H-chromen-4-one | 3',4'-d...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50077325(2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one |...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM50445691(CHEMBL243677)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed