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PubMed code 24583357

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50044260
PNG
(CHEMBL3310053)
Show SMILES Cc1ncc(n1CCOc1ncnc2ccccc12)[N+]([O-])=O
Show InChI InChI=1S/C14H13N5O3/c1-10-15-8-13(19(20)21)18(10)6-7-22-14-11-4-2-3-5-12(11)16-9-17-14/h2-5,8-9H,6-7H2,1H3
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Article
PubMed
n/an/a 2.70n/an/an/an/an/an/a



Quaid-i-Azam University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin)


Eur J Med Chem 76: 193-244 (2014)


Article DOI: 10.1016/j.ejmech.2014.02.005
BindingDB Entry DOI: 10.7270/Q26T0P8M
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50044259
PNG
(CHEMBL3310052)
Show SMILES Oc1ncnc2c(ccc(Nc3ccc(NC(=O)Nc4ccc(cc4Cl)C(F)(F)F)cc3)c12)[N+]([O-])=O
Show InChI InChI=1S/C22H14ClF3N6O4/c23-14-9-11(22(24,25)26)1-6-15(14)31-21(34)30-13-4-2-12(3-5-13)29-16-7-8-17(32(35)36)19-18(16)20(33)28-10-27-19/h1-10,29H,(H,27,28,33)(H2,30,31,34)
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n/an/a 12n/an/an/an/an/an/a



Quaid-i-Azam University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin)


Eur J Med Chem 76: 193-244 (2014)


Article DOI: 10.1016/j.ejmech.2014.02.005
BindingDB Entry DOI: 10.7270/Q26T0P8M
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50044261
PNG
(CHEMBL3310054)
Show SMILES Brc1ccc(Nc2ncnc3ccc(NC(=O)Cc4cccc(Br)c4)cc23)cc1
Show InChI InChI=1S/C22H16Br2N4O/c23-15-4-6-17(7-5-15)28-22-19-12-18(8-9-20(19)25-13-26-22)27-21(29)11-14-2-1-3-16(24)10-14/h1-10,12-13H,11H2,(H,27,29)(H,25,26,28)
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n/an/a 27n/an/an/an/an/an/a



Quaid-i-Azam University

Curated by ChEMBL


Assay Description
Inhibition of c-Src (unknown origin)


Eur J Med Chem 76: 193-244 (2014)


Article DOI: 10.1016/j.ejmech.2014.02.005
BindingDB Entry DOI: 10.7270/Q26T0P8M
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50331095
PNG
(CHEMBL1289494 | Tivozanib)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
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Article
PubMed
n/an/a 340n/an/an/an/an/an/a



Quaid-i-Azam University

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 (unknown origin)


Eur J Med Chem 76: 193-244 (2014)


Article DOI: 10.1016/j.ejmech.2014.02.005
BindingDB Entry DOI: 10.7270/Q26T0P8M
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%