BindingDB logo
myBDB logout

PubMed code 24412111

Compile data set for download or QSAR
Found 70 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447475
PNG
(CHEMBL3115390)
Show SMILES Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(ccc4[C@H]3CC(O)=O)C(F)(F)F)c2)cn1
Show InChI InChI=1S/C25H23F3N4O4/c1-15-5-6-18(14-30-15)36-17-4-2-3-16(11-17)12-22(33)32-10-9-29-24-19(20(32)13-23(34)35)7-8-21(31-24)25(26,27)28/h2-8,11,14,20H,9-10,12-13H2,1H3,(H,29,31)(H,34,35)/t20-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.5n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447481
PNG
(CHEMBL3115384)
Show SMILES OCCC1N(CCNc2nc(ccc12)C(F)(F)F)C(=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C25H24F3N3O3/c26-25(27,28)22-10-9-20-21(11-14-32)31(13-12-29-24(20)30-22)23(33)16-17-5-4-8-19(15-17)34-18-6-2-1-3-7-18/h1-10,15,21,32H,11-14,16H2,(H,29,30)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447490
PNG
(CHEMBL3115375)
Show SMILES CCOc1cccc(CC(=O)N2CCNc3nc(ccc3C2)C(F)(F)F)c1
Show InChI InChI=1S/C19H20F3N3O2/c1-2-27-15-5-3-4-13(10-15)11-17(26)25-9-8-23-18-14(12-25)6-7-16(24-18)19(20,21)22/h3-7,10H,2,8-9,11-12H2,1H3,(H,23,24)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.21E+3n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447496
PNG
(CHEMBL3115400)
Show SMILES Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(ccc4C3)C(F)(F)F)c2)cc1
Show InChI InChI=1S/C24H22F3N3O2/c1-16-5-8-19(9-6-16)32-20-4-2-3-17(13-20)14-22(31)30-12-11-28-23-18(15-30)7-10-21(29-23)24(25,26)27/h2-10,13H,11-12,14-15H2,1H3,(H,28,29)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447497
PNG
(CHEMBL3115399)
Show SMILES Fc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(ccc4C3)C(F)(F)F)c2)cc1
Show InChI InChI=1S/C23H19F4N3O2/c24-17-5-7-18(8-6-17)32-19-3-1-2-15(12-19)13-21(31)30-11-10-28-22-16(14-30)4-9-20(29-22)23(25,26)27/h1-9,12H,10-11,13-14H2,(H,28,29)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.70n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447501
PNG
(CHEMBL3115395)
Show SMILES FC(F)(F)c1ccc2CN(CCNc2n1)C(=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C23H20F3N3O2/c24-23(25,26)20-10-9-17-15-29(12-11-27-22(17)28-20)21(30)14-16-5-4-8-19(13-16)31-18-6-2-1-3-7-18/h1-10,13H,11-12,14-15H2,(H,27,28)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 12n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447504
PNG
(CHEMBL3115392)
Show SMILES CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(nc3Nc3ccccc23)C(F)(F)F)cc1
Show InChI InChI=1S/C25H24F3N3O/c1-24(2,3)18-11-8-16(9-12-18)14-22(32)31-15-17-10-13-21(25(26,27)28)30-23(17)29-19-6-4-5-7-20(19)31/h4-13H,14-15H2,1-3H3,(H,29,30)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 227n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447487
PNG
(CHEMBL3115378)
Show SMILES CC(C)COc1cccc(CC(=O)N2CCNc3nc(ccc3C2)C(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N3O2/c1-14(2)13-29-17-5-3-4-15(10-17)11-19(28)27-9-8-25-20-16(12-27)6-7-18(26-20)21(22,23)24/h3-7,10,14H,8-9,11-13H2,1-2H3,(H,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 70n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447488
PNG
(CHEMBL3115377)
Show SMILES CCCCOc1cccc(CC(=O)N2CCNc3nc(ccc3C2)C(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N3O2/c1-2-3-11-29-17-6-4-5-15(12-17)13-19(28)27-10-9-25-20-16(14-27)7-8-18(26-20)21(22,23)24/h4-8,12H,2-3,9-11,13-14H2,1H3,(H,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 59n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447495
PNG
(CHEMBL3115401)
Show SMILES FC(F)(F)c1ccc2CN(CCNc2n1)C(=O)Cc1cccc(Oc2ccccn2)c1
Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)18-8-7-16-14-29(11-10-27-21(16)28-18)20(30)13-15-4-3-5-17(12-15)31-19-6-1-2-9-26-19/h1-9,12H,10-11,13-14H2,(H,27,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 254n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447473
PNG
(CHEMBL3115369)
Show SMILES CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H36N4O2/c1-23(2)29-22-33(20-24-9-4-3-5-10-24)28-14-7-6-11-25(28)21-34(29)30(35)31-26-12-8-13-27(19-26)32-15-17-36-18-16-32/h3-14,19,23,29H,15-18,20-22H2,1-2H3,(H,31,35)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 34n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447483
PNG
(CHEMBL3115382)
Show SMILES OCC1N(CCNc2nc(ccc12)C(F)(F)F)C(=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C24H22F3N3O3/c25-24(26,27)21-10-9-19-20(15-31)30(12-11-28-23(19)29-21)22(32)14-16-5-4-8-18(13-16)33-17-6-2-1-3-7-17/h1-10,13,20,31H,11-12,14-15H2,(H,28,29)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 19n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447484
PNG
(CHEMBL3115381)
Show SMILES FC(F)(F)c1ccc2CN(CCNc2n1)C(=O)Cc1cccc(OC2CCCCC2)c1
Show InChI InChI=1S/C23H26F3N3O2/c24-23(25,26)20-10-9-17-15-29(12-11-27-22(17)28-20)21(30)14-16-5-4-8-19(13-16)31-18-6-2-1-3-7-18/h4-5,8-10,13,18H,1-3,6-7,11-12,14-15H2,(H,27,28)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 8.70n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447485
PNG
(CHEMBL3115380)
Show SMILES FC(F)(F)c1ccc2CN(CCNc2n1)C(=O)Cc1cccc(OC2CCCC2)c1
Show InChI InChI=1S/C22H24F3N3O2/c23-22(24,25)19-9-8-16-14-28(11-10-26-21(16)27-19)20(29)13-15-4-3-7-18(12-15)30-17-5-1-2-6-17/h3-4,7-9,12,17H,1-2,5-6,10-11,13-14H2,(H,26,27)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 100n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447491
PNG
(CHEMBL3115374)
Show SMILES COc1cccc(CC(=O)N2CCNc3nc(ccc3C2)C(F)(F)F)c1
Show InChI InChI=1S/C18H18F3N3O2/c1-26-14-4-2-3-12(9-14)10-16(25)24-8-7-22-17-13(11-24)5-6-15(23-17)18(19,20)21/h2-6,9H,7-8,10-11H2,1H3,(H,22,23)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.78E+3n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447500
PNG
(CHEMBL3115396)
Show SMILES FC(F)(F)c1ccc2CN(CCNc2n1)C(=O)Nc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)19-10-9-15-14-29(12-11-26-20(15)28-19)21(30)27-16-5-4-8-18(13-16)31-17-6-2-1-3-7-17/h1-10,13H,11-12,14H2,(H,26,28)(H,27,30)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.38E+3n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447502
PNG
(CHEMBL3115394)
Show SMILES FC(F)(F)c1ccc2CN(C(=O)Cc3cccc(Oc4ccccc4)c3)c3ccccc3Nc2n1
Show InChI InChI=1S/C27H20F3N3O2/c28-27(29,30)24-14-13-19-17-33(23-12-5-4-11-22(23)31-26(19)32-24)25(34)16-18-7-6-10-21(15-18)35-20-8-2-1-3-9-20/h1-15H,16-17H2,(H,31,32)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 46n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447503
PNG
(CHEMBL3115393)
Show SMILES FC(F)(F)c1ccc2CN(C(=O)Cc3ccc(Oc4ccccc4)cc3)c3ccccc3Nc2n1
Show InChI InChI=1S/C27H20F3N3O2/c28-27(29,30)24-15-12-19-17-33(23-9-5-4-8-22(23)31-26(19)32-24)25(34)16-18-10-13-21(14-11-18)35-20-6-2-1-3-7-20/h1-15H,16-17H2,(H,31,32)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50394618
PNG
(CHEMBL2164575)
Show SMILES Cc1ccc2Nc3nc(ccc3CN(c2c1C)S(=O)(=O)c1ccc(cc1)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C25H26F3N3O2S/c1-15-6-12-20-22(16(15)2)31(14-17-7-13-21(25(26,27)28)30-23(17)29-20)34(32,33)19-10-8-18(9-11-19)24(3,4)5/h6-13H,14H2,1-5H3,(H,29,30)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 33n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447478
PNG
(CHEMBL3115387)
Show SMILES OC(=O)C[C@@H]1N(CCNc2nc(ccc12)C(F)(F)F)C(=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C25H22F3N3O4/c26-25(27,28)21-10-9-19-20(15-23(33)34)31(12-11-29-24(19)30-21)22(32)14-16-5-4-8-18(13-16)35-17-6-2-1-3-7-17/h1-10,13,20H,11-12,14-15H2,(H,29,30)(H,33,34)/t20-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.07E+3n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447479
PNG
(CHEMBL3115386)
Show SMILES OC(=O)C[C@H]1N(CCNc2nc(ccc12)C(F)(F)F)C(=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C25H22F3N3O4/c26-25(27,28)21-10-9-19-20(15-23(33)34)31(12-11-29-24(19)30-21)22(32)14-16-5-4-8-18(13-16)35-17-6-2-1-3-7-17/h1-10,13,20H,11-12,14-15H2,(H,29,30)(H,33,34)/t20-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.60n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447486
PNG
(CHEMBL3115379)
Show SMILES CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(ccc3C2)C(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N3O2/c1-21(2,3)14-30-17-6-4-5-15(11-17)12-19(29)28-10-9-26-20-16(13-28)7-8-18(27-20)22(23,24)25/h4-8,11H,9-10,12-14H2,1-3H3,(H,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 199n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447503
PNG
(CHEMBL3115393)
Show SMILES FC(F)(F)c1ccc2CN(C(=O)Cc3ccc(Oc4ccccc4)cc3)c3ccccc3Nc2n1
Show InChI InChI=1S/C27H20F3N3O2/c28-27(29,30)24-15-12-19-17-33(23-9-5-4-8-22(23)31-26(19)32-24)25(34)16-18-10-13-21(14-11-18)35-20-6-2-1-3-7-20/h1-15H,16-17H2,(H,31,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 368n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447479
PNG
(CHEMBL3115386)
Show SMILES OC(=O)C[C@H]1N(CCNc2nc(ccc12)C(F)(F)F)C(=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C25H22F3N3O4/c26-25(27,28)21-10-9-19-20(15-23(33)34)31(12-11-29-24(19)30-21)22(32)14-16-5-4-8-18(13-16)35-17-6-2-1-3-7-17/h1-10,13,20H,11-12,14-15H2,(H,29,30)(H,33,34)/t20-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.40n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447488
PNG
(CHEMBL3115377)
Show SMILES CCCCOc1cccc(CC(=O)N2CCNc3nc(ccc3C2)C(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N3O2/c1-2-3-11-29-17-6-4-5-15(12-17)13-19(28)27-10-9-25-20-16(14-27)7-8-18(26-20)21(22,23)24/h4-8,12H,2-3,9-11,13-14H2,1H3,(H,25,26)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 52n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447493
PNG
(CHEMBL3115372)
Show SMILES FC(F)(F)c1ccc2CN(CCNc2n1)C(=O)Cc1cccc(Oc2ccncc2)c1
Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)19-5-4-16-14-29(11-10-27-21(16)28-19)20(30)13-15-2-1-3-18(12-15)31-17-6-8-26-9-7-17/h1-9,12H,10-11,13-14H2,(H,27,28)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 621n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447499
PNG
(CHEMBL3115397)
Show SMILES Fc1ccccc1Oc1cccc(CC(=O)N2CCNc3nc(ccc3C2)C(F)(F)F)c1
Show InChI InChI=1S/C23H19F4N3O2/c24-18-6-1-2-7-19(18)32-17-5-3-4-15(12-17)13-21(31)30-11-10-28-22-16(14-30)8-9-20(29-22)23(25,26)27/h1-9,12H,10-11,13-14H2,(H,28,29)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.5n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447485
PNG
(CHEMBL3115380)
Show SMILES FC(F)(F)c1ccc2CN(CCNc2n1)C(=O)Cc1cccc(OC2CCCC2)c1
Show InChI InChI=1S/C22H24F3N3O2/c23-22(24,25)19-9-8-16-14-28(11-10-26-21(16)27-19)20(29)13-15-4-3-7-18(12-15)30-17-5-1-2-6-17/h3-4,7-9,12,17H,1-2,5-6,10-11,13-14H2,(H,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 41n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447493
PNG
(CHEMBL3115372)
Show SMILES FC(F)(F)c1ccc2CN(CCNc2n1)C(=O)Cc1cccc(Oc2ccncc2)c1
Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)19-5-4-16-14-29(11-10-27-21(16)28-19)20(30)13-15-2-1-3-18(12-15)31-17-6-8-26-9-7-17/h1-9,12H,10-11,13-14H2,(H,27,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 977n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447497
PNG
(CHEMBL3115399)
Show SMILES Fc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(ccc4C3)C(F)(F)F)c2)cc1
Show InChI InChI=1S/C23H19F4N3O2/c24-17-5-7-18(8-6-17)32-19-3-1-2-15(12-19)13-21(31)30-11-10-28-22-16(14-30)4-9-20(29-22)23(25,26)27/h1-9,12H,10-11,13-14H2,(H,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.60n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447501
PNG
(CHEMBL3115395)
Show SMILES FC(F)(F)c1ccc2CN(CCNc2n1)C(=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C23H20F3N3O2/c24-23(25,26)20-10-9-17-15-29(12-11-27-22(17)28-20)21(30)14-16-5-4-8-19(13-16)31-18-6-2-1-3-7-18/h1-10,13H,11-12,14-15H2,(H,27,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 8.5n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447505
PNG
(CHEMBL3115391)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)N1Cc2ccc(nc2Nc2ccccc12)C(F)(F)F
Show InChI InChI=1S/C24H22F3N3O/c1-23(2,3)17-11-8-15(9-12-17)22(31)30-14-16-10-13-20(24(25,26)27)29-21(16)28-18-6-4-5-7-19(18)30/h4-13H,14H2,1-3H3,(H,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50381914
PNG
(CHEMBL2023109 | MK-7725)
Show SMILES CC(C)(O)c1nc(no1)-c1cccc2Nc3nc(ccc3CN(c12)S(=O)(=O)c1ccc(OC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C25H19F6N5O5S/c1-23(2,37)22-34-21(35-41-22)16-4-3-5-17-19(16)36(12-13-6-11-18(24(26,27)28)33-20(13)32-17)42(38,39)15-9-7-14(8-10-15)40-25(29,30)31/h3-11,37H,12H2,1-2H3,(H,32,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.40n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447480
PNG
(CHEMBL3115385)
Show SMILES OC(=O)CC1N(CCNc2nc(ccc12)C(F)(F)F)C(=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C25H22F3N3O4/c26-25(27,28)21-10-9-19-20(15-23(33)34)31(12-11-29-24(19)30-21)22(32)14-16-5-4-8-18(13-16)35-17-6-2-1-3-7-17/h1-10,13,20H,11-12,14-15H2,(H,29,30)(H,33,34)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 15n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447486
PNG
(CHEMBL3115379)
Show SMILES CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(ccc3C2)C(F)(F)F)c1
Show InChI InChI=1S/C22H26F3N3O2/c1-21(2,3)14-30-17-6-4-5-15(11-17)12-19(29)28-10-9-26-20-16(13-28)7-8-18(27-20)22(23,24)25/h4-8,11H,9-10,12-14H2,1-3H3,(H,26,27)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 121n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447487
PNG
(CHEMBL3115378)
Show SMILES CC(C)COc1cccc(CC(=O)N2CCNc3nc(ccc3C2)C(F)(F)F)c1
Show InChI InChI=1S/C21H24F3N3O2/c1-14(2)13-29-17-5-3-4-15(10-17)11-19(28)27-9-8-25-20-16(12-27)6-7-18(26-20)21(22,23)24/h3-7,10,14H,8-9,11-13H2,1-2H3,(H,25,26)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 62n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447489
PNG
(CHEMBL3115376)
Show SMILES CC(C)Oc1cccc(CC(=O)N2CCNc3nc(ccc3C2)C(F)(F)F)c1
Show InChI InChI=1S/C20H22F3N3O2/c1-13(2)28-16-5-3-4-14(10-16)11-18(27)26-9-8-24-19-15(12-26)6-7-17(25-19)20(21,22)23/h3-7,10,13H,8-9,11-12H2,1-2H3,(H,24,25)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 569n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447492
PNG
(CHEMBL3115373)
Show SMILES Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(ccc4C3)C(F)(F)F)c2)cn1
Show InChI InChI=1S/C23H21F3N4O2/c1-15-5-7-19(13-28-15)32-18-4-2-3-16(11-18)12-21(31)30-10-9-27-22-17(14-30)6-8-20(29-22)23(24,25)26/h2-8,11,13H,9-10,12,14H2,1H3,(H,27,29)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.80n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447476
PNG
(CHEMBL3115389)
Show SMILES CC(C)COc1cccc(CC(=O)N2CCNc3nc(ccc3[C@H]2CC(O)=O)C(F)(F)F)c1
Show InChI InChI=1S/C23H26F3N3O4/c1-14(2)13-33-16-5-3-4-15(10-16)11-20(30)29-9-8-27-22-17(18(29)12-21(31)32)6-7-19(28-22)23(24,25)26/h3-7,10,14,18H,8-9,11-13H2,1-2H3,(H,27,28)(H,31,32)/t18-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 17n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447483
PNG
(CHEMBL3115382)
Show SMILES OCC1N(CCNc2nc(ccc12)C(F)(F)F)C(=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C24H22F3N3O3/c25-24(26,27)21-10-9-19-20(15-31)30(12-11-28-23(19)29-21)22(32)14-16-5-4-8-18(13-16)33-17-6-2-1-3-7-17/h1-10,13,20,31H,11-12,14-15H2,(H,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 12n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447490
PNG
(CHEMBL3115375)
Show SMILES CCOc1cccc(CC(=O)N2CCNc3nc(ccc3C2)C(F)(F)F)c1
Show InChI InChI=1S/C19H20F3N3O2/c1-2-27-15-5-3-4-13(10-15)11-17(26)25-9-8-23-18-14(12-25)6-7-16(24-18)19(20,21)22/h3-7,10H,2,8-9,11-12H2,1H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.05E+3n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447499
PNG
(CHEMBL3115397)
Show SMILES Fc1ccccc1Oc1cccc(CC(=O)N2CCNc3nc(ccc3C2)C(F)(F)F)c1
Show InChI InChI=1S/C23H19F4N3O2/c24-18-6-1-2-7-19(18)32-17-5-3-4-15(12-17)13-21(31)30-11-10-28-22-16(14-30)8-9-20(29-22)23(25,26)27/h1-9,12H,10-11,13-14H2,(H,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.90n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50394618
PNG
(CHEMBL2164575)
Show SMILES Cc1ccc2Nc3nc(ccc3CN(c2c1C)S(=O)(=O)c1ccc(cc1)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C25H26F3N3O2S/c1-15-6-12-20-22(16(15)2)31(14-17-7-13-21(25(26,27)28)30-23(17)29-20)34(32,33)19-10-8-18(9-11-19)24(3,4)5/h6-13H,14H2,1-5H3,(H,29,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 97n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50381914
PNG
(CHEMBL2023109 | MK-7725)
Show SMILES CC(C)(O)c1nc(no1)-c1cccc2Nc3nc(ccc3CN(c12)S(=O)(=O)c1ccc(OC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C25H19F6N5O5S/c1-23(2,37)22-34-21(35-41-22)16-4-3-5-17-19(16)36(12-13-6-11-18(24(26,27)28)33-20(13)32-17)42(38,39)15-9-7-14(8-10-15)40-25(29,30)31/h3-11,37H,12H2,1-2H3,(H,32,33)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 22n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447477
PNG
(CHEMBL3115388)
Show SMILES OC(=O)C[C@H]1N(CCNc2nc(ccc12)C(F)(F)F)C(=O)Cc1cccc(Oc2ccc(F)cc2)c1
Show InChI InChI=1S/C25H21F4N3O4/c26-16-4-6-17(7-5-16)36-18-3-1-2-15(12-18)13-22(33)32-11-10-30-24-19(20(32)14-23(34)35)8-9-21(31-24)25(27,28)29/h1-9,12,20H,10-11,13-14H2,(H,30,31)(H,34,35)/t20-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.70n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447477
PNG
(CHEMBL3115388)
Show SMILES OC(=O)C[C@H]1N(CCNc2nc(ccc12)C(F)(F)F)C(=O)Cc1cccc(Oc2ccc(F)cc2)c1
Show InChI InChI=1S/C25H21F4N3O4/c26-16-4-6-17(7-5-16)36-18-3-1-2-15(12-18)13-22(33)32-11-10-30-24-19(20(32)14-23(34)35)8-9-21(31-24)25(27,28)29/h1-9,12,20H,10-11,13-14H2,(H,30,31)(H,34,35)/t20-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.70n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447491
PNG
(CHEMBL3115374)
Show SMILES COc1cccc(CC(=O)N2CCNc3nc(ccc3C2)C(F)(F)F)c1
Show InChI InChI=1S/C18H18F3N3O2/c1-26-14-4-2-3-12(9-14)10-16(25)24-8-7-22-17-13(11-24)5-6-15(23-17)18(19,20)21/h2-6,9H,7-8,10-11H2,1H3,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.04E+3n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447494
PNG
(CHEMBL3115371)
Show SMILES FC(F)(F)c1ccc2CN(CCNc2n1)C(=O)Cc1cccc(Oc2cccnc2)c1
Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)19-7-6-16-14-29(10-9-27-21(16)28-19)20(30)12-15-3-1-4-17(11-15)31-18-5-2-8-26-13-18/h1-8,11,13H,9-10,12,14H2,(H,27,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 156n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447474
PNG
(CHEMBL3115370)
Show SMILES CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(C)=O
Show InChI InChI=1S/C21H26N2O/c1-16(2)21-15-22(13-18-9-5-4-6-10-18)20-12-8-7-11-19(20)14-23(21)17(3)24/h4-12,16,21H,13-15H2,1-3H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 256n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447474
PNG
(CHEMBL3115370)
Show SMILES CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(C)=O
Show InChI InChI=1S/C21H26N2O/c1-16(2)21-15-22(13-18-9-5-4-6-10-18)20-12-8-7-11-19(20)14-23(21)17(3)24/h4-12,16,21H,13-15H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 916n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447478
PNG
(CHEMBL3115387)
Show SMILES OC(=O)C[C@@H]1N(CCNc2nc(ccc12)C(F)(F)F)C(=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C25H22F3N3O4/c26-25(27,28)21-10-9-19-20(15-23(33)34)31(12-11-29-24(19)30-21)22(32)14-16-5-4-8-18(13-16)35-17-6-2-1-3-7-17/h1-10,13,20H,11-12,14-15H2,(H,29,30)(H,33,34)/t20-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.12E+3n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447498
PNG
(CHEMBL3115398)
Show SMILES Fc1cccc(Oc2cccc(CC(=O)N3CCNc4nc(ccc4C3)C(F)(F)F)c2)c1
Show InChI InChI=1S/C23H19F4N3O2/c24-17-4-2-6-19(13-17)32-18-5-1-3-15(11-18)12-21(31)30-10-9-28-22-16(14-30)7-8-20(29-22)23(25,26)27/h1-8,11,13H,9-10,12,14H2,(H,28,29)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 8.70n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447482
PNG
(CHEMBL3115383)
Show SMILES OC(=O)C1N(CCNc2nc(ccc12)C(F)(F)F)C(=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C24H20F3N3O4/c25-24(26,27)19-10-9-18-21(23(32)33)30(12-11-28-22(18)29-19)20(31)14-15-5-4-8-17(13-15)34-16-6-2-1-3-7-16/h1-10,13,21H,11-12,14H2,(H,28,29)(H,32,33)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.56E+3n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447484
PNG
(CHEMBL3115381)
Show SMILES FC(F)(F)c1ccc2CN(CCNc2n1)C(=O)Cc1cccc(OC2CCCCC2)c1
Show InChI InChI=1S/C23H26F3N3O2/c24-23(25,26)20-10-9-17-15-29(12-11-27-22(17)28-20)21(30)14-16-5-4-8-19(13-16)31-18-6-2-1-3-7-18/h4-5,8-10,13,18H,1-3,6-7,11-12,14-15H2,(H,27,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 8.10n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447492
PNG
(CHEMBL3115373)
Show SMILES Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(ccc4C3)C(F)(F)F)c2)cn1
Show InChI InChI=1S/C23H21F3N4O2/c1-15-5-7-19(13-28-15)32-18-4-2-3-16(11-18)12-21(31)30-10-9-27-22-17(14-30)6-8-20(29-22)23(24,25)26/h2-8,11,13H,9-10,12,14H2,1H3,(H,27,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 9.5n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447500
PNG
(CHEMBL3115396)
Show SMILES FC(F)(F)c1ccc2CN(CCNc2n1)C(=O)Nc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)19-10-9-15-14-29(12-11-26-20(15)28-19)21(30)27-16-5-4-8-18(13-16)31-17-6-2-1-3-7-17/h1-10,13H,11-12,14H2,(H,26,28)(H,27,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 4.38E+3n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447504
PNG
(CHEMBL3115392)
Show SMILES CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(nc3Nc3ccccc23)C(F)(F)F)cc1
Show InChI InChI=1S/C25H24F3N3O/c1-24(2,3)18-11-8-16(9-12-18)14-22(32)31-15-17-10-13-21(25(26,27)28)30-23(17)29-19-6-4-5-7-20(19)31/h4-13H,14-15H2,1-3H3,(H,29,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 48n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447494
PNG
(CHEMBL3115371)
Show SMILES FC(F)(F)c1ccc2CN(CCNc2n1)C(=O)Cc1cccc(Oc2cccnc2)c1
Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)19-7-6-16-14-29(10-9-27-21(16)28-19)20(30)12-15-3-1-4-17(11-15)31-18-5-2-8-26-13-18/h1-8,11,13H,9-10,12,14H2,(H,27,28)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 106n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447495
PNG
(CHEMBL3115401)
Show SMILES FC(F)(F)c1ccc2CN(CCNc2n1)C(=O)Cc1cccc(Oc2ccccn2)c1
Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)18-8-7-16-14-29(11-10-27-21(16)28-18)20(30)13-15-4-3-5-17(12-15)31-19-6-1-2-9-26-19/h1-9,12H,10-11,13-14H2,(H,27,28)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 244n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447505
PNG
(CHEMBL3115391)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)N1Cc2ccc(nc2Nc2ccccc12)C(F)(F)F
Show InChI InChI=1S/C24H22F3N3O/c1-23(2,3)17-11-8-15(9-12-17)22(31)30-14-16-10-13-20(24(25,26)27)29-21(16)28-18-6-4-5-7-19(18)30/h4-13H,14H2,1-3H3,(H,28,29)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447475
PNG
(CHEMBL3115390)
Show SMILES Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(ccc4[C@H]3CC(O)=O)C(F)(F)F)c2)cn1
Show InChI InChI=1S/C25H23F3N4O4/c1-15-5-6-18(14-30-15)36-17-4-2-3-16(11-17)12-22(33)32-10-9-29-24-19(20(32)13-23(34)35)7-8-21(31-24)25(26,27)28/h2-8,11,14,20H,9-10,12-13H2,1H3,(H,29,31)(H,34,35)/t20-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.70n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447481
PNG
(CHEMBL3115384)
Show SMILES OCCC1N(CCNc2nc(ccc12)C(F)(F)F)C(=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C25H24F3N3O3/c26-25(27,28)22-10-9-20-21(11-14-32)31(13-12-29-24(20)30-22)23(33)16-17-5-4-8-19(15-17)34-18-6-2-1-3-7-18/h1-10,15,21,32H,11-14,16H2,(H,29,30)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447489
PNG
(CHEMBL3115376)
Show SMILES CC(C)Oc1cccc(CC(=O)N2CCNc3nc(ccc3C2)C(F)(F)F)c1
Show InChI InChI=1S/C20H22F3N3O2/c1-13(2)28-16-5-3-4-14(10-16)11-18(27)26-9-8-24-19-15(12-26)6-7-17(25-19)20(21,22)23/h3-7,10,13H,8-9,11-12H2,1-2H3,(H,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 381n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447496
PNG
(CHEMBL3115400)
Show SMILES Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(ccc4C3)C(F)(F)F)c2)cc1
Show InChI InChI=1S/C24H22F3N3O2/c1-16-5-8-19(9-6-16)32-20-4-2-3-17(13-20)14-22(31)30-12-11-28-23-18(15-30)7-10-21(29-23)24(25,26)27/h2-10,13H,11-12,14-15H2,1H3,(H,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.30n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447473
PNG
(CHEMBL3115369)
Show SMILES CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C30H36N4O2/c1-23(2)29-22-33(20-24-9-4-3-5-10-24)28-14-7-6-11-25(28)21-34(29)30(35)31-26-12-8-13-27(19-26)32-15-17-36-18-16-32/h3-14,19,23,29H,15-18,20-22H2,1-2H3,(H,31,35)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 131n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447476
PNG
(CHEMBL3115389)
Show SMILES CC(C)COc1cccc(CC(=O)N2CCNc3nc(ccc3[C@H]2CC(O)=O)C(F)(F)F)c1
Show InChI InChI=1S/C23H26F3N3O4/c1-14(2)13-33-16-5-3-4-15(10-16)11-20(30)29-9-8-27-22-17(18(29)12-21(31)32)6-7-19(28-22)23(24,25)26/h3-7,10,14,18H,8-9,11-13H2,1-2H3,(H,27,28)(H,31,32)/t18-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 62n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
Bombesin receptor subtype-3


(Mus musculus)
BDBM50447482
PNG
(CHEMBL3115383)
Show SMILES OC(=O)C1N(CCNc2nc(ccc12)C(F)(F)F)C(=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C24H20F3N3O4/c25-24(26,27)19-10-9-18-21(23(32)33)30(12-11-28-22(18)29-19)20(31)14-15-5-4-8-17(13-15)34-16-6-2-1-3-7-16/h1-10,13,21H,11-12,14H2,(H,28,29)(H,32,33)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2.26E+3n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447480
PNG
(CHEMBL3115385)
Show SMILES OC(=O)CC1N(CCNc2nc(ccc12)C(F)(F)F)C(=O)Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C25H22F3N3O4/c26-25(27,28)21-10-9-19-20(15-23(33)34)31(12-11-29-24(19)30-21)22(32)14-16-5-4-8-18(13-16)35-17-6-2-1-3-7-17/h1-10,13,20H,11-12,14-15H2,(H,29,30)(H,33,34)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 13n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447498
PNG
(CHEMBL3115398)
Show SMILES Fc1cccc(Oc2cccc(CC(=O)N3CCNc4nc(ccc4C3)C(F)(F)F)c2)c1
Show InChI InChI=1S/C23H19F4N3O2/c24-17-4-2-6-19(13-17)32-18-5-1-3-15(11-18)12-21(31)30-10-9-28-22-16(14-30)7-8-20(29-22)23(25,26)27/h1-8,11,13H,9-10,12,14H2,(H,28,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.80n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
BRS3


(HUMAN)
BDBM50447502
PNG
(CHEMBL3115394)
Show SMILES FC(F)(F)c1ccc2CN(C(=O)Cc3cccc(Oc4ccccc4)c3)c3ccccc3Nc2n1
Show InChI InChI=1S/C27H20F3N3O2/c28-27(29,30)24-14-13-19-17-33(23-12-5-4-11-22(23)31-26(19)32-24)25(34)16-18-7-6-10-21(15-18)35-20-8-2-1-3-9-20/h1-15H,16-17H2,(H,31,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 25n/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay


Bioorg Med Chem Lett 24: 750-5 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.106
BindingDB Entry DOI: 10.7270/Q2J967WH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%