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PubMed code 24634219

Compile data set for download or QSAR
Found 2 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tumor necrosis factor


(Homo sapiens (Human))
BDBM50103596
PNG
((E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phen...)
Show SMILES OC(=O)c1cc(ccc1O)\N=N\c1ccc(cc1)S(=O)(=O)Nc1ccccn1
Show InChI InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
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MMDB

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PC cid
PC sid
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Similars

Article
PubMed
n/an/an/a 9.00E+3n/an/an/a7.0n/a



Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College



Assay Description
Surface plasmon resonance (SPR) assays were carried out on a BIAcore 3000 instrument (Biacore, Inc). Briefly, purified hTNFα was dissolved at 32...


J Biol Chem 289: 12457-66 (2014)


Article DOI: 10.1074/jbc.M113.521708
BindingDB Entry DOI: 10.7270/Q2J9658M
More data for this
Ligand-Target Pair
Tumor necrosis factor


(Homo sapiens (Human))
BDBM228654
PNG
((E)-4-(2-(4-chloro-3-nitrophenyl)) (C87))
Show SMILES [O-][N+](=O)c1cc(N\N=C2\C(=O)N(N=C2c2ccccc2)c2nc(cs2)-c2ccccc2)ccc1Cl
Show InChI InChI=1S/C24H15ClN6O3S/c25-18-12-11-17(13-20(18)31(33)34)27-28-22-21(16-9-5-2-6-10-16)29-30(23(22)32)24-26-19(14-35-24)15-7-3-1-4-8-15/h1-14,27H/b28-22+
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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 110n/an/an/a7.0n/a



Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College



Assay Description
Surface plasmon resonance (SPR) assays were carried out on a BIAcore 3000 instrument (Biacore, Inc). Briefly, purified hTNFα was dissolved at 32...


J Biol Chem 289: 12457-66 (2014)


Article DOI: 10.1074/jbc.M113.521708
BindingDB Entry DOI: 10.7270/Q2J9658M
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%