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PubMed code 24560540

Compile data set for download or QSAR
Found 119 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449292
PNG
(CHEMBL3125395)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21BrN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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n/an/a 3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449305
PNG
(CHEMBL3125379)
Show SMILES CC1Cc2c(cccc2Cl)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20ClN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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n/an/a 8n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449311
PNG
(CHEMBL3125384)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20BrN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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n/an/a 10n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449293
PNG
(CHEMBL3125394)
Show SMILES CC1Cc2c(cccc2Cl)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21ClN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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n/an/a 10n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449312
PNG
(CHEMBL3125390)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Br)N1CCOCC1
Show InChI InChI=1S/C18H19BrN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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n/an/a 11n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449301
PNG
(CHEMBL3125383)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Br)N1CCOCC1
Show InChI InChI=1S/C18H18BrN3O4S/c19-12-2-1-3-14-11(12)4-5-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-6-8-26-9-7-21/h1-3H,4-10H2,(H,24,25)
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n/an/a 11n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449293
PNG
(CHEMBL3125394)
Show SMILES CC1Cc2c(cccc2Cl)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21ClN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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n/an/a 13n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449292
PNG
(CHEMBL3125395)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21BrN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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n/an/a 13n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449291
PNG
(CHEMBL3125375)
Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21FN4O3S/c1-11-8-12-9-13(20)2-3-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-4-6-27-7-5-23/h2-3,9,11H,4-8,10H2,1H3,(H2,21,26)
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n/an/a 14n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449296
PNG
(CHEMBL3125391)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(F)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19FN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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n/an/a 15n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449303
PNG
(CHEMBL3125381)
Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20FN3O4S/c1-11-8-12-9-13(20)2-3-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-4-6-27-7-5-22/h2-3,9,11H,4-8,10H2,1H3,(H,25,26)
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n/an/a 15n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449292
PNG
(CHEMBL3125395)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21BrN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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n/an/a 17n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449291
PNG
(CHEMBL3125375)
Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21FN4O3S/c1-11-8-12-9-13(20)2-3-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-4-6-27-7-5-23/h2-3,9,11H,4-8,10H2,1H3,(H2,21,26)
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n/an/a 20n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449312
PNG
(CHEMBL3125390)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Br)N1CCOCC1
Show InChI InChI=1S/C18H19BrN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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n/an/a 22n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449296
PNG
(CHEMBL3125391)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(F)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19FN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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n/an/a 22n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449306
PNG
(CHEMBL3125378)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Cl)N1CCOCC1
Show InChI InChI=1S/C18H18ClN3O4S/c19-12-2-1-3-14-11(12)4-5-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-6-8-26-9-7-21/h1-3H,4-10H2,(H,24,25)
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n/an/a 23n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449304
PNG
(CHEMBL3125380)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2cc(F)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H18FN3O4S/c19-12-1-2-14-11(9-12)3-4-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-5-7-26-8-6-21/h1-2,9H,3-8,10H2,(H,24,25)
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n/an/a 25n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449300
PNG
(CHEMBL3125385)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C18H20N4O3S/c19-17(24)16-13(20-18(26-16)21-7-9-25-10-8-21)11-15(23)22-6-5-12-3-1-2-4-14(12)22/h1-4H,5-11H2,(H2,19,24)
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n/an/a 25n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449298
PNG
(CHEMBL3125388)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2F)N1CCOCC1
Show InChI InChI=1S/C18H19FN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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n/an/a 38n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449299
PNG
(CHEMBL3125386)
Show SMILES CC1Cc2ccccc2N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H22N4O3S/c1-12-10-13-4-2-3-5-15(13)23(12)16(24)11-14-17(18(20)25)27-19(21-14)22-6-8-26-9-7-22/h2-5,12H,6-11H2,1H3,(H2,20,25)
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n/an/a 40n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449309
PNG
(CHEMBL3125541)
Show SMILES NC(=O)c1sc(nc1CC(=O)Nc1ccc(F)c(Cl)c1)N1CCOCC1
Show InChI InChI=1S/C16H16ClFN4O3S/c17-10-7-9(1-2-11(10)18)20-13(23)8-12-14(15(19)24)26-16(21-12)22-3-5-25-6-4-22/h1-2,7H,3-6,8H2,(H2,19,24)(H,20,23)
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n/an/a 45n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449297
PNG
(CHEMBL3125389)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Cl)N1CCOCC1
Show InChI InChI=1S/C18H19ClN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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n/an/a 49n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449292
PNG
(CHEMBL3125395)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21BrN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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n/an/a 58n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449293
PNG
(CHEMBL3125394)
Show SMILES CC1Cc2c(cccc2Cl)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21ClN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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n/an/a 58n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449311
PNG
(CHEMBL3125384)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20BrN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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n/an/a 63n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449304
PNG
(CHEMBL3125380)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2cc(F)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H18FN3O4S/c19-12-1-2-14-11(9-12)3-4-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-5-7-26-8-6-21/h1-2,9H,3-8,10H2,(H,24,25)
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n/an/a 64n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449300
PNG
(CHEMBL3125385)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C18H20N4O3S/c19-17(24)16-13(20-18(26-16)21-7-9-25-10-8-21)11-15(23)22-6-5-12-3-1-2-4-14(12)22/h1-4H,5-11H2,(H2,19,24)
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n/an/a 71n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449310
PNG
(CHEMBL3125387)
Show SMILES CC1CN(C(=O)Cc2nc(sc2C(N)=O)N2CCOCC2)c2ccccc12
Show InChI InChI=1S/C19H22N4O3S/c1-12-11-23(15-5-3-2-4-13(12)15)16(24)10-14-17(18(20)25)27-19(21-14)22-6-8-26-9-7-22/h2-5,12H,6-11H2,1H3,(H2,20,25)
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n/an/a 75n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449311
PNG
(CHEMBL3125384)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20BrN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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n/an/a 84n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449292
PNG
(CHEMBL3125395)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21BrN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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n/an/a 92n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449295
PNG
(CHEMBL3125392)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(Cl)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19ClN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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n/an/a 110n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449297
PNG
(CHEMBL3125389)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Cl)N1CCOCC1
Show InChI InChI=1S/C18H19ClN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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n/an/a 122n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449291
PNG
(CHEMBL3125375)
Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21FN4O3S/c1-11-8-12-9-13(20)2-3-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-4-6-27-7-5-23/h2-3,9,11H,4-8,10H2,1H3,(H2,21,26)
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n/an/a 127n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449310
PNG
(CHEMBL3125387)
Show SMILES CC1CN(C(=O)Cc2nc(sc2C(N)=O)N2CCOCC2)c2ccccc12
Show InChI InChI=1S/C19H22N4O3S/c1-12-11-23(15-5-3-2-4-13(12)15)16(24)10-14-17(18(20)25)27-19(21-14)22-6-8-26-9-7-22/h2-5,12H,6-11H2,1H3,(H2,20,25)
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n/an/a 130n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449301
PNG
(CHEMBL3125383)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Br)N1CCOCC1
Show InChI InChI=1S/C18H18BrN3O4S/c19-12-2-1-3-14-11(12)4-5-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-6-8-26-9-7-21/h1-3H,4-10H2,(H,24,25)
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n/an/a 133n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449296
PNG
(CHEMBL3125391)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(F)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19FN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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n/an/a 134n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449298
PNG
(CHEMBL3125388)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2F)N1CCOCC1
Show InChI InChI=1S/C18H19FN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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n/an/a 138n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449311
PNG
(CHEMBL3125384)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20BrN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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n/an/a 140n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449305
PNG
(CHEMBL3125379)
Show SMILES CC1Cc2c(cccc2Cl)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20ClN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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n/an/a 149n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449295
PNG
(CHEMBL3125392)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(Cl)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19ClN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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n/an/a 166n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449299
PNG
(CHEMBL3125386)
Show SMILES CC1Cc2ccccc2N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H22N4O3S/c1-12-10-13-4-2-3-5-15(13)23(12)16(24)11-14-17(18(20)25)27-19(21-14)22-6-8-26-9-7-22/h2-5,12H,6-11H2,1H3,(H2,20,25)
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n/an/a 178n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449312
PNG
(CHEMBL3125390)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Br)N1CCOCC1
Show InChI InChI=1S/C18H19BrN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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n/an/a 178n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449303
PNG
(CHEMBL3125381)
Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20FN3O4S/c1-11-8-12-9-13(20)2-3-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-4-6-27-7-5-22/h2-3,9,11H,4-8,10H2,1H3,(H,25,26)
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n/an/a 219n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449309
PNG
(CHEMBL3125541)
Show SMILES NC(=O)c1sc(nc1CC(=O)Nc1ccc(F)c(Cl)c1)N1CCOCC1
Show InChI InChI=1S/C16H16ClFN4O3S/c17-10-7-9(1-2-11(10)18)20-13(23)8-12-14(15(19)24)26-16(21-12)22-3-5-25-6-4-22/h1-2,7H,3-6,8H2,(H2,19,24)(H,20,23)
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n/an/a 227n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449300
PNG
(CHEMBL3125385)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C18H20N4O3S/c19-17(24)16-13(20-18(26-16)21-7-9-25-10-8-21)11-15(23)22-6-5-12-3-1-2-4-14(12)22/h1-4H,5-11H2,(H2,19,24)
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n/an/a 230n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449294
PNG
(CHEMBL3125393)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(Br)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19BrN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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n/an/a 240n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449306
PNG
(CHEMBL3125378)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Cl)N1CCOCC1
Show InChI InChI=1S/C18H18ClN3O4S/c19-12-2-1-3-14-11(12)4-5-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-6-8-26-9-7-21/h1-3H,4-10H2,(H,24,25)
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n/an/a 245n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449308
PNG
(CHEMBL3125376)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C18H19N3O4S/c22-15(21-6-5-12-3-1-2-4-14(12)21)11-13-16(17(23)24)26-18(19-13)20-7-9-25-10-8-20/h1-4H,5-11H2,(H,23,24)
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n/an/a 270n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449297
PNG
(CHEMBL3125389)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Cl)N1CCOCC1
Show InChI InChI=1S/C18H19ClN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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n/an/a 277n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449311
PNG
(CHEMBL3125384)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20BrN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449302
PNG
(CHEMBL3125382)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2cc(Br)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H18BrN3O4S/c19-12-1-2-14-11(9-12)3-4-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-5-7-26-8-6-21/h1-2,9H,3-8,10H2,(H,24,25)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449307
PNG
(CHEMBL3125377)
Show SMILES CC1Cc2ccccc2N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H21N3O4S/c1-12-10-13-4-2-3-5-15(13)22(12)16(23)11-14-17(18(24)25)27-19(20-14)21-6-8-26-9-7-21/h2-5,12H,6-11H2,1H3,(H,24,25)
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n/an/a 340n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kbeta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449311
PNG
(CHEMBL3125384)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20BrN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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n/an/a 395n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449294
PNG
(CHEMBL3125393)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(Br)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19BrN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449292
PNG
(CHEMBL3125395)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21BrN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449299
PNG
(CHEMBL3125386)
Show SMILES CC1Cc2ccccc2N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H22N4O3S/c1-12-10-13-4-2-3-5-15(13)23(12)16(24)11-14-17(18(20)25)27-19(21-14)22-6-8-26-9-7-22/h2-5,12H,6-11H2,1H3,(H2,20,25)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449294
PNG
(CHEMBL3125393)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(Br)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19BrN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449298
PNG
(CHEMBL3125388)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2F)N1CCOCC1
Show InChI InChI=1S/C18H19FN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449310
PNG
(CHEMBL3125387)
Show SMILES CC1CN(C(=O)Cc2nc(sc2C(N)=O)N2CCOCC2)c2ccccc12
Show InChI InChI=1S/C19H22N4O3S/c1-12-11-23(15-5-3-2-4-13(12)15)16(24)10-14-17(18(20)25)27-19(21-14)22-6-8-26-9-7-22/h2-5,12H,6-11H2,1H3,(H2,20,25)
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n/an/a 567n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449303
PNG
(CHEMBL3125381)
Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20FN3O4S/c1-11-8-12-9-13(20)2-3-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-4-6-27-7-5-22/h2-3,9,11H,4-8,10H2,1H3,(H,25,26)
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n/an/a 817n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449311
PNG
(CHEMBL3125384)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20BrN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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n/an/a 861n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449305
PNG
(CHEMBL3125379)
Show SMILES CC1Cc2c(cccc2Cl)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20ClN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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n/an/a 876n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449302
PNG
(CHEMBL3125382)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2cc(Br)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H18BrN3O4S/c19-12-1-2-14-11(9-12)3-4-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-5-7-26-8-6-21/h1-2,9H,3-8,10H2,(H,24,25)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449301
PNG
(CHEMBL3125383)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Br)N1CCOCC1
Show InChI InChI=1S/C18H18BrN3O4S/c19-12-2-1-3-14-11(12)4-5-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-6-8-26-9-7-21/h1-3H,4-10H2,(H,24,25)
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n/an/a 1.12E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449292
PNG
(CHEMBL3125395)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21BrN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449292
PNG
(CHEMBL3125395)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21BrN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449308
PNG
(CHEMBL3125376)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C18H19N3O4S/c22-15(21-6-5-12-3-1-2-4-14(12)21)11-13-16(17(23)24)26-18(19-13)20-7-9-25-10-8-20/h1-4H,5-11H2,(H,23,24)
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n/an/a 1.42E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449308
PNG
(CHEMBL3125376)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C18H19N3O4S/c22-15(21-6-5-12-3-1-2-4-14(12)21)11-13-16(17(23)24)26-18(19-13)20-7-9-25-10-8-20/h1-4H,5-11H2,(H,23,24)
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n/an/a 1.56E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449304
PNG
(CHEMBL3125380)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2cc(F)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H18FN3O4S/c19-12-1-2-14-11(9-12)3-4-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-5-7-26-8-6-21/h1-2,9H,3-8,10H2,(H,24,25)
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n/an/a 1.73E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449301
PNG
(CHEMBL3125383)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Br)N1CCOCC1
Show InChI InChI=1S/C18H18BrN3O4S/c19-12-2-1-3-14-11(12)4-5-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-6-8-26-9-7-21/h1-3H,4-10H2,(H,24,25)
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n/an/a 1.78E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449295
PNG
(CHEMBL3125392)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(Cl)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19ClN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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n/an/a 1.86E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449306
PNG
(CHEMBL3125378)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Cl)N1CCOCC1
Show InChI InChI=1S/C18H18ClN3O4S/c19-12-2-1-3-14-11(12)4-5-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-6-8-26-9-7-21/h1-3H,4-10H2,(H,24,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449312
PNG
(CHEMBL3125390)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Br)N1CCOCC1
Show InChI InChI=1S/C18H19BrN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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n/an/a 2.15E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449306
PNG
(CHEMBL3125378)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Cl)N1CCOCC1
Show InChI InChI=1S/C18H18ClN3O4S/c19-12-2-1-3-14-11(12)4-5-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-6-8-26-9-7-21/h1-3H,4-10H2,(H,24,25)
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n/an/a 2.21E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449307
PNG
(CHEMBL3125377)
Show SMILES CC1Cc2ccccc2N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H21N3O4S/c1-12-10-13-4-2-3-5-15(13)22(12)16(23)11-14-17(18(24)25)27-19(20-14)21-6-8-26-9-7-21/h2-5,12H,6-11H2,1H3,(H,24,25)
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n/an/a 2.31E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM50449307
PNG
(CHEMBL3125377)
Show SMILES CC1Cc2ccccc2N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H21N3O4S/c1-12-10-13-4-2-3-5-15(13)22(12)16(23)11-14-17(18(24)25)27-19(20-14)21-6-8-26-9-7-21/h2-5,12H,6-11H2,1H3,(H,24,25)
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n/an/a 2.72E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kdelta after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (human))
BDBM50449302
PNG
(CHEMBL3125382)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2cc(Br)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H18BrN3O4S/c19-12-1-2-14-11(9-12)3-4-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-5-7-26-8-6-21/h1-2,9H,3-8,10H2,(H,24,25)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449311
PNG
(CHEMBL3125384)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20BrN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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n/an/a 3.11E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449292
PNG
(CHEMBL3125395)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21BrN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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n/an/a 3.26E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449300
PNG
(CHEMBL3125385)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C18H20N4O3S/c19-17(24)16-13(20-18(26-16)21-7-9-25-10-8-21)11-15(23)22-6-5-12-3-1-2-4-14(12)22/h1-4H,5-11H2,(H2,19,24)
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n/an/a 4.08E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449310
PNG
(CHEMBL3125387)
Show SMILES CC1CN(C(=O)Cc2nc(sc2C(N)=O)N2CCOCC2)c2ccccc12
Show InChI InChI=1S/C19H22N4O3S/c1-12-11-23(15-5-3-2-4-13(12)15)16(24)10-14-17(18(20)25)27-19(21-14)22-6-8-26-9-7-22/h2-5,12H,6-11H2,1H3,(H2,20,25)
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n/an/a 4.20E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449311
PNG
(CHEMBL3125384)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20BrN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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n/an/a 4.35E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449297
PNG
(CHEMBL3125389)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Cl)N1CCOCC1
Show InChI InChI=1S/C18H19ClN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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n/an/a 6.33E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449296
PNG
(CHEMBL3125391)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(F)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19FN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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n/an/a 6.97E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449298
PNG
(CHEMBL3125388)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2F)N1CCOCC1
Show InChI InChI=1S/C18H19FN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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n/an/a 7.23E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449312
PNG
(CHEMBL3125390)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Br)N1CCOCC1
Show InChI InChI=1S/C18H19BrN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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n/an/a 8.14E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449309
PNG
(CHEMBL3125541)
Show SMILES NC(=O)c1sc(nc1CC(=O)Nc1ccc(F)c(Cl)c1)N1CCOCC1
Show InChI InChI=1S/C16H16ClFN4O3S/c17-10-7-9(1-2-11(10)18)20-13(23)8-12-14(15(19)24)26-16(21-12)22-3-5-25-6-4-22/h1-2,7H,3-6,8H2,(H2,19,24)(H,20,23)
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n/an/a 8.28E+3n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449291
PNG
(CHEMBL3125375)
Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21FN4O3S/c1-11-8-12-9-13(20)2-3-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-4-6-27-7-5-23/h2-3,9,11H,4-8,10H2,1H3,(H2,21,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449307
PNG
(CHEMBL3125377)
Show SMILES CC1Cc2ccccc2N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H21N3O4S/c1-12-10-13-4-2-3-5-15(13)22(12)16(23)11-14-17(18(24)25)27-19(20-14)21-6-8-26-9-7-21/h2-5,12H,6-11H2,1H3,(H,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449308
PNG
(CHEMBL3125376)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C18H19N3O4S/c22-15(21-6-5-12-3-1-2-4-14(12)21)11-13-16(17(23)24)26-18(19-13)20-7-9-25-10-8-20/h1-4H,5-11H2,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449310
PNG
(CHEMBL3125387)
Show SMILES CC1CN(C(=O)Cc2nc(sc2C(N)=O)N2CCOCC2)c2ccccc12
Show InChI InChI=1S/C19H22N4O3S/c1-12-11-23(15-5-3-2-4-13(12)15)16(24)10-14-17(18(20)25)27-19(21-14)22-6-8-26-9-7-22/h2-5,12H,6-11H2,1H3,(H2,20,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449294
PNG
(CHEMBL3125393)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(Br)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19BrN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449295
PNG
(CHEMBL3125392)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(Cl)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19ClN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449297
PNG
(CHEMBL3125389)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Cl)N1CCOCC1
Show InChI InChI=1S/C18H19ClN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449304
PNG
(CHEMBL3125380)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2cc(F)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H18FN3O4S/c19-12-1-2-14-11(9-12)3-4-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-5-7-26-8-6-21/h1-2,9H,3-8,10H2,(H,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449302
PNG
(CHEMBL3125382)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2cc(Br)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H18BrN3O4S/c19-12-1-2-14-11(9-12)3-4-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-5-7-26-8-6-21/h1-2,9H,3-8,10H2,(H,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449303
PNG
(CHEMBL3125381)
Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20FN3O4S/c1-11-8-12-9-13(20)2-3-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-4-6-27-7-5-22/h2-3,9,11H,4-8,10H2,1H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449304
PNG
(CHEMBL3125380)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2cc(F)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H18FN3O4S/c19-12-1-2-14-11(9-12)3-4-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-5-7-26-8-6-21/h1-2,9H,3-8,10H2,(H,24,25)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449299
PNG
(CHEMBL3125386)
Show SMILES CC1Cc2ccccc2N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H22N4O3S/c1-12-10-13-4-2-3-5-15(13)23(12)16(24)11-14-17(18(20)25)27-19(21-14)22-6-8-26-9-7-22/h2-5,12H,6-11H2,1H3,(H2,20,25)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449293
PNG
(CHEMBL3125394)
Show SMILES CC1Cc2c(cccc2Cl)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21ClN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449296
PNG
(CHEMBL3125391)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(F)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19FN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449298
PNG
(CHEMBL3125388)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2F)N1CCOCC1
Show InChI InChI=1S/C18H19FN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449295
PNG
(CHEMBL3125392)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(Cl)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19ClN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449305
PNG
(CHEMBL3125379)
Show SMILES CC1Cc2c(cccc2Cl)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20ClN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449305
PNG
(CHEMBL3125379)
Show SMILES CC1Cc2c(cccc2Cl)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20ClN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449306
PNG
(CHEMBL3125378)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Cl)N1CCOCC1
Show InChI InChI=1S/C18H18ClN3O4S/c19-12-2-1-3-14-11(12)4-5-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-6-8-26-9-7-21/h1-3H,4-10H2,(H,24,25)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449309
PNG
(CHEMBL3125541)
Show SMILES NC(=O)c1sc(nc1CC(=O)Nc1ccc(F)c(Cl)c1)N1CCOCC1
Show InChI InChI=1S/C16H16ClFN4O3S/c17-10-7-9(1-2-11(10)18)20-13(23)8-12-14(15(19)24)26-16(21-12)22-3-5-25-6-4-22/h1-2,7H,3-6,8H2,(H2,19,24)(H,20,23)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449293
PNG
(CHEMBL3125394)
Show SMILES CC1Cc2c(cccc2Cl)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21ClN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449294
PNG
(CHEMBL3125393)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(Br)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H19BrN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449299
PNG
(CHEMBL3125386)
Show SMILES CC1Cc2ccccc2N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H22N4O3S/c1-12-10-13-4-2-3-5-15(13)23(12)16(24)11-14-17(18(20)25)27-19(21-14)22-6-8-26-9-7-22/h2-5,12H,6-11H2,1H3,(H2,20,25)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449311
PNG
(CHEMBL3125384)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20BrN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449291
PNG
(CHEMBL3125375)
Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21FN4O3S/c1-11-8-12-9-13(20)2-3-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-4-6-27-7-5-23/h2-3,9,11H,4-8,10H2,1H3,(H2,21,26)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449292
PNG
(CHEMBL3125395)
Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1
Show InChI InChI=1S/C19H21BrN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449300
PNG
(CHEMBL3125385)
Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C18H20N4O3S/c19-17(24)16-13(20-18(26-16)21-7-9-25-10-8-21)11-15(23)22-6-5-12-3-1-2-4-14(12)22/h1-4H,5-11H2,(H2,19,24)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449302
PNG
(CHEMBL3125382)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2cc(Br)ccc12)N1CCOCC1
Show InChI InChI=1S/C18H18BrN3O4S/c19-12-1-2-14-11(9-12)3-4-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-5-7-26-8-6-21/h1-2,9H,3-8,10H2,(H,24,25)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449303
PNG
(CHEMBL3125381)
Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H20FN3O4S/c1-11-8-12-9-13(20)2-3-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-4-6-27-7-5-22/h2-3,9,11H,4-8,10H2,1H3,(H,25,26)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449307
PNG
(CHEMBL3125377)
Show SMILES CC1Cc2ccccc2N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1
Show InChI InChI=1S/C19H21N3O4S/c1-12-10-13-4-2-3-5-15(13)22(12)16(23)11-14-17(18(24)25)27-19(20-14)21-6-8-26-9-7-21/h2-5,12H,6-11H2,1H3,(H,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (human))
BDBM50449308
PNG
(CHEMBL3125376)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C18H19N3O4S/c22-15(21-6-5-12-3-1-2-4-14(12)21)11-13-16(17(23)24)26-18(19-13)20-7-9-25-10-8-20/h1-4H,5-11H2,(H,23,24)
PDB
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kalpha after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50449301
PNG
(CHEMBL3125383)
Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Br)N1CCOCC1
Show InChI InChI=1S/C18H18BrN3O4S/c19-12-2-1-3-14-11(12)4-5-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-6-8-26-9-7-21/h1-3H,4-10H2,(H,24,25)
PDB
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UniProtKB/SwissProt

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DrugBank
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human PI3Kgamma after 15 mins


Bioorg Med Chem Lett 24: 1506-10 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.004
BindingDB Entry DOI: 10.7270/Q25H7HR2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%