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PubMed code 24507919

Compile data set for download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448230
PNG
(CHEMBL3120819)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C22H29F2N3O4S/c1-21(2,27-32(30,31)17-4-3-15(23)7-16(17)24)11-18(28)26-19-13-5-12-6-14(19)10-22(8-12,9-13)20(25)29/h3-4,7,12-14,19,27H,5-6,8-11H2,1-2H3,(H2,25,29)(H,26,28)/t12?,13?,14?,19-,22-
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n/an/a 1n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448235
PNG
(CHEMBL3120758)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O
Show InChI InChI=1S/C23H32ClN3O4S/c1-13-17(24)5-4-6-18(13)32(30,31)27-22(2,3)12-19(28)26-20-15-7-14-8-16(20)11-23(9-14,10-15)21(25)29/h4-6,14-16,20,27H,7-12H2,1-3H3,(H2,25,29)(H,26,28)/t14?,15?,16?,20-,23-
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n/an/a 1n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448225
PNG
(CHEMBL3120824)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1c(F)cc(F)cc1F
Show InChI InChI=1S/C22H28F3N3O4S/c1-21(2,28-33(31,32)19-15(24)5-14(23)6-16(19)25)10-17(29)27-18-12-3-11-4-13(18)9-22(7-11,8-12)20(26)30/h5-6,11-13,18,28H,3-4,7-10H2,1-2H3,(H2,26,30)(H,27,29)/t11?,12?,13?,18-,22-
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n/an/a 1n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448224
PNG
(CHEMBL3120825)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C22H30ClN3O4S/c1-21(2,26-31(29,30)17-5-3-4-16(23)8-17)12-18(27)25-19-14-6-13-7-15(19)11-22(9-13,10-14)20(24)28/h3-5,8,13-15,19,26H,6-7,9-12H2,1-2H3,(H2,24,28)(H,25,27)/t13?,14?,15?,19-,22-
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n/an/a 1n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448231
PNG
(CHEMBL3120818)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C22H29Cl2N3O4S/c1-21(2,27-32(30,31)16-5-3-4-15(23)18(16)24)11-17(28)26-19-13-6-12-7-14(19)10-22(8-12,9-13)20(25)29/h3-5,12-14,19,27H,6-11H2,1-2H3,(H2,25,29)(H,26,28)/t12?,13?,14?,19-,22-
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n/an/a 1n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448229
PNG
(CHEMBL3120820)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1cccc(F)c1F
Show InChI InChI=1S/C22H29F2N3O4S/c1-21(2,27-32(30,31)16-5-3-4-15(23)18(16)24)11-17(28)26-19-13-6-12-7-14(19)10-22(8-12,9-13)20(25)29/h3-5,12-14,19,27H,6-11H2,1-2H3,(H2,25,29)(H,26,28)/t12?,13?,14?,19-,22-
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n/an/a 1n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448232
PNG
(CHEMBL3120817)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1cccc(Cl)c1F
Show InChI InChI=1S/C22H29ClFN3O4S/c1-21(2,27-32(30,31)16-5-3-4-15(23)18(16)24)11-17(28)26-19-13-6-12-7-14(19)10-22(8-12,9-13)20(25)29/h3-5,12-14,19,27H,6-11H2,1-2H3,(H2,25,29)(H,26,28)/t12?,13?,14?,19-,22-
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n/an/a 1n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448221
PNG
(CHEMBL3120828)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H30FN3O4S/c1-21(2,26-31(29,30)17-5-3-16(23)4-6-17)12-18(27)25-19-14-7-13-8-15(19)11-22(9-13,10-14)20(24)28/h3-6,13-15,19,26H,7-12H2,1-2H3,(H2,24,28)(H,25,27)/t13?,14?,15?,19-,22-
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n/an/a 1n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448222
PNG
(CHEMBL3120827)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C22H30FN3O4S/c1-21(2,26-31(29,30)17-5-3-4-16(23)8-17)12-18(27)25-19-14-6-13-7-15(19)11-22(9-13,10-14)20(24)28/h3-5,8,13-15,19,26H,6-7,9-12H2,1-2H3,(H2,24,28)(H,25,27)/t13?,14?,15?,19-,22-
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n/an/a 2n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448223
PNG
(CHEMBL3120826)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C22H30FN3O4S/c1-21(2,26-31(29,30)17-6-4-3-5-16(17)23)12-18(27)25-19-14-7-13-8-15(19)11-22(9-13,10-14)20(24)28/h3-6,13-15,19,26H,7-12H2,1-2H3,(H2,24,28)(H,25,27)/t13?,14?,15?,19-,22-
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n/an/a 2n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448226
PNG
(CHEMBL3120823)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H29F2N3O4S/c1-21(2,27-32(30,31)15-3-4-16(23)17(24)7-15)11-18(28)26-19-13-5-12-6-14(19)10-22(8-12,9-13)20(25)29/h3-4,7,12-14,19,27H,5-6,8-11H2,1-2H3,(H2,25,29)(H,26,28)/t12?,13?,14?,19-,22-
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n/an/a 2n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448227
PNG
(CHEMBL3120822)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1c(F)cccc1F
Show InChI InChI=1S/C22H29F2N3O4S/c1-21(2,27-32(30,31)19-15(23)4-3-5-16(19)24)11-17(28)26-18-13-6-12-7-14(18)10-22(8-12,9-13)20(25)29/h3-5,12-14,18,27H,6-11H2,1-2H3,(H2,25,29)(H,26,28)/t12?,13?,14?,18-,22-
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n/an/a 2n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448237
PNG
(CHEMBL3120755)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2
Show InChI InChI=1S/C22H31ClN2O4S/c1-13-17(23)5-4-6-18(13)30(28,29)25-21(2,3)12-19(26)24-20-15-7-14-8-16(20)11-22(27,9-14)10-15/h4-6,14-16,20,25,27H,7-12H2,1-3H3,(H,24,26)/t14?,15?,16?,20-,22-
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n/an/a 4n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448238
PNG
(CHEMBL3120754)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)NC1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C22H31ClN2O3S/c1-13-18(23)5-4-6-19(13)29(27,28)25-22(2,3)12-20(26)24-21-16-8-14-7-15(10-16)11-17(21)9-14/h4-6,14-17,21,25H,7-12H2,1-3H3,(H,24,26)
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n/an/a 4n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50319665
PNG
((S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-...)
Show SMILES CC(C)[C@]1(C)SC(N[C@H]2C[C@@H]3CC[C@H]2C3)=NC1=O
Show InChI InChI=1S/C14H22N2OS/c1-8(2)14(3)12(17)16-13(18-14)15-11-7-9-4-5-10(11)6-9/h8-11H,4-7H2,1-3H3,(H,15,16,17)/t9-,10+,11+,14+/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448228
PNG
(CHEMBL3120821)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1cc(F)cc(F)c1
Show InChI InChI=1S/C22H29F2N3O4S/c1-21(2,27-32(30,31)17-6-15(23)5-16(24)7-17)11-18(28)26-19-13-3-12-4-14(19)10-22(8-12,9-13)20(25)29/h5-7,12-14,19,27H,3-4,8-11H2,1-2H3,(H2,25,29)(H,26,28)/t12?,13?,14?,19-,22-
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n/an/a 7n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448229
PNG
(CHEMBL3120820)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1cccc(F)c1F
Show InChI InChI=1S/C22H29F2N3O4S/c1-21(2,27-32(30,31)16-5-3-4-15(23)18(16)24)11-17(28)26-19-13-6-12-7-14(19)10-22(8-12,9-13)20(25)29/h3-5,12-14,19,27H,6-11H2,1-2H3,(H2,25,29)(H,26,28)/t12?,13?,14?,19-,22-
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n/an/a 9n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448231
PNG
(CHEMBL3120818)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C22H29Cl2N3O4S/c1-21(2,27-32(30,31)16-5-3-4-15(23)18(16)24)11-17(28)26-19-13-6-12-7-14(19)10-22(8-12,9-13)20(25)29/h3-5,12-14,19,27H,6-11H2,1-2H3,(H2,25,29)(H,26,28)/t12?,13?,14?,19-,22-
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n/an/a 9n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448232
PNG
(CHEMBL3120817)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1cccc(Cl)c1F
Show InChI InChI=1S/C22H29ClFN3O4S/c1-21(2,27-32(30,31)16-5-3-4-15(23)18(16)24)11-17(28)26-19-13-6-12-7-14(19)10-22(8-12,9-13)20(25)29/h3-5,12-14,19,27H,6-11H2,1-2H3,(H2,25,29)(H,26,28)/t12?,13?,14?,19-,22-
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n/an/a 10n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448233
PNG
(CHEMBL3120816)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC1(CC(=O)NC2C3CC4CC(C3)CC2C4)CC1
Show InChI InChI=1S/C22H29ClN2O3S/c1-13-18(23)3-2-4-19(13)29(27,28)25-22(5-6-22)12-20(26)24-21-16-8-14-7-15(10-16)11-17(21)9-14/h2-4,14-17,21,25H,5-12H2,1H3,(H,24,26)
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n/an/a 12n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448235
PNG
(CHEMBL3120758)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O
Show InChI InChI=1S/C23H32ClN3O4S/c1-13-17(24)5-4-6-18(13)32(30,31)27-22(2,3)12-19(28)26-20-15-7-14-8-16(20)11-23(9-14,10-15)21(25)29/h4-6,14-16,20,27H,7-12H2,1-3H3,(H2,25,29)(H,26,28)/t14?,15?,16?,20-,23-
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n/an/a 12n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448227
PNG
(CHEMBL3120822)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1c(F)cccc1F
Show InChI InChI=1S/C22H29F2N3O4S/c1-21(2,27-32(30,31)19-15(23)4-3-5-16(19)24)11-17(28)26-18-13-6-12-7-14(18)10-22(8-12,9-13)20(25)29/h3-5,12-14,18,27H,6-11H2,1-2H3,(H2,25,29)(H,26,28)/t12?,13?,14?,18-,22-
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n/an/a 16n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448223
PNG
(CHEMBL3120826)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C22H30FN3O4S/c1-21(2,26-31(29,30)17-6-4-3-5-16(17)23)12-18(27)25-19-14-7-13-8-15(19)11-22(9-13,10-14)20(24)28/h3-6,13-15,19,26H,7-12H2,1-2H3,(H2,24,28)(H,25,27)/t13?,14?,15?,19-,22-
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n/an/a 21n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448230
PNG
(CHEMBL3120819)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C22H29F2N3O4S/c1-21(2,27-32(30,31)17-4-3-15(23)7-16(17)24)11-18(28)26-19-13-5-12-6-14(19)10-22(8-12,9-13)20(25)29/h3-4,7,12-14,19,27H,5-6,8-11H2,1-2H3,(H2,25,29)(H,26,28)/t12?,13?,14?,19-,22-
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n/an/a 22n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448221
PNG
(CHEMBL3120828)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H30FN3O4S/c1-21(2,26-31(29,30)17-5-3-16(23)4-6-17)12-18(27)25-19-14-7-13-8-15(19)11-22(9-13,10-14)20(24)28/h3-6,13-15,19,26H,7-12H2,1-2H3,(H2,24,28)(H,25,27)/t13?,14?,15?,19-,22-
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n/an/a 24n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448225
PNG
(CHEMBL3120824)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1c(F)cc(F)cc1F
Show InChI InChI=1S/C22H28F3N3O4S/c1-21(2,28-33(31,32)19-15(24)5-14(23)6-16(19)25)10-17(29)27-18-12-3-11-4-13(18)9-22(7-11,8-12)20(26)30/h5-6,11-13,18,28H,3-4,7-10H2,1-2H3,(H2,26,30)(H,27,29)/t11?,12?,13?,18-,22-
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n/an/a 28n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448222
PNG
(CHEMBL3120827)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C22H30FN3O4S/c1-21(2,26-31(29,30)17-5-3-4-16(23)8-17)12-18(27)25-19-14-6-13-7-15(19)11-22(9-13,10-14)20(24)28/h3-5,8,13-15,19,26H,6-7,9-12H2,1-2H3,(H2,24,28)(H,25,27)/t13?,14?,15?,19-,22-
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n/an/a 28n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448224
PNG
(CHEMBL3120825)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C22H30ClN3O4S/c1-21(2,26-31(29,30)17-5-3-4-16(23)8-17)12-18(27)25-19-14-6-13-7-15(19)11-22(9-13,10-14)20(24)28/h3-5,8,13-15,19,26H,6-7,9-12H2,1-2H3,(H2,24,28)(H,25,27)/t13?,14?,15?,19-,22-
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n/an/a 46n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448240
PNG
(CHEMBL3120761)
Show SMILES C[C@H](CC(=O)NC1C2CC3CC(C2)CC1C3)NS(=O)(=O)c1cccc(Cl)c1C
Show InChI InChI=1S/C21H29ClN2O3S/c1-12(24-28(26,27)19-5-3-4-18(22)13(19)2)6-20(25)23-21-16-8-14-7-15(10-16)11-17(21)9-14/h3-5,12,14-17,21,24H,6-11H2,1-2H3,(H,23,25)/t12-,14?,15?,16?,17?,21?/m1/s1
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n/an/a 53n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448234
PNG
(CHEMBL3120759)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O
Show InChI InChI=1S/C23H33ClN2O5S2/c1-14-18(24)6-5-7-19(14)33(30,31)26-22(2,3)13-20(27)25-21-16-8-15-9-17(21)12-23(10-15,11-16)32(4,28)29/h5-7,15-17,21,26H,8-13H2,1-4H3,(H,25,27)/t15?,16?,17?,21-,23-
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n/an/a 54n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448236
PNG
(CHEMBL3120756)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(O)=O
Show InChI InChI=1S/C23H31ClN2O5S/c1-13-17(24)5-4-6-18(13)32(30,31)26-22(2,3)12-19(27)25-20-15-7-14-8-16(20)11-23(9-14,10-15)21(28)29/h4-6,14-16,20,26H,7-12H2,1-3H3,(H,25,27)(H,28,29)/t14?,15?,16?,20-,23-
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n/an/a 57n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448237
PNG
(CHEMBL3120755)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2
Show InChI InChI=1S/C22H31ClN2O4S/c1-13-17(23)5-4-6-18(13)30(28,29)25-21(2,3)12-19(26)24-20-15-7-14-8-16(20)11-22(27,9-14)10-15/h4-6,14-16,20,25,27H,7-12H2,1-3H3,(H,24,26)/t14?,15?,16?,20-,22-
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n/an/a 70n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448239
PNG
(CHEMBL3120753)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H31ClN2O3S/c1-14-18(23)5-4-6-19(14)29(27,28)25-21(2,3)13-20(26)24-22-10-15-7-16(11-22)9-17(8-15)12-22/h4-6,15-17,25H,7-13H2,1-3H3,(H,24,26)
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n/an/a 80n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448241
PNG
(CHEMBL3120760)
Show SMILES C[C@@H](CC(=O)NC1C2CC3CC(C2)CC1C3)NS(=O)(=O)c1cccc(Cl)c1C
Show InChI InChI=1S/C21H29ClN2O3S/c1-12(24-28(26,27)19-5-3-4-18(22)13(19)2)6-20(25)23-21-16-8-14-7-15(10-16)11-17(21)9-14/h3-5,12,14-17,21,24H,6-11H2,1-2H3,(H,23,25)/t12-,14?,15?,16?,17?,21?/m0/s1
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n/an/a 89n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448233
PNG
(CHEMBL3120816)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC1(CC(=O)NC2C3CC4CC(C3)CC2C4)CC1
Show InChI InChI=1S/C22H29ClN2O3S/c1-13-18(23)3-2-4-19(13)29(27,28)25-22(5-6-22)12-20(26)24-21-16-8-14-7-15(10-16)11-17(21)9-14/h2-4,14-17,21,25H,5-12H2,1H3,(H,24,26)
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n/an/a 94n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448228
PNG
(CHEMBL3120821)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1cc(F)cc(F)c1
Show InChI InChI=1S/C22H29F2N3O4S/c1-21(2,27-32(30,31)17-6-15(23)5-16(24)7-17)11-18(28)26-19-13-3-12-4-14(19)10-22(8-12,9-13)20(25)29/h5-7,12-14,19,27H,3-4,8-11H2,1-2H3,(H2,25,29)(H,26,28)/t12?,13?,14?,19-,22-
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n/an/a 99n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448238
PNG
(CHEMBL3120754)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)NC1C2CC3CC(C2)CC1C3
Show InChI InChI=1S/C22H31ClN2O3S/c1-13-18(23)5-4-6-19(13)29(27,28)25-22(2,3)12-20(26)24-21-16-8-14-7-15(10-16)11-17(21)9-14/h4-6,14-17,21,25H,7-12H2,1-3H3,(H,24,26)
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n/an/a 113n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448243
PNG
(CHEMBL3120752)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)NC1CCCCCC1
Show InChI InChI=1S/C19H29ClN2O3S/c1-14-16(20)11-8-12-17(14)26(24,25)22-19(2,3)13-18(23)21-15-9-6-4-5-7-10-15/h8,11-12,15,22H,4-7,9-10,13H2,1-3H3,(H,21,23)
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n/an/a 190n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448226
PNG
(CHEMBL3120823)
Show SMILES CC(C)(CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O)NS(=O)(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H29F2N3O4S/c1-21(2,27-32(30,31)15-3-4-16(23)17(24)7-15)11-18(28)26-19-13-5-12-6-14(19)10-22(8-12,9-13)20(25)29/h3-4,7,12-14,19,27H,5-6,8-11H2,1-2H3,(H2,25,29)(H,26,28)/t12?,13?,14?,19-,22-
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n/an/a 196n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448244
PNG
(CHEMBL3120751)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)NC1CCCCC1
Show InChI InChI=1S/C18H27ClN2O3S/c1-13-15(19)10-7-11-16(13)25(23,24)21-18(2,3)12-17(22)20-14-8-5-4-6-9-14/h7,10-11,14,21H,4-6,8-9,12H2,1-3H3,(H,20,22)
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n/an/a 390n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50319665
PNG
((S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-...)
Show SMILES CC(C)[C@]1(C)SC(N[C@H]2C[C@@H]3CC[C@H]2C3)=NC1=O
Show InChI InChI=1S/C14H22N2OS/c1-8(2)14(3)12(17)16-13(18-14)15-11-7-9-4-5-10(11)6-9/h8-11H,4-7H2,1-3H3,(H,15,16,17)/t9-,10+,11+,14+/m1/s1
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n/an/a 470n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448239
PNG
(CHEMBL3120753)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H31ClN2O3S/c1-14-18(23)5-4-6-19(14)29(27,28)25-21(2,3)13-20(26)24-22-10-15-7-16(11-22)9-17(8-15)12-22/h4-6,15-17,25H,7-13H2,1-3H3,(H,24,26)
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n/an/a 640n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448234
PNG
(CHEMBL3120759)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O
Show InChI InChI=1S/C23H33ClN2O5S2/c1-14-18(24)6-5-7-19(14)33(30,31)26-22(2,3)13-20(27)25-21-16-8-15-9-17(21)12-23(10-15,11-16)32(4,28)29/h5-7,15-17,21,26H,8-13H2,1-4H3,(H,25,27)/t15?,16?,17?,21-,23-
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n/an/a>1.00E+3n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Mus musculus (mouse))
BDBM50448236
PNG
(CHEMBL3120756)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(O)=O
Show InChI InChI=1S/C23H31ClN2O5S/c1-13-17(24)5-4-6-18(13)32(30,31)26-22(2,3)12-19(27)25-20-15-7-14-8-16(20)11-23(9-14,10-15)21(28)29/h4-6,14-16,20,26H,7-12H2,1-3H3,(H,25,27)(H,28,29)/t14?,15?,16?,20-,23-
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n/an/a>1.00E+3n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in mouse liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM50448242
PNG
(CHEMBL3120757)
Show SMILES Cc1c(Cl)cccc1S(=O)(=O)NC(C)(C)CC(=O)N[C@H]1C2CC3CC1C[C@@](C3)(C2)C(N)=O
Show InChI InChI=1S/C23H32ClN3O4S/c1-13-17(24)5-4-6-18(13)32(30,31)27-22(2,3)12-19(28)26-20-15-7-14-8-16(20)11-23(9-14,10-15)21(25)29/h4-6,14-16,20,27H,7-12H2,1-3H3,(H2,25,29)(H,26,28)/t14?,15?,16?,20-,23+
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n/an/a>1.00E+3n/an/an/an/an/an/a



Yonsei University

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human liver microsomes using cortisone as substrate after 2 hrs by HTRF assay


Bioorg Med Chem Lett 24: 1421-5 (2014)


Article DOI: 10.1016/j.bmcl.2014.01.017
BindingDB Entry DOI: 10.7270/Q2BG2QG8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%